الصفحة 2
الصفحة 2
Formulating poorly water soluble drugs
A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
Flux-corrected transport : Principles, algorithms, and applications
Addressing students and researchers as well as CFD practitioners, this book describes the state of the art in the development of high-resolution schemes based on the Flux-Corrected Transport (FCT) paradigm. Intended for readers who have a solid background in Computational Fluid Dynamics, the book begins with historical notes by J.P. Boris and D.L. Book. Review articles that follow describe recent advances in the design of FCT algorithms as well as various algorithmic aspects. The topics addressed in the book and its main highlights include: the derivation and analysis of classical FCT schemes with special emphasis on the underlying physical and mathematical constraints; flux limiting for hyperbolic systems; generalization of FCT to implicit time-stepping and finite element discretizations on unstructured meshes and its role as a subgrid scale model for Monotonically Integrated Large Eddy Simulation (MILES) of turbulent flows. The proposed enhancements of the FCT methodology also comprise the prelimiting and 'failsafe' adjustment of antidiffusive fluxes, the use of characteristic variables, and iterative flux correction. The cause and cure of detrimental clipping/terracing effects are discussed. Many numerical examples are presented for academic test problems and large-scale applications alike.
Flower Breeding and Genetics : Issues, Challenges and Opportunities for the 21st Century
This book provides a unique and valuable resource on the many issues and challenges facing flower breeders, as well as the industry at-large. In this volume, the first comprehensive assemblage of its kind, a team of 32 international authorities has contributed to make this book a ‘must-have’ reference to research and develop flower crops for the 21st century consumers. Part 1 of this book (flower breeding program issues) contains unique features of interest to horticultural professionals and students, include coverage of plant protection strategies, cultivar trialing methodology, germplasm collection/preservation, preventing invasiveness, and other timely topics. The collective body of knowledge for 24 flower crops (Part 2: Crop-specific Breeding and Genetics) represents the in-depth science and art of breeding technology available for bedding plants, flowering potted plants, cut flowers, and herbaceous perennials. Each author provides crop-specific history, evolution, biology, taxonomy, state-of-the-art breeding/genetics, classical/molecular technologies, species traits, interspecific hybridization, and directions for future development/enhancement.
Flexibility : A concise guide to conditioning, performance enhancement, injury prevention, and rehabilitation
This groundbreaking book is a definitive guide to flexibility and revises the conceptual framework of the field. In Flexibility: A Concise Guide, the authors provide a fresh perspective on flexibility, one that challenges current thinking and professional practice, from the conceptual foundations of research to the practical applications of stretching techniques in a number of domains.
Expert VB 2005 Business Objects
Rockford Lhotka started writing his Business Objects books in 1996, and over the years, he’s become one of the world's foremost authorities on building distributed object-oriented systems. This second edition of his industry-standard VB .NET Business Objects book not only addresses changes in .NET 2.0 and Visual Studio 2005, but also reflects substantial enhancements and improvements to the CSLA .NET Framework and how it can be used to create enterprise-level .NET applications.
Expert C# 2005 Business Objects
Rockford Lhotka started writing his Business Objects books in 1996, and over the years, he's become one of the world's foremost authorities on building distributed object-oriented systems. His industry-standard VB .NET Business Objects book not only addresses changes in .NET 2.0 and Visual Studio 2005, but also reflects substantial enhancements and improvements to the CSLA .NET Framework and how it can be used to create enterprise-level .NET applications. The depth of Rockford's thinking now influences developers across language boundaries. With this book, you can learn directly from the expert whose framework has become universally accepted and respected.
European Ombudsman-Institutions : A comparative legal analysis regarding the multifaceted realisatin of an idea
This book aims to comprehensively demonstrate the legal basis of parliamentary ombudsman institutions throughout Europe, analysing them in a comparative way and thereby revealing their organisational and functional diversity. It comprises the results of a research project carried out at the University of Vienna under the direction of the editor which was also intended to provide an incentive for the discussion of the legal political enhancement of such institutions.
Empathy in Patient Care : Antecedents, Development, Measurement, and Outcomes
Empathy has long been recognized as a key element of the healing professions. Yet it is not always clear how to define the concept, how to measure it, whether there are effective methods to enhance empathy , or whether empathy really helps make treatment more effective. Drawing on evolutionary research, neurological findings, developmental and psychodynamic perspectives, and systems theory, Empathy in Patient Care explains why this human quality is essential to positive health outcomes—and how it can be measured and how professionals can benefit from its enhancement.
Emerging Conceptual, Ethical and Policy Issues in Bionanotechnology
This volume provides a critical overview of the nature of nanotechnology (and its applications in the biomedical sciences, i.e. bionanotechnology) and the philosophical and ethico-legal issues it raises.
E-Content: Technologies and Perspectives for the European Market
Technologies develop rapidly and reach hurricane levels of velocity but quality E-Content and innovative applications lag behind. This book addresses the question how content industries change within a digital environment and what role information and communication technologies play in transforming the competitive landscape. The authors argue that post-industrial societies tend to pay substantial amounts for equipment and gadgets but invest far too little in the quality of the content. As a result, much effort is and has to be spent on the enhancement of E-Content.
Échographie de contraste : Méthodologie et applications cliniques = Contrast ultrasound : Methodology and clinical applications
The availability of ultrasound contrast agents has introduced a new dimension in ultrasound examination with the possibility of real-time exploration of the kinetics of contrast enhancement of various lesions. The potential indications for these microbubbles affect almost all deep and superficial organs, but also the possibilities of pharmacological studies for neoangiogenesis or therapeutic guidance by physical methods. Finally, new applications are emerging in the field of targeted products and the transport of active ingredients. It seemed opportune to us to attempt to take stock of this changing world through intense collaboration between the various teams involved and recognized in this field, of which unfortunately, only some are represented here. We want this book to be a current reference point for contrast ultrasound, a point that will certainly require development in the coming years. He strongly demonstrates that ultrasound can play a very important role in modern diagnostic and therapeutic imaging because of their diagnostic performance but also because of their non-invasive nature. We hope you enjoy looking for useful information as much as we did discovering real-time functional ultrasound imaging and writing these various chapters.
Dynamics of Flexible Multibody Systems : Rigid Finite Element Method
A new approach is presented for modelling multi-body systems, which constitutes a substantial enhancement of the Rigid Finite Element method. The new approach is based on homogeneous transformations and joint coordinates, and it yields the advantage that equations of motion are automatically generated for systems consisting of alternate rigid and flexible links. Apart from its simple physical interpretation and easy computer implementation, the method is also valuable for educational purposes since it impressively illustrates the impact of mechanical features on the mathematical model. This novel modelling approach is then applied to systems such as offshore-cranes and telescopic rapiers.
Durability of reinforced concrete structures
Reinforced concrete structures corrode as they age, with significant financial implications, but it is not immediately clear why some are more durable than others. This book looks at the mechanisms for corrosion and how corrosion engineering can be used for these problems to be minimized in future projects. Several different examples of reinforced concrete structures with corrosion problems are described and the various life enhancement solutions considered and applied are discussed. The book includes a chapter on the effectiveness of corrosion monitoring techniques and questions why the reality is at odds with current theory and standards.
Deep structure, singularities, and computer vision ; 1st international workshop, DSSCV 2005, Maastricht, The Netherlands, June 9-10, 2005, revised selected papers
Constitutes the refereed post-proceedings of the First International Workshop on Deep Structure, Singularities, and Computer Vision, DSSCV 2005, held in Maastricht. This book represents in understanding the relation between structural, topological information represented by singularities and metric information of signals, shapes, and colors.
Cyber-physical systems : Foundations and techniques
Covers the various aspects associated with Cyber-Physical Systems (CPS) such as algorithms, application areas, and the improvement of existing technology such as machine learning, big data and robotics. The scope of CPS is tremendous. In CPS, one sees the applications of various emerging technologies such as artificial intelligence (AI), Internet of Things (IoT), machine learning (ML), deep learning (DL), big data (BD), robotics, quantum technology, etc. In almost all sectors, whether it is education, health, human resource development, skill improvement, startup strategy, etc., one sees an enhancement in the quality of output because of the emergence of CPS into the field.
Creating and Enhancing Digital Astro Images
Digital imaging is now available to all amateur astronomers at a reasonable price. The advent of CCDs, DSLRs and – perhaps most significantly – webcams mean today’s astronomers can make colorful planetary or deep-sky images of breathtaking beauty. The results obtained with even modest equipment can be spectacular, but of course they depend crucially on the computer processing of the images after they have been captured. Enhancing Digital Images is not just an introduction to image processing, it is a deeply practical, comprehensive and fully illustrated in-depth guide to using a digital camera, performing image reduction and undertaking image enhancement – all without jargon or math. Here is everything you need to know about processing digital astronomical images, regardless of whether you are experienced or a relative beginner!
Concepts in pharmaceutical biotechnology and drug development
Provides comprehensive coverage of the development of new pharmaceuticals and the enhancement of existing ones. It offers a comprehensive understanding of pharmaceutical biotechnology, including its underlying principles and practical applications from an industrial standpoint. While introducing the roles and applications of biotechnology in drug design and development, the book describes how developments in other fields, like genomics, proteomics, and high-throughput screening, have facilitated the discovery of novel therapeutic targets and drug development methods. It included concepts that are essential to biotechnology and apply to protein therapies. And provides a thorough overview of the ways in which biotechnology influences drug development, production, and regulation, and is a valuable resource for those seeking to enhance their understanding in this area.
Computer vision and graphics ; International Conference, ICCVG 2020, Warsaw, Poland, September 14–16, 2020, Proceedings
This book constitutes the refereed proceedings of the International Conference on Computer Vision and Graphics, ICCVG 2020, held in Warsaw, Poland, in September 2020. The 20 full papers were selected from 49 submissions. The contributions cover topics such as: modelling of human visual perception; computational geometry; geometrical models of objects and scenes; illumination and reflection models and methods; image formation; image and video coding; image filtering and enhancement; biomedical image processing; biomedical graphics; colour image processing; multispectral image processing; pattern recognition in image processing
Computational methods in engineering and science ; Proceedings of enhancement and promotion of computational methods in engineering and science X" Aug. 21-23, 2006, Sanya, China
Here are the printed proceedings of EPMESC X, held on August 21-23, 2006 in Sanya, Hainan Island of China. It includes 14 full papers of plenary and semi-plenary lectures and approximately 166 one-page summaries. The accompanying CD-ROM includes all 180 full papers presented at the conference.
Computational methods for nanoscale applications : Particles, plasmons and waves
Computational Methods for Nanoscale Applications: Particles, Plasmons and Waves presents new perspectives on modern nanoscale problems where fundamental science meets technology and computer modeling. This book describes well-known computational techniques such as finite-difference schemes, finite element analysis and Ewald summation, as well as a new finite-difference calculus of Flexible Local Approximation MEthods (FLAME) that qualitatively improves the numerical accuracy in a variety of problems. Application areas in the book include long-range particle interactions in homogeneous and heterogeneous media, electrostatics of colloidal systems, wave propagation in photonic crystals, photonic band structure, plasmon field enhancement, and metamaterials with backward waves and negative refraction.
