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الصفحة 2
الصفحة 2
Lagomorph Biology : Evolution, Ecology, and Conservation
Lagomorphs are a mammalian order which includes rabbits, hares and pikas. They are distributed throughout the world and are of both scientific and public interest as they are classified between endangered and pest species. In addition, some have a high economic value as important game species. In the last few decades, a huge amount of information was made available to the scientific community and resulted in remarkable advances on all aspects of Lagomorph biology. However, this information is dispersed in multiple scientific and non-scientific journals. This book provides an updated synthesis of the current knowledge on Lagomorph biology.
Lactic acid bacteria : Methods and protocols
This updated volume presents experimentation-based approaches to lactic acid bacteria (LAB) research. Split into three parts, the book explores techniques for analyzing lactic acid bacteria metabolism and characteristics, applications for food-related industries, such as yogurt production, beer, and wine making, and functions of LAB in human health. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topic, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
La gonarthrose : Traitement chirurgical : De l´arthroscopie à la prothèse = Knee osteoarthritis : Surgical treatment : from arthroscopy to prosthesis
The aim of this work is to take stock in a clear and didactic way on all the current knowledge on osteoarthritis of the knee and its treatment. It successively addresses the diagnosis and the medical treatment, then the surgical treatments then finally the various aspects of the total knee prosthesis. This book is designed to be read at several levels: basic information is intended particularly for non-specialist or trainee surgeons, rheumatologists, rehabilitation physicians, radiologists and physiotherapists. More specialized aspects are discussed in a second part of the book concerning the future of medical treatment (biology, gene therapy) and certain complex problems of surgical techniques. The points of controversy concerning the total knee replacement are discussed in the last part of the book, of interest to physicians and surgeons.
Köhlers Invention
This scientific biography commemorates the 10th anniversary of Köhler's untimely death. It describes his scientific and personal biography, based on 10 years of close personal and professional relationship between Eichmann and Köhler, as well as interviews with many colleagues and friends, including his "Doktorvater" and mentor Fritz Melchers. Köhler's scientific achievements are explained in a way to make them understandable for the general public and discussed in the historical context of the immunological research at the time.
Kinase Drug Discovery : Modern Approaches
Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations.
Killer Lymphocytes
This extensively documented, comprehensive survey of cell-mediated cytotoxicity (CMC) traces the history of killer lymphocytes from 1960 to the present, providing a definitive resource for specialists and non-specialists alike.
Ketamine for Treatment-Resistant Depression : Neurobiology and Applications
Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics.
Java for Bioinformatics and Biomedical Applications
Illustrates how individual bioinformatics applications (such as BLAST and Genscan) can be stitched together into a pipeline so that users can direct the output of one tool (for example, gene predictions using Genscan) to perform further analysis (say, homology searching using BLAST).
Issues of Decapod Crustacean Biology
This volume presents the proceedings of the eighth Colloquium Crustacea Decapoda Mediterranea, which was held at the Ionian University on Corfu Island, Greece, from 2 to 6 September 2002, and reflects recent advancements in decapod crustacean research. The meeting is the oldest European carcinological event, organized regularly at 3-year intervals since 1972. Although focused on the Mediterranean Sea, worldwide contributions provided a forum for fruitful contact and scientific exchange. The book covers up-to-date issues in decapod crustacean research, including genetics, morphology, reproduction, ecology, behaviour and fisheries, and it is primarily aimed at scientists interested in decapod crustacean research, but other scientists and decision-makers working on marine ecology and fisheries will also find up-to-date information on relevant issues.
Computational biology in drug discovery and repurposing
Takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designin
Complex Intracellular Structures in Prokaryotes
The new series "Microbiology Monographs" begins with two volumes on intracellular components in prokaryotes. In this second volume, "Complex Intracellular Structures in Prokaryotes", the components, labeled complex intracellular structures, encompass a multitude of important cellular functions. Continuing and newly initiated research will provide a clearer understanding of the complex intracellular structures known at present and will bring to light surprising new ones as well.
Complement and Kidney Disease
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality, with at least one third of cases requiring hospitalization, exceeding the numbers admitted for myocardial infarction and stroke. Despite a broad armamentarium of antimicrobials available, it remains an important cause of death in industrialized countries. CAP is caused by a variety of pathogens with their order of importance dependent on the location and population studied. Despite the importance of CAP, reliable data and a recommended evidence-based therapy are lacking, and basic research must be improved. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered. The volume is of interest to researchers and clinicians in virology, epidemiology and biomedicine.
Communication in Plants : Neuronal Aspects of Plant Life
Plant neurobiology is a newly emerging field of plant sciences. It covers signalling and communication at all levels of biological organization – from molecules up to ecological communities. In this book, plants are presented as intelligent and social organisms with complex forms of communication and information processing. Authors from diverse backgrounds such as molecular and cellular biology, electrophysiology, as well as ecology treat the most important aspects of plant communication, including the plant immune system, abilities of plants to recognize self, signal transduction, receptors, plant neurotransmitters and plant neurophysiology. Further, plants are able to recognize the identity of herbivores and organize the defence responses accordingly. The similarities in animal and plant neuronal/immune systems are discussed too. All these hidden aspects of plant life and behaviour will stimulate further intense investigations in order to understand the communicative plants in their whole complexity.
Clinical Neuroembryology : Development and Developmental Disorders of the Human Central Nervous System
Combines data from human embryology, animal research and developmental neuropathology. This book provides an overview of the development of the human Central Nervous System (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic causes. It highlights numerous clinical cases and contains over 400 figures.
Clinical microbiology made ridiculously simple
Is a brief, clear, thorough, and updated approach to clinical microbiology, brimming with mnemonics, humor, summary charts, and illustrations. Topics include Ebola, AIDS, flesh-eating bacteria, mad cow disease, hantavirus, anthrax, smallpox, and tuberculosis; the latest antibiotics; pandemic flu, including H7N9; SARS-like coronavirus; hepatitis C treatment options; HIV diagnostics and approved HIV meds; Zika virus; measles; and a new chapter on the latest emerging infectious diseases and drug-resistant bacteria. The major update to this book is the addition of a new chapter on the SARS-COV-2 virus and COVID-19 disease, which delves into the nature of the virus such as infectivity within the body, transmission between individuals, timeline of infectivity, symptoms, risk factors, therapeutics, and vaccines approved for use.
Clinical metabolomics applications in genetic diseases
Helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. Covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms.
Clinical applications of mass spectrometry in drug analysis : Methods and protocols
This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls.
Clinical and Basic Immunodermatology
Clinical and Basic Immunodermatology is a comprehensive, yet readable and easily digested disease-focused textbook designed for Residents and Fellows in dermatology and immunology.
Climate-Smart Forestry in Mountain Regions
This book offers a cross-sectoral reference for both managers and scientists interested in climate-smart forestry, focusing on mountain regions. It provides a comprehensive analysis on forest issues, facilitating the implementation of climate objectives. CLIMO has provided scientific analysis on issues including criteria and indicators, growth dynamics, management prescriptions, long-term perspectives, monitoring technologies, economic impacts, and governance tools.
