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25 Years of P53 Research
Communication, awareness and access to information: Given the complexity of the field and the fact that data pertaining to each particular aspects of p53 biology or deregulation are scattered in many different publications, it is extremely difficult to access the full scale of relevant information of any specific p53-related topic. This book may help in this task by putting into perspective both general considerations on the p53 pathway and more specific information on various aspects of p53. In the longer term, however, open access to p53 complexity will require the development of knowledge bases accessible through the web and using simple navigation tools to guide users towards the specific information they need. Several efforts are currently being developed in that direction. They need to be strenghtened and better integrated within the rapidly growing galaxy of web-based information sources on molecular and individual variations in cancer. 2. Reference functional assays and structural analysis: Given the huge diversity of cellular and animal models for wild-type or mutant p53 functions, it will be important to set up standard, universally accepted assays to measure critical p53 protein functions.
An Introduction to international criminal law and Procedure
Offers readers comprehensive coverage and a high level of academic rigour while maintaining its signature accessible and engaging style. Introducing the readers to the fundamental concepts of international criminal law, as well as the domestic and international institutions that enforce that law, this book engages with critical questions, political and moral challenges, and alternatives to international justice.
An assessment framework for compliance with international space law and norms : Promoting equitable access and Use of space for emerging actors
proposes a framework for assessing countries’ levels of compliance with international space law and norms. It begins by exploring the development of two movements – the evidence-based policymaking and programming movement, and the rise of ratings and rankings research – and their growth across various disciplines. The analysis suggests that such efforts are useful in gauging the behavior of countries in space according to how well they adhere to existing space law and norms. To date, there is no comprehensive, periodic, and systematic measure of countries’ efforts to comply with space law and norms; this work endeavors to fill that gap by offering a framework in which to assess compliance.
AI and law : How automation is changing the law
Provides insights into how AI is changing legal practice, government processes, and individuals’ access to those processes, encouraging each of us to consider how technological advances are changing the legal system. Particularly, and distinct from current debates on how to regulate AI, this books focuses on how the progressive merger between computational methods and legal rules changes the very structure and application of the law itself.
Access to medicines and vaccines : Implementing flexibilities under intellectual property law
This book is the outcome of a Global Forum on Innovation, Intellectual Property and Access to Medicines held in December 2019 at the Max Plank Instititute in Munich, organised by the South Centre and the Max Plank Institute. The academics and experts from international organisations participating have contributed chapters to this book. The book is for policy makers (in Ministries of Health, Ministries of Trade, Ministries of Foreign Affairs, patent offices), but also relevant for academics (law, trade, public health), on the flexibilities available in the Agreement on Trade Related Aspects of Intellectual Property Rights (TRIPS) of the World Trade Organization to promote access to medicines.
Mastering Oracle SQL and SQL*Plus
This exceptional book explains fundamentals in detail, supported by realistic examples, while most other books on the market do not properly cover such basics. If you work with relational databases you need to understand the SQL language. And you will gain full competence to define, access, and manipulate data in an Oracle database, if you do so following this book's guidance.
Managed Software Evolution
This open access book presents the outcomes of the “Design for Future – Managed Software Evolution” .The different lifecycles of software and hardware platforms lead to interoperability problems in such systems. Instead of separating the development, adaptation and evolution of software and its platforms, as well as aspects like operation, monitoring and maintenance, they should all be integrated into one overarching process. Accordingly, the book is split into three major parts, the first of which includes an introduction to the nature of software evolution, followed by an overview of the specific challenges and a general introduction to the case studies used in the project. The second part of the book consists of the main chapters on knowledge carrying software, and cover tacit knowledge in software evolution, continuous design decision support, model-based round-trip engineering for software product lines, performance analysis strategies, maintaining security in software evolution, learning from evolution for evolution, and formal verification of evolutionary changes. In turn, the last part of the book presents key findings and spin-offs. The individual chapters there describe various case studies, along with their benefits, deliverables and the respective lessons learned. An overview of future research topics rounds out the coverage.
Machine Learning Refined : Foundations, Algorithms, and Applications
Provides students with the fundamental knowledge and practical tools needed to conduct research and build data-driven products. The authors prioritize geometric intuition and algorithmic thinking, and include detail on all the essential mathematical prerequisites, to offer a fresh and accessible way to learn. Practical applications are emphasized, with examples from disciplines including computer vision, natural language processing, economics, neuroscience, recommender systems, physics, and biology.
Long-Term Preservation of Digital Documents : Principles and Practices
Key to our culture is that we can disseminate information, and then maintain and access it over time. While we are rapidly advancing from vulnerable physical solutions to superior, digital media, preserving and using data over the long term involves complicated research challenges and organization efforts. Uwe Borghoff and his coauthors address the problem of storing, reading, and using digital data for periods longer than 50 years. They briefly describe several markup and document description languages like TIFF, PDF, HTML, and XML, explain the most important techniques such as migration and emulation, and present the OAIS (Open Archival Information System) Reference Model. To complement this background information on the technology issues the authors present the most relevant international preservation projects, such as the Dublin Core Metadata Initiative, and experiences from sample projects run by the Cornell University Library and the National Library of the Netherlands. A rated survey list of available systems and tools completes the book.
LINQ for Visual C# 2008
Every C# programmer needs to learn about LINQ (Language–Integrated Query), Microsoft's breakthrough technology for simplifying and unifying data access from any data source. With LINQ, you can write more elegant and flexible code—not just to access databases and files, but to manipulate data structures and XML. This book is a short, yet comprehensive guide to the major features of LINQ and the significant enhancements introduced with .NET 3.5. There is no better source for getting a head–start on the future of these technologies than this book.
Java Illuminated ; 5th ed.
Provides learners with an interactive, user-friendly approach to learning the Java programming language. Comprehensive but accessible, the text takes a progressive approach to object-oriented programming, allowing students to build on established skills to develop new and increasingly complex classes. Java Illuminated follows an activity-based active learning approach that ensures student engagement and interest.
Java 6 Platform Revealed
New editions of the platform don't happen that frequently, but when they do, there is a lot to learn about quickly. If you want to come up to speed on the feature set as quickly as possible, Java 6 Platform Revealed will place you well ahead of the pack. You'll find 10 chapters of how to use the JSR implementations and library improvements that are now a part of Mustang. You'll learn about the scripting features of AWT and Swing, like splash screens, system tray access, and table sorting and filtering and lots more. What you won't find in Java 6 Platform Revealed is a "getting started with Java" tutorial. Come prepared with a good working knowledge of Java 5 platform for best results.
Complexity Theory and Cryptology : An Introduction to Cryptocomplexity
Modern cryptology employs mathematically rigorous concepts and methods from complexity theory. Conversely, current research in complexity theory often is motivated by questions and problems arising in cryptology. This book takes account of this trend, and therefore its subject is what may be dubbed "cryptocomplexity,'' some sort of symbiosis of these two areas. This textbook is suitable for undergraduate and graduate students of computer science, mathematics, and engineering, and can be used for courses on complexity theory and cryptology, preferably by stressing their interrelation. Starting from scratch, it is an accessible introduction to cryptocomplexity and works its way to the frontiers of current research. It provides the necessary mathematical background, has numerous figures, exercises, and examples, and presents some central, up-to-date research topics and challenges. Due to its comprehensive bibliography and subject index, it is also a valuable source for researchers, teachers, and practitioners working in these fields.
Beginning xml with C# 2008 : From novice to professional
Beginning XML with C# 2008 focuses on XML and how it is used within .NET 3.5. As you'd expect of a modern application framework, .NET 3.5 has extensive support for XML in everything from data access to configuration, from raw parsing to code documentation. This book demystifies all of this. It explains the basics of XML as well as the namespaces and objects you need to know in order to work efficiently with XML. You will see clear, practical examples that illustrate best practices in action. With this book, you'll learn everything you need to know from the basics of reading and writing XML data to using the DOM, from LINQ and SQL Server integration to SOAP and web services.
Beginning Visual Web Programming in VB .NET : From novice to professional
Beginning Web Programming in VB .NET: From Novice to Professional will teach you the fundamentals of the web environment and how Visual Studio .NET (VS .NET) makes it accessible to VB programmers. You'll build a working website that demonstrates all the elements of a VB web application. Author Daniel Cazzulino takes a step-by-step approach to each example to explore the essential technologies and how VS .NET helps to integrate them into a highly interactive, attractive web application.
Beginning VB 2008 Databases : From novice to professional
Beginning VB 2008 Databases teaches you everything you need to know about relational databases, SQL, and ADO.NET 2.0, giving you a sound start in developing console and Windows database applications. The book also includes chapters on the SQL Server XML data type and the LINQ enhancements to the next version of Visual Basic. In addition to teaching you database basics like using SQL to communicate with databases, this book provides you with detailed, code-practical techniques to access data in Visual Basic 2008 across a range of coding situations. Code-heavy and full of practical detail, this book has been fully revised and upgraded for .NET 3.5 and offers you the best contemporary practice in this core programming area, so that you'll find yourself using it in nearly all your .NET projects.
Beginning jOOQ : Learn to Write Efficient and Effective Java-Based SQL Database Operations
Learn to use the jOOQ library to manage SQL database operations in Java and JVM applications. This book walks you through what JOOQ is, how to install and get started with it, and then gets you working with it. You will: Comparing equivalent features between Hibernate, JPA and jOOQ. Unlock the power of your SQL database with high performing, flexible and typesafe SQL queries. Seamlessly work with many different SQL database vendors without changing your code. Effortlessly generate Java code based on the content of your database. Write reactive SQL database access code with R2DBC. Integrating jOOQ into popular frameworks and platforms like Hibernate, Spring boot and Quarkus tools like IDEs. Testing jOOQ-based code with modern integration testing frameworks like TestContainers and Docker. Learn how to safely handle data access code within frameworks like the Java Persistence API (JPA)
Beginning HTML with CSS and XHTML : Modern Guide and Reference
Beginning HTML with CSS and XHTML: Modern Guide and Reference incorporates practical examples that will show you how to structure your data correctly using (X)HTML, along with styling and layout basics using Cascading Style Sheets (CSS). Youll also learn how to add dynamic behavior to your data using the JavaScript™ language.
Beginning DB2 : From novice to professional
IBM’s DB2 Express Edition is one of the most capable of the free database platforms available in today’s marketplace. In Beginning DB2, author Grant Allen gets you started using DB2 Express Edition for web sites, desktop applications, and more. The author covers the basics of DB2 for developers and database administrators, shows you how to manage data in both XML and relational form, and includes numerous code examples so that you are never in doubt as to how things work.
Beginning Database Design : From novice to professional
Beginning Database Design: From Novice to Professional provides short, easy-to-read explanations of how to get database design right the first time. Through the help of use cases and class diagrams modeled in the UML, youll learn how to discover and represent the details and scope of the problem in question.
