الصفحة 16
الصفحة 16
Bioanalytical aspects in biological therapeutics
The book discusses the challenges and considerations for bioanalytical support, covering a wide range of central topics in the field, including overview and basic immunology for testing of biological therapeutics, pharmacokinetic aspects, clinical immunogenicity prediction and testing, biomarker testing, biotransformation assessment for biologics, statistical aspects of bioanalytical testing, regulatory expectations, and more
Bioactive Molecules and Medicinal Plants
Use of medicinal plants is as old as human civilization and continuous efforts are being made to improve medicinal plants or produce their products in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identifed from higher plants and microorganisms. Some plant-based drugs have been used for centuries and there is no alternative medicine for many drugs, such as cardiac glycosides. However, natural products research was sidelined to pave the way for com- natorial chemistry, which was expected to produce large numbers of synthetic compounds for high-throughput screening (HTS). This line of work has failed to deliver desirable results. Moreover, it is not possible for all pharmaceutical companies and institutions to adopt costly HTS technology. Therefore, medi- nal plants and their bioactive molecules are always in demand and are a central point of research. While planning this book, we endeavored to incorporate - ticles that cover the entire gamut of current medicinal plants research.
Binary Rare Earth Oxides
The book begins with a brief introduction to binary rare earth oxides, their physical and chemical stabilities, polymorphism, crystal structures and phase transformation and the association with current applications. The book goes on to present the band structure of the oxides using several quantum chemical calculations, which belong to a newly developed area in the binary rare earth oxides. Central to this chapter are the characterizations of electrical, magnetic and optical properties, as well as details of single crystal growth and particle preparation methods that have progressed in recent years. Later chapters concentrate on thermo-chemical properties and trace determination techniques. The final chapter contains a variety of useful applications in various fields such as phosphors, glass abrasives, automotive catalysts, fuel cells, solid electrolytes, sunscreens, iron steels, and biological materials.
Between Mobility and Migration : The Multi-Level Governance of Intra-European Movement
Offers a critical perspective on intra-European mobility and migration by using new empirical data and theoretical discussions. It develops a theoretical and empirical analysis of the consequences of intra-European movement for sending and receiving urban regions in The Netherlands, Sweden, Austria, Turkey, Poland and Czech Republic.The book conceptualizes Central and Eastern European (CEE) migration by distinguishing between different types of CEE migrants and consequences. This involves a mapping of migration corridors within Europe, a unique empirical analysis of consequences for urban regions, and an analysis of governance responses. Next to the European and country perspectives on this phenomenon, the book focuses on the local perspective of urban regions where most mobile citizens settle (either permanently or temporarily). This way the book puts the analysis of intra-European movement in the perspective of broader theoretical debates in migration studies and beyond.
Bell's oral and facial pain
Includes advanced understanding of the neurophysiology and central processing of pain and the resulting changes to diagnostic, classi cation, and treatment guidelines. To assist clinicians in the dif cult and often complicated task of managing patients suffering from oral and facial pain, this textbook provides documented information concerning pain and pain behavior so that one may better understand what pain is, how it behaves, and how it might best be managed; develops a useful classi cation of orofacial pain disorders; offers practical diagnostic criteria by which the different orofacial pain disorders can be identi ed on a clinical level; and suggests guidelines for the effective management of patients who suffer from pain in the region of the mouth and face.
Behavioral interventions for prevention and control of sexually transmitted diseases
Before AIDS, the role of behavioral interventions in preventing transmission of sexually transmitted diseases was acknowledged in text books and journals but rarely promoted effectively in public health practice. Informed by a comprehensive knowledge of behavioral theory, intervention methods, and affected populations, the authors of this important book examine the central role of behavioral interventions in combating STDs. The book addresses the complexities and social contexts of human behaviors which spread STDs, the cultural barriers to STD education (ranging from conservative mores to "stay out of my bedroom" libertarianism), and the sociopolitical nuances surrounding treatment.
Basic Probability Theory with Applications
This book presents elementary probability theory with interesting and well-chosen applications that illustrate the theory. An introductory chapter reviews the basic elements of differential calculus which are used in the material to follow. The theory is presented systematically, beginning with the main results in elementary probability theory. This is followed by material on random variables. Random vectors, including the all important central limit theorem, are treated next. The last three chapters concentrate on applications of this theory in the areas of reliability theory, basic queuing models, and time series. Examples are elegantly woven into the text and over 400 exercises reinforce the material and provide students with ample practice.
Basic & Clinical Pharmacology
Covers the important concepts students need to know about the science of pharmacology and its application to clinical practice. This edition has been extensively updated to provide expanded coverage of transporters, pharmacogenomics, and new drugs Delivers the knowledge and insight needed to excel in every facet of pharmacology!. Encompasses all aspects of medical pharmacology, including botanicals and over-the-counter drugs Major revisions of the chapters on immunopharmacology, antiseizure, antipsychotic, antidepressant, antidiabetic, anti-inflammatory, and antiviral drugs, prostaglandins, and central nervous system neurotransmitters New chapter on the increasingly relevant topic of cannabis pharmacology Each chapter opens with a case study, covers drug groups and prototypes, and closes with summary tables and diagrams that encapsulate important information Revised full-color illustrations provide more information about drug mechanisms and effects and help clarify important concepts Trade Name/Generic Name tables are provided at end of each chapter for easy reference when writing a chart order or prescription Includes descriptions of important new drugs released through May 2019 New and updated coverage of general concepts relating to recently discovered receptors, receptor mechanisms, and drug transporters
Balancing Agility and Formalism in Software Engineering ; 2nd IFIP TC 2 Central and East European Conference on Software Engineering Techniques, CEE-SET 2007, Poznan, Poland, October 10-12, 2007, Revised Selected Papers
This book constitutes the thoroughly refereed post-conference proceedings of the Second IFIP TC 2 Central and East Conference on Software Engineering Techniques, CEE-SET 2007, held in Poznan, Poland, in October 2007.
Autonomes fahren : Technische, rechtliche und gesellschaftliche aspekte = Autonomous driving : Technical, legal and social aspects
This book provides answers to a wide range of these and other questions. Experts from Germany and the USA describe central topics related to the automation of vehicles on public roads from an engineering and social science perspective. They show which "decisions" are required of an autonomous vehicle or which "ethics" must be programmed. The authors discuss expectations and concerns that characterize the individual and societal acceptance of autonomous driving. An increased safety potential through autonomous vehicles is compared to the challenges and solution approaches that play a role in securing the safety concept. In addition, they explain what possibilities for change and opportunities arise for our mobility and the reorganization of traffic, not least for freight traffic. The book thus offers an up-to-date, comprehensive and scientifically sound examination of the topic of "autonomous driving".
Auditory Trauma, Protection, and Repair
Protection and Repair presents recent developments in auditory research and their potential translation to the clinical setting. In particular the authors address the major entities of peripheral auditory trauma, discuss the underlying mechanisms, the central nervous system consequences, protective interventions and finally explore the possibilities to restore cochlear morphology and function.Two themes run through the chapters in this book: cellular homeostasis and cell death. In the broadest sense, all auditory pathologies are disorders of cellular homeostasis.
Atomic structure theory : Lectures on atomic physics
This is a textbook for students with a background in quantum mechanics. The text is designed to give hands-on experience with atomic structure calculations. Material covered includes angular momentum methods, the central field Schrödinger and Dirac equations, Hartree-Fock and Dirac-Hartree-Fock equations, multiplet structure, hyperfine structure, the isotope shift, dipole and multipole transitions, basic many-body perturbation theory, configuration interaction, and correlation corrections to matrix elements.
Atlas of seeds and fruits of Central and East-European Flora : The carpathian mountains region
The Carpathian flora occurs not only in the Carpathian Mountains, but also in large lowlands extending towards the south, north and east and involves introduced and invading flora of more than 7,500 species. Since the morphological characteristics of the seeds are usually constant they are very important for determination of systematic units. The present atlas of seeds with nearly 4,800 seed illustrations is supplemented with detailed seed descriptions, brief plant descriptions, locality and the native source of plants. This publication is unique, both in its extent – with so many plant seeds from such a wide-ranging region - and in the form of its presentation – with such detailed descriptions.
Asymptotic Theory of Statistics and Probability
An encyclopedic treatment of classic as well as contemporary large sample theory, dealing with both statistical problems and probabilistic issues and tools. It is written in an extremely lucid style, with an emphasis on the conceptual discussion of the importance of a problem and the impact and relevance of the theorems. The book has 34 chapters over a wide range of topics, nearly 600 exercises for practice and instruction, and another 300 worked out examples. It also includes a large compendium of 300 useful inequalities on probability, linear algebra, and analysis that are collected together from numerous sources, as an invaluable reference for researchers in statistics, probability, and mathematics.
Astronomical image and data analysis
With information and scale as central themes, this comprehensive survey explains how to handle real problems in astronomical data analysis using a modern arsenal of powerful techniques. It treats those innovative methods of image, signal, and data processing that are proving to be both effective and widely relevant. The coverage includes chapters or appendices on: detection and filtering; image compression; multichannel, multiscale, and catalog data analytical methods; wavelets transforms, Picard iteration, and software tools. This second edition of Starck and Murtagh's highly appreciated reference again deals with topics that are at or beyond the state of the art. It presents material which is more algorithmically oriented than most alternatives and broaches new areas like ridgelet and curvelet transforms. Throughout the book various additions and updates have been made.
Artificial intelligence : Methodology, systems, and applications ; 10th International Conference, AIMSA 2002, Varna, Bulgaria, September 4-6, 2002. Proceedings
The AIMSA conference series was frst conceived in 1984 as a gathering of AI researchers and students from Eastern and Central Europe.Sincethenthecon- rence has followed a biennial schedule of meetings in Bulgaria, attracting parti- pantsfrom awidergeographicalarea.The AIMSA organizers are delighted to present you with another exciting program, coveringmostareasof Artifcial Intelligence.Inkeepingwithitsm- sion to inform the research community and excite the commercial sector, AIMSA presents this year two invited contributions from world-leading European rese- chersworkingoncutting-edgeAIresearch: Prof.CaroleGoble, ontheSemantic Web.
Arctic-Subarctic Ocean Fluxes : Defining the Role of the Northern Seas in Climate
The two-way oceanic exchanges that connect the Arctic and Atlantic oceans through subarctic seas are of fundamental importance to climate. Change may certainly be imposed on the Arctic Ocean from subarctic seas, including a changing poleward ocean heat flux that is central to determining the present state and future fate of the perennial sea-ice. And the signal of Arctic change is expected to have its major climatic impact by reaching south through subarctic seas, either side of Greenland, to modulate the Atlantic thermohaline ‘conveyor’. Developing the predictive skills of climate models is seen to be the most direct way of extending the ability of society to mitigate for or adapt to 'global change' and is the main justification for continuing an intense observational effort in these waters. As records have lengthened, they have shown that important aspects of oceanic exchange through subarctic seas are currently at a long-term extreme state, providing further motivation for their study.
Architecture and the housing question
Examines how the design and provision of housing around the world have become central both to competing political projects and to the architecture profession. How have architects acting as housing experts helped alleviate or enforce class, race, and gender inequality? What are the disciplinary implications of taking on shelter for the multitude as an architectural assignment and responsibility? The book features essays in the historiography of architecture and the housing question, and a collection of historical case studies from Belgium, China, France, Ghana, the Netherlands, Kenya, the Soviet Union, Turkey, and the United States.
Apprehension and Argument : Ancient Theories of Starting Points for Knowledge
This book offers the first synoptic study of how the primary elements in knowledge structures were analysed in antiquity from Plato to late ancient commentaries, the main emphasis being on the Platonic-Aristotelian tradition. It argues that, in the Platonic-Aristotelian tradition, the question of starting points was treated from two distinct points of view: from the first perspective, as a question of how we acquire basic knowledge; and from the second perspective, as a question of the premises we may immediately accept in the line of argumentation. It was assumed that we acquire some general truths rather naturally and that these function as starting points for inquiry. In the Hellenistic period, an alternative approach was endorsed: the very possibility of knowledge became a central issue when sceptics began demanding that true claims should always be distinguishable from false ones.
Applying the Kaizen in Africa : A New Avenue for Industrial Development
At present, how to develop industries is a burning issue in Africa, where population growth remains high and economic development has thus far failed to provide sufficient jobs for many, especially young people and women. The creation of productive jobs through industrial development ought to be a central issue in steering economic activity across the continent.The authors of this book, consisting of two development economists and five practitioners, argue that the adoption of Kaizen management practices, which originated in Japan and have become widely used by manufacturers in advanced and emerging economies, is decisively the most effective first step for industrial development in Africa.This open access book discusses what Kaizen management is, why it is applicable to Africa, and why it can provide Africa with a springboard for sustainable economic growth and employment generation.
