الصفحة 12
الصفحة 12
Neonatal Pain : Suffering, Pain and Risk of Brain Damage in the Fetus and Newborn
Until the 1980s it was denied that fetuses and neonates feel pain. With the advent of a deeper understanding of the pathophysiology and new diagnostic tools, the last 30 years have seen great developments in this field. This volume aims to give an overview of current knowledge in the field.
Neonatal Immunity
New advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens. Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.
Neonatal Cranial Ultrasonography
It provides important information on brain maturation in the (preterm) neonate and enables the detection of frequently occurring brain anomalies in both preterm and full term neonates. Furthermore, it can be repeated as often as is necessary. In this edition of Neonatal Cranial Ultrasonography, the focus is on the basics of the technique, from patient preparation through to screening strategies and the classification of abnormalities. Many new ultrasound images have been included to reflect the improvements in image quality since the first edition. Essential information is provided about both the procedure itself and the normal ultrasound anatomy. Standard technique using the anterior fontanelle as the acoustic window is described and illustrated, but emphasis is also placed on the value of supplementary acoustic windows.
Neighbourhoods in Transition : Brownfield Regeneration in European Metropolitan Areas
This book is focused on the intersection between urban brownfields and the sustainability transitions of metreopolitan areas, cities and neighbourhoods. It provides both a theoretical and practical approach to the topic, offering a thorough introduction to urban brownfields and regeneration projects as well as an operational monitoring tool.
Neglected tropical diseases and phytochemicals in drug discovery
Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections.
Nearest Neighbor Search : A Database Perspective
Modern applications are both data and computationally intensive and require the storage and manipulation of voluminous traditional (alphanumeric) and nontraditional data sets (images, text, geometric objects, time-series). Examples of such emerging application domains are: Geographical Information Systems (GIS), Multimedia Information Systems, CAD/CAM, Time-Series Analysis, Medical Information Sstems, On-Line Analytical Processing (OLAP), and Data Mining. These applications pose diverse requirements with respect to the information and the operations that need to be supported. From the database perspective, new techniques and tools therefore need to be developed towards increased processing efficiency. This monograph explores the way spatial database management systems aim at supporting queries that involve the space characteristics of the underlying data, and discusses query processing techniques for nearest neighbor queries. It provides both basic concepts and state-of-the-art results in spatial databases and parallel processing research, and studies numerous applications of nearest neighbor queries.
Neanderthals Revisited : New Approaches and Perspectives
This volume presents cutting-edge research by leading scientists re-examining the major debates in Neanderthal research with the use of innovative state-of-the art methods and exciting new theoretical approaches.Topics addressed include the re-evaluation of Neanderthal anatomy, inferred adaptations and habitual activities, developmental patterns, phylogenetic relationships, and the Neanderthal extinction; new methods include computer tomography, 3D geometric morphometrics, ancient DNA and bioenergetics. The diverse contributions offer fresh insights and advances in Neanderthal and modern human origins research.
Nb3Sn Accelerator Magnets : Designs, Technologies and Performance
This book is written by world-recognized experts in the fields of applied superconductivity and superconducting accelerator magnet technologies. It provides a contemporary review and assessment of the experience in research and development of high-field accelerator dipole magnets based on Nb3Sn superconductor over the past five decades. The reader attains clear insight into the development and the main properties of Nb3Sn composite superconducting wires and Rutherford cables, and details of accelerator dipole designs, technologies and performance. Special attention is given to innovative features of the developed Nb3Sn magnets. The book concludes with a discussion of accelerator magnet needs for future circular colliders.
Navigational Surgery of the Facial Skeleton and Skull Base
Computer-assisted techniques in the surgery of the facial skeleton including the skull base are depicted for the very first time in this atlas of navigational surgery. Experienced surgeons as well as trainees will benefit from the detailed and well-illustrated information on the use of computer technology in clinical routine, accompanied by the experimental basis of intraoperative accuracy.The interdisciplinary approach brings together maxillofacial surgeons, plastic surgeons, ENT surgeons, and neurosurgeons. New methods of non-invasive referencing and the use of virtual models in the field of oral and cranio-maxillofacial surgery are demonstrated. Clinical cases illustrate the practical use of this new technique.
Navigation and MIS in Orthopaedic Surgery
This textbook offers new insights into the use of computer assisted surgery and minimally invasive surgery in orthopaedic surgery. A comprehensive presentation of scientific work and clinical experience is included encompassing areas of spine, trauma, sports and reconstructive surgery. We have added sections that discuss minimally invasive surgery, as we believe CAS will be an enabling technology for these more challenging approaches by providing a virtual digital "surgical exposure". We have explored areas of new endeavor that may not have current applications.
Nature, Value, Duty : Life on Earth with Holmes Rolston, III
"Nature Value and Duty: Life on Earth with Holmes Rolston, III" is a collection of contemporary writings on the work of Holmes Rolston, III. The authors contributing to this volume are a mixture of senior scholars in environmental ethics and new voices in philosophy and in literature. Together they provide an in depth evaluation of many of the topics discussed by Rolston. They probe the strengths and weaknesses of his work and suggest valuable correctives. Rolston himself, in a detailed reply to each of his critics at the end of the volume, reveals where some of these criticisms sting him the most and in the process provides one of the most detailed and articulate defenses of his position ever offered."
Natural Resistance Mechanisms of Plants to Viruses
Resistance phenomena such as the local lesion response, induced resistance, "green islands" and resistance in various crop plants are linked with new information on gene-silencing mechanisms, gene silencing suppressors, movement proteins and plasmodesmatal gating, downstream signalling components, and more.
Natural products and human diseases : Pharmacology, molecular targets, and therapeutic benefits
Provides insight into the clinical and translational application of natural products in human diseases Details the impact of natural products on a molecular basis Describes the identification of biomarkers, therapeutic effects of phytochemicals, and and new targets
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Natural Product Synthesis II : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural Product Synthesis I : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural poisons and venoms: Plant toxins : Polyketides, phenylpropanoids and further compounds
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural poisons and venoms : Animal toxins
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural poisons and venom : Plant toxins : Terpenes and steroids
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural language and information systems ; 13th International Conference on Applications of Natural Language to Information Systems, NLDB 2008 London, UK, June 24-27, 2008 Proceedings
This volume contains the papers presented at NLDB 2008, the 13th Inter- tional Conference on Natural Language and Information Systems, held June 25-27,2008.It also containssome of the best researchproposalsas submitted to the NLDB2008 doctoral symposium heldonJune24,2008.Theprogrammealso includes three invited talks covering the main perspectives of the application of naturallanguageto informationsystems: the wayhumansprocess, communicate and understand natural language, what are the implications and challenges - wardssemanticsearchfor the new Webgeneration, how naturallanguageapplies to the well-established database way of querying as a means to unlock data and information for end users.
