الصفحة 10
الصفحة 10
Introduzione alla medicina molecolare = Introduction to molecular medicine
An indispensable guide for understanding a young science with rapid and promising developments. Now in its third completely revised edition, it presents in a concise yet comprehensive way the scientific and technological principles of this discipline and provides, in widely accessible language, the basic conceptual tools for understanding the human genome, gene expression and regulation, the various aspects of genetic engineering that allow for the manipulation of DNA, and human cloning.
Introduction to Computational Biology : An Evolutionary Approach
Molecular biology has changed dramatically over the past two decades. Until the early 1990s genes were studied one at a time by small teams of researchers; today entire genomes are sequenced by internationally collaborating laboratories. In the bygone gene-centered era the accumulation of data was the rate-limiting step in research. Now that step is often data interpretation. This is increasingly dependent on computational methods and as a consequence, computational biology has emerged in the past decade as a new subdiscipline of biology. This introduction to computational biology is centered on the analysis of molecular sequence data. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models. In the second part evolutionary time takes center stage and phylogenetic reconstruction, the analysis of sequence variation, and the dynamics of genes in populations are explained in detail. In addition, the book contains a computer program with a graphical user interface that allows the reader to experiment with a number of key concepts developed by the authors.
Introduction to basics of pharmacology and toxicology ; Vol.1 : General and molecular pharmacology : Principles of drug action
Illustrates the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases.
Introducing Molecular Electronics
This volume presents a summary of our current understanding of molecular electronics combined with selected state-of-the-art results at a level accessible to the advanced undergraduate or novice postgraduate. This single book comprises the basic knowledge of both theory and experiment underpinning this rapidly growing field. Concepts and techniques such as density functional theory and charge transport, break junctions and scanning probe microscopy are introduced step-by-step and are subsequently used in specific examples. The text addresses a wide range of systems including molecular junctions made of single-molecules, self-assembled monolayers, carbon nanotubes and DNA.
Intrinsic Molecular Mobility and Toughness of Polymers II
The series Advances in Polymer Science presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science . the authors highlight the dual role of segmental jumps and displacements to improve toughness by energy dissipation and relaxation of critical stresses and to influence without exception all damage mechanisms. The dynamic response of a chain segment to thermo-mechanical excitation strongly depends on in-chain cooperative motions. By combining the powerful techniques of multi-dimensional Nuclear Magnetic Resonance and of dielectric and dynamic mechanical analysis Monnerie,
Intrinsic Molecular Mobility and Toughness of Polymers I
The series Advances in Polymer Science presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science . the authors highlight the dual role of segmental jumps and displacements to improve toughness by energy dissipation and relaxation of critical stresses and to influence without exception all damage mechanisms. The dynamic response of a chain segment to thermo-mechanical excitation strongly depends on in-chain cooperative motions. By combining the powerful techniques of multi-dimensional Nuclear Magnetic Resonance and of dielectric and dynamic mechanical analysis Monnerie,
Interstitial fibrosis in heart failure
Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.
Interphases and Mesophases in Polymer Crystallization III
In polymer crystallization the challenge is to identify and clarify the transformations by which chain molecules pass from a disordered, molten state to the ordered supra-molecular organization known as the semi-crystalline state. The subject is highly relevant in terms of both basic science and technology; it is indeed clear that many modern applications require complete control of the structure and the morphology of polymers from macroscopic dimensions down to below the nanoscale. As a simple example, making the crystallites in a polymer fiber equally oriented and reducing the number of chain folds (or hairpins) therein, usually turn out to be very favorable requisites for mechanical performance . .This series presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science. It is adressed to ali scientists at universities and in industry who wish to keep abreast of advances in the topics covered
Interphases and Mesophases in Polymer Crystallization II
Polymer crystallisation is a field of science whose widespread practica! and technological implications add to its scientific relevance. Unlike most molecular substances, synthetic polymers consist oflong, linear chains usually covering a broad distribution of molecular lengths. It is no surprise that only rarely may they give rise to regularly shaped crystals, if at all. As a rule, especially from the bulk state, polymers solidify as very tiny crystals interspersed in an amorphous matrix and randomly interconnected by disordered chains.This series presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and material science. It is adressed to ali scientists at universities and in industry who wish to keep abreast of advances in the topics covered
Interphases and Mesophases in Polymer Crystallization I
Polyethylene forms a two-dimensional hexagonal phase, stable at 3 GPa depending on molecular length, which in recent years has been claimed to intervene in crystallization prior to the formation of the usual orthorhombic phase even at atmospheric pressure. This claim is evaluated and shown to be without substance. There is very little evidence that the theoretical possibility of thin lamellae being more stable in the hexagonal phase than the orthorhombic at atmospheric pressure, if the former has sufficiently low fold surface free energy, does occur in practice. But the existence of single crystals of the orthorhombic phase unambiguously shows that they did not have a hexagonal precursor; that would have made them threefold twins. The overwhelming mass of evidence is that orthorhombic and hexagonal phases crystallize independently in accordance with the phase diagram and kinetic competition during growth, as has been understood since the hexagonal phase was discovered.
Intermolecular Forces and Clusters II
This slim volume, contains papers written by leading researchers of intermolecular forces and clusters in honor of Anthony Stone. Taken together, the articles provide an accurate snapshot of current work on selected aspects of intermolecular forces and clusters that are primarily, but not exclusively, theoretical, Scientists and students interested in pursuing research on intermolecular forces and/or clusters would benefit
Intermolecular Forces and Clusters I
the present volume is a collection of reviews, here intended to describe the present state-of-the-art in the construction and use of intermolecular force fields. In particular, this is Part I of a two-part collection dedicated to Anthony J. Stone, a pioneer in both high-level ab initio quantum chemistry and the theory and practice of intermolecular forces. ...
Interfacial Processes and Molecular Aggregation of Surfactants
Given the enormous interest in surface phenomena in areas ranging from materials science to applications in life science, this volume is a very timely addition to the literature. Emphasis is on surfactants mediating interfacial and molecular aggregation phenomena, and the following topics are reviewed in particular: dissolution rates, equilibrium adsorption, mixing rules, and spreading on a solid surface of surfactants, as well as the role of surfactants in mediating a range of processes, such as the fabrication of various nanomaterials.
Interfacial Nanochemistry : Molecular Science and Engineering at Liquid-Liquid Interfaces
The presence of liquid-liquid interface means that real liquids are far from ideal liquids that must be miscible with any kinds of liquids and have no interface. Thus it can be said that the non-ideality of liquids might generate the liquid-liquid interface indeed and that biological systems might be generated from the non-ideal interface. The liquid-liquid interface has been, therefore, studied as a model of biological membrane. From pairing two-phases of gas, liquid and solid, nine different pairs can be obtained, which include three homo-pairs of gas-gas, liquid-liquid and solid-solid pairs. The gas-gas interface, however, is practically no use under the ordinary conditions. Among the interfaces produced by the pairing, the liquid-liquid interface is most slippery and difficult to be studied experimentally in comparison with the gas-liquid and solid-liquid interfaces, as the liquid-liquid interface is flexible, thin and buried between bulk liquid phases. Therefore, in order to study the liquid-liquid interface, the invention of innovative measurement methods has a primary importance.
Interactions Between Neurons and Glia in Aging and Disease
The subject material covered by the book is a crucial competitive area with critical implications for human health and will be of key interest to the scientific community. This unique volume will be invaluable not only to those interested in neuroscience, but also cell biology, molecular biology, biochemistry, and pharmaceutical sciences.
Intelligent Computing Theories and Application ; 16th International Conference, ICIC 2020, Bari, Italy, October 2–5, 2020, Proceedings, Part I
This two-volume set of LNCS 12463 and LNCS 12464 constitutes - in conjunction with the volume LNAI 12465 - the refereed proceedings of the 16th International Conference on Intelligent Computing, ICIC 2020, held in Bari, Italy, in October 2020. The 162 full papers of the three proceedings volumes were carefully reviewed and selected from 457 submissions The ICIC theme unifies the picture of contemporary intelligent computing techniques as an integral concept that highlights the trends in advanced computational intelligence and bridges theoretical research with applications. The theme for this conference is “Advanced Intelligent Computing Methodologies and Applications.” Papers related to this theme are especially solicited, addressing theories, methodologies, and applications in science and technology.
Intelligent Algorithms in Ambient and Biomedical Computing
The rapid growth in electronic systems in the past decade has boosted research in the area of computational intelligence. As it has become increasingly easy to generate, collect, transport, process, and store huge amounts of data, the role of intelligent algorithms has become prominent in order to visualize, manipulate, retrieve, and interpret the data. For instance, intelligent search techniques have been developed to search for relevant items in huge collections of web pages, and data mining and interpretation techniques play a very important role in making sense out of huge amounts of biomolecular measurements. As a result, the added value of many modern systems is no longer determined by hardware only, but increasingly by the intelligent software that supports and facilitates the user in realizing his or her objectives.
Integrated Molecular and Cellular Biophysics
Biophysics represents perhaps one of the best examples of interdisciplinary research areas, where concepts and methods from disciplines such as physics, biology, b- chemistry, colloid chemistry, and physiology are integrated. It is by no means a new ?eld of study and has actually been around, initially as quantitative physiology and partly as colloid science, for over a hundred years. For a long time, biophysics has been taught and practiced as a research discipline mostly in medical schools and life sciences departments, and excellent biophysics textbooks have been published that are targeted at a biologically literate audience. With a few exceptions, it is only relatively recently that biophysics has started to be recognized as a physical science and integrated into physics departments’ curr- ula, sometimes under the new name of biological physics.
Integrated diagnostics and theranostics of thyroid diseases
Provides basic concepts on Integrated Diagnostics and Theranostics with special emphasis on different human thyroid diseases. Thyroid diseases are increasingly detected (incidentally in many cases) but are clinically negligible in a significant proportion of patients. Accordingly, it is urgent to move from the simple disease detection to a reliable disease characterization in order to concentrate efforts on patients in need of tailored disease management.
Innovative Medicine : Basic Research and Development
Devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”.
