تحسين النتائح
ترتيب حسب
من
الى
الصفحة 1
الصفحة 1
Manual of intracytoplasmic sperm injection in human assisted reproduction
For around half of the couples who have trouble conceiving the cause of infertility is sperm-related. Intracytoplasmic sperm injection (ICSI) is the most common and successful treatment for male infertility. Here, the pioneers for the technique, along with authorities in the field, describe the underlying science of ICSI and other micromanipulation techniques. Practical advice for performing the techniques is covered in depth, including sperm selection, laser-assisted ICSI, and the use of piezo in ICSI. Examining the safety of ICSI in animal models as well as the impact of ICSI on the health and well-being of the children conceived through the procedure is discussed. This manual is an essential resource for clinical embryologists and laboratory personnel wishing to refine or develop techniques and improve outcomes.
Mangroves and Halophytes : Restoration and Utilisation
Focusing on Venezuela and Mexico, this edited volume from the International Society of Halophyte Utilisation (ISHU) explores the environmental issues facing South and Central America's coastal ecosystems, and discusses the uses of mangrove species and other halophytes in addressing issues of both coastal pollution and upland soil salinisation. The book draws on expertise from Europe and South America to present a series of case studies that detail Venezuela’s saline ecosystems and examine the economic potential of mangrove restoration and halophyte production. It includes cutting-edge research into the establishment of new mangrove stands which could serve as prototypes for the sustainable use of halophytes, including Chenopodium quinoa and Tamarix aphylla. Moreover, the detailed examples from Venezuela and other Caribbean countries provide useful models for comparison with halophyte utilisation in other parts of the world – especially the Mediterranean region, where much of the earlier research of the ISHU had been conducted.
Malignant Mesothelioma : Pathogenesis, Diagnosis, and Translational Therapies
(Review from JAMA) Malignant mesothelioma is an uncommon neoplasm usually associated with exposure to asbestos. Because of its low incidence, thorough reviews of the topic are hard to find. Harvey Pass and colleagues have edited an up-to-date, comprehensive book that includes a wide range of information, from a historical perspective to descriptions of the latest treatment. The authors . . . have written chapters on the carcinogenesis, molecular genetics, and clinical aspects of mesothelioma. Malignant Mesothelioma is suitable for a broad audience. Laboratory researchers will use it as a resource for information about the pathogenesis, animal models, molecular genetics, and cell lines of mesothelioma. . . . Clinicians will benefit from this complete guide to the presentation, prognosis, imaging, and treatment of the disease. I highly recommend this book to all who are interested in mesothelioma.
Longevity and Frailty
Contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship. The result is a unique, innovative and timely blend of papers on topics ranging from frailty concepts in animal models and early Homo sapiens, to documentation of progress in morbidity compression, on the relationships between frailty and impairments and inflammation, and perspectives on long-term health care needs in an aging world.
Liver carcinogenesis : Methods and protocols
Discusses the latest advancements in modern methodologies used to study liver carcinogenesis. The first half of this book describes pertinent preclinical models of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), established either through orthotopic induction of ectopic implantation. The second half of this book covers a diverse array of techniques applied to characterize the biochemical and cellular composition of hepatic malignancies that operate at the single-cell and histological levels. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Leptomeningeal Metastases
Leptomeningeal Metastases provides the reader with an overview of the state-of-the-art therapy for the leptomeningeal patient with additional information on epidemiology, symptom management, new clinical trials, and current basic research in animal models for experimental therapies. "Leptomeningeal metastases remains a devastating manifestation of hematologic malignancies and solid tumors. Leading figures in the field review the pathophysiology and clinical consequences of this process. State-of-the-art treatment strategies are presented highlighting advances in current management."
L’insuffisance rénale aiguë = Acute renal failure
The aim of this book is to make current data from the experimental and clinical literature accessible to readers. More than a thousand articles are published each year on the theme and the authors aim to synthesize this information. These data relate in particular to the identification of early markers of renal dysfunction without which screening, recognition of the main pathophysiological determinants and prevention remain uncertain. This book focuses attention on clinical situations characterized by the renal impact of the main dysfunctions of vital functions, the prognosis of which is worsened by the occurrence of this renal failure. The following will be treated in particular: the renal consequences of oxidative stress, the renal consequences of respiratory dysfunction, cardiac dysfunction, hepatic dysfunction, alterations in hemostasis, septic shock and hemorrhagic shock. Finally, the physiopathological data from experimental models are gradually finding their echo in the clinical field, opening up therapeutic avenues whose recent evaluations will be analyzed.
KRAS : Methods and protocols
Details protocols ranging from high yield production metabolically labeled KRAS for NMR studies to approaches that quantify engagement of novel molecules that bind KRAS in live cells. Chapters focus on protein production and characterization, biochemical assays, cell-based assays, KRAS-membrane interactions, targeting KRAS, and cell models.
Comparative Placentation : Structures, Functions and Evolution
Science produces fascinating puzzles: why is there such a range of placental structures when other mammalian organs are so structurally uniform ? Why and how did the different placental structures evolve ? Comparative placental studies can facilitate the identification of the common factors in placental growth, differentiation and function and their relevance to possible evolutionary pathways. Comparative Placentation is the only book presenting up-to-date data illustrating the great variety of structure but uniform function of vertebrate placentas from fish to man. This information is essential for selection of suitable models to investigate particular practical problems of impaired or anomalous growth in human and animal placentation. The unique collection of the best light and electron micrographs from the last thirtyfive years which precisely illustrate the structural range in each taxon, make the book the most authoritative publication in this field and a vital source of information for anyone interested on reproductive physiology, anatomy and medicine.
Comparative genomics ; Vol.15 : Using Fungi as Models
Fungal comparative genomics started in 2000 by the genome sequencing of several yeast species other than the canonical Saccharomyces cerevisiae. Since then, over 30 fungal genome sequences have become available. This set represents a total evolutionary divergence comparable to that between vertebrates and arthropods, but also contains closely related genomes. This volume describes how we can use this set of genomes to trace large and small-scale events in genome evolution, to extract information about highly conserved and less conserved sequence elements, and to develop novel methods in genomics that will have an impact on genomics at large.
Clinical metabolomics applications in genetic diseases
Helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. Covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms.
Chromatin Dynamics in Cellular Function
This volume includes timely reviews of several aspects of chromatin biology written by scientists at the forefront of this rapidly moving field. Topics covered include the structure and function of protein modules within chromatin-remodeling proteins, newly characterized histone modifications (methylation, ubiquitylation) and their functional consequences, transcription and histone dynamics, roles of chromatin remodeling factors in DNA replication and repair, and current models of nucleosome-remodeling mechanisms.
Chemokine biology : Basic research and clinical application ; Vol.2 : Pathophysiology of chemokines
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Charting Spiritual Care : The emerging role of Chaplaincy Records in Global Health Care
This book is the first academic book on the controversial issue of including spiritual care in integrated electronic medical records (EMR). Based on an international study group comprising researchers from Europe (The Netherlands, Belgium and Switzerland), the United States, Canada, and Australia, this edited collection provides an overview of different charting practices and experiences in various countries and healthcare contexts.
Cell-secreted vesicles : Methods and protocols
Pesents hands-on technological protocols used to target an array of cell-secreted extracellular vesicles (EVs) in a variety of biological systems. Beginning with methods for EV purification and analysis, the book continues with sections on the study of EV functions as well as specific systems and models allowing for the study of EVs of different origin. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cell Surface Receptors : A Short Course on Theory and Methods
Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest.
Cell Cycle Regulation
The cell cycle is tightly regulated on many different levels to ensure properly controlled proliferation. Deregulation of cell cycle regulation is a hallmark of cancer. In this book, many aspects of cell cycle regulation are discussed, which include G1, S, M phase control, ubiquitin-mediated degradation, DNA damage response, mitotic spindle checkpoint, the centrosome cycle, Retinoblastoma protein family, the Myc oncogene, and mouse models for tumor suppressors, cyclin-dependent kinases, and meiosis. These chapters written by experts provide an updated view on how the cell cycle is regulated in vivo and about the involvement of cell cycle regulators in cancer.
CD137 Pathway : Immunology and Diseases
This comprehensive volume, written by experts in the field, covers nearly all aspects of ongoing research related to the CD137 pathway. Recent research has shown that the manipulation of CD137 pathway molecules is very promising in the treatment of cancer, viral infection, transplantation rejection and autoimmune diseases in experimental animal models. The volume includes research related to the identification and understanding of functional consequences of CD137 receptor and ligand molecules which represents a major effort in the field of immunology. CD137 Pathway: Immunology and Diseases is an ideal book for immunologists, microbiologists, cancer researchers, molecular biologists, biochemists, and pharmaceutical and biotechnology company scientists.
Care-Related Quality of Life in Old Age : Concepts, Models and Empirical Findings
Care-Related Quality of Life in Old Age explains the theory behind Care Keys, its methodology, empirical findings, and practical considerations in promoting effective, efficient elder care aimed at social and emotional well-being and including disabled and cognitively impaired patients.
Cancer Prevention
This volume contains the main proceedings of the fourth international conference on "Cancer Prevention 2006," which was held during February 16–18, 2006, in St. Gallen, Switzerland. Written by international experts in the field, the book comprises a comprehensive update on the most recent developments in the upsurging fields of molecular biology and cancer genetics and their interactions with clinical epidemiology and cancer prevention at various levels: genetic/biologic predisposition and definition of high-risk groups; preclinical models and tumor prevention; prospects of surrogate endpoints and biomarkers; progress in imaging and detection of neoplastic precursor lesions.
