الصفحة 1
الصفحة 1
Transient Receptor Potential (TRP) Channels
The main goal of this volume is to provide up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels.
Transgenesis and the Management of Vector-Borne Disease
Parasitic, bacterial and viral agents continue to challenge the welfare of humans, livestock, wild life and plants worldwide. The public health impact and financial consequences of these diseases are particularly hard on the already overburdened economies of developing countries especially in the tropics. Many of these disease agents utilize insect hosts (vectors) to achieve their transmission to mammals. In the past, these diseases were largely controlled by insecticide-based vector reduction strategies. Now, many of these diseases have reemerged in the tropics, recolonizing their previous range, and expanding into new territories previously not considered to be endemic. Habitat change, irrigation practices, atmospheric and climate change, insecticide and drug resistance as well as increases in global tourism, human traffic and commercial activities, have driven the reemergence and spread of vector borne diseases. While these diseases can be controlled through interventions aimed at both their vertebrate and invertebrate hosts, no effective vaccines exist, and only limited therapeutic prospects are available for their control in mammalian hosts. Molecular technologies such as transgenesis, which is the subject of this book, stand to increase the toolbox and benefit disease management strategies.
The Ecology of Browsing and Grazing
Extensive grazing and browsing by domestic and wild herbivores shape the vegetation composition, structure and dynamics of many terrestrial ecosystems. This volume investigates how large herbivores not only influence the structure and distribution of the vegetation, but also affect nutrient flows and the responses of associated fauna. The mechanisms and processes underlying the herbivores' behaviour, distribution, movement and direct impact on the vegetation, and the dynamics of nutrients, plant species, and vegetation composition in terrestrial ecosystems are discussed in detail. It is shown that an understanding of plant/animal interactions can provide practical advice on the management of large herbivores to integrate production and conservation in terrestrial systems, particularly in the face of environmental and climate change.
The Cell Cycle in the Central Nervous System
Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system (CNS) to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
The Brain and Its Self : A Neurochemical Concept of the Innate and Acquired Drives
The main message of this monograph is that the appearance of the mammalian brain with the ability to acquire drives ensured the development of social life, and eventually led to the evolution of the human society. This most sophisticated form of organized life on earth is still in the trial and error phase of its development. It seeks to outgrow the myth-directed era of its history and come to its final state, the ration-directed human society.
Somatic Cell Nuclear Transfer
The volume reviews the progress of SCNT technology in major mammalian species including mouse, pig, and cattle, while at the same time, parallels can be drawn and distinctions made between the cellular and molecular basis of nuclear transfer and fertilization.
Selective autophagy : Methods and protocols
Presents the latest techniques used by researchers to study selective autophagy in a broad range of organisms such as yeast, plants, worms, fruit flies, and mammals. The chapters in this book cover several types of selective autophagy such as mitophagy, aggrephagy, ER-phagy, ferritinophagy, pexophagy, and nucleophagy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
RNA Interference
The use of RNA interference (RNAi) to evoke gene silencing in mammalian cells has almost become routine laboratory practice. Through refinement of double-stranded RNA (dsRNA) triggers of RNAi and creation of genome-scale libraries, the first genome-wide loss of function screens have been carried out in mammals. This review discusses some of the key features of RNAi in mammalian systems.
Reviews of Physiology Vol 154
Reviews of Physiology, Biochemistry and Pharmacology Contents: - Pheromone Reception in Mammals / - Elucidation of Mammalian Bitter Taste / - Synaptic Modulation in Pain Pathways / - The Vertebrate Phototransduction Cascade, Amplification and Termination Mechanisms
Reoviruses : Entry, Assembly and Morphogenesis
This book reviews our current understanding of Reoviridae entry, disassembly/assembly and egress in addition to updating high resolution structures of viral proteins and capsids from three different genera of the family.
Regulation of Gene Expression : Molecular Mechanisms
This volume provides a clear, concise overview of the protocols and techniques used to examine chemically or disease-mediated alterations in gene expression in mammalian systems.
Primate Craniofacial Function and Biology
Primates have unusual heads among mammals. Their big brains, relatively short faces and forward-facing eyes are part of a unique combination of traits that have captured the interest of biological anthropologists for decades. Describing the patterns of primate craniofacial evolution as well as sorting out the functional consequences of this evolutionary history has been fundamental in developing our current understanding of primates. Primate Craniofacial Function and Biology surveys current research on primate heads emphasizing the recent progress and diversity of functional studies into primate and mammalian craniofacial form. Much of the work included in this volume was inspired by William L. Hylander and his life-long contribution to research on primate craniofacial form and function.
Polycomb group proteins : Methods and protocols
Explores the latest technologies used in the Polycomb Group of proteins field and helps scientists--working on PcG proteins--investigate all functions of PcG proteins in diverse cellular contexts. The chapters in this book cover topics such the distribution of histone marks by CUT&Tag in Drosophila embryos; Co-IP in mammalian cells; replication timing of gene loci in different cell cycle phases; STORM and electronmicroscopy and relative data analysis; and polycomb mediated epigenetic modification in spheroids.
Piezoelectric Sensors
Chemically and biologically functionalized piezoelectric sensors are attractive alternatives to surface-sensitive transducers due to their surpassing versatility. The fourth volume of the Springer Series on Chemical Sensors and Biosensors includes a comprehensive theoretical treatment and current state-of-the art applications of the quartz crystal microbalance (QCM). Interface circuits and the study of viscoelasticity and micromechanics as well as surface roughness with the QCM are discussed. The broad field of analytical applications of piezoelectric sensors is covered, which ranges from nucleic acid detection, immunosensors, protein-membrane interactions and monitoring cells by imprinted polymers to the viscoelastic response of living mammalian cells on QCM-resonators.
Origin and evolution of the vertebrate telencephalon, with special reference to the mammalian neocortex
Following an approach that has been termed "developmental evolutionary genetics," this book seeks to establish a correspondence between embryological processes and the phylogenetic history of an organism.
NASH and Nutritional Therapy
This collection of research and clinical findings on nonalcoholic steatchepatitis (NASH) and nutritional therapy contains significant new findings in several fields . As NASH frequently causes liver cirrhosis, the nutritional aspects of its treatment are discussed . Other areas covered include nonalcoholic fatty liver, the role of leptin in the pathogenesis of NASH, restricted diets and exercise therapy, mammalian targets of the peptide rapamycin, and genetic factors influencing the development of NASH.
Molecular Mechanisms of Parasite Invasion
All of the parasitic organisms highlighted in this new book represent medically important human pathogens that contribute significantly to the global burden of disease. As such there is intense interest in understanding the molecular basis of infection by these pathogens—not only with regard to their clinical relevance but also the fascinating biology they reveal. For most of the parasites discussed here the ability to penetrate biological barriers and/or to establish intracellular residence is critical to survival of the pathogen in the mammalian hosts. For other parasites, a tissue invasive phenotype is a key virulence determinant. In the ensuing 18 chapters, select members of this diverse set of protozoan parasites, as well as some examples of the extremely reduced fungal parasites classified as Microsporidia, are discussed within the context of the fascinating molecular strategies employed by these organisms to migrate across biological barriers and to establish residence within target host cells.
Iron metabolism : Methods and protocols
Explores classical and cutting-edge methods optimized and validated to analyze various aspects of iron metabolism, from in vitro to multi-organ level. Opening with a section on basic iron metabolism methods, the book continues with methods applicable to a variety of systems, ranging from bacteria to cultured mammalian cells and tissues, with a focus on cellular heme and iron-sulfur cluster species, as well as mitochondrial iron and its derivatives. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Innervation of the Mammalian Esophagus
The esophagus is a relatively simple though vital organ. Beyond its role of propelling food from the pharynx to the stomach by a propulsive contraction wave representing the esophageal phase of deglutition, it is more recognized as a sensory organ from which a variety of respiratory and cardiovascular reflexes can be triggered.
Innate Immunity of Plants, Animals, and Humans
This book wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system.
