Chromatin and Disease
- المؤلف
- Tapas K. Kundu, R. Bittman, D. Dasgupta, …
- سنة النشر
- 2007
- الناشر
- Springer
- لغة الملف
- انكليزي
- نوع الملف
- Book
- تصنيف الكتاب
- Medical Science
- تحميل الكتاب قراءة الكتاب
It is more evident now than ever before that dynamic organization of human genome into nucleoprotein structure, chromatin confers the unique regulatory mechanisms for most of the cellular phenomena, which include replication, transcription, DNA repair, recombination and also apoptosis. The dynamic nature of the chromatin is regulated by chromatin modifications (epigenetic alterations), remodeling, histone chaperones and functional interactions of different chromatin interacting n- histone proteins. Dysfunction of this highly inter connected machineries disturb the cellular homoeostasis, and thereby causes several diseases. As we advance in our knowledge of chromatin function and also disease mechanisms in more details, their causal relationship is becoming more evident. This has lead to the identification of chromatin function as target for new generation therapeutics.
الكلمات المفتاحية: Biomedical and life sciences / Chromatin Structure, Dynamics & Transcription / DNA / Epignetic Regulation / Histone Chaperone / Histone Modifications / Histone modifying enzymes as a drug target / Chromosome / Dynamics / Gene expression / Genetics / Recombination / Transcription
