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Human battle against obesity
Obesity is one of the most common preventable diseases and it is a medical condition in which excess fat has accumulated in the body, mostly in the subcutaneous tissues. Clinical obesity is considered to be present when a person has a body mass index of 30 or over. Obesity results from a chronic positive energy balance regulated by a complex interaction between endocrine tissues and the central nervous system, This activity reviews the pathophysiology of obesity, inflammatory markers secreted by excessive fat deposition in adipose tissue, and their effects on chronic diseases such as hypertension, diabetes, and dyslipidemia.
Hormones, metabolism and the benefits of exercise
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Leptin
The discovery of leptin little more than a decade ago, as a hormone produced in white adipose tissue with an important role in satiety and energy expenditure, was a seminal event in our understanding of adiposity. This initial advance in the new endocrinology of obesity was soon followed by the realization that leptin was not only produced in adipose tissue, but in many different tissues of the body, and that receptors were similarly distributed. Additionally, the early recognition of infertility that was associated with leptin deficiency prompted research that identified roles for the polypeptide in virtually every area of reproductive biology.
Aesthetic Surgery of the Abdominal Wall
We have come a long way since the days when abdominal wall contouring was p- formed by simple dermolipectomies, with no attention to diastasis correction and muscular reinforcement, and little regard for the final aesthetic result. Nowadays, an abdominoplasty may be indicated for even the most demanding of patients. Details such as placement of the incision and umbilicoplasty are meticulously planned so as to conceal undesirable scars. Since the advent of suction-assisted lipectomy, in as- ciation with a classical operation or as an isolated procedure, the plastic surgeon has become capable of remodeling the entire trunk, assuring removal of considerable amounts of adipose tissue.
Adult stem cells : Methods and protocols
Expands on the previous edition with updated chapters covering a broader range of tissues and techniques pertaining to stem cell technologies. The chapters also cover topics such as the generation of iPSC-derived cells unique to the individual human genome addressing the possibility of more personalized clinical applications to an individual with a specific degenerative disease; and the use of nanoparticles such as 3D scaffolds and biomaterials as a means of improving stem cell viability after transplantation in the host tissue. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Adipose-derived stem cells : Methods and protocols
Discusses of the latest technology and advancements in the field of human-derived ASC and SVF. The chapters in this book are organized into four parts. Part One focuses on human ASC’s isolation, characterization, and differentiation. Part Two describes the isolation and characterization of ASC and SVF from canine, feline, and murine tissues. Part Three looks at hydrogels, scaffolds, and microphysiological systems, and Part Four talks about the new assays and applications using ASC. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Adipose Tissue and Adipokines in Health and Disease
The aim of Adipose Tissue and Adipokines in Health and Disease is to provide comprehensive information regarding adipose tissue, its physiological functions and its role in disease. This volume contains a collection of information spanning the entire range of adipose tissue studies, from basic anatomical and physiological research to epidemiology and clinical aspects, in one place. This book is indispensable for basic researchers and clinicians interested in the fields of obesity, metabolic diseases, inflammation and immunity, and specialists in each of the pathologies associated with obesity.
