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In Silico Dreams : How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future
In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare.
In Search of Dark Matter
The dark matter problem is one of the most fundamental and profoundly difficult to solve problems in the history of science. Not knowing what makes up most of the known universe goes to the heart of our understanding of the Universe and our place in it. In Search of Dark Matter is the story of the emergence of the dark matter problem, from the initial erroneous ‘discovery’ of dark matter by Jan Oort to contemporary explanations for the nature of dark matter and its role in the origin and evolution of the Universe. Written for the educated non-scientist and scientist alike, it spans a variety of scientific disciplines, from observational astronomy to particle physics. Concepts that the reader will encounter along the way are at the cutting edge of scientific research. However the themes are explained in such a way that no prior understanding of science beyond a high school education is necessary.
Improving Psychiatric Care for Older People : Barbara Robb’s Campaign 1965-1975
This book tells the story of Barbara Robb and her pressure group, Aid for the Elderly in Government Institutions (AEGIS). In 1965, Barbara visited 73-year-old Amy Gibbs in a dilapidated and overcrowded National Health Service psychiatric hospital back-ward. She was so appalled by the low standards that she set out to make improvements. Barbara’s book Sans Everything: A case to answer was publicly discredited by a complacent and self-righteous Ministry of Health. However, inspired by her work, staff in other hospitals ‘whistle-blew’ about events they witnessed, which corroborated her allegations. Barbara influenced government policy, to improve psychiatric care and health service complaints procedures, and to establish a hospitals' inspectorate and ombudsman.
Improving Oral Health for the Elderly : An Interdisciplinary Approach
Improving Oral Health for the Elderly: An Interdisciplinary Approach examines in depth a crucial yet frequently overlooked indicator of seniors’ quality of life. By combining a lifespan approach to health with a biopsychosocial perspective on health disparities, this book places oral health in the larger context of physical and mental well-being.
Improving Healthcare : A Dose of Competition
Improving Healthcare: A Dose of Competition systematically examines the American health care system from a competition-oriented perspective. The volume surveys the performance of each major sector of the health care system, and identifies impediments to more effective competition. Improving Healthcare examines such issues as competition v. regulation, public and private sector approaches to health care financing, cross-subsidies, licensure, provider market concentration, financial and clinical integration, payment for performance, quality, pharmacy benefit managers, direct-to-consumer advertising of pharmaceuticals, certificates of need, mandates, unionization, the significance of organizational status (nonprofit v. for-profit), and the role of antitrust and consumer protection in health care. It offers concrete recommendations to improve the quality and cost-effectiveness of the American health care marketplace.
Improving concrete and mortar using modified ash and slag cements
Presents the results of a study of high-tech concrete on composite Portland cement and slag Portland cement. The possibilities of significantly improving the properties of cements and concrete with the introduction of superplasticizers and hardening activators are shown. Experimental dependences that make it possible to predict the properties of concrete and mortars and to design mixtures with given properties are given.
Improvement in the Quality of Delivery of Electrical Energy using Power Electronics Systems
Electrical power is ubiquitous and continuously increasing in demand, with the result that power systems often operate close to their stability and thermal ratings. In order to tackle this problem, extraordinary changes are now taking place in the electrical supply industry worldwide, and conventional electromechanical technologies are becoming replaced by power electronics equipment. Improvement in the Quality of Delivery of Electrical Energy using Power Electronics Systems provides a detailed review of power electronics systems, covering both Flexible AC Transmissions Systems (FACTS) and Custom Power Systems (CUPS).
Impossible Bodies, Impossible Selves : Exclusions and Student Subjectivities
This book looks inside the school to examine how every-day, school-level processes act to place particular students 'outside' the educational endeavour and argues for new strategies for thinking critically about and interrupting educational exclusions and inequalities.The book uses tools offered by post-structural theory to read ethnographic data and show how the discourses that circulate inside schools at once mobilize and elide gender, sexuality, social class, ability, disability, race, ethnicity, religious and cultural belongings at the same time as they open up and close down 'who' students can be as learners.
Implants in the Aesthetic Zone : A Guide for Treatment of the Partially Edentulous Patient
This book concisely elucidates the science underlying implant treatment in the aesthetic zone in partially edentulous patients and clearly describes the techniques and protocols used by world-leading experts in the field.
Implant surfaces and their biological and clinical impact
Provides the reader with the knowledge required in order to understand the chemical, physical, mechanical, and topographical aspects of implant surfaces, as well as their impact on the biological response.
Implant prosthodontics : A patient-oriented strategy
Presents a coherent, evidence-based concept of prosthesis-oriented implant placement and individual esthetic prosthodontic restoration, conceptualized in detail from the first stages of planning to the aftercare period. The key interfaces between implantologist and prosthodontist, prosthodontist and dental technician, and also between the patient and the treatment team, are explained in detail.Sure to become a future standard text, this book is a must-have, not only for implantologists and prosthodontists, but also for the overwhelming majority of dentists and dental technicians.
Implant Aesthetics : Keys to Diagnosis and Treatment
Provides clinicians with detailed guidelines on the nature of the ideal anterior dental implant and, more importantly, how the desired aesthetic outcome is to be achieved. It reflects the incredible paradigm shift that has taken place within implant dentistry during the past 5 years, with recognition of the importance of a ‘crown down’ approach to diagnosis, planning, and treatment, especially in the anterior zone.
Immunology of Pregnancy
Reproductive Immunology is a growing area in both immunology and reproductive sciences and is helping us to better understand several complications of pregnancy. Immunology of Pregnancy is the first book to give a complete and up to date review of our knowledge related to the role of the immune system during pregnancy and the interactions between the placenta and the maternal immune system. This new title covers in detail all the different hypotheses and studies related to the immunology of implantation and provide a practical approach for the application of basic reproductive immunology research to pregnancy complications such as preeclampsia, pre-term labor and IUGR.
Immunogenicity of Biopharmaceuticals
This book is intended to give a broad overview of the current state-of-the-art regarding the immune response to biopharmaceuticals. The chapters range from an overview of the immune system and factors that may trigger the immune system, via detection of antibodies and clinical implications, to various case examples and the regulatory view on immunogenicity.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Immobilisation of DNA on Chips II
DNA chips are gaining increasing importance in different fields ranging from medicine to analytical chemistry with applications in the latter in food safety and food quality issues as well as in environmental protection. In the medical field, DNA chips are frequently used in arrays for gene expression studies to identify diseased cells due to over- or under-expression of certain genes, to follow the response of drug treatments, or to grade cancers), for genotyping of individuals, for the detection of single nucleotide polymorphisms, point mutations, and short tandem reports, or moreover for genome and transcriptome analyses in the quasi post-genomic sequencing era. Furthermore, due to some unique properties of DNA molecules, self-assembled layers of DNA are promising candidates in the field of molecular electronics.the main focus of these two volumes is on the immobilization chemistry, considering the various aspects of the immobilization process itself, since different types of nucleic acids, support materials, surface activation chemistries and patterning tools are of key concern.
Immobilisation of DNA on Chips I
the main focus of these two volumes is on the immobilization chemistry, considering the various aspects of the immobilization process itself, since different types of nucleic acids, support materials, surface activation chemistries and patterning tools are of key concern.the focus of the major part of the chapters lies on the coupling chemistry used for DNA immobilization. Successful immobilization techniques for DNA appear to either involve a multi-site attachment of DNA (preferentially by electrochemical and/or physical adsorption) or a single-point attachment of DNA (mainly by surface activation and covalent immobilization or (strept)avidin-biotin linkage).
Immigration Policy and the Labor Market : The German Experience and Lessons for Europe
German and European immigration policies have only recently begun to cope with the inevitable: growing labor demand in the face of high unemployment and a shrinking labor force due to demographic change. Despite the implementation of Germany's first immigration act and several European initiatives towards legal harmonization at the EU level, an actively controlling immigration policy, which would be needed to master the challenges ahead, is not yet in sight. Against this background, the book draws conclusions from the German history of immigration policy. It analyzes the country's future demand for immigration and develops an economic model for the effective selection and integration of labor migrants that could provide the foundation for a joint European immigration strategy.
Imaging Technologies and Transdermal Delivery in Skin Disorders
This important, timely book covers the latest understanding about today's major skin disorders, the development of imaging technologies for skin diagnosis, and the applications of micro/nano-technologies for the treatment of skin complications. It also places great emphasis on the critical role that interdisciplinary science occupies to achieve the requisite level of understanding of skin conditions and their management, which is essential to creating technologies that work.
Imaging of Carotid Artery Stenosis
This book take the reader step by step through illustrated descriptions of state-of-the-art imaging techniques that they have helped to develop, and demonstrate that these techniques are crucial in the management of patients. This book covers all facets of imaging in carotid artery stenosis and gives an outlook to future aspects. The "take-home-messages" at the end of each chapter are a quick help in daily practice.
