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N-Heterocyclic Carbenes in Transition Metal Catalysis
It was only in the early 1990s that carbenes with the carbene carbon being incorporated in a nitrogen containing heterocycle (N-heterocyclic carbenes or NHCs) were found to be stable enough to be isolated. Since the first report on the application of NHCs as ligands in transition metal catalysis in 1995, NHC have found numerous applications and have been established as a versatile and indispensable class of ligands. For many reactions like metathesis or cross-coupling reactions NHCs have often become the ligands of choice, allowing otherwise difficult transformations. In this book leading experts have surveyed major areas of application of NHC metal complexes in catalysis. The authors have placed a special focus on nickel- and palladium-catalyzed reactions, on applications in metathesis reactions, on oxidation reactions and on the use of chiral NHC-based catalysts. This compilation is rounded out by an introductory chapter and a chapter dealing with synthetic routes to NHC metal complexes.
New Aspects of Zirconium Containing Organic Compounds
Metal carbene complexes have made their way from organometallic curiosities to valuable reagents and catalysts. They offer novel synthetic opportunities in carbon-carbon bond formation based on either carbene-centered reactions or on metal-templated processes which makes them indispensable in modern synthetic methodology. The most prominent metal carbenes are now either commercially available or easy to synthesize and handle with modern laboratory techniques. This volume organized in eight chapters written by the leading scientists in the field illustrates the theoretical background, non-classical nucleophilic and cycloaddition patterns, chromium-templated benzannulation and photo-induced reactions, rhodium-catalyzed carbene transfer as well as the principles and applications of olefin metathesis which has coined the progress in synthetic methodology over the past decade. Designed for researchers in academia and industry as well as graduate students it presents the state-of-the-art potential of carbene complexes in modern organic synthesis.
Neodymium Based Ziegler Catalysts - Fundamental Chemistry
In this volume we try to review the available literature by two independentapproaches to Nd and Ln-catalyzed diene polymerizations. In the first part ofthe volume, which is entitled “Neodymium-Based Ziegler/Natta Catalysts andtheir Application in Diene Polymerization”, a polymer chemist’s view is givenwith strong emphasis on Nd-based catalyst systems. Also technological andindustrial aspects of Nd-catalyzed diene polymerizations are addressed. In thesecond part of the volume, which is entitled “Rare-Earth Metals and AluminumGetting Close in Ziegler-type Organometallics”, a more organometallic per-spective is given and Ln-based catalyst systems are addressed. By the synopsisof these different perspectives, the reader will comprehend the complexity ofLn-based Ziegler catalyst systems and their application to the polymerizationof dienes.
Molecular Wires : From Design to Properties
In the emerging field of nanoscience the desire to construct objects which in the molecular scale can resemble and act as macroscopic devices is a constant trend. Amongst the simplest but also most attractive functional component molecular wires are surely the most investigated. The reason for such interest is quite obvious since wires, in today world, are used all around us and are the most indispensable unit to assemble any type of electronic devices.In this issue the synthesis and characterization of molecular wires based on organic or metal complexes components, their properties and some theoretical background will be illustrated.
Metathesis Polymerization
Clearly illustrated and demonstrated by the entire series of Advances in Polymer Science., the area of polymer science is a rapidly developing and growing field, strongly influencing other areas of chemistry. Among other polymerization techniques, those based on metathesis polymerization have experienced significant progress. With a rapidly developing armory of initiators on hand, one is now capable of polymerizing various types of functional monomers by metathesis-based techniques.The latest developments in all these areas of metathesis-based polymerizations are summarized in this book. It is designed to attract equally students and advanced scientists working in the areas of polymer science, physical, and organometallic chemistry by providing both extensive background information and up-to-date interdisciplinary knowledge. Special consideration has been given to the literature sections in order to facilitate further reading.
Metathesis Chemistry : From Nanostructure Design to Synthesis of Advanced Materials
Recently, an important scientific event in metathesis chemistry, the NATO-Advanced Study Institute New Frontiers in Metathesis Chemistry: From Nanostructure Design to Sustainable Technologies for . Synthesis of Advanced Materials was organized in Antalya, Turkey (September 4-16, 2006). Prominent scientists, young researchers and students, convened for two weeks to debate on the newest trends in olefin metathesis and identify future perspectives in this fascinating field of synthetic organic, organometallic and polymer chemistry with diverse potential applications in materials science and technology. Following the fruitful practice of the previous NATO ASI meetings, selected contributions comprising plenary lectures, short communications and posters are compiled in this special volume dedicated to this outstanding international scientific meeting.
Metallocenes in Regio- and Stereoselective Synthesis
Metallocene is a well known sandwich complex with two cyclopentadienyl ligands such as ferrocene. Recently, such metallocene compounds have been found to be very characteristic and they have become very important, not only in the area of organic synthesis, but also in polymerization in industry. Metal complexes with one cyclopentadienyl ligand have also become popular as half sandwich complexes. The number of researchers in the field of metallocenes has increased rapidly. However, the origin of the characteristic reactivity of metallocenes is not fully understood. In this volume, the chemistry of metal complexes with at least one cyclopentadienyl ligand is comprehensively covered by leading experts. Reactions discussed here are (i) natural product synthesis, (ii) catalytic asymmetric synthesis, (iii) cyclization reactions, (iv)catalytic reactions, (iv) polymerization reactions and (v) carbon-carbon bond cleavage reactions. The reader will have access to useful information about the current state of metallocene chemistry.
Metal Catalyzed Reductive C-C Bond Formation : A Departure from Preformed Organometallic Reagents
The prototypical catalytic reductive C–C bond formations, the Fischer-Tropsch reaction [1] and alkene hydroformylation [2], were discovered in 1922 and 1938, respectively [3,4]. These processes, which involve reductive coupling to carbon monoxide, have long been applied to the industrial manufacture of commodity chemicals [5]. Notably, alkene hydroformylation, also known as the oxo-synthesis, has emerged as the largest volume application of homogeneous metal catalysis, accounting for the production of over 7 million metrictons of aldehyde annually. Despite the impact of these prototypical reductive C–C bond formations, this field of research lay fallow for several decades.
Metal Catalyzed Cascade Reactions
Transition metal-catalyzed cascade reactions are an elegant approach to complex molecular scaffolds. Besides their esthetics and increase in structural complexity, they have also become mechanistic challenges for the combination of organometallic elementary steps. As a consequence, cascade reactions have revolutionized synthetic strategies and conceptual thinking. The authors highlight cyclization via carbopalladation and acylpalladation and Heck-pericyclic sequences. They discuss p-allyl palladium-based cascade reactions, Michael-type additions as an entry to transition-metal-promoted cyclizative transformations, and sequential or consecutive palladium-catalyzed processes, and show Pauson-Khand cascades, metal-catalyzed cyclizations of acyclic precursors, as well as cascade and sequential ruthenium-catalyzed transformations. Therefore, the reader finds overview of an exciting and highly dynamic field of a new and innovative methodological concept
Inorganic and Organometallic Polymers
This book has its origins in courses taught by the author to various und- graduate and graduate students at the Indian Institute of Technology, K- pur, India. The diversity of inorganic chemistry and its impact on polymer chemistry has been profound. This subject matter has grown considerably in the last decade and the need to present it in a coherent manner to young minds is a pedagogic challenge. The aim of this book is to present to the students an introduction to the developments in Inorganic and - ganometallic polymers. This book is divided into eight chapters. Chapter 1 provides a general overview on the challenges of Inorganic polymer synthesis. This is f- lowed by a survey of organic polymers and also includes some basic f- tures of polymers. Chapters 3-8 deal with prominent families of inorganic and organometallic polymers. Although the target group of this book is the undergraduate and graduate students of chemistry, chemical engineering and materials science it is also hoped that chemists and related scientists in industry would find this book useful.
Inorganic and Organometallic Macromolecules : Design and Applications
Polymers containing metals and metal-like atoms are essential materials for the extended opportunities and demands of the 21st century. This book describes the synthesis of some of these polymers and their potential application in many fields such as materials, biomedicine, engineering, communications, and ceramics.
Directed Metallation
a new chelation-assisted methodology has been developed not only for controlling regio- and stereoselectivity of reactions, but also for accelerating reactions. In particular, chelation-methodology has been utilized as a new activation method, in which a carbon-metal bond is generated directly from a C-H bond; a reaction rarely achieved using conventional methods. A wide variety of catalytic functionalization reactions of C-H bonds by the utilization of a chelation, have been developed recently and are comprehensively discussed in this book by leading experts. In addition, new approaches to directed hydrometalation and directed carbometalation as a key step are also discussed. A unique stereo- and regioselective hydroformylation has been developed through the utilization of directed hydrometalation.
Dendrimer Catalysis
catalytically active dendrimers have emerged as a class of molecular catalysts that has substantially enriched the field of homogeneous (and in part heterogeneous) catalysis. A general survey of transition metal dendrimer catalysts and the way they have developed is followed by in-depth discussions of dendritic transition metal catalysis based on non-covalent catalyst-support interaction and an overview of the rapidly growing field of stereoselective dendrimer catalysis. The development of dendrimer-encapsulated bimetallic nanoparticles has provided the interface with heterogeneous colloid catalysis. As cheaper and readily accessible alternatives to regular dendrimers, hyperbranched polymers are increasingly being used as catalyst platforms. These topics are complemented by a review of metallodendritic exoreptors for the redox recognition of oxo-anions and halides.
Combinatorial Chemistry on Solid Supports
In this volume, state-of-the-art solid-phase synthesis is presented from different angles. Ranging from methodology development to application in the synthesis of complex native and designed structures, a complete overview is presented. We are confident that addressing the fascinating interface between chemistry and biology is only possible by innovative methods in both disciplines. Combinatorial chemistry is surely one of these.This book, written by an international group of renowned experts in their respective field, covers recent advances in important topics regarding combinatorial chemistry on solid supports
Chiral Diazaligands for Asymmetric Synthesis
The use of phosphine derivatives has historically induced the tremendous development of catalysis (both non-asymmetric and asymmetric). Although the chemistry of amines is more documented, the use of nitrogen-containing ligands only appeared recently. Nevertheless, during the last ten years, the results describing chiral diamine preparations and their uses in asymmetric catalysis and synthesis are increasing faster than their phosphorus counterparts. The reader will find in this volume the most recent methods for the synthesis of chiral diamines as well as their applications in asymmetric catalysis of CC bond formation. Particular attention will be given to spartein and derivatives of such diamines. Recently, the particular properties and the chemistry of amines allowed to obtain catalysts easy to separate and recycle and new types of ligands such as diaminocarbenes, ureas and thioureas. Finally, the complexing properties of some diamines allowed the formation of complexes with chirality "at the metal " which is of major theoretical interest and presents numerous potential applications.
Catalytic role of amino acids in organic reactions
Asymmetric organometallic and organocatalytic processes have attracted great interest. Asymmetric synthesis using both natural and unnatural amino acids has been tremendously important from synthetic as well as industrial viewpoints, and numerous new methodologies have been developed in the last decades. Herein we provide an overview of old and very recent (since 1900 till now) advances and applications in the area of heterogeneous catalysis, homogeneous catalysis, electrocatalysis, photocatalysis, organocatalysis, thermal catalysis using amino acids [proline, glycine, alanine, valine, serine, threonine, cysteine, methionine, asparagine, glutamine, lysine, arginine, histidine, aspartate, glutamate, phenylalanine, and tryptophan], (supported or unsupported), an amino acid containing materials or amino acids derivatives as an essential component of catalysts, this book highlights the most important and recent developments to immobilize or support amino acids on various support materials. This book is suitable as supplementary reading for courses targeting the design, synthesis, and application of chiral catalysts, asymmetric catalysis, and sustainable production.
Catalytic Carbonylation Reactions
Carbonylation reactions are of major importance in both organic and industrial chemistry. Due to the availability, price and reactivity pattern, carbon monoxide is becoming a more and more important building block for fine and bulk chemicals. The major reaction types of carbon monoxide are comprehensively discussed by leading experts from academia and industry. The authors highlight important carbonylation reactions such as hydroformylation, alkoxy-carbonylations, co/olefin-copolymerization, Pauson-Khand reactions and others. They illustrate applications in organic synthesis and give industrial examples.
Bioorganometallic Chemistry
Bioorganometallic Chemistry has become a mature area of science and is comprehensively covered by leading experts in this book. Naturally occuring bioorganometallic complexes, such as vitamin B12 and recently discovered iron and nickel hydrogenases, including a possible role of the latter in the geochemical theory of the origin of life, are considered.
Asymmetric organo-metal catalysis : Concepts, principles, and applications
In Asymmetric Organo-Metal Catalysis: Concepts, Principles, and Applications, accomplished chemist Liu-Zhu Gong delivers a comprehensive discussion of how to design efficient organo/metal combined catalyst systems, new cooperatively catalyzed asymmetric reactions, relay catalytic cascades, and multicomponent reactions. The distinguished author covers critical topics, like the combined catalysis of chiral phase transfer catalysts, enamine, iminium, nucleophilic Lewis base, or Bronsted acids with metal complexes, while also covering the cooperative catalysis of photocatalysts and organocatalysts.
