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Imaging in Treatment Planning for Sinonasal Diseases
Provides both basic and advanced information on the clinical presentation, imaging findings and treatment of sinonasal diseases. For each specific disease, the rationale underlying the treatment strategy is discussed and the imaging findings critical to the decision-making process are identified. This is an original approach and reflects the constant team effort at the editors' institute over the past 15 years to integrate clinical and radiological information with the aim of establishing the most appropriate treatment. Special emphasis is placed on the identification of clinical and imaging data that allow selection of an endonasal or an external approach in surgical candidates. The value of planning an integrated endoscopic and radiological follow-up in the different diseases is also thoroughly reviewed. Through the correlation of imaging with endoscopic or clinical findings, this book will enable radiologists to familiarise themselves with the "otorhinolaryngological world" and clinicians to understand more fully the significance of specific radiological findings. It will serve as an invaluable guide to the selection of imaging techniques.
Imaging in Drug Discovery and Early Clinical Trials
Efficient tools for the selection and validation of drug targets both at the preclinical and clinical level are required. Non-invasive imaging and in particular molecular imaging methods are becoming essential technologies to support drug discovery and dvelopment. Imaging provides structural, functional, metabolic and molecular readouts that are being applied to characterize a disease phenotype (diagnosis), to elucidate molecular mechanisms involved, to evaluate drug efficacy and safety, and to identify potential biomarkers of the drug's mechanism-of-action, efficacy and safety. Non-invasive imaging techniques constitute a bridge between preclinical and clinical drug evaluation. In this monograph the contribution of imaging modalities to the various stages of drug discovery and development, from early target validation to their use in clinical development programs, is described. Chapters are devoted to the description of the drug discovery process as such, to the various imaging modalities being used both preclinically and clinically, to applications of imaging during the optimization of a lead compound (addressing issues such as bioavailability and efficacy) and during the drug safety evaluation.
