Page 1
Page 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontologies for Urban Development
Action C21 of the European programme for Cooperation in the field of Scientific and Technical Research (COST—http://www.cost.esf.org/) is dedicated to investigating urban ontologies for an improved communication in urban civil engineering projects. The Action, known informally as "Towntology", brings together a large and heterogeneous grouping from across Europe, whose interests range from construction to urban tourism and from transport infrastructure to resource visualisation. On 6-7 November 2006, in Geneva, the Action convened a successful workshop to address emerging issues in the field. This volume presents the contributions to that workshop, in many cases revised afterwards to capture some of the outcomes of discussion.
Online Storage Systems and Transportation Problems with Applications : Optimization Models and Mathematical Solutions
This books covers the analysis and development of online algorithms involving exact optimization and heuristic techniques, and their application to solve two real life problems. The first problem is concerned with a complex technical system: a special carousel based high-speed storage system - Rotastore. It is shown that this logistic problem leads to an NP-hard Batch PreSorting problem which is not easy to solve optimally in offline situations. The second problem originates in the health sector and leads to a vehicle routing problem. Reasonable solutions for the offline case covering a whole day with a few hundred orders are constructed with a heuristic approach, as well as by simulated annealing. Optimal solutions for typical online instances are computed by an efficient column enumeration approach leading to a set partitioning problem and a set of routing-scheduling subproblems. The latter are solved exactly with a branch-and-bound method which prunes nodes if they are value-dominated by previous found solutions or if they are infeasible with respect to the capacity or temporal constraints.
Oncologic and Cardiologic PET/CT-Diagnosis : An Interdisciplinary Atlas and Manual
Since 1999/2000 simultaneous imaging of anatomical features and metabolic activities using fused PET and CT images has complemented and in many cases even replaced what was originally done as separate analysis. – Is this a small revolution? – In fact, this new approach can be considered to be without a rival for imaging diagnosis. The complementary efforts of nuclear medicine physicians and radiologists have improved the diagnostic value of PET/CT scans. The successful use of PET/CT in the field of oncology has been documented world-wide, and in cardiology we can take advantage of the significant findings of PET diagnosis, particularly in the USA. New prospects are now available for paediatric oncology and molecular medicine.
On Bypass : Advanced Perfusion Techniques
With the introduction of cardiac surgery more than five decades ago and the use of the heart-lung machine for open heart surgical procedures granting the surgeon unlimited time in which to operate inside the heart, a complex task has been given to the Perfusionist. With a pairing of a perfusionist and a surgeon for each chapter, On Bypass: Advanced Perfusion Techniques is an essential collection of techniques and protocols to aid in the difficult and immediate decision making in the operating room. Among the topics covered in this comprehensive text are pediatric perfusion techniques for complex congenital, separation from cardiopumonary bypass, blood flow during cardiopumonary bypass, and minimally invasive perfusion techniques. Also covered is ultrafiltration in cardiac surgery, echocardiography and cardiopulmonary bypass, and advances in long-term pulmonary support.
olution Sets for Net Zero Energy Buildings : Feedback from 30 Buildings Worldwide
Presents a unique study of 30 NZEBs that have been constructed and have had their performance measured for at least 12 months. The study is based upon an international collaborative research initiated by the International Energy Agency. It is the first book to evaluate building strategies in houses, educational buildings and offices that have been demonstrated to work in practice. It examines how the design challenges of climate and building type have been addressed, and to what extent the various design approaches have been successful. This book presents convincing evidence that a careful re-thinking of conventional design norms can achieve a far greater performance benefit than is normally feasible. It identifies 'solution sets' that work at the whole building level and at the individual building design challenge level for each climate and building type. In doing so, the book provides guidance as to how to improve the design by learning from these cases. Unusually for a book of this type it has examples of buildings in what are conventionally labeled 'hot' and 'cold' climates.
Office and SharePoint 2007 User’s Guide : Integrating SharePoint with Excel, Outlook, Access, and Word
Web sites. Collaboration. Document management. Paperless offices. We want it all in business today, but how do you achieve all of these goals? More importantly, if you work for one of the millions of small to medium–sized businesses, how do you find the time and build the expertise necessary to reach these goals? Even the most powerful tool will not allow you to succeed unless you can get the majority of your staff to use it efficiently and effectively. You need a guide that demonstrates a platform small to medium–sized businesses can use to reach these goals.
Observing the Sun with Coronado™ Telescopes
At around the turn of the millennium, the introduction of the Coronado range of solar telescopes and filters heralded the ‘coming of age’ of amateur solar astronomy. Before then, solar astronomy was mostly white-light only. Hydrogen-alpha systems were expensive and difficult to use, but today even the budget-priced Coronado PST (Personal Solar Telescope) provides a band pass of one Angstrom and is thermally stable. That means that today’s amateur solar observers can see – and image – sunspots, flares, prominences, plage, filaments, and active regions of the Sun, all in amazing detail.
Objective information theory
Objective Information Theory (OIT) is proposed to represent and compute the information in a large-scale complex information system with big data in this monograph. To formally analyze, design, develop, and evaluate the information, OIT interprets the information from essential nature, measures the information from mathematical properties, and models the information from concept, logic, and physic. As the exemplified applications, Air Traffic Control System (ATCS) and Smart Court SoSs (System of Systems) are introduced for practical OITs.
Nutrition of cancer patient
According to world statistics, nutrition is estimated to contribute to about one-third of preventable cancers, nearly the same amount as the contribution of smoking. It is defined as the processes by which living organisms' intake of food and drink is used by the body for fuel, growth, reproduction, and the overall maintenance of health. Thus, sufficient nutritional consumption is essential for well-being. Consequently, it is an important part of life, cancer treatment, recovery, and prevention; eating the necessary nutrients prior to, during, and after a cancer treatment would aid the patient in the recovery process. A healthy diet means a stable nourishment, and includes obtaining sufficient amounts of essential nutrients (vitamins, minerals, protein, carbohydrates, fat, and water) the body needs. Inadequate intake of essential vitamins and minerals might explain the epidemiological findings that people who eat only small amounts of fruits and vegetables have an increased risk of developing cancer.
Nucleic Acids and Proteins in Soil
With millions of different bacterial species living in soil, the microbial community is extremely complex, varying at very small scales. Microbe-driven functions are essential for most processes in soil. Thus, a better understanding of this microbial diversity will be invaluable for the management of the various soil functions. Nucleic Acids and Proteins in Soil combines traditional approaches in soil microbiology and biochemistry with the latest techniques in molecular microbial ecology. Included are methods to analyse the presence and importance of nucleic acids and proteins both inside and outside microbial cells, the horizontal gene transfer which drives bacterial diversity, as well as soil proteomes. Further chapters describe techniques such as PCR, fingerprinting, the challenging use of gene arrays for structural and functional analysis, stable isotope probing to identify in situ metabolic functions, and the use of marker and reporter genes in soil microbial ecology.
Nuclear Condensed Matter Physics with Synchrotron : Basic Principles, Methodology and Applications
This book provides a comprehensive introduction to the growing field of nuclear condensed matter physics with synchrotron radiation, a technique which finds numerous applications in fields such as magnetism, physics of surfaces and interfaces, lattice dynamics and more. Due to the enormous brilliance of modern synchrotron radiation sources, the method is particularly suited for the investigation of low-dimensional structures such as thin films and nanoparticles. The use of isotopic probe layers, for example, allows one to determine magnetic and vibrational properties with very high spatial resolution; focusing techniques and x-ray interference effects lead to a very high sensitivity for smallest amounts of material. The book is written on an introductory level with many examples employed to illustrate the special experimental possibilities.
Nonlinear Oscillations of Hamiltonian PDEs
After introducing the reader to classical finite-dimensional dynamical system theory, including the Weinstein–Moser and Fadell–Rabinowitz resonant center theorems,the author develops the analogous theory for completely resonant nonlinear wave equations. Within this theory, both problems of small divisors and infinite bifurcation phenomena occur, requiring the use of Nash–Moser theory as well as minimax variational methods. These techniques are presented in a self-contained manner together with other basic notions of Hamiltonian PDEs and number theory.
Noetherian Semigroup Algebras
This work presents a comprehensive treatment of the main results and methods of the theory of Noetherian semigroup algebras. These general results are then applied and illustrated in the context of important classes of algebras that arise in a variety of areas and have been recently intensively studied. Several concrete constructions are described in full detail, in particular intriguing classes of quadratic algebras and algebras related to group rings of polycyclic-by-finite groups. These give new classes of Noetherian algebras of small Gelfand-Kirillov dimension. The focus is on the interplay between their combinatorics and the algebraic structure.
New Partnerships for Innovation in Microfinance
"The book presents valuable information with a strong analytical tilt. … targets economists and managers in banking and development finance organizations, as well as policy makers, international development organizations, and development agencies. Because it covers a range of issues related to funding microfinance, and is written in relatively simple language, yet intelligently argued, it can be used as a resource book for courses on microfinance funding and development. … a useful read for practitioners in the sector."
New Frontiers in Angiogenesis
New Frontiers in Angiogenesis starts with a comprehensive overview of the field and continues with topics that have been minimally explored. The topics deal with dynamics of vasculogenesis using imaging techniques, bone marrow-derived endothelial cell precursors as potential therapeutic tools, regulation of post-angiogenic vessel regression, vascular mimicry, design and construction of artificial vessels, bioengineering of angiogenesis, and lymphangiogenesis recapitulating angiogenesis in health and disease states. Each chapter is written by leading experts of the subjects. It is hoped that this volume will challenge all of us interested in the field of angiogenesis and cardiovascular biology, in particular those in academia and industries, to think "outside the box" and explore angiogenesis from a fresh angle. It is hoped that New Frontiers in Angiogenesis is thought provoking and serve as a road map for discovering new findings to help betterments of human health.
New developments in nanosensors for pharmaceutical analysis ; 1st ed.
Presents an overview of developments in nanosensor usage in pharmaceutical analysis, thereby helping pharmaceutical companies attain reliable, precise, and accurate analysis of pharmaceuticals. This book presents very simple, precise, sensitive, selective, fast, and relatively inexpensive methods for pre-treatment, prior to analysis. These methods may be considered for further application in clinical studies and assays. The book includes the manufacturing of sensors for pharmaceutical analysis at nano- or smaller scales, and gives simple and relatable designs for the fabrication of sensors.
New Challenges in Gastrointestinal Endoscopy
Gastrointestinal (GI) endoscopy has become indispensable in both diagnosis and treatment of GI disorders. It has been 10 years now since the first Endoscopy Forum Japan was held, and in that time, leading young endoscopists, including colleagues from Asia, Australia, Europe, and the United States, have participated in the forum, discussing issues at the forefront of the field. Through their efforts, GI endoscopy has advanced with many new methods for both diagnoses and treatments, and those achievements are included in this book. Contributing to the development of endoscopic medicine all over the world, this is a groundbreaking, edifying, and engrossing publication offering the most recent advances in the field, precisely presented and depicted with more than 250 color photographs. Novel technologies are described in detail and will be of interest to those in the field of medicine and in engineering as well.
Network Control and Engineering for QOS, Security and Mobility, III ; IFIP TC6 / WG6.2, 6.6, 6.7 and 6.8. Third International Conference on Network Control and Engineering for QoS, Security and Mobility, NetCon 2004 on November 2-5, 2004, Palma de Mallorca, Spain
This volume contains the proceedings of the Third International Conference on Network Control and Engineering for Quality of Service, Security and Mobility (Net-Con'2004), celebrated in Palma de Mallorca (Illes Balears, Spain) during November 2-5, 2004. This IFIP TC6 Conference was organized by the Universitat de les Illes Balears and sponsored by the following Working Groups: WG6.2 (Network and Internetwork Architectures), WG6.6 (Management of Networks and Distributed Systems), WG6.7 (Smart Networks) and WG6.8 (Mobile and Wireless Communications). The rapid evolution of the networking industry introduces new exciting challenges that need to be explored by the research community. The adoption of Internet as the global network infrastructure places the issue of quality of service among one of the hot topics nowadays: a huge diversity of applications with quite different service requirements must be supported over a basic core of protocols. Also, the open and uncontrolled nature of Internet enforces the need to guarantee secure transactions among users, thus placing security as another hot topic. Finally, the explosion of mobility and its integration as part of the global infrastructure are probably now the most challenging issues in the networking field.
Navigation and MIS in Orthopaedic Surgery
This textbook offers new insights into the use of computer assisted surgery and minimally invasive surgery in orthopaedic surgery. A comprehensive presentation of scientific work and clinical experience is included encompassing areas of spine, trauma, sports and reconstructive surgery. We have added sections that discuss minimally invasive surgery, as we believe CAS will be an enabling technology for these more challenging approaches by providing a virtual digital "surgical exposure". We have explored areas of new endeavor that may not have current applications.
