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Ocular Transporters in Ophthalmic Diseases and Drug Delivery
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.
Obstructions in Security-Aware Business Processes : Analysis, Detection, and Handling
This book explores the dilemma-like stalemate between security and regulatory compliance in business processes on the one hand and business continuity and governance on the other. The growing number of regulations, e.g., on information security, data protection, or privacy, implemented in increasingly digitized businesses can have an obstructive effect on the automated execution of business processes. Such security-related obstructions can particularly occur when an access control-based implementation of regulations blocks the execution of business processes. By handling obstructions, security in business processes is supposed to be improved. For this, the book presents a framework that allows the comprehensive analysis, detection, and handling of obstructions in a security-sensitive way. Thereby, methods based on common organizational security policies, process models, and logs are proposed. The Petri net-based modeling and related semantic and language-based research, as well as the analysis of event data and machine learning methods finally lead to the development of algorithms and experiments that can detect and resolve obstructions and are reproducible with the provided software.
Objective information theory
Objective Information Theory (OIT) is proposed to represent and compute the information in a large-scale complex information system with big data in this monograph. To formally analyze, design, develop, and evaluate the information, OIT interprets the information from essential nature, measures the information from mathematical properties, and models the information from concept, logic, and physic. As the exemplified applications, Air Traffic Control System (ATCS) and Smart Court SoSs (System of Systems) are introduced for practical OITs.
Nuclear fusion research : Understanding plasma-Surface interactions
It became clear in the early days of fusion research that the effects of the containment vessel (erosion of "impurities") degrade the overall fusion plasma performance. Progress in controlled nuclear fusion research over the last decade has led to magnetically confined plasmas that, in turn, are sufficiently powerful to damage the vessel structures over its lifetime. This book reviews current understanding and concepts to deal with this remaining critical design issue for fusion reactors. It reviews both progress and open questions, largely in terms of available and sought-after plasma-surface interaction data and atomic/molecular data related to these "plasma edge" issues.
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders : from Genes to Therapeutics
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Non-Linear Optical Properties of Matte : From molecules to condensed phases
Non-Linear Optical Properties of Matter: From Molecules to Condensed Phases attempts to draw together both theory and application in this field. As such it will be of interest to both experimentalists and theoreticians alike. Divided into two parts, Part 1 is concerned with the theory and computing of non-linear optical (NLO) properties while Part 2 reviews the latest developments in experimentation.This book will be invaluable to researchers and students in academia and industry. It will be of particular interest to anyone involved in materials science, theoretical and computational chemistry, chemical physics, and molecular physics.
New Frontiers in Angiogenesis
New Frontiers in Angiogenesis starts with a comprehensive overview of the field and continues with topics that have been minimally explored. The topics deal with dynamics of vasculogenesis using imaging techniques, bone marrow-derived endothelial cell precursors as potential therapeutic tools, regulation of post-angiogenic vessel regression, vascular mimicry, design and construction of artificial vessels, bioengineering of angiogenesis, and lymphangiogenesis recapitulating angiogenesis in health and disease states. Each chapter is written by leading experts of the subjects. It is hoped that this volume will challenge all of us interested in the field of angiogenesis and cardiovascular biology, in particular those in academia and industries, to think "outside the box" and explore angiogenesis from a fresh angle. It is hoped that New Frontiers in Angiogenesis is thought provoking and serve as a road map for discovering new findings to help betterments of human health.
Neurovascular Surgery : Surgical Approaches for Neurovascular Diseases
This book presents the diagnosis, investigation and treatment of neurovascular diseases, and offers expert opinions and advice on avoiding complications in neurovascular surgery. It also covers complication management and post-operative follow-up care. The book is divided in to three parts; the first part discusses common approaches in neurovascular surgery, describing the steps, indications for and limitations of the approach, as well as the associated complications and how to avoid them. The second part addresses surgical treatment based on pathology, taking the different locations of lesions into consideration. The third part focuses on the technological developments that support neurovascular surgery, which may not be available everywhere, but have been included to help vascular surgeon understand the principles.
Neuroendocrine cells and peptidergic innervation in human and rat prostrate
Introduction The prostate causes a signi?cant number of medical problems in the adult male, and the lower urinary tract symptoms are accepted as an unavoidable consequence of male aging. Most of these symptoms are mainly due to clinical benign prostatic hyperplasia (BPH), which is the most frequent benign tumor in the male, in- pendent of race or culture. On the other hand, cancer of the prostate shows an increasing incidence, being the second leading cause of death in men, after lung cancer.
Networked Control Systems: Theory and Applications
Networked Control Systems presents the most recent results in stability and robustness analysis as well as new developments related to networked fuzzy and optimal control. Many of the chapters contain details of case-studies, experimental, simulation and/or other application-related work showing how the theories put forward can be implemented in real systems.
Network-Aware Security for Group Communications
Network-Aware Security for Group Communications fills a growing need in the research community for a reference that describes the state-of-the-art in securing group communications in emerging networks and for future applications. The growth of multi-user services makes it essential that a complementary suite of security solutions are deployed in order to protect these services from a broad spectrum of security threats that are unique to group communications. This book is focused on tailoring security solutions to the underlying network architecture (such as the wireless cellular network, or ad hoc and sensor networks), or to targeted applications using methods tailored for that application (such as multimedia multicasts).
Nanostructured Soft Matter : Experiment, Theory, Simulation and Perspectives
This book provides an interdisciplinary overview of a new and broad class of materials under the unifying name Nanostructured Soft Matter. It covers materials ranging from short amphiphilic molecules to block copolymers, proteins, colloids and their composites, microemulsions and bio-inspired systems.
Multiscale Dissipative Mechanisms and Hierarchical Surfaces : Friction, Superhydrophobicity, and Biomimetics
Multiscale Dissipative Mechanisms and Hierarchical Surfaces covers the rapidly developing topics of hierarchical surfaces, roughness-induced superhydrophobicity and biomimetic surfaces. The research in these topics has been progressing rapidly in the recent years due to the advances in the nanosciences and surfaces science and due to potential applications in nanotechnology. The first in its field, this monograph provides a comprehensive review of these subject and presents the background introduction as well as recent and new results in the area.
Multimedia technology and enhanced learning ; 2nd EAI International conference, ICMTEL 2020, Leicester, UK, April 10-11, 2020, Proceedings, Part II
This two-volume book constitutes the refereed proceedings of the Second International Conference on Multimedia Technology and Enhanced Learning, ICMTEL 2020, held in Leicester, United Kingdom, in April 2020. Due to the COVID-19 pandemic all papers were presented in YouTubeLive. The 83 revised full papers have been selected from 158 submissions. They describe new learning technologies which range from smart school, smart class and smart learning at home and which have been developed from new technologies such as machine learning, multimedia and Internet of Things.
Multimedia Technology and Enhanced Learning ; 2nd EAI International Conference, ICMTEL 2020, Leicester, UK, April 10-11, 2020, Proceedings, Part I
This two-volume book constitutes the refereed proceedings of the Second International Conference on Multimedia Technology and Enhanced Learning, ICMTEL 2020, held in Leicester, United Kingdom, in April 2020. Due to the COVID-19 pandemic all papers were presented in YouTubeLive. The 83 revised full papers have been selected from 158 submissions. They describe new learning technologies which range from smart school, smart class and smart learning at home and which have been developed from new technologies such as machine learning, multimedia and Internet of Things.
Multimedia Content Analysis and Mining ; International Workshop, MCAM 2007, Weihai, China, June 30-July 1, 2007, Proceedings
The workshop gives a snapshot of the current wor- wide research in multimedia analysis. Through recent advances in computing, networking, and data storage, multimedia will create new interesting technical possibilities in a wide range of ?elds, such as entertainment, commerce, science, medicine, and public safety.
Molecules in Superfluid Helium Nanodroplets : Spectroscopy, Structure, and Dynamics
This book covers recent advances in experiments using the ultra-cold, very weakly perturbing superfluid environment provided by helium nanodroplets for high resolution spectroscopic, structural and dynamic studies of molecules and synthetic clusters. The recent infra-red, UV-Vis studies of radicals, molecules, clusters, ions and biomolecules, as well as laser dynamical and laser orientational studies, are reviewed. The Coulomb explosion studies of the uniquely quantum structures of small helium clusters, X-ray imaging of large droplets and electron diffraction of embedded molecules are also described. Particular emphasis is given to the synthesis and detection of new species by mass spectrometry and deposition electron microscopy.
Molecular Sensors for Cardiovascular Homeostasis
This book reveals state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases.It offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.
Models and Algorithms for Global Optimization : Essays Dedicated to Antanas Žilinskas on the Occasion of His 60th Birthday
The research of Antanas Žilinskas has focused on developing models for global optimization, implementing and investigating the corresponding algorithms, and applying those algorithms to practical problems. This volume, dedicated to Professor Žilinskas on the occasion of his 60th birthday, contains new survey papers in which leading researchers from the field present various models and algorithms for solving global optimization problems.
Modeling of Soft Matter
Soft matter plays a role in a wide variety of important processes and application. For example, gel swelling and dynamics are an essential part of many biological and individual processes, such as motility mechanisms in bacteria and the transport and absorption of drugs. Ferroelectrics, liquid crystals, and elastomers are being used to design ever faster switching devices. Experimental studies, such as scattering, optical and electron microscopy, have provided a great deal of detailed information on structures. But the integration of mathematical modeling and analysis with experimental approaches promises to greatly increase our understanding of structure-property relationships and constitutive equations. The workshop on Modeling of Soft Matter has taken such an integrated approach.
