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Formulating poorly water soluble drugs
A pharmaceutical scientist’s approach toward solubility enhancement of a poorly water-soluble molecule typically includes detailed characterization of the compound’s physiochemical properties, solid-state modifications, advanced formulation design, non-conventional process technologies, advanced analytical characterization, and specialized product performance analysis techniques. The scientist must also be aware of the unique regulatory considerations pertaining to the non-conventional approaches often utilized for poorly water-soluble drugs. One faced with the challenge of developing a drug product from a poorly soluble compound must possess at a minimum a working knowledge of each of the above mentioned facets and detailed knowledge of most. In light of the magnitude of the growing solubility problem to drug development, this is a significant burden especially when considering that knowledge in most of these areas is relatively new and continues to develop.
Developing Organogel of CoEnzyme Q10
Coenzyme Q10 is a small lipophilic molecule composed of a benzoquinone ring and a hydrophobic isoprenoid tail and is present in all cell membranes. It is also an antioxidant. It plays a substantial role in energy production by acting as a mobile electron carrier in the electron transport chain. It has poor intestinal absorption and is prepared in topical forms. Organogel is a non-crystalline, non-glassy thermoreversible (thermoplastic) solid material and viscoelastic system can be regarded as a semi-solid preparation which has an immobilized external apolar phase, it is compatible with high molecular weight ingredients. The objective of present work is to prepare new dosage form with studying of different factors and conditions affecting preparation. Materials and methods: stearic acid and Flaxseed oil organogel was prepared by three methods and confirmed by quality assessment methods including: transparency, structure analysis, inverted tube test, kinetic of organogalation and stability test.
Bigel : An innovative drug delivery system
Bigel is a promising drug delivery system that modifies the pharmacotherapeutic characteristics of knowing active pharmaceutical ingredient (API).It is a mix between hydrogel and organogel (oleogel). The objective of the present work demonstrates the ability of bigel to overcome the disadvan- tages of both types of gels, including the limited ability to cross lipophilic barriers of the skin for hydrogels and the low patient compliance for organogels due to their stickiness and oily residues. Materials andmethods : Carbomer934, PolyvinylpyrrolidoneK 90 and Castor oil where mixed in a high shear mixer using diferent weight percentages of each. Hence,13 for mulations (BG1 to BG13) prepared by simplex mixture design modelis used to study the inuenceofafore- mentioned ingredients on appearance, dynamicviscosity, pH, stability, microscopicstructure of bigel and to understand the chemical interactions between bigel components, Fouriertrans- form infrared (FTIR) analysis will bereported.
