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Dioxygen Binding and Sensing Proteins : A Tribute to Beatrice and Jonathan Wittenberg
Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments.This book is dedicated to Jonathan’s and Bea’s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
A Study about Prevalence of Thalassemia Complications in Syrian Patients
Inherited haemoglobin disorders, including thalassemia and sickle-cell disease, are the most common monogenic diseases worldwide. Several clinical forms of α-thalassemia and β-thalassemia, including the co-inheritance of β-thalassemia with haemoglobin E resulting in haemoglobin E/β-thalassemia, have been described. The disease hallmarks include imbalance in the α/β-globin chain ratio, ineffective erythropoiesis, chronic hemolytic anemia, compensatory hemopoietin expansion, hypercoagulability, and increased intestinal iron absorption. The complications of iron overload, arising from transfusions that represent the basis of disease management in most patients with severe thalassemia. The mature Hb molecule is a tetramer composed of 2 a-globin and 2 b-globin polypeptides, which assemble, along with a heme prosthetic group, to form the complete molecule.
