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Obstetric medicine : A problem-based approach
This book is a collection of exam questions and case studies which illustrates both common and more unusual problems in obstetric medicine. Using a problem–based approach to both teach and test knowledge, it incorporates many different approaches to obstetric medicine, in Q & A format. The ‘Extended Matched Questions’ section covers the breadth of theoretical knowledge. The ‘Short Answers / Data Interpretation’ section requires a systematic approach to a clinical problem. Most of the case reports are based on real cases and all are accompanied by a brief literature review to further broaden the learning experience.
Neonatal Immunity
New advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens. Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.
Multiple pregnancy
Multiple pregnancy affects 0.9-3.1% of births worldwide. Prevalence rates vary significantly due to differences in dizygotic twinning rates and use of assisted reproduction. Both maternal and fetal/neonatal complications are more common in multiple compared to singleton pregnancies, and there are specific problems for the fetuses related to monochorionicity. Multiple pregnancies require specialised and individualised care. Complicated multiple pregnancies should be managed in a tertiary care centre where there is additional expertise, such as the laser ablation needed to treat monochorionic monozygotic pregnancies with conjoined circulations. Cornerstones of management in pregnancy are the need for accurate fetal measurement to optimise dating of gestational age, and documentation of chorionicity. High-level ultrasound expertise is needed. The mothers need frequent assessment to detect hypertension and anemia, and early identification and management of preterm labour.
Molecular mechanisms in nutritional epigenetics
The field of nutritional epigenetics/nutri-epigenetics has expanded significantly, shedding light on how environmentally-driven epigenetic pathways can be modulated through nutrition and eating habits. The book provides a comprehensive introduction to the various epigenetic mechanisms affected by dietary compounds and focuses on specific topics such as the relationship between diet and the gut microbiome, the impact of diet on cardiovascular disease and psychopathology and the role of diet in pregnancy.
Handbook of Life Course Health Development
Synthesizes and analyzes the growing knowledge base on life course health development (LCHD) from the prenatal period through emerging adulthood, with implications for clinical practice and public health. It presents LCHD as an innovative field with a sound theoretical framework for understanding wellness and disease from a lifespan perspective, replacing previous medical, biopsychosocial, and early genomic models of health. Interdisciplinary chapters discuss major health concerns (diabetes, obesity), important less-studied conditions (hearing, kidney health), and large-scale issues (nutrition, adversity) from a lifespan viewpoint. In addition, chapters address methodological approaches and challenges by analyzing existing measures, studies, and surveys. The book concludes with the editors’ research agenda that proposes priorities for future LCHD research and its application to health care practice and health policy.
Fetus abnormalities relating drug
Drugs use in pregnancy remains a major public health problem. Fetal teratogenicity results from the effect of these substances during fetal development, particularly when used in combination. Approximately 3-5% of live births are complicated by a birth defect each year totaling around 120,000 babies. Additionally, more women taking any kind of medication has more than doubled in the last 30 years. Current evidence suggests that between 65%-94 % of women take at least one prescription drug during pregnancy. Nearly 70% of women are taking a medication in the first trimester during organogenesis. On average, women are taking 3 medications in pregnancy with over 50% of women using four or more. This includes over the counter medications and herbal supplements. During pregnancy, drugs are often required to treat certain disorders.
Fetal compromise in labor
Sixty years ago, the purpose of introducing electronic fetal heart rate monitoring (EFM) was to reduce the incidence of intrapartum stillbirth. However, by the early 1980s, with falling stillbirth rates, fetal blood sampling had been widely abandoned, as many considered that EFM was sufficient on its own. Unfortunately, while the sensitivity of EFM for the detection of potential fetal compromise is high, specificity is low, and there is a high false positive rate which has been associated with a rising cesarean section rate. The authors suggest that EFM is considered and analyzed as a classic screening test and not a diagnostic test. Furthermore, it requires contextualization with other risk factors to achieve improved performance. A new proposed metric, the Fetal Reserve Index, takes into account additional risk factors and has demonstrated significantly improved performance metrics. It is going through the phases of further development, evaluation, and wider clinical implementation.
Fetal and Neonatal Pathology
The book presenting the same practical approach to the examination of both fetuses and perinatal deaths. It provides essential clinical and pathophysiological information and discusses the pathogenesis of abnormalities as a basis for appropriate methods of investigation. Part 1 deals with the examination of the products of conception after the termination of pregnancy for fetal anomalies. The range of pathological abnormalities is described and their relevance discussed. Special attention is paid to the differences in pathological findings of specific conditions between the second and third trimesters. Part 2 is organised by system, describing and illustrating those pathological problems which are likely to be encountered in the fetus and neonate. Each chapter is introduced by a concise account of the development of the relevant system. There is also a discussion, as appropriate, of changes at birth as well as changes in normal function that may occur during the neonatal period.
Echocardiographic Anatomy in the Fetus
With recent advances in ultrasound systems, storing multiple digital frames and clips with superb image quality has become a reality. These advances have brought innovative applications into the clinical field and can be integrated into powerful multimedia presentations for teaching purposes.
Doppler Ultrasound in Obstetrics and Gynecology
Doppler Ultrasound in Obstetrics & Gynecology encompasses the full spectrum of clinical applications of Doppler ultrasound for the practicing obstetrician-gynecologist, including the latest advances in 3D and color Doppler and the newest techniques in 4D fetal echocardiography. Written by preeminent experts in the field, the book covers the basic and physical principles of Doppler ultrasound; the use of Doppler for fetal examination, including fetal cerebral circulation; Doppler echocardiography of the fetal heart; and the use of Doppler for postdated pregnancy and in cases of multiple gestation. Chapters on the use of Doppler for gynecologic investigation include ultrasound in ectopic pregnancy, for infertility, for benign disorders and for gynecologic malignancies.
Crib Death : Sudden Unexplained Death of Infants : The Pathologist's Viewpoint
A systematic study of the autonomic nervous system and cardiac system has been performed on a large number of infants and fetuses who died suddenly and unexpectedly, as well as in age-matched control cases. The neurological and cardiac findings are described here, and the relationship between SIDS and unexplained fetal death is discussed.
Congenital torch infections : torch panel
TORCH is a group of infections that can be passed from the pregnant mother to her fetus through the placenta. TORCH, includes Toxoplasmosis, Other (syphilis, varicella-zoster, parvovirus B19, Hepatitis B), Rubella, Cytomegalovirus (CMV), and Herpes infections are some of the most common infections associated with congenital anomalies. Most of the TORCH infections have serious fetal consequences and there has no impact on fetal outcome. In the present article, we wanted to discuss about the causative agents/organism, mode of infection, symptoms, treatment, vaccination, available molecular biological techniques and public awareness regarding this infection, Our objective in this project is to assess the awareness of and knowledge about mother-to-child infections and prevention
Congenital infections : Toxoplasmosis and rubella
Torch syndrome is caused by a uterine infection with one of the factors that cause Torch syndrome, which disrupts the development of the fetus. Torch syndrome can be prevented by treating the infected pregnant woman, and thus preventing transmission of the infection to the fetus. And some of the factors that cause Torch Syndrome can give the mother permanent immunity, preventing the arrival of the disease and thus fetal malformations. They include a group of symptoms caused by a congenital infection such as toxoplasmosis, rubella, CMV and herpes, or due to other organisms such as syphilis, small viruses, and varicella zoster virus. The Toxoplasma parasite and the rubella virus can provide lasting immunity if the mother was infected before pregnancy in both or if she was vaccinated before pregnancy in Rubella.
Child Neuropsychology : Assessment and Interventions for Neurodevelopmental Disorders
Child Neuropsychology guides therapists and neurologists toward common goals: early, accurate diagnosis and finely focused interventions across disciplines. By analyzing the affects of brain development on children and adolescents’ behavioral, cognitive, learning, and psychosocial abilities and deficits, this groundbreaking volume brings vital perspectives to assessment and treatment. Leading experts Ellison and Semrud-Clikeman start with the basics of child clinical neuropsychology and functional neuroanatomy, taking readers through examination protocols and assessment instruments to treatment planning and methods. In this volume, the authors address the full range of neurodevelopmental pathologies, from learning disabilities to autism, ADHD to CNS disorders, traumatic brain injury to fetal alcohol syndrome.
Advances in Electromagnetic Fields in Living Systems ; Vol.4
Advances in Electromagnetic Fields in Living Systems , Volume 4 begins with fetal magnetocardiography (fMCG), a noninvasive method of detecting components of the magnetic field produced by the electrical activity of the fetal heart. FMCG is experiencing steady growth, and is expected to gain influence in diagnosing certain congenital fetal heart defects while at the same time providing optimal care for patients. FMCG provides a distinct signal, free of maternal cardiac interference, which can be detected throughout the last half of pregnancy.
