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Obesity and Diabetes
The increasing prevalence of diabetes and obesity in western societies today makes these two diseases the leading epidemics of the 21st century. Closely linked with the development of serious complications, including cardiovascular disease and several malignancies, the morbidity and mortality associated with obesity and diabetes will continue to escalate as the population ages and becomes more sedentary. In Obesity and Diabetes, international experts from world-renowned medical schools comprehensively review for practicing clinicians and scientists alike the latest understanding of the epidemiology, causation, and consequences of diabetes and obesity.
Nuucleic acids in medicinal chemistry and chemical biology : Drug development and clinical applications
Delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders : from Genes to Therapeutics
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
Nonunion of the Long Bones : Diagnosis and treatment with compression-distraction techniques
The primary purpose of this book is to discuss currently available tools for diagnosing long bone nonunions, to illustrate the means of prevention, and to specify the indications for management using compression-distraction techniques.
Nonlinear Time Series Analysis in the Geosciences : Applications in Climatology, Geodynamics and Solar-Terrestrial Physics
This book presents recent developments in nonlinear time series which have been motivated by present day problems in geosciences. Modern methods of spatio-temporal data analysis, time-frequency analysis, dimension analysis, nonlinear correlation and synchronization analysis and other nonlinear concepts are used to study emerging questions in climatology, geophysics, solar-terrestrial physics and related scientific disciplines. This volume collects contributions of some of the world's leading experts in geoscientific time series analysis.
Nonlinear Dynamics in Geosciences
Nonlinear Dynamics in Geosciences is comprised of the proceedings of "20 Years of Nonlinear Dynamics in Geosciences", held June 11-16, 2006 in Rhodes, Greece as part of the Aegean Conferences. The volume brings together the most up-to-date research from the atmospheric sciences, hydrology, geology, and other areas of geosciences, and discusses the advances made in the last two decades and the future directions of nonlinear dynamics. Topics covered include predictability, ensemble prediction, nonlinear prediction, nonlinear time series analysis, low-dimensional chaos, nonlinear modeling, fractals and multifractals, bifurcation, complex networks, self-organized criticality, extreme events, and other aspects of nonlinear science.
Non-equilibrium Thermodynamics and the Production of Entropy: Life, Earth, and Beyond
The present volume studies the application of concepts from non-equilibrium thermodynamics to a variety of research topics. Emphasis is on the Maximum Entropy Production (MEP) principle and applications to Geosphere-Biosphere couplings. Written by leading researchers form a wide range of background, the book proposed to give a first coherent account of an emerging field at the interface of thermodynamics, geophysics and life sciences.
New Trends in Soil Micromorphology
The soil water retention curve, the saturated hydraulic conductivity and the unsaturated hydraulic conductivity function are basic soil hydraulic functions and parameters. Ample apprehension of the soil hydraulic functions and parameters is required for a successful formulation of the principles leading to sustainable soil management, agricultural production and environmental protection. From these, all the other parameters, required in the solution of the practical tasks, are derived.
New Perspectives in Magnesium Research : Nutrition and Health
New Perspectives in Magnesium Research is essential reading for researchers in magnesium and calcium field, nutrition, and specialists in many areas (cardiologists, neurologists, orthopeadic specialists etc.)
New Materials in Civil Engineering
A valuable guide to the properties, selection criteria, products, applications, lifecycle and recyclability of advanced materials. It presents an A-to-Z approach to all types of materials, highlighting their key performance properties, principal characteristics and applications. Traditional materials covered include concrete, soil, steel, timber, fly ash, geosynthetic, fiber-reinforced concrete, smart materials, carbon fiber and reinforced polymers. In addition, the book covers nanotechnology and biotechnology in the development of new materials.
New Living Cases on Corporate Governance
This unique book features a selection of Living Cases on Corporate Governance, which were developed and compiled by chairpersons, members of the board of directors, and CEOs in various countries, working in close collaboration with prominent researchers.
New Frontiers in Lifestyle-Related Diseases
Akiyoshi Hosoyamada, M.D., Ph.D. President, Showa University Tokyo, Japan September 2007 v Preface The leading cause of death in Western countries and some developing countries is atherosclerotic cardiovascular diseases. Among them, acute myocardial infarction is the most common type of fatal disease, caused by the progression of atherosclerosis characterized by accumulation of choles terol in vascular walls. Development of atherosclerosis is greatly enhanced by major risk factors for cardiovascular diseases such as obesity, hyperlip idemia, diabetes (hyperglycemia), and hypertension. Among those, obesity frequently initiates a metabolic change that subsequently induces hyperlip idemia, diabetes, hypertension, and eventually atherosclerotic cardiovascu lar diseases. Because obesity and its related disorders largely depend on lifestyle factors such as high calorie intake and low physical activity, a series of disorders are termed lifestyle-related diseases.
Neutrophil : Methods and Protocols
Neutrophils, the most abundant white cells in humans, serve as the primary cellular defense against infection. This volume provides a concise set of protocols for assessing basic neutrophil functions and investigating specialized areas in neutrophil biology. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. Part I contains overviews of neutrophil biology, function, and disorders. Part II describes commonly used methods to isolate neutrophils from humans and other animal species. Part III details methods for investigating chemotaxis, transmigration, phagocytosis, and bactericidal activity. Part IV includes protocols that measure neutrophil apoptosis, calcium signal transduction, degranulation and detection of cytoplasmic granules, gene expression, transcription factors, and apoptosis. Part V provides multiple assays for measuring production of intracellular and/or extracellular reactive oxygen species, and a method that details use of the cell-free NADPH oxidase assay, an iconic assay for studies of the neutrophil NADPH oxidase. Part VI provides chapters that describe how to analyze formation and function of neutrophil extracellular traps.
Neuroendocrine Correlates of Sleep/Wakefulness
This new volume on Neuroendocrine Correlates of Sleep/Wakefulness is an up-to-date resource of research summaries and reviews written by major contributors to the fields of sleep, biological rhythms and neuroendocrinology.
Natriuretic Peptides : The Hormones of the Heart
The rapid knowledge in the field of neuro-humoral regulation of cardiovascular pathophysiology is changing the picture of current diagnosis and treatment of cardiac patients. The emerging conceptual revolutionary idea is that heart acts not as a pump, merely, but as a "gland", that is as a regulator of circulatory homeostasis and salt-water balance. Cardiovascular pathophysiology has to be written, indeed, on this basis: this physiology textbook gives an up-to-date description of the complexity and novelty of actual knowledge, with all its potential clinical implications.
Myeloproliferative disorders
Contains a series of contributions from internationally renowned academics with special expertise in one or other diseases which collectively are grouped under the heading myeloproliferative disorders. This term includes Ph-positive chronic myeloid leukemia as well as the various Ph-negative variants.
Munson, Young and Okiishi's fundamentals of fluid mechanics ; 9th ed.
ffers comprehensive topical coverage, with varied examples and problems, application of the visual component of fluid mechanics, and a strong focus on effective learning. The authors have designed their presentation to enable the gradual development of reader confidence in problem solving. Each important concept is introduced in easy-to-understand terms before more complicated examples are discussed. The 9th Edition includes new coverage of finite control volume analysis and compressible flow, as well as a selection of new problems. Continuing this important work’s tradition of extensive real-world applications, each chapter includes The Wide World of Fluids case study boxes in each chapter. In addition, there are a wide variety of videos designed to enhance comprehension, support visualization skill building and engage students more deeply with the material and concepts.
Multilevel Urban Governance and the `European City : Discussing Metropolitan Reforms in Stockholm and Helsinki
Urban scholars have come up with very different answers to the question of what the main defining characteristics of urban Europe are and whether they can be described in a distinct ideal-typical model, the ’European City’. In order to fully understand the prevailing political arrangements and ongoing transformations in urban Europe, they have increasingly turned towards ‘multilevel governance approaches’ to conduct more comprehensive and comparative analyses of urban politics and policies. Nico Giersig reflects on these debates and exemplifies the specificities of Nordic cities within Europe as a whole. He accomplishes this by means of a systematic comparison of governance arrangements and their dynamics in two Nordic capital regions.
Mountain Ecosystems : Studies in Treeline Ecology
This volume focuses on interaction between vegetation, relief, climate, soil and fauna in the treeline ecotone, and the effects of climate change and land use in North America and Europe.
Monographs in contact allergy ; Vol.4 : Systemic drugs
Presents : Identification section; Occupational allergic contact dermatitis; and Cutaneous adverse drug reactions from systemic drugs caused by type IV (delayed-type) hypersensitivity, as shown by positive patch tests (e.g. maculopapular eruption, acute generalized exanthematous pustulosis [AGEP], symmetrical drug-related intertriginous and flexural exanthema [SDRIFE], fixed drug eruption, drug reaction with eosinophilia and systemic symptoms [DRESS], and photosensitivity). Separate chapters present an overview of the spectrum of allergic cutaneous drug reactions, diagnostic tests, immediate contact reactions (contact urticaria), and systemic drugs that have acquired delayed-type hypersensitivity only by cross-reactivity.
