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Molecular biology : Structure and dynamics of genomes and proteomes
Illustrates the essential principles behind the transmission and expression of genetic information at the level of DNA, RNA, and proteins. Emphasis is on the experimental basis of discovery and the most recent advances in the field while presenting a rigorous, yet still concise, summary of the structural mechanisms of molecular biology. Topics new to this edition include the CRISPR-Cas gene editing system, Coronaviruses – structure, genome, vaccine and drug development, and newly recognized mechanisms for transcription termination.
COVID-19 and new aspects of treatment that might lower the risks and mortality rate
Coronaviruses are enveloped non-segmented positive-sense RNA viruses belonging to the family Coronaviridae. The human coronavirus infections are mild; the epidemics of the two βcoronaviruses, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have caused more than ten thousand cumulative cases in the past two decades. There is a new public health crisis threatening the world with the emergence and spread of 2019 novel coronavirus (2019nCoV). The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province in China during the month of December 2019. After the pandemic have started the scientists and researchers started immediately to find ways and technics to diagnose the virus in a different analytical and chemical methods to investigate and find out more about the new species
Coronaviruses with Special Emphasis on First Insights Concerning SARS
This book series focuses on relevant and trending topics in microbiology and infectious diseases with emphasis on emerging pathogens and related diseases.This interdisciplinary series presents latest advances and new approaches in molecular biology as well as insights into human and veterinary clinical medicine. Furthermore, matters in epidemiology, disease management, hygiene and prevention of infectious diseases are discussed. Emerging or novel pathogens are a grand challenge in medical science. Therefore, we focused the first volume of this series on the outbreak of SARS. The advent of SARS is a threat for people around the globe. Our modern technologies in communication and mobility have figuratively transformed the world into a village. This traffic, however, reprensents a new opportunity to spread diseases, particularly such of infectious nature from tiny villages throughout the entire world. In-depth knowledge of a novel pathogen's characteristics will help to manage or event prevent pandemias.
Coronaviruses : Methods and Protocols
Aims to describe a variety of techniques that reflects the wide range of research currently performed in the field of coronavirology, and begins with an overview of current understandings of coronavirus replication and pathogenesis to introduce specialists and non-specialists to the field. The rest of the book is divided into several sections of chapters beginning with those that describe identification, diagnosis, and study of the evolution of coronaviruses. The next few chapters discuss the preparation of cells and organ cultures useful in propagating coronaviruses and titration techniques, as well as techniques for analyzing virus functions that require purification of the viruses. The next chapters describe two commonly used reverse genetics techniques for coronaviruses, and techniques detailing identification of cellular receptors, binding profiles of viral attachment proteins, and virus-cell fusion. The final chapters cover a broad spectrum of techniques to identify virus-host protein-protein interactions, confirm the functional role of these proteins in virus replication, study host cell responses through genome-wide or pathway-specific approaches, and visualize virus replication complexes. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.
Coronavirus therapeutics ; Vol. II : Clinical management and public health
Provides the most comprehensive review on contemporary knowledge on the consequences during the outbreak of Coronavirus. This also describes the clinical features, diagnostic evaluation and management of Coronavirus patients. Using an integrative approach to the understanding of paradigm gap in host-pathogen interaction studies to the management of Coronavirus patients in the Intensive Care Unit to the current challenges for the effective management of Coronavirus pandemic risk factors including diabetes, hypertension, obesity and repercussion on the central and peripheral nervous system.
Coronavirus therapeutics ; Vol. I : Basic science and therapy development
Provides the most comprehensive review on contemporary knowledge on the origin and structural biology and molecular aspects of Coronaviruses. This also describes the etiology and pathogeny and therapeutic targets including vaccine drug candidates against Coronaviruses in the light of current scientific knowledge. Using an integrative approach to the understanding of Coronaviruses structure, function and immunobiology, the contributors provide a synopsis of novel mechanisms by which Coronaviruses can be treated.
Clinical laboratory finding in COVID-19: Diagnosis and prognosis
Coronaviruses belong to a family of viruses that comes under the order “Nidovirales”. This order includes the viruses that use a nested set of mRNAs for their replication. Further, the coronavirus sub-family has four genera (alpha, beta, gamma, and delta coronaviruses). The coronaviruses infecting humans (HCoVs) belong to two of these genera (alpha coronaviruses and beta coronaviruses).
Antiviral drug discovery and development
Summarizes antiviral drug design and discovery approaches Provides the latest update in the field of antiviral therapeutics Includes antiviral research of coronaviruses
