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Ocular Transporters in Ophthalmic Diseases and Drug Delivery
This exceptionally important new work represents recent discoveries and advancements in the study of ocular transporters and their roles in ocular physiology, pathology, and drug delivery. Transporters are found on the membranes of cells and play a key role in transmitting signals between cells. In Ocular Transporters in Ophthalmic Diseases and Drug Delivery, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium, and the transport of nutrients across the retinal pigment epithelium. It also provides an in-depth look at how mutations or dysfunction of specific transporters can contribute to various disorders in the eye, including blindness, and provides readers with potential targets and strategies to allow safe passage of therapeutic drugs into the eye.
Numerical Mathematics and Advanced Applications ENUMATH 2019 ; European Conference, Egmond aan Zee, The Netherlands, September 30 - October 4
It contians basic aspects and new trends in numerical mathematics and scientific and industrial applications, all examined at the highest level of international expertise.
Multiple pregnancy
Multiple pregnancy affects 0.9-3.1% of births worldwide. Prevalence rates vary significantly due to differences in dizygotic twinning rates and use of assisted reproduction. Both maternal and fetal/neonatal complications are more common in multiple compared to singleton pregnancies, and there are specific problems for the fetuses related to monochorionicity. Multiple pregnancies require specialised and individualised care. Complicated multiple pregnancies should be managed in a tertiary care centre where there is additional expertise, such as the laser ablation needed to treat monochorionic monozygotic pregnancies with conjoined circulations. Cornerstones of management in pregnancy are the need for accurate fetal measurement to optimise dating of gestational age, and documentation of chorionicity. High-level ultrasound expertise is needed. The mothers need frequent assessment to detect hypertension and anemia, and early identification and management of preterm labour.
Multiobjective Problem Solving from Nature : From Concepts to Applications
he book focuses on how MOEAs and related techniques can be used to solve problems, particularly in the disciplines of science and engineering. Contributions by leading researchers show how the concepts of multiobjective optimization can be used to reformulate and resolve problems in broad areas such as constrained optimization, coevolution, classification, inverse modelling and design. The book is distinguished from other texts on MOEAs in that it is not primarily about the algorithms, nor specific applications, but about the concepts and processes involved in solving problems using a multiobjective approach. Each chapter contributes to the central, deep concepts and themes of the book: evaluating the utility of the multiobjective approach; discussing alternative problem formulations; showing how problem formulation affects the search process; and examining solution selection and decision making.
Morse Theoretic Methods in Nonlinear Analysis and in Symplectic Topology
It covered an ample spectrum of subjects which are re ected in the present volume: Morse theory and related techniques in in nite dim- sional spaces, Floer theory and its recent extensions and generalizations, Morse and Floer theory in relation to string topology, generating functions, structure of the group of Hamiltonian difieomorphisms and related dynamical problems, applications to robotics and many others. We thank all our main speakers for their stimulating lectures and all p- ticipants for creating a friendly atmosphere
Model-Based Engineering of Collaborative Embedded Systems : Extensions of the SPES Methodology
This book presents the results of the "Collaborative Embedded Systems" (CrESt) project, aimed at adapting and complementing the methodology underlying modeling techniques developed to cope with the challenges of the dynamic structures of collaborative embedded systems (CESs) based on the SPES development methodology.
Model Based Inference in the Life Sciences : A Primer on Evidence
The abstract concept of "information" can be quantified and this has led to many important advances in the analysis of data in the empirical sciences. This text focuses on a science philosophy based on "multiple working hypotheses" and statistical models to represent them. The fundamental science question relates to the empirical evidence for hypotheses in this set—a formal strength of evidence. Kullback-Leibler information is the information lost when a model is used to approximate full reality. Hirotugu Akaike found a link between K-L information (a cornerstone of information theory) and the maximized log-likelihood (a cornerstone of mathematical statistics). This combination has become the basis for a new paradigm in model based inference. The text advocates formal inference from all the hypotheses/models in the a priori set—multimodel inference.
Microbial Sulfur Metabolism
In nature, sulfur occurs in many different oxidation states and is one of the most versatile elements in life. It is an integral part of many important cell constituents, such as the amino acids cysteine and methionine, and many sulfur compounds serve as the basis for energy-related processes in prokaryotes. In recent years, new methods have been applied to study the biochemistry and molecular biology of reactions of the global sulfur cycle, the microorganisms involved and their physiology, metabolism and ecology. These activities have uncovered fascinating new insights for the understanding of aerobic and anaerobic sulfur metabolism.
MEMS/NEMS : (1) Handbook Techniques and Applications Design Methods, (2) Fabrication Techniques, (3) Manufacturing Methods, (4) Sensors and Actuators, (5) Medical Applications and MOEMS
Micro-Electro Mechanical Systems (MEMS) is the integration of mechanical elements, sensors, actuators, and electronics on a common silicon substrate. While the electronics are fabricated using integrated circuit (IC) process sequences (e.g., CMOS, Bipolar, or BICMOS processes),the micromechanical components are fabricated using compatible micromachining processes that selectively etch away parts of the silicon wafer or add new structural layers to form the mechanical and electromechanical devices. MEMS promises to revolutionize nearly every product category by bringing together silicon-based microelectronics with micromachining technology, thereby, making possible the realization of complete systems-on-a-chip.
Interior Point Methods for Linear Optimization
Linear Optimization (LO) is one of the most widely applied and taught techniques in mathematics, with applications in many areas of science, commerce and industry. The dramatically increased interest in the subject is due mainly to advances in computer technology and the development of Interior Point Methods (IPMs) for LO. This book provides a unified presentation of the field. The authors present a self-contained comprehensive interior point approach to both the theory of LO and algorithms for LO (design, convergence, complexity, asymptotic behaviour and computational issues). A common thread throughout the book is the role of strictly complementary solutions, which play a crucial role in the interior point approach and distinguishes the new approach from the classical Simplex-based approach
Information Storage : A Multidisciplinary Perspective
Examines some of the underlying processes behind different forms of information management, including how we store information in our brains, the impact of new technologies such as computers and robots on our efficiency in storing information, and how information is stored in families and in society.
Il cielo sopra Roma : I luoghi dell’astronomia = The sky above Rome : The places of astronomy
Astronomy in Rome has always been there, but a little hidden: it was in the palaces, in the churches or, better, above the churches, speculas scattered along a path that few know by now. Intrigued and frightened, the Romans witnessed the burning of Giordano Bruno in a familiar corner of Campo de 'Fiori, but they probably didn't quite understand what guilt he was accused of. They certainly did not think that he was a philosopher and a scientist who had tried to imagine what the world was like.
Glaucoma
The series Essentials in Ophthalmology was initi- to discuss clinically relevant and appropriate t- ated two years ago to expedite the timely trans- ics. Summaries of clinically relevant information fer of new information in vision science and have been provided throughout each chapter. evidence-based medicine into clinical practice.
Geometry for Computer Graphics : Formulae, Examples and Proofs
Geometry is the cornerstone of computer graphics and computer animation, and provides the framework and tools for solving problems in two and three dimensions. This may be in the form of describing simple shapes such as a circle, ellipse, or parabola, or complex problems such as rotating 3D objects about an arbitrary axis. Geometry for Computer Graphics draws together a wide variety of geometric information that will provide a sourcebook of facts, examples, and proofs for students, academics, researchers, and professional practitioners.
Foot-and-Mouth Disease Virus
The chapters in this volume provide an account of the present knowledge and understanding of Foot and Mouth disease virus pathogenesis and global epidemiology, the detailed structure of the virus itself and the properties of its RNA genome. Also considered are the immune response of the host and the state of the art in vaccine production, and the nature of virus evolution.
Field Manual of Techniques in Invertebrate Pathology : Application and Evaluation of Pathogens for Control of Insects and other Invertebrate Pests
The Field Manual of Techniques in Invertebrate Pathology is designed to provide background and instruction on a broad spectrum of techniques and their use in the evaluation of entomopathogens in the field. The second edition of the Field Manual provides updated information and includes two additional chapters and 12 new contributors. The intended audience includes researchers, graduate students, practitioners of integrated pest management (IPM), regulators and those conducting environmental impact studies of entomopathogens. Although it can function as a stand alone reference, the Field Manual is complementary to the laboratory oriented Manual of Techniques in Insect Pathology and to comprehensive texts in insect pathology.
Eye Tracking Methodology : Theory and Practice
Despite the availability of cheap, fast, accurate and usable eye trackers, there is still little information available on how to develop, implement and use these systems. This second edition of Andrew Duchowski’s successful guide to these systems contains significant additional material on the topic and fills this gap in the market with this accessible and comprehensive introduction. Opening with useful background information, including an introduction to the human visual system and key issues in visual perception and eye movement, the second part surveys eye-tracking devices and provides a detailed introduction to the technical requirements necessary for installing a system and developing an application program. The book focuses on video-based, corneal-reflection eye trackers – the most widely available and affordable type of system, before closing with a look at a number of interesting and challenging applications in human factors, collaborative systems, virtual reality, marketing and advertising.
Exponentially Dichotomous Operators and Applications
In this monograph the natural evolution operators of autonomous first-order differential equations with exponential dichotomy on an arbitrary Banach space are studied in detail. Characterizations of these so-called exponentially dichotomous operators in terms of their resolvents and additive and multiplicative perturbation results are given. The general theory of the first three chapters is then followed by applications to Wiener-Hopf factorization and Riccati equations, transport equations, diffusion equations of indefinite Sturm-Liouville type, noncausal infinite-dimensional linear continuous-time systems, and functional differential equations of mixed type.
Essential Topology
Taking a direct route, Essential Topology brings the most important aspects of modern topology within reach of a second-year undergraduate student. Based on courses given at the University of Wales Swansea, it begins with a discussion of continuity and, by way of many examples, leads to the celebrated ""Hairy Ball theorem"" and on to homotopy and homology: the cornerstones of contemporary algebraic topology. While containing all the key results of basic topology, Essential Topology never allows itself to get mired in details. Instead, the focus throughout is on providing interesting examples that clarify the ideas and motivate the student, reflecting the fact that these are often the key examples behind current research.
Embedded finance : When payments become an experience
In Embedded Finance: When Payments Become An Experience, veteran growth strategists, entrepreneurs, and fintech disruptors Scarlett Sieber and Sophie Guibaud deliver a thought-provoking and page-turning discussion on the most impactful and exciting trend of fintech yet: embedded finance. In the book, you’ll explore the past, present, and future of fintech, from how embedded finance is being leveraged today by industry heavyweights like Google and Amazon to supercharge their customers’ experience to the offerings of smaller, niche players who stand poised to dominate their own corners of the market as their answer unmet customers’ needs.
