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Noninvasive Imaging of Myocardial Ischemia
Non-invasive imaging plays a very important role in the assessment of patients investigated for coronary artery disease, providing valuable information for diagnosis and aiding management decisions. It covers a broad spectrum of investigations including radionuclide imaging, echocardiography, magnetic resonance imaging and computed tomography. Progress towards the most efficacious means of assessing a patient is relentless, with recent years seeing an important shift in emphasis from invasive to noninvasive techniques. This informative book compares the various modalities in a practical diagnostic environment. It thus provides a forum for fertile discussion, bringing the discussion of these various methodologies together in one reference for the first time. The narrative flow is unique and will ensure that all levels of medical practitioners with an interest in cardiac imaging will find this an unparalleled resource for use in guiding their practice.
Nicotine addiction and its treatment = إدمان النيكوتين وكيفية علاجه
Nicotine is the main cause of smoking addiction, and the custom of preparation for smoking itself and smell of cigarettes create addictive behavior among smokers. Today, nicotine is socially most widely accepted legal drug in the world, and its uptake into the organism through the respiratory tract is 10 times stronger than heroin. Addiction and necessity for cigarettes are constant and intense, and the treatment for smoking addicts is long and difficult. Smoking is a worldwide epidemic, which is closely connected to other addictions such as coffee, alcohol, drugs, and gambling. Smoking cessation is associated with clear health benefits. Cigarette smoking is the leading preventable cause of death in worldwide. In this project we will discuss the nicotine, the mechanism of its addiction and medications used for smoking cessation
New Trends in Cancer for the 21st Century
It is difficult to imagine anyone who has not heard of cancer. This disease can affect families, friends or any one of us at any time in our lives. Every year nearly 3 million Europeans are diagnosed with cancer, leading to around 800,000 deaths per year. These deaths occur not only in aging populations, but also in children and adults who are in the most active period of their lives. This represents a tremendous problem that cannot be ignored by politicians or citizens. Fortunately, there is a constantly growing awareness that although cancer is a problem to be dealt with by clinicians, it should also be the concern of everyone. This volume contains the lectures held at the International Symposium on Cancer "New Trends in Cancer for the 21st Century". Fundamental researchers, politicians and representatives from patient coalitions share here their knowledge and interests as well as their concerns and experiences. Not only do these papers provide state-of-the-art information on cancer, they are also an opportunity to look at the problem from different points of view. It can be encouraging to realise that we are not alone in this fight.
New Mechanisms for Tissue-Selective Estrogen-Free Contraception
Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.
New challenges in software engineering ; Vol 1
Explores the key challenges shaping the future of software development, including automation, AI-driven development, security-focused engineering, resilient and autonomous architectures, business process optimization, cloud computing, microservices, high-performance distributed systems, and sustainable technologies. Software engineering is undergoing a constant transformation, driven by rapid technological advances and evolving market demands. additionally, it delves into the ethical considerations of AI, the evolution of intuitive user interfaces, and the importance of multidisciplinary collaboration.
Neonatal Immunity
New advances in cellular immunology, molecular biology, recombinant DNA and proteins, and the function of cytokines and chemokines have revolutionized the study of neonatal immune responsiveness. In Neonatal Immunity, Constantin Bona, MD, critically reviews the classic, as well as most recent-and quite seminal-findings concerning the phenotypic and molecular characteristics of both fetal and neonatal B and T cells, the cells that mediate antibody and cellular immune responses in newborns and infants. Dr. Bona shows how the antibody response of neonates is modulated by maternal antibodies and how, in certain cases, this can cause transient or life-threatening neonatal autoimmune disease. He also describes the characteristics of neonatal tolerance induced by foreign allo- and self-antigens, which are the basis for understanding impaired infant immune response and which provide a rationale for the development of efficient neonatal vaccines. By making clear the characteristics and differences between the immune system and the immune responses of both newborns and infants, compared to those of adults, Dr. Bona offers insights and challenging hypotheses that promise to help overcome the poor responses of neonates to various antigens. Authoritative and forward-looking, Neonatal Immunity critically reviews what we know of the neonatal immune response today, and how this is dramatically opening new therapeutic horizons in such areas as infant vaccination, stem cells, gene therapy, and transplantation.
Myocardial Ischemia : From Mechanisms to Therapeutic Potentials
This book is meant to bridge the gap between original literature and textbook reviews. It brings together investigators of various backgrounds who share their expertise in the biology of myocardial ischemia. Each chapter is a self-contained mini-review, but it will soon become apparent to the reader that there is also a common thread: Molecular and cellular cardiology has never been more exciting than now, but ever more exciting times are yet to come.
Multiscale processes in the earth’s magnetosphere : From interball to cluster ; Proceedings of the NATO ARW on Multiscale Processes in the Earth's Magnetosphere: From Interball to Cluster, Prague, Czech Republic from 9 to 12 September 2003
The past forty years of space research have seen a substantial improvement in our understanding of the Earth’s magnetosphere and its coupling with the solar wind and interplanetary magnetic ?eld (IMF). The magnetospheric str- ture has been mapped and major processes determining this structure have been de?ned. However, the picture obtained is too often static. We know how the magnetosphere forms via the interaction of the solar wind and IMF with the Earth’s magnetic ?eld. We can describe the steady state for various upstream conditions but do not really understand the dynamic processes leading from one state to another. The main dif?culty is that the magnetosphere is a comp- cated system with many time constants ranging from fractions of a second to days and the system rarely attains a steady state. Two decades ago, it became clear that further progress would require multi-point measurements. Since then, two multi-spacecraft missions have been launched — INTERBALL in 1995/96 and CLUSTER II in 2000. The objectives of these missions d- fered but were complementary: While CLUSTER is adapted to meso-scale processes, INTERBALL observed larger spatial and temporal scales. However, the number of papers taking advantage of both missions simul- neously is rather small.
Multi-Scale Approaches in Drug Discovery : From Empirical Knowledge to In silico Experiments and Back
Drug discovery is an expensive, time-consuming process and the modern drug discovery community is constantly challenged not only with discovering novel bioactive agents to combat resistance from known diseases and fight against new ones, but to do so in a way that is economically effective. Advances in both experimental and theoretical/computational methods envisage that the greatest challenges in drug discovery can be most successfully addressed by using a multi-scale approach, drawing on the specialties of a whole host of different disciplines. Multi-Scale Approaches to Drug Discovery furnishes chemists with the detail they need to identify drug leads with the highest potential before isolating and synthesizing them to produce effective drugs with greater swiftness than classical methods may allow. This significantly speeds up the search for more efficient therapeutic agents.
Molecular Wires : From Design to Properties
In the emerging field of nanoscience the desire to construct objects which in the molecular scale can resemble and act as macroscopic devices is a constant trend. Amongst the simplest but also most attractive functional component molecular wires are surely the most investigated. The reason for such interest is quite obvious since wires, in today world, are used all around us and are the most indispensable unit to assemble any type of electronic devices.In this issue the synthesis and characterization of molecular wires based on organic or metal complexes components, their properties and some theoretical background will be illustrated.
Molecular Pharmacognosy
This book discusses the application of molecular biology in resource science and authentication of traditional Chinese medicine (TCM). It also reviews the latest developments in pharmacognosy, introduces new perspectives and insights, discusses the hotspots and focuses in the field of molecular pharmacognosy, and predicts new directions of study. In the last five years, the technologies and scope of molecular pharmacognosy have constantly expanded and evolved. As such, this new edition includes extra content, such as the molecular phylogeography of medicinal plants, functional genome of medicinal plants, and synthetic biology of active compounds. Elucidating the concept, theory, and methodology of molecular pharmacognosy, it promotes the full use of the newly developed technologies and methodologies within the framework of molecular pharmacognosy to solve problems in the field.
Modern Aspects of Electrochemistry ; Vol. 42
MODERN ASPECTS OF ELECTROCHEMISTRY No. 42 Edited by Constantinos Vayenas University of Patras, Greece Topics in Number 42 include: The electrochemistry and electrocatalysis of Ruthenium in regards to the development of electrodes for Polymer Electrolyte Membrane (PEM) fuel cells Breakthroughs in Solid Oxide Fuel Cell (SOFC) anodes and cathodes leading to improved electrocatalysis Electrocatalysis of the electrochemical reduction of CO2 on numerous metals The interfacial phenomena of electrodeposition and codeposition, and the need for new theoretical analyses of the electrode-electrolyte interface Advantages of scanning tunneling microscopy (STM) in understanding the basics of catalysis, electrocatalysis and electrodeposition The role of electrochemistry in emerging technologies including electrodeposition and electroforming at the micro and nano levels, semiconductor and information storage, including magnetic storage devices.
Modern Aspects of Electrochemistry ; Vol. 41
The 41st volume in this series covers a range of topics that touch on issues of potential interest to those working in electrochemistry-related fields. … Overall, this text contains a diverse collection of topics that would be of varying degrees of interest to the broader electrochemistry community. More likely, the individual chapters would be most valued by specialists working in these areas."As the most recent volume of a successful series established 1954 and carefully continued this book provides a timely collection of four review papers covering widely distributed aspects of electrochemistry in representative contributions.
Modelling, Monitoring and Diagnostic Techniques for Fluid Power Systems
Modelling, Monitoring and Diagnostic Techniques for Fluid Power Systems covers the background theory of fluid power and indicates the range of concepts necessary for a modern approach to condition monitoring and fault diagnosis in a readable and understandable fashion. The theory is constantly leavened by 15 years' worth of practical measurements by the author, working in association with major fluid power companies, and real industrial case studies – hot-strip-mill monitoring in conjunction with Corus p.l.c. being just one example. Comprising four parts, it provides: • an introduction to component behaviour. • a guide to the modelling methods employed for circuit analysis. • methods for doing condition monitoring. • common faults and breakdowns.
Model Reduction and Coarse-Graining Approaches for Multiscale Phenomena
Model reduction and coarse-graining are important in many areas of science and engineering. How does a system with many degrees of freedom become one with fewer? How can a reversible micro-description be adapted to the dissipative macroscopic model? These crucial questions, as well as many other related problems, are discussed in this book. Specific areas of study include dynamical systems, non-equilibrium statistical mechanics, kinetic theory, hydrodynamics and mechanics of continuous media, (bio)chemical kinetics, nonlinear dynamics, nonlinear control, nonlinear estimation, and particulate systems from various branches of engineering. The generic nature and the power of the pertinent conceptual, analytical and computational frameworks helps eliminate some of the traditional language barriers, which often unnecessarily impede scientific progress and the interaction of researchers between disciplines such as physics, chemistry, biology, applied mathematics and engineering. All contributions are authored by experts, whose specialities span a wide range of fields within science and engineering.
Migration, Agriculture and Rural Development : IMISCOE Short Reader
This short reader looks into the dynamics which have reshaped rural development and human landscapes in European agriculture and the role of immigrant people. Within this framework it analyses contemporary rural migrations and the emergence of immigrants in relation to the incorporation of agrarian systems into global markets, the European agricultural governance (CAP), and the struggle of local territories as differentiated practices in constant stress between innovation and resilience
M-Health : Emerging Mobile Health Systems
M-health: Emerging Mobile Health Systems presents recent advances in this area and explores future trends in the applications of current and emerging wireless communication and network technologies for healthcare delivery and new wireless telemedical services. This work also evaluates the impact of the synergies between the 2.5G and 3G systems and beyond for healthcare applications and explores the augmentation of these technologies for the next generation of m-health services. M-health is commonly defined as the ‘emerging mobile communications and network technologies for healthcare systems’.
Methods in Nonlinear Analysis
Nonlinear analysis has developed rapidly in the last three decades. Theories, techniques and results in many different branches of mathematics have been combined in solving nonlinear problems. This book collects and reorganizes up-to-date materials scattered throughout the literature from the methodology point of view, and presents them in a systematic way. It contains the basic theories and methods with many interesting problems in partial and ordinary differential equations, differential geometry and mathematical physics as applications.There are five chapters that cover linearization, fixed-point theorems based on compactness and convexity, topological degree theory, minimization and topological variational methods. Each chapter combines abstract, classical and applied analysis. Particular topics included are bifurcation, perturbation, gluing technique, transversality, Nash–Moser technique, Ky Fan's inequality and Nash equilibrium in game theory, setvalued mappings and differential equations with discontinuous nonlinear terms, multiple solutions in partial differential equations, direct method, quasiconvexity and relaxation, Young measure, compensation compactness method and Hardy space, concentration compactness and best constants, Ekeland variational principle, infinite-dimensional Morse theory, minimax method, index theory with group action, and Conley index theory.
Mean Oscillations and Equimeasurable Rearrangements of Functions
Various applications of equimeasurable function rearrangements to the ''best constant"-type problems are considered in this volume. Several classical theorems are presented along with some very recent results. In particular, the text includes a product-space extension of the Rising Sun lemma, a product-space version of the John-Nirenberg inequality for bounded mean oscillation (BMO) functions with sharp exponent, a refinement of the Gurov-Reshetnyak lemma, sharp embedding theorems for Muckenhoupt, Gurov-Reshetnyak, reverse Hölder, and Gehring classes, etc. This volume is interesting for graduate students and mathematicians involved with these topics.
Intumescent Coating and Fire Protection of Steel Structures
Introduced are the features and applications of intumescent coatings for protecting steel structures against fire. The constant effective thermal conductivity is defined and employed to simplify the quantification for the thermo-resistance of intumescent coatings. An experimental investigation into the hydrothermal aging effects on insulative properties of intumescent coatings is presented, as well as the influence of topcoat on insulation and aging of intumescent coatings. Also described is a practical method for calculating the temperature of the protected steel structures with intumescent coatings in order to evaluate the fire safety of a structure.
