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Ontologies : A Handbook of Principles, Concepts and Applications in Information Systems
The primary objective of ONTOLOGIES: A Handbook of Principles, Concepts and Applications in Information Systems is to mobilize a collective awareness in the research community to the leading and emerging developments in ODIS, and consequently, highlight the enormous potential of ODIS research to both fundamentally transform and create innovative solutions to several problems in various domains. This book is a compilation of 32 leading-edge chapter contributions from some of the top researchers in the community working in various fundamental and applied disciplines related to ODIS. These chapters are organized into four broad themes: Foundations of ODIS, Ontological Engineering, ODIS Architectures, and ODIS Applications.
Nuclear Law : The Global Debate
This open access book traces the journey of nuclear law: its origins, how it has developed, where it is now, and where it is headed. As a discipline, this highly specialized body of law makes it possible for us to benefit from the life-saving applications of nuclear science and technology, including diagnosing cancer as well as avoiding and mitigating the effects of climate change. This book seeks to give readers a glimpse into the future of nuclear law, science and technology. It intends to provoke thought and discussion about how we can maximize the benefits and minimize the risks inherent in nuclear science and technology. This compilation of essays presents a global view in discipline as well as in geography.
NPY Family of Peptides in Neurobiology, Cardiovascular and Metabolic Disorders : from Genes to Therapeutics
The NPY-family of peptides encompasses several groups of neurotransmitters and hormones, which exert diverse biological and pathological actions that bear on all major vital systems. This book is a unique compilation of the most recent breakthroughs in NPY/PYY neurobiology, cardiovascular and metabolic disorders. The identification of multiple receptors for the members of the NPY and PYY family of peptides provides new opportunities for discovery of specific NPY antagonists and agonists that have vast clinical potential. The recognition of the role of NPY in stimulation of food intake has already resulted in discovery of potent and selective NPY receptor Y-5 antagonists, which are in clinical development for obesity. NPY Y1 receptor antagonists are targeted for cardiovascular indications. Research into the multiple functions of NPY and its receptors in neurological and affective disorders is also actively pursued. The chapters in this book are written by internationally renowned experts with the objective to synthesize leading concepts and data in support for translational medicine.
N-Heterocyclic Carbenes in Transition Metal Catalysis
It was only in the early 1990s that carbenes with the carbene carbon being incorporated in a nitrogen containing heterocycle (N-heterocyclic carbenes or NHCs) were found to be stable enough to be isolated. Since the first report on the application of NHCs as ligands in transition metal catalysis in 1995, NHC have found numerous applications and have been established as a versatile and indispensable class of ligands. For many reactions like metathesis or cross-coupling reactions NHCs have often become the ligands of choice, allowing otherwise difficult transformations. In this book leading experts have surveyed major areas of application of NHC metal complexes in catalysis. The authors have placed a special focus on nickel- and palladium-catalyzed reactions, on applications in metathesis reactions, on oxidation reactions and on the use of chiral NHC-based catalysts. This compilation is rounded out by an introductory chapter and a chapter dealing with synthetic routes to NHC metal complexes.
Neurosurgery : Principles and Practice
This book provides coverage of a broad range of topics in the ?eld of neurosurgery, 5 for residents and registrars in training and for recent graduates of training programs. 6 As neurosurgical training incorporates expertise from centers worldwide, there is a 7 need to have input from specialists in neurosurgery from various countries. This text 8 is a compilation by expert authors in the USA and the UK to provide information on 9 the basic knowledge and clinical management required for optimal care of neuro- 2011 surgical patients. 1 The text is an up-to-date synopsis of the ?eld of neurosurgery from American and 2 British perspectives, which covers the most common clinical conditions encountered 3 by neurosurgeons. The chapters are organized under broad topics, including inves- 4 tigative studies, perioperative care, the role of newer techniques and the management 5 of tumors, vascular and traumatic lesions. Additional topics are then covered, includ- 6 ing pediatrics, spine and peripheral nerve lesions, as well as functional neurosurgery 7 and infections. We anticipate that trainees will ?nd this information useful for certi?- 8 cation examinations and recent graduates of neurosurgical training programs can 9 utilize this text as an update of the most important neurosurgical topics.
National Systems of Innovation in Comparison : Structure and Performance Indicators for Knowledge Societies
The book documents major elements of the joint work of eight leading German institutes, elaborated in the context of a regular annual report on Germany's technological performance. It provides much more than the pure compilation of quantitative indicators for international benchmarking, but gives support to an appropriate interpretation of the referring results and suggests relevant conclusions for innovation policy. A special focus is on Germany; so the book also aims at non-German readers interested in specific features of the German innovation system.
Nanoformulations in Human Health: Challenges and Approaches
This book is an amalgamation of knowledge, experience, and expertise in various aspects of nanotechnology, by experts who are proficient in designing novel nanoformulations that are used in the treatment of various challenging and prevalent diseases. It is an exhaustive compilation of the multi-faceted arena of nanoformulations and the healthcare system that caters to the needs of academicians, scholars, researchers, etc. The most important aspect of the book covers various types of nanoformulations and their applications in the treatment of communicable and non-communicable diseases. Each chapter focuses on a particular nanoformulation as well as a disease including the pathophysiology of the disease, the current treatment modalities of diseases, the role of nanoformulation in treatment and other future aspects and directions for further work. Coverage includes neuropathic pain, colon targeting, nose-to-brain drug delivery, cancer, arthritis and tuberculosis.
Molecular Mechanisms of Synaptogenesis
Molecular Mechanisms of Synaptogenesis is a compilation of recent exciting findings that summarizes the ever-expanding knowledge of how neuronal contacts develop in the normal brain and how their functions are affected in mental disorders. In the last decade, advances in molecular and cellular biology, combined with the development of sophisticated fluorescence microscopy tools to visualize synapses in live neurons, have revealed many intriguing and unexpected findings regarding the dynamics of synapse formation. Studies by a number of researchers have identified several critical protein components of synapses and shown the time course of their arrival at the synapse. Several molecules serve to hold the synaptic contacts between nerve cells and regulate their function.
Modern natural product synthesis
Describes the details of the synthesis routes including unexpected reactions and syntheses. By presenting detailed stories behind the total synthesis developments, including those routes that were unsuccessful the book provides the reader with a better understanding of how other researchers devise their strategy and overcome difficulties in their studies. The contributions in the book have focused on highlighting the research from Japan however it is appealing to researchers and students worldwide. This compilation of cutting-edge natural product synthesis provides high-quality expertise, especially to graduate students and young researchers, regarding research on synthetic organic chemistry. It can be utilized as teaching material in university seminars as well as provide guidance to researchers in the area of total synthesis.
Modern Formal Methods and Applications
Formal methods are a robust approach for problem solving. It is based on logic and algebraic methods where problems can be formulated in a way that can help to find an appropriate solution. This book shows the basic concepts of formal methods and highlights modern modifications and enhancements to provide a more robust and efficient problem solving tool.Applications are presented from different disciplines such as engineering where the operation of chemical plants is synthesized using formal methods. Computational biology becomes easier and systematic using formal methods. Also, hardware compilation and systems can be managed using formal methods.
Mineral Deposit Research : Meeting the Global Challenge ; Proceedings of the Eighth Biennial SGA Meeting, Beijing, China, 18 - 21 August 2005
Represents a comprehensive summary of the developments across a range of subject matters that are relevant to the global research, mining and exploration community. This proceedings volume (including CD-ROM) is a compilation of approximately 400 extended abstracts (up to 4 pages long) of presentations given at the 8th Biennial SGA Meeting.
Introduction pratique aux bases de données relationnelles = A practical introduction to relational databases
Cet ouvrage introduit le lecteur dans le domaine des bases de données relationnelles en présentant une vaste sélection de sujets portant sur la modélisation des données, les langages de base de données, l'architecture des systèmes et l'évolution post-relationnelle. - Notions fondamentales: le modèle relationnel, les composants d’un système de gestion de bases de données, l’organisation de la mise en œuvre d’une base de données, les tâches de gestion des données. - De l'analyse à la base de données : le modèle entité association, la généralisation et l’agrégation, les dépendances et les formes normales,les contraintes d’intégrité. - Aperçu des langages de requête et de manipulation des données: l’algèbre relationnelle, le calcul des prédicats, SQL, QUEL, QBE, le traitement des valeurs nulles, la protection des données. - Les composants de l'architecture d'un système de bases de données : la compilation, l’interprétation et l’optimisation des requêtes, l’environnement multiutilisateur, le concept de transaction et la sérialisation, les méthodes optimiste et pessimiste, les structures de stockage et les méthodes d’accès. L’intégration et la migration des bases de données: l’exploitation des bases de données hétérogènes, les bases de données sur le Web, les règles de conversion pour effectuer l’intégration et la migration, les variantes de migration des bases de données hétérogènes, la planification de l’intégration et de la migration.
Information Systems Outsourcing : Enduring Themes, New Perspectives and Global Challenges
This book deals with enduring themes, new perspectives, and global challenges. In addition to classical themes like Sourcing Determinants (Part I), Relationship Aspects (Part II), and Experiences (Part III), we felt it worthwhile to add three new parts. They cover information systems outsourcing from a Vendor and Individual Perspective (Part IV), Application Service Providing (Part V) as well as Offshoring and Global Outsoucing (Part VI). Again we have thoughtfully tried to arrange a compilation of contemporary outsourcing research as a primer and a platform for scientific discourse
Implementation and Application of Functional Languages ; 19th International Workshop, IFL 2007, Freiburg, Germany, September 27-29, 2007. Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the 19th International Workshop on Implementation and Applications of Functional Languages, IFL 2007, held in Freiburg, Germany in September 2007.The 15 revised full papers presented went through two rounds of reviewing and improvement and were selected from 33 submissions. The papers address all current theoretical and methodological issues on functional and function-based languages such as type checking, contract checking, compilation, parallelism, development and debugging, data structures, parsing as well as various performance related concepts.
High performance embedded architectures and compilers ; 3rd International Conference, HiPEAC 2008, Göteborg, Sweden, January 27-29, 2008. Proceedings
This book constitutes the refereed proceedings of the Third International Conference on High Performance Embedded Architectures and Compilers, HiPEAC 2008, held in Göteborg, Sweden, January 27-29, 2008. The 25 revised full papers presented together with 1 invited keynote paper were carefully reviewed and selected from 77 submissions. The papers are organized in topical sections on Multithreaded and Multicore Processors, Reconfigurable - ASIP, Compiler Optimizations, Industrial Processors and Application Parallelization, Power-Aware Techniques, High-Performance Processors, Profiles: Collection and Analysis as well as Optimizing Memory Performance.
High performance embedded architectures and compilers ; 2nd International Conference, HiPEAC 2007, Ghent, Belgium, January 28-30, 2007. Proceedings
This book constitutes the refereed proceedings of the Second International Conference on High Performance Embedded Architectures and Compilers, HiPEAC 2007, held in Ghent, Belgium, in January 2007. The 19 revised full papers presented together with one invited keynote paper were carefully reviewed and selected from 65 submissions.
High performance embedded architectures and compilers ; 1st International Conference, HiPEAC 2005, Barcelona, Spain, November 17-18, 2005, Proceedings
The ProgramCommittee received a total of 84 submissions; only 17 were selected for presentation as full-length papers and another one as an invited paper. Each paper was rigorously reviewed by three ProgramCommittee members and at least one external referee. Many reviewers spent a great amount of e?ort to provide detailed feedback. In many cases, such feedback along with constructive shepherding resulted in dramatic improvement in the quality of accepted papers. The names of the Program Committee m- bers and the referees are listed in the proceedings. The net result of this team e?ort is that the symposium proceedings include outstanding contributions by authors from nine countries in three continents. In addition to paper presentations, this ?rst HiPEAC conference featured two keynotes delivered by prominent researchers from industry and academia.
Hedgehog-Gli Signaling in Human Disease
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
Handbook on Drowning : Prevention, Rescue, Treatment
this congress book, the fruit of much effort in recent years of many devoted researchers in the fields of prevention, rescue and treatment of drowned people. It is a compilation of the results of their successful studies, as laid down during the World Congress on Drowning held in Amsterdam on 26–28 June 2002.
Handbook of pharmacokinetics and toxicokinetics
An effort to blend the common approaches to pharmacokinetics and toxicokinetics. It integrates the principles held in common by both fields through a logical and systematic approach, which includes mathematical descriptions of physical and physiological processes employed in approaches to PK/TK modeling. It emphasizes general principles and concepts and related isolated applications and case studies observations.The systematic compilation of mathematical concepts and methodologies allows readers to decide on relevant concepts and approaches for their research, scientific or regulatory decisions, or for offering advance courses/workshops and seminars.
