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GPCRs : From Deorphanization to Lead Structure Identification
The book highlights the following topics: Structure of GPCRs, Design of GPCR Ligands, GPCR Signalling, Deorphanization and Assay Development. All chapters are written by leading experts in the field, discussing the most recent state of the art. They give insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. The book reflects the actual trends in the fast-emerging field of GPCR research in academia and industry.
Government and Research : Thirty Years of Evolution
This revised and augmented version updates the original text for current policy concerns and takes account of changes in science policy studies, whilst preserving its essential themes. It contains a succinct account of where matters now stand as well as an extended analysis of the themes that continue to dominate research and science policy.
Governing the Sustainable Development Goals : Quantification in Global Public Policy
This book conceptualises the Sustainable Development Goals as epistemic infrastructures that connect numbers, networks and governing paradigms.The book approaches quantification not merely as a tool for governing, but rather as a broader epistemic system through which global public policy is produced. This book focuses on the role of international organisations in shaping and implementing the 2030 Agenda and demonstrates how the SDGs have transformed and accelerated trends in quantification.
Governing the Pandemic : The politics of navigating a Mega-Crisis
This book offers unique insights into how governments and governing systems, particularly in advanced economies, have responded to the immense challenges of managing the coronavirus pandemic and the ensuing disease COVID-19.
Governing social protection in the long term : Social policy and employment relations in Australia and New Zealand
This book examines the comparative evolution of social protection in Australia and New Zealand from 1890 to the present day, focusing on the relationship between employment relations and social policy. Utilising longstanding and more recent developments in historical institutionalist methodology, Ramia investigates the relationship between these two policy domains in the context of social protection theory.
Governing knowledge : A study of continuity and change in higher education : A Festschrift in Honour of Maurice Kogan
In this book, an international group of leading higher education researchers draw on a wealth of social theory and comparative, empirical research to analyse current developments and their implications. Different contributions focus on different levels of higher education, the system, the institution and the academic practitioner, in different national and international contexts. However, strong common themes bind these contributions together. They include not only the significance of massification, globalisation, neo-liberalism and managerialism for the governance of higher education, its knowledge and values, but also the complexities of change processes, the importance of context and history and the strength of the stabilities that remain.
Governing Europe under a Constitution : The Hard Road from the European Treaties to a European Constitutional Treaty
At the summit in Laeken in December 2001 the European Council opened the debate on the reform of the supranational structures through its "Declaration on the Future of the European Union" and proposed a wide-ranging agenda. The European Convention, with the mandate of the European Council, has been forming proposals for a more democratic, transparent and efficient European Union and presented a draft of a Treaty establishing a Constitution for Europe on 20th of June 2003. On these fundaments the Intergovernmental Conference finally came to a compromise in summer 2004 after wrestling especially with the problem of qualified majority voting within the Council. On 29th of October 2004 the Heads of State and Governments of the 25 Member States signed the Treaty.
Governance of Communication Networks : Connecting Societies and Markets with IT
The articles collected in this book shed light on several aspects that are crucial for the success of global communication networks: they range from an appropriate framework for regulation and suitable strategies of firms that act as international players, to the inclusion of customers in defining product and service strategies, and from problems of access to advanced technology and networks for all groups in society regardless of their social status or geographical location to the role of new technologies in facilitating universal communication.
Governance of Arctic Shipping : Rethinking Risk, Human Impacts and Regulation
This is a result of the Dalhousie-led research project Safe Navigation and Environment Protection, supported by a grant from the Ocean Frontier Institute’s the Canada First Research Excellent Fund (CFREF).
Governance for drought resilience : Land and water drought management in Europe
This book will aid regional water authorities and other relevant stakeholders interested in governance assessment, whether that context is about water, more specifically about drought or flooding events, or other environmental issues. Further, the GAT can and has also been applied more broadly to a range of governance contexts for water management and beyond.
Governance as a trialogue
Focusing specifically on water, this book talks about the core elements of governance, and analyses the linkages between key variables in an effort to increase our understanding of what makes governance good. It is useful for any professional tasked with the responsibility of implementing Integrated Environmental and Water Resource Management.
Governance and performance of education systems
The proposed book is unique in that it brings together a wide range of disciplines and experience from several countries. What are possible models of governance? How do we measure their effects in terms of efficiency and equity? What type of contribution can financial and information systems make? How do we adapt the prevailing culture to the challenge of better performance? These are some of the concrete questions to which this book provides an answer.
Gottfried Wilhelm Leibniz : The Art of Controversies
All these perspectives (and more) are united in what this book identifies as his Art of Controversies, which might also be called an Art of Dialectical Cooperation. For it is based on the idea that knowledge production, acquisition, and evolution is not a one-man affair, but the result of the cooperation of many, coming from different perspectives; whence it follows that not only tolerance vis-à-vis the other, but also valuing the other’s contribution and integrating it – whether it stems from another age, continent, culture, discipline, religion, or individual – is indispensable. This dialectical Leibniz that emerges from the selected texts here translated, commented, and interpreted in the light of their context, isn’t for sure the familiar one. Yet, perhaps surprisingly.
Goodman and Gilman's the pharmacological basis of therapeutics ; 14th ed.
A collaboration between two friends and professors at Yale, Louis Goodman and Alfred Gilman. Over the years, “G&G” has been acclaimed as the “blue bible” of pharmacology. Surely much of that acclaim reflects the book’s purpose, delineated by the original authors and steadily adhered to over 81 years: to correlate pharmacology with related medical sciences, to reinterpret the actions and uses of drugs in light of advances in medicine and the basic biomedical sciences, to emphasize the application of pharmacodynamics to therapeutics, and to create a book that would be useful to students of pharmacology and to healthcare practitioners.
Goodman & Gilman's the pharmacological basis of therapeutics ; 13th ed.
Correlates pharmacology with related medical sciences, to reinterpret the actions and uses of drugs in light of advances in medicine and the basic biomedical sciences, to emphasize the applications of pharmacodynamics to therapeutics, and to create a book that would be useful to students of pharmacology and to physicians.
Good Research Practice in Non-Clinical Pharmacology and Biomedicine
This book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.
Good pharmacovigilance practice (GVP) : Focus on risk mangement plan (RMP)
Pharmacovigilance which is the science and activities relating to the detection, assessment, understanding and prevention of adverse drug reactions or any other possible drug related problems and Risk Management Strategies which provides a structured and coherent approach to identifying, assessing and managing risk and builds in a process for regularly updating and reviewing the assessment based on new developments or actions taken, conference provides the foundation for strong strategic planning and practical decision-making in pharmacovigilance programs. Stakeholders from medicines research, global regulation, and healthcare will join together to analyse the challenges for safety and pharmacovigilance efforts in this uncertain environment and examine effective strategies for addressing gaps and needs.
Good laboratory practice : The why and the how
The GLP regulations have developed from rules on how to exactly document the planning, conduct and reporting of toxicity studies to a quality system for the management of a multitude of study types, from the simple determination of a physical/chemical parameter to the most complex field studies or ecotoxicology studies. At the same time the term “Good Laboratory Practice” has become somewhat of a slogan with the aim to characterise any reliably conducted laboratory work.
Good and Evil in Art and Law : An Extended Essay
This is an interdisciplinary essay. It looks at art and especially literature in juxtaposition with law and speculates how the two disciplines approach, in their separate but inter-related ways, the notions of "good" and "evil". Full of detail, it examines how the two disciplines deal with these notions, why the evil-doer is often agrandicized in literature but is base in real life and how good and evil change with time. Though one discipline cannot influence the reasoning process of the other, this book, addressed to the general educated reader, is a plea for a broader humanistic education.
Goguen Categories : A Categorical Approach to L-fuzzy Relations
This book introduces several categorical formulations of an abstract theory of relations such as allegories, Dedekind categories and related structures. It is shown that neither theory is sufficiently rich to describe basic operations on fuzzy relations. The book then introduces Goguen categories and provides a comprehensive study of these structures including their representation theory, and the definability of norm-based operations.
