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Equitable research partnerships : A global code of conduct to counter ethics dumping
This book offers insights into the development of the ground-breaking Global Code of Conduct for Research in Resource-Poor Settings (GCC) and the San Code of Research Ethics. Using a new, intuitive moral framework predicated on fairness, respect, care and honesty, both codes target ethics dumping – the export of unethical research practices from a high-income setting to a lower- or middle-income setting. The book is a rich resource of information and argument for any research stakeholder who opposes double standards in research. It will be indispensable for applicants to European Union framework programmes, as the GCC is now a mandatory reference document for EU funding.
Equilibrium Between Phases of Matter : Phenomenology and Thermodynamics
The phase behaviour of materials and their thermodynamic properties are a central subject in all fields of materials research. The first Volume of the work, meant for graduate students in chemistry, geology, physics, and metallurgy, and their engineering counterparts, is split up in three levels, such that from level to level the portion and importance of thermodynamics and mathematics are increased. In the ground level it is shown that the basic principles of phase equilibria can be understood without the use of thermodynamics – be it that the concept of chemical potential is introduced right from the beginning. The intermediate level is an introduction to thermodynamics; culminating in the Gibbs energy as the arbiter for equilibrium – demonstrated for systems where the phases in equilibrium are pure substances. In the third level the accent is on binary systems, where one or more phases are solutions of the components.
Equazioni a derivate parzial I : Complementi ed esercizi
La presente raccolta di problemi ed esercizi nasce dall'esperienza maturata durante il corso di Equazioni a Derivate Parziali (EDP), tenuto nell'ambito delle lauree di primo e secondo livello presso il Politecnico di Milano. Il volume è diviso in due parti; nei primi quattro capitoli l'obiettivo è l'uso di tecniche classiche, come la separazione delle variabili, il principio di massimo o le trasformate di Laplace e Fourier, per risolvere problemi di diffusione, trasporto e vibrazione. Il quinto capitolo invita a familiarizzare con i risultati di base negli spazi di Hilbert, nella teoria delle distribuzioni (o funzioni generalizzate) di Schwartz e in quella degli spazi di Sobolev più comuni. Il sesto ed ultimo capitolo riguarda la formulazione variazionale o debole dei più importanti problemi iniziali e/o al bordo per equazioni ellittiche e di evoluzione. L'introduzione ad ogni capitolo contiene una sintesi degli strumenti teorici più utilizzati.
EQ-5D value sets
For various reasons, cost benefit analysis is usually rejected in favour of cost-effectiveness or cost-utility analyses, often involving the estimation of the incremental cost per Quality Adjusted Life Year (QALY) gained (Drummond et al, 2005). The estimation of QALYs gained requires valuations for all relevant health states on a scale anchored at 1 = Full health and 0 = Dead. The EQ-5D is widely used in this context and a number of value sets are available for all the health states generated by the EQ-5D descriptive system. These can be readily applied to health outcomes measured as EQ-5D profiles. EQ-5D has become one of the valuation approaches recommended by several reimbursement authorities and academic bodies in European countries
EQ-5D concepts and methods : a developmental history
The EuroQol Group is an international, cross-disciplinary group set up in 1987 to investigate issues related to the valuation of health. This book presents a series of papers from the early 1990s that illustrate the aspects of the development of EQ-5D including: the descriptive system, self-rated health, valuation issues, and semantic issues. Read less
Epiphyseal Growth Plate Fractures
This comprehensive reference work covers all aspects of growth plate fractures and their complications. Following general reviews of growth plate fractures, 21 chapters deal with each epiphyseal growth plate in the body. All of these chapters are constructed similarly for easy and quick retrieval of the required information. The main emphasis is on evaluation (diagnosis) and management (treatment). A separate section is devoted to premature partial physeal arrest, as this is by far the most common and feared complication of a growth plate fracture and its treatment is involved and controversial. The case studies included are often based on 20- to 30-year follow-ups, revealing cases that originally appeared to be quite satisfactory at the conclusion of growth but were found to have turned out quite poorly years later.
Epigenome editing : Methods and protocols
This second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Epigenetics and chromatin
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility.
Epigenetic Drug Discovery
This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease.
Enzymes and drugs
Enzyme dysfunction, an essential catalyst for the smooth running of biochemical reactions and the maintenance of vital processes, is at the root of many pathologies that have paved the way for the development of numerous drugs. Aimed at pharmacists, biologists, biochemists, doctors, veterinarians, medicinal chemists and students from a wide range of disciplines, Enzymes and Drugs brings together, for the first time, extensive documentation highlighting the relationships between a large number of drugs and enzymes. The book also highlights new prospects for therapeutic discoveries offered by enzyme targeting. Numerous applications have been developed thanks to strategies for studying enzyme inhibition or activation, as well as the development of allosteric effectors, presented with their advantages and disadvantages. Various rare diseases, known as "orphan" diseases, have resulted from enzyme deficiency or absence. For their treatment, the introduction of substitute enzymes has led to major therapeutic advances.
Enzyme-Based Organic Synthesis
In Enzyme-Based Organic Synthesis, expert chemist Dr. Cheanyeh Cheng delivers a comprehensive discussion of the principles, methods, and applications of enzymatic and microbial processes for organic synthesis. The book thoroughly explores this growing area of green synthetic organic chemistry, both in the context of academic research and industrial practice.
Enzyme Biocatalysis : Principles and Applications
This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds.
Environmentally-Friendly Product Development: Methods and Tools
Presents a survey of eco-friendly product design. This work is aimed at researchers and academics in design engineering and practitioners and managers in the industry
Environmental Security and Public Safety ; Problems and Needs in Conversion Policy and Research after 15 Years of Conversion in Central and Eastern Europe
Although the end of the Cold War has paved the way to a substantial demilitarisation and conversion, the leftovers of this process – such as former military installations, military training areas, and huge quantities of unserviceable ammunition and equipment – still pose a severe threat to the environment of both NATO and Partner countries.The rehabilitation of these areas for civilian uses is extremely costly and is generally in the short and medium term not possible. For this reason, the development of new methods for the estimation avoidance of risks should receive special priority. In the context of this ARW, the reconnaissance and appraisal of conversion areas with respect to costs, returns, and legal considerations were discussed. The decades-long use of some areas led to the heavy loading of contaminates. Every task of conversion has as its goal the elimination of dangers to humans and nature, and the return of areas to civil use, such that these areas can be used realise economic interests of the society.
Environmental security and environmental management : The role of risk assessment ; Proceedings of the NATO Advanced Research Workhop on The Role of Risk Assessment in Environmental Security and Emergency Preparedness in the Mediterranean Region, held in Eilat, Israel, April 15-18, 2004
The concept of “environmental security” has emerged as one basis for understanding international conflicts. This phrase can mean a variety of things. It can signify security issues stemming from environmental concerns or conflicting needs, or it can mean that the environment is treated as a resource for the long term, and the question is what should be done today to preserve the quality of the environment in the future. In the same way that energy security is about ensuring access to energy for the long run, it can also mean that pressing environmental concerns create a situation where different countries and communities are forced to collaboratively design a unified response, even if cooperation is not generally in the logic of their relations. Over the last several years, the authors of this book and their colleagues have tried to demonstrate the power of risk assessment and decision analysis as valuable tools that decision makers should use for a broad range of environmental problems, including environmental security. Risk analysis is almost more a state of mind or a way of looking at problems than it is a kind of algorithm or a set of recipes. It projects a kind of rationality on problems and forces a certain degree of quantitative rigor, as opposed to the all too common tendency of making environmental recommendations based on anecdotal evidence.
Environmental Role of Wetlands in Headwaters
Internationally, the wetlands of headwater and upland regions provide many valuable environmental services. This book moves towards a more comprehensive inventory of the benefits and costs of headwater wetlands. It evaluates the research that tries to understand the tolerances, exchanges, checks and balances within headwater landscapes and the downstream impacts of changes in wetlands. It employs case studies and reviews from 21 nations spanning Europe, Africa, Asia and the Americas. It explores the new policy frameworks, changes in land husbandry, new systems for community education, participatory processes and technological interventions required for the effective management of headwater wetlands and the full integration of wetlands (including newly constructed wetlands) into environmental management and planning. In the past, most research dealt with wetlands as isolated features, this book examines wetlands in their watershed management context.
Environmental Issues in Latin America and the Caribbean
This book is a non-technical interdisciplinary collection of 12 essays, each of which uses natural or social science methods. The essays analyze a representative set of environmental issues in Latin America and the Caribbean. They consider problems at international, regional, national, and local levels and examine current and historical environmental policy. The essays are organized according to theme and approach into five parts: -conservation challenges; -national policies, local communities, and rural development; -market mechanisms for protecting public goods; -public participation and environmental justice; -the effects of development policies on the environment. Contributors are researchers from Canada, Europe, Latin America, and the United States
Environmental impact assessment of recycled wastes on surface and ground waters ; Vol.3 : Engineering modeling and sustainability
The state of the art of the impact assessment of recycled hazardous waste materials on surface and ground waters is presented. The topics include chemodynamics, toxicology, modeling and information systems. The book serves as a practical conceptual guide for those who have professional responsibility for the monitoring, design, management, or conduct of environmental impact assessment. It is believed that the book will prove useful to the reader who, regardless of disciplinary background, wants to examine in greater detail the kinds of interdisciplinary contributions to contemporary decision-making processes that characterize modern impact assessment project development.
Environmental Impact Assessment of Recycled Wastes on Surface and Ground Waters ; Vol.2 : Risk analysis
The state of the art of the impact assessment of recycled hazardous waste materials on surface and ground waters is presented. The topics include chemodynamics, toxicology, modeling and information systems. The book serves as a practical conceptual guide for those who have professional responsibility for the monitoring, design, management, or conduct of environmental impact assessment. It is believed that the book will prove useful to the reader who, regardless of disciplinary background, wants to examine in greater detail the kinds of interdisciplinary contributions to contemporary decision-making processes that characterize modern impact assessment project development.
Environmental Impact Assessment of Recycled Wastes on Surface and Ground Waters ; Vol.1 : Concepts, methodology and cemical analysis
The state of the art of the impact assessment of recycled hazardous waste materials on surface and ground waters is presented. The topics include chemodynamics, toxicology, modeling and information systems. Due to the wealth of information on this topic, the texts of T. Kassim (ed.): Environmental Impact Assessment are published in three separate volumes: vol. 1: Concepts, Methodology and Chemical Analysis; vol. 2: Risk Analysis and vol. 3: Engineering Modeling and Sustainability. The book serves as a practical conceptual guide for those who have professional responsibility for the monitoring, design, management, or conduct of environmental impact assessment. It is believed that the book will prove useful to the reader who, regardless of disciplinary background, wants to examine in greater detail the kinds of interdisciplinary contributions to contemporary decision-making processes that characterize modern impact assessment project development.
