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The Painlevé Handbook
This book introduces the reader to methods allowing one to build explicit solutions to these equations. A prerequisite task is to investigate whether the chances of success are high or low, and this can be achieved without any a priori knowledge of the solutions, with a powerful algorithm presented in detail called the Painlevé test. If the equation under study passes the Painlevé test, the equation is presumed integrable. If on the contrary the test fails, the system is nonintegrable or even chaotic, but it may still be possible to find solutions.
The p53 Tumor Suppressor Pathway and Cancer
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse teratocarcinoma cell line. A decade after its discovery, p53 was shown to be a tumor suppressor that protects against cancer. It is now recognized that approximately half of all human tumors arise due to mutations within the p53 gene. As remarkable as this number may seem, it signil cantly underrepresents how often the p53 pathway is targeted during tumorigenesis. It is my personal view, as well as many in the p53 ?eld, that the p53-signaling pathway is corrupted in nearly 100% of tumors. If you are interested in understanding cancer and how it develops, you must begin by studying p53 and its pathway. After demonstrating that p53 functions as a tumor suppressor the ?eld exploded and p53 became a major focus of scientists around the world.
The Outer Planets and their Moons : Comparative Studies of the Outer Planets prior to the Exploration of the Saturn System by Cassini-Huygens
This volume gives an integrated summary of the science related to the four giant planets in our solar system. It is the result of an ISSI workshop on «A comparative study of the outer planets before the exploration of Saturn by Cassini-Huygens» which was held at ISSI in Bern on January 12-16, 2004. Representatives of several scientific communities, such as planetary scientists, astronomers, space physicists, chemists and astrobiologists have met with the aim to review the knowledge on four major themes: (1) the study of the formation and evolution processes of the outer planets and their satellites, beginning with the formation of compounds and planetesimals in the solar nebula, and the subsequent evolution of the interiors of the outer planets, (2) a comparative study of the atmospheres of the outer planets and Titan, (3) the study of the planetary magnetospheres and their interactions with the solar wind, and (4) the formation and properties of satellites and rings, including their interiors, surfaces, and their interaction with the solar wind and the magnetospheres of the outer planets.
The Outer Limits of the Continental Shelf : Legal Aspects of their Establishment
The Outer Limits of the Continental Shelf The 1982 United Nations Convention on the Law of the Sea (herein- ter the "Convention") marks the beginning of a new era in the law of 1 the sea. Previously, in the 1958 Con- 2 vention on the Continental Shelf (hereinafter the "1958 Convention"), no limits were established for the continental shelf.
The Origins of Language : Unraveling Evolutionary Forces
Developments in cognitive science indicate that human and nonhuman primates share a range of behavioral and physiological characteristics that speak to the issue of language origins. This volume has three major themes, woven throughout the chapters. First, it is argued that scientists in animal behavior and anthropology need to move beyond theoretical debate to a more empirically focused and comparative approach to language. Second, those empirical and comparative methods are described, revealing underpinnings of language, some of which are shared by humans and other primates and others of which are unique to humans. New insights are discussed, and several hypotheses emerge concerning the evolutionary forces that led to the "design" of language. Third, evolutionary challenges that led to adaptive changes in communication over time are considered with an eye toward understanding various constraints that channeled the process.
The Origin of Clay Minerals in Soils and Weathered Rocks
This book stress the role of plants at the bio-interface and the importance of microsystems at the water/ rock interface. We believe that the literature at our and anyone’s disposal shows that the system of clay formation and reaction is highly dynamic, especially at the surface.
The Organized Crime Community : Essays in Honor of Alan A. Block
In his social investigative writings on "the serious crime community" which describes the loose merger of corporate interests, organized crime and political crime, professor Alan A. Block of Penn State University has proven to be one of the most inspiring criminologists in the field. An international group of pupils and friends dedicate this book to him which contains original contributions on the troubled concept of organized crime, the social history of crime groups in the United States, corruption in the United Nations Oil-for-Food Program in Iraq, the struggle against identity fraud, the world of drugs and the adverse consequences of criminalization, the money-laundering control movement, International Tribunals against war crimes and a Jewish studies chapter on the role of bystanders during the Holocaust.
The Open Knowlege Society : A Computer Science and Information Systems Manifesto ; First World Summit on the Knowledge Society, WSKS 2008, Athens, Greece, September 24-26, 2008. Proceedings
This book, in conjunction with the volume LNAI 5288, constitutes the refereed proceedings of theFirst World Summit, WSKS 2008, held in Athens, Greece, in September 2008. The 95 revised full papers presented were carefully reviewed and selected from 286 submissions. The topics include applications for the human and the society; information systems and information technology; knowledge management and e-learning; libraries, digital culture and electronic tourism; e-business, egovernment and e-banking; politics and policies for the knowledge society; sustainable development for the knowledge society.
The Onlife Manifesto : Being Human in a Hyperconnected Era
What is the impact of information and communication technologies (ICTs) on the human condition? In order to address this question, in 2012 the European Commission organized a research project entitled The Onlife Initiative: concept reengineering for rethinking societal concerns in the digital transition. This volume collects the work of the Onlife Initiative. It explores how the development and widespread use of ICTs have a radical impact on the human condition. ICTs are not mere tools but rather social forces that are increasingly affecting our self-conception (who we are), our mutual interactions (how we socialise); our conception of reality (our metaphysics); and our interactions with reality (our agency).
The Once-Only Principle : The TOOP Project
This Book State-of-the-Art Survey describes and documents the developments and results of the Once-Only Principle Project (TOOP). The Once-Only Principle (OOP) is part of the seven underlying principles of the eGovernment Action Plan 2016-2020. It aims to make the government more effective and to reduce administrative burdens by asking citizens and companies to provide certain standard information to the public authorities only once. The project was horizontal and policy-driven with the aim of showing that the implementation of OOP in a cross-border and cross-sector setting is feasible. The book summarizes the results of the project from policy, organizational, architectural, and technical points of view. This book has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 737460
The olfactory system
Cover topics such as techniques for manipulating and measuring olfactory cilia function; approaches for investigating spatial RNA expression in olfactory mucosa; the use of chromatin immunoprecipitation with olfactory neurons; in vivo methods to label and identify activated olfactory neurons; defining organization in the olfactory bulbs and cortex; and the use of optical recording in the mouse olfactory bulb for acute or chronic experiments.
The Oceanic Thermohaline Circulation : An Introduction
In this book different aspects of the oceanic thermohaline circulation, the dominant meridionally overturning mode of the global ocean circulation, are presented. The topics, presented in this book, are the aspects of thermodynamics of seawater and geophysical fluid dynamics that are important for the understanding of this current system, basic observational hydrographic methods to study the thermohaline circulation, and a description of the thermohaline circulation, based on observational evidence. This includes the deep circulation in the abyssal basins, global deep upwelling, the shallow return flow to high latitudes, and the formation and descent of high-density deep water masses in these cold regions. This book is intended to be used by advanced undergraduates and graduate students in physical oceanography, climatology, geography and environmental sciences, paleoceanography, marine biology and marine chemistry.
The Observers Year : 366 Nights in the Universe
There are 365 nights in every year (366 in a leap year!) and from an amateur astronomer’s point of view, no two are alike.And that is why Sir Patrick Moore – the world’s most widely known and respected TV broadcaster and writer on astronomy – has produced this unique book to highlight special objects of interest on each and every night of the year. Using easy-to-follow star maps, he talks about the science and history of stars, double stars, galaxies, nebulae, the Moon, planets, constellations and even asteroids.This second edition has been fully updated for astronomical events through until the year 2010.
The Observers Sky Atlas : With 50 Star Charts Covering the Entire Sky
The Observer's Sky Atlas contains star charts and information for all those who observe the night sky with unaided eyes, with binoculars, or with small telescopes, and also for those who just wish to look at constellations and interesting objects. Equally useful for the beginning observer and the old hand.
The Nuclear Imperative : A Critical Look at the Approaching Energy Crisis
In this well documented global wake-up call, nuclear physicist Jeff Eerkens explores remedies for the impending energy crisis, when oil and natural gas are depleted. Because burning coal worsens the problem ofglobal warming, alternate energy sources must be instituted. The Nuclear Imperative demonstrates with scientific documentation that solar, wind, and biomass power, while helpful, are incapable of supplying and sustaining the enormous quantities of electricity and heat needed for manufacturing portable synthetic fuels (synfuels) to replace our current use of fossil fuels. Instead, it offers a fresh look at uranium-produced energy as the optimal affordable solution.
The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer
Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis. In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
The Novikov Conjecture : Geometry and Algebra
These lecture notes contain a guided tour to the Novikov Conjecture and related conjectures due to Baum-Connes, Borel and Farrell-Jones. They begin with basics about higher signatures, Whitehead torsion and the s-Cobordism Theorem. Then an introduction to surgery theory and a version of the assembly map is presented. Using the solution of the Novikov conjecture for special groups some applications to the classification of low dimensional manifolds are given.
The Nonlinear Universe : Chaos, Emergence, Life
The book explains the wide-ranging implications of nonlinear phenomena for future developments in many areas of modern science, including mathematics, physics, engineering, chemistry, biology, and neuroscience.
The NMR Probe of High-Tc Materials
The NMR probe has yielded a vast array of data for the high-Tc materials, corresponding to different compounds, ionic sites, and nuclear species, as well as to a wide variety of experimental conditions. Over the twenty years, since the discovery of superconducting cuprates, ongoing analysis and discussion of cuprate NMR data have resulted in a wealth of important insights into the physics of these exotic systems. The aims of this monograph are threefold. First, it reviews NMR methodology as it has been applied to the cuprate studies. This is addressed to NMR practitioners and to physics laypersons alike. Next, it presents a review of cuprate NMR measurements and the wide variety of phenomena which they represent. The third phase is to recount the theoretical model calculations and other proposals which have been put forward to account for these data.
The Night Sky Companion : A Yearly Guide to Sky-Watching 2008-2009
The The Night Sky Companion is far more than just an observing guide. It is a year’s journey into the science and facts of astronomy and space travel, along with some of its history and the and the men and women who made it. If you’re a sky watcher equipped with any kind of astronomical telescope, binoculars, or even just your eyes, you are sure to find this book absolutely fascinating. Taking a day-by-day look at the sky over the course of the whole year, Tammy Plotner has assembled a digest to appeal to all astronomers and would-be astronomers. Turn these pages and you’ll find observing recommendations – including how to locate the object you’re looking for – along with a wealth of information touching on every aspect of your observation.
