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Dynamic Modeling of Monetary and Fiscal Cooperation Among Nations
The first four chapters introduce the reader to the dynamics of fiscal and monetary policy cooperation. Issues covered include: fiscal coordination, fiscal stringency requirements, structural and bargaining power asymmetries and the design of monetary and fiscal policymaking in a monetary union. In the four last chapters multiple-player settings with aspects of fiscal and/or monetary coordination are analyzed using the endogenous coalition formation approach. The analysis is focused on shock and model asymmetries and issues of multi-country coordination in the presence of (possibly many) monetary unions.
Dynamic Games : Theory and Applications
Dynamic games continue to attract strong interest from researchers interested in modelling competitive as well as conflict situations exhibiting an intertemporel aspect. Applications of dynamic games have proven to be a suitable methodology to study the behaviour of players (decision-makers) and to predict the outcome of such situations in many areas including engineering, economics, management science, military, biology and political science. Dynamic Games: Theory and Applications collects thirteen articles written by established researchers.
Dynamic Assessment : A Vygotskian Approach to Understanding and Promoting L2 Development
This book presents the first in-depth analysis of DA’s application to particular problems of L2 development. It includes detailed discussions of the core theoretical tenets as well as guidelines for implementing DA principles in L2 classrooms. The book will be of interest to language teacher educators, language testers, classroom practitioners, and students and researchers in the areas of SLA, language pedagogy, and assessment.
Dualisability : Unary Algebras and Beyond
Natural duality theory is one of the major growth areas within general algebra. This text provides a short path to the forefront of research in duality theory. It presents a coherent approach to new results in the area, as well as exposing open problems. Unary algebras play a special role throughout the text. Individual unary algebras are relatively simple and easy to work with. But as a class they have a rich and complex entanglement with dualisability. This combination of local simplicity and global complexity ensures that, for the study of natural duality theory, unary algebras are an excellent source of examples and counterexamples.
Dryland Ecohydrology
By combining the analysis of biotic and abiotic components of terrestrial ecosystems, this volume provides a synthesis of material on arid and semiarid landscapes, which is currently scattered in a number of books and journal articles. The focus on water-limited ecosystems is motivated by their high sensitivity to daily, seasonal, and decadal perturbations in water availability, and by the ecologic, climatic, and economic significance of most of the world's drylands. Conceived as a tool for scientists working in the area of the earth and environmental sciences, this book presents the basic principles of eco-hydrology as well as a broad spectrum of topics and advances in this research field.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Drug Selectivity : An Evolving Concept in Medicinal Chemistry
Provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Drug Metabolism: Current Concepts
The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development.
Drug discovery and development
Presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of efficacy and safety of drug candidates through preclinical testing. This book also greatly expands the focus on the clinical pharmacology, regulatory, and business aspects of bringing new drugs to the market and offers coverage of essential topics for companies involved in drug development. Historical perspectives and predicted trends are also provided.
Drug development for rare diseases
A disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans or 10% of the US population. This diverse and complex disease area poses challenges for patients, caregivers, regulators, drug developers, and other stakeholders. This book is proposed to give an overview of the common issues facing rare disease drug developers, summarize challenges specific to clinical development in small populations, discuss drug development strategies in the evolving regulatory environment, explain generation and utilization of different data and evidence
Drug design : A conceptual overview
The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and proteomics assists in the Rational Drug Design (RDD). This emerging discipline is known as “Computer-Aided Drug Design" (CADD), which has profound application in RDD. The advanced and adequate practice in drug design informatics is essential for pharmacy graduates. Hence, a companion for acquiring knowledge on these concepts is vital. The students of B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry, Pharmacology, and Pharmaceutics), biotechnology, biomedical engineering and other interdisciplinary fields may find this book as a reference guide.
Drawing the Ground - Landscape Urbanism Today : The Work of Palmbout Urban Landscapes
Documents some fifteen projects organized into six thematic blocks, including such extensive projects as Amsterdam Ijburg, a design for an urban extension to Amsterdam with a total area of 450 hectares, 18,000 residences, 100,000 square meters of office space, 30,000 square meters of stores, and other facilities, and Maastricht Belvedere, a restructuring of 280 hectares of a former industrial site with 4,000 residences, 100,000 square meters of office space, parking lots, and a vehicle bridge.
Domain Modeling and the Duration Calculus : International Training School, Shanghai, China, September 17-21, 2007, Advanced Lectures
The book presented provide competent coverage of software security, domain modeling of software engineering, and duration calculus for real time systems - originating from lectures of leading experts in these fields from Europe and Asia.It addressed in detail are: development of real-time systems, domain engineering using abstract modeling, the area of duration calculus, and formal methods like language description using the operational semantics approach.
Domain Decomposition Methods in Science and Engineering XVII
This volume contains a selection of papers presented at the 17th International Conference on Domain Decomposition Methods in Science and Engineering held at St. Wolfgang / Strobl, Austria, July 3 - 7, 2006. Domain decomposition is an active, interdisciplinary research area concerned with the development, analysis, and implementation of coupling and decoupling strategies in mathematical and computational models. Domain decomposition techniques provide efficient tools for treating problems in all Computational Sciences. The reader will become familiar with the newest domain decomposition technologies and their use for modeling and simulating of complex problems from different fields of applications.
Domain Decomposition Methods in Science and Engineering XVI
The present volume sets forth new contributions in areas of numerical analysis, computer science, scientific and industrial applications, and software development.
Domain Decomposition Methods in Science and Engineering
Domain decomposition is an active, interdisciplinary research area that is devoted to the development, analysis and implementation of coupling and decoupling strategies in mathematics, computational science, engineering and industry.This book special focus has been on numerical analysis, computational issues,complex heterogeneous problems, industrial problems, and software development.
DNA Binders and Related Subjects
advances in technology and the application of new methods to outstanding problems have played a major part in the development of ideas about drug-nucleic acid recognition. The field has undergone an explosive diversification as wider and wider problems became accessible to study using the new ideas and techniques. This volume reflects that diversification by offering accounts of selected areas that illustrate recent advances in the study of ligand–nucleic acid binding over disparate areas of the subject. There are chapters dealing specifically with the invention and application of new methodology, and a particularly thoughtful essay on the interpretation of X-ray diffraction data which may not be as straightforward as is often imagined. Other chapters illustrate the diversity and complexity of drug-DNA binding from several perspectives, referring to particular groups of related compounds or the potential attractions of the less-preferred DNA major groove as a target for nucleotide sequence recognition by ligands.
D-Modules, Perverse Sheaves, and Representation Theory
D-modules continues to be an active area of stimulating research in such mathematical areas as algebra, analysis, differential equations, and representation theory. Key to D-modules, Perverse Sheaves, and Representation Theory is the authors' essential algebraic-analytic approach to the theory, which connects D-modules to representation theory and other areas of mathematics. Significant concepts and topics that have emerged over the last few decades are presented, including a treatment of the theory of holonomic D-modules, perverse sheaves, the all-important Riemann-Hilbert correspondence, Hodge modules, and the solution to the Kazhdan-Lusztig conjecture using D-module theory.
Distributed systems : Concurrency and consistency
Explores the gray area of distributed systems and draws a map of weak consistency criteria, identifying several families and demonstrating how these may be implemented into a programming language. Unlike their sequential counterparts, distributed systems are much more difficult to design, and are therefore prone to problems. On a large scale, usability reminiscent of sequential consistency, which would provide the same global view to all users, is very expensive or impossible to achieve.
Distributed Search by Constrained Agents : Algorithms, Performance, Communication
This book presents a comprehensive discussion on the field of distributed constraints, its algorithms and its active research areas. It introduces distributed constraint satisfaction and optimization problems and proceeds to present a complete state-of-the-art in DisCSP & DisCOP research.
