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Novel mouse model for future autism research
Autism spectrum disorder (ASD) is a set of neurodevelopmental disorders characterized by a deficit in social behaviors and nonverbal interactions such as reduced eye contact, facial expression, and body gestures in the first 3 years of life. It is not a single disorder, and it is broadly considered to be a multi-factorial disorder resulting from genetic and non-genetic risk factors and their interaction. Genetic studies of ASD have identified mutations that interfere with typical neurodevelopment in utero through childhood. These complexes of genes have been involved in synaptogenesis and axon motility. Recent developments in neuroimaging studies have provided many important insights into the pathological changes that occur in the brain of patients with ASD in vivo. Especially, the role of amygdala, a major component of the limbic system and the affective loop of the cortico-striatothalamo-cortical circuit, in cognition and ASD has been proved in numerous neuropathological and neuroimaging studies.
Novel Drug Delivery Systems for Chinese Medicines
Describes the essential and cutting-edge concepts based on the frontier of pharmaceutical research in TCM, underlying scientific principles, and current advancements of drug delivery systems for Chinese medicines, including sustained-release drug delivery systems, trans-nasal drug delivery systems, dermal and transdermal drug delivery systems, etc. Novel carriers and emerging technologies (such as 3D printing) are also covered. The book provides readers with an overall picture of drug delivery systems for Chinese medicines and also yields benefits for the pharmaceutical industry with regard to TCM-based drug development.
Novel drug delivery systems : Fundamentals and applications
Serves as a unique resource on the field of novel drug delivery systems (NDDSs). The evolving nature of diseases and the emergence of new health complications have driven a significant shift in drug therapy. Coupled with changes in human lifestyles and economic conditions, these factors have compelled the pharmaceutical industry to develop novel, efficient, and affordable drug products. The rise of promising technologies aimed at enhancing therapeutic performance further underscores the importance of novel drug delivery systems (NDDSs), making this field one of the most dynamic in pharmaceutical sciences today.
Novel Developments for Sustainable Hydropower
This book presents (selected) new and innovative developments for sustainable and fish-friendly hydropower. It offers unique insights into the challenges, practices and policies of hydropower developments across 8 European countries, providing examples from on-site studies and European-wide analyses. The case studies throughout the book are practical “real-world” examples, which are intended to serve as inspiration for anyone who would like to know more about how solutions for more sustainable hydropower production can be designed and implemented. Hydropower is an important renewable energy source, which, however, can also impact aquatic ecosystems, fish populations and hydro-morphology. EU and national water, environmental and energy legislation strive for sustainable energy and water resource management as well as the protection of important habitats and species. These have an effect on the requirements and decision making processes for hydropower planning, commissioning and operation. With a high variety of measures existing and site-specific conditions as well as national and EU level legal requirements to consider, it can be difficult to determine, what issues to address and which measures to implement.
Novel Carrier Systems for Targeted and Controlled Drug Delivery
Presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers.
Notions of Convexity
The first two chapters of this book are devoted to convexity in the classical sense, for functions of one and several real variables respectively. This gives a background for the study in the following chapters of related notions which occur in the theory of linear partial differential equations and complex analysis such as (pluri-)subharmonic functions, pseudoconvex sets, and sets which are convex for supports or singular supports with respect to a differential operator. In addition, the convexity conditions which are relevant for local or global existence of holomorphic differential equations are discussed, leading up to Trépreau’s theorem on sufficiency of condition (capital Greek letter Psi) for microlocal solvability in the analytic category.
Notes on Coxeter Transformations and the McKay Correspondence
One of the beautiful results in the representation theory of the finite groups is McKay's theorem on a correspondence between representations of the binary polyhedral group of SU(2) and vertices of an extended simply-laced Dynkin diagram. The Coxeter transformation is the main tool in the proof of the McKay correspondence, and is closely interrelated with the Cartan matrix and Poincaré series. The Coxeter functors constructed by Bernstein, Gelfand and Ponomarev plays a distinguished role in the representation theory of quivers.
Notch Signaling in Embryology and Cancer : Notch Signaling in Cancer
This thoroughly revised second edition is an up-to-date overview of the current knowledge of Notch and Notch signaling in embryology and cancer. It discusses this topic from Notch’s role in the development of the embryo to the Notch signaling pathway’s role in the development of a number of cancers, including breast cancer, malignant melanoma, Non-melanoma skin cancer, intestinal cancer and others. In the years since the previous edition, there have been numerous developments and insights within this rapidly moving field, making this new edition urgently needed. This volume also features discussions of current insights on Notch’s role in senescence, the regulation of Notch signaling by microRNAs, Notch’s role in the microbiome, diet and its influence on Notch signaling and more.
Nostalgia and Hope : Intersections between Politics of Culture, Welfare, and Migration in Europe
This book shows how the politics of migration affect community building in the 21st century, drawing on both retrogressive and progressive forms of mobilization. It elaborates theoretically and shows empirically how the two master frames of nostalgia and hope are used in local, national and transnational settings, in and outside conventional forms of doing politics.
Norwegian Shipping in the 20th Century : Norway's Successful Navigation of the World's Most Global Industry
This open access book discusses how Norwegian shipping companies played a crucial role in global shipping markets in the 20th century, at times transporting more than ten per cent of world seaborne trade. Chapters explore how Norway managed to remain competitive, despite being a high labour-cost country in an industry with global competition. Among the features that are emphasised are market developments, business strategies and political decisions The Norwegian experience was shaped by the main breaking points in 20th century world history, such as the two world wars, and by long-term trends, such as globalization and liberalization. The shipping companies introduced technological and organizational innovations to build or maintain a competitive advantage in a rapidly changing world. The growing importance of offshore petroleum exploration in the North Sea from the 1970s was both a threat and an opportunity to the shipping companies. By adapting both business strategies and the political regime to the new circumstances, the Norwegian shipping sector managed to maintain a leading position internationally.
Northeast Asia : Ripe for Integration?
Can regional mechanisms better institutionalize the increasing complexity of economic and security ties among the countries in Northeast Asia? As the international state system undergoes dramatic changes in both security and economic relations in the wake of the end of the Cold War, the Asian financial crisis, and the attack of 9/11, this question is now at the forefront of the minds of both academics and policymakers. Still, little research has been done to integrate the analysis of security and economic analysis of changes in the region within a broader context that will give us theoretically-informed policy insights. Against this backdrop, this book investigates the origins and evolution of Northeast Asia's new institutional architecture in trade, finance, and security from both a theoretical and empirical perspective.
Nordic Mediation Research
Presents twelve unique studies on mediation from researchers in Denmark, Finland, Norway and Sweden, respectively. Each study highlights important aspects of mediation, including the role of children in family mediation, the evolution and ambivalent application of restorative justice in the Nordic countries, the confusion of roles in court-connected mediation, and the challenges in dispute systems.
Non-University Higher Education in Europe
This book represents the first-of-its-kind comprehensive discussion of the non-university higher education sector in Europe. Higher education throughout the world is facing rapid change. Despite the enormous attention devoted to that reality, this volume fills an important void. It describes and offers critical comparisons between the systems in 10 European countries. The book brings together the thinking of leading scholars on the non-university sectors in Austria, Belgium, Finland, Germany, Ireland, the Netherlands, Norway, Portugal, Spain, and the United Kingdom, with a chapter devoted to each country. National case studies are presented for the non-university sector in these countries that address issues such as historical developments, policy changes, governance structures, levels of institutional autonomy and future trends.
Nonunion of the Long Bones : Diagnosis and treatment with compression-distraction techniques
The primary purpose of this book is to discuss currently available tools for diagnosing long bone nonunions, to illustrate the means of prevention, and to specify the indications for management using compression-distraction techniques.
Nonstandard Analysis
The book is an introduction with emphasis on those more advanced applications in analysis which are hardly accessible by other methods. Examples of such topics are a deeper analysis of certain functionals like Hahn-Banach limits or of finitely additive measures: From the viewpoint of classical analysis these are strange objects whose mere existence is even hard to prove. From the viewpoint of nonstandard analysis, these are rather 'explicit' objects.
Non-spectral Asymptotic Analysis of One-Parameter Operator Semigroups
In this book, non-spectral methods are presented and discussed that have been developed over the last two decades for the investigation of asymptotic behavior of one-parameter operator semigroups in Banach spaces. This concerns in particular Markov semigroups in L1-spaces, motivated by applications to probability theory and dynamical systems. Recently many results on the asymptotic behaviour of Markov semigroups were extended to positive semigroups in Banach lattices with order-continuous norm, and to positive semigroups in non-commutative L1-spaces. Related results, historical notes, exercises, and open problems accompany each chapter.
Nonsmooth Variational Problems and their Inequalities : Comparison Principles and Applications
The main purpose of this book is to provide a systematic and unified exposition of comparison principles based on a suitably extended sub-supersolution method. This method is an effective and flexible technique to obtain existence and comparison results of solutions. Also, it can be employed for the investigation of various qualitative properties, such as location, multiplicity and extremality of solutions. In the treatment of the problems under consideration a wide range of methods and techniques from nonlinear and nonsmooth analysis is applied, a brief outline of which has been provided in a preliminary chapter in order to make the book self-contained.
Non-metallic biomaterials for tooth repair and replacement
Focuses on the use of biomaterials for a range of applications in tooth repair and, in particular, dental restoration. Part one reviews the structure, modification and repair of dental tissues. The properties of enamel and dentin and their role in adhesive dental restoration are discussed, along with biomineralization and biomimicry of tooth enamel, and enamel matrix proteins (EMPs) for periodontal regeneration. Part two goes on to discuss the processing, bonding and wear properties of dental ceramics, glasses and sol-gel derived bioactive glass ceramics for tooth repair and replacement. Dental composites for tooth repair and replacement are then the focus of part three, including composite adhesive and antibacterial restorative materials for dental applications. T
NonlinearWaves and Solitons on Contours and Closed Surfaces
The present volume is an introduction to nonlinear waves and soliton theory in the special environment of compact spaces such a closed curves and surfaces and other domain contours. It assumes familiarity with basic soliton theory and nonlinear dynamical systems.
Nonlinear Waves : Classical and Quantum Aspects
Leading scientists discuss the most recent physical and experimental results in the physics of Bose-Einstein condensate theory, the theory of nonlinear lattices (including quantum and nonlinear lattices), and nonlinear optics and photonics. Classical and quantum aspects of the dynamics of nonlinear waves are considered. The contributions focus on the Gross-Pitaevskii equation and on the quantum nonlinear Schrödinger equation. Recent experimental results on atomic condensates and hydrogen bonded systems are reviewed. Particular attention is given to nonlinear matter waves in periodic potential.
