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Carbon monoxide in drug discovery, basics, pharmacology, and therapeutic potential
Carbon monoxide, one of the smallest organic natural molecules, is widely known for its toxicity. Formation of CO via incomplete combustion is a major contributing factor to accidental or intentional CO poisoning, leading to severe health consequences or death. In addition, CO is a by-product of tobacco smoking, and has been associated with some of the harmful effects of smoking. However, less known and probably far more important is the recognition of the essential physiological roles of CO as a signaling molecule in mammals. Against over more than a century of negative connotation, the last few decades have proven that CO possesses a multitude of physiological roles and therapeutic functions including regulation of the immune response, cellular proliferation, and control of cell survival. This concept is supported by the discovery that CO is produced by all cells and more so under conditions of stress. This book comprehensively summarizes key aspects of CO's endogenous roles, therapeutic functions, and challenges that we face in its development as a therapeutic agent. We hope this preface will provide a thread for reading this book and a birds-eye view of the landscape for understanding this field, and more importantly lay out the challenges ahead in understanding the detailed mechanisms of action of CO and in its development as a therapeutic agent.
Carbon Inventory Methods Handbook for Greenhouse Gas Inventory, Carbon Mitigation and Roundwood Production Projects
Carbon Inventory Methods Handbook provides detailed step-by-step information on sampling procedures, field and laboratory measurements, application of remote sensing and GIS techniques, modeling, and calculation procedures along with sources of data for carbon inventory. The unique feature of this handbook is that it provides practical guidance on carbon inventory methods for four kinds of projects, namely, 1) development, implementation and monitoring of carbon mitigation in forest, agriculture and grassland sectors, 2) national greenhouse gas inventory in agriculture, forest, and other land-use categories, 3) forest, grassland and agroforestry development and 4) commercial and community forestry roundwood production.
Carbon in the Geobiosphere : Earth's outer shell
Carbon and carbon dioxide always played an important role in the geobiosphere that is part of the Earth’s outer shell and surface environment. The book’s eleven chapters cover the fundamentals of the biogeochemical behavior of carbon near the Earth’s surface, in the atmosphere, minerals, waters, air-sea exchange, and inorganic and biological processes fractionating the carbon isotopes, and its role in the evolution of inorganic and biogenic sediments, ocean water, the coupling to nutrient nitrogen and phosphorus cycles, and the future of the carbon cycle in the Anthropocene. This book is mainly a reference text for Earth and environmental scientists; it presents an overview of the origins and behavior of the carbon cycle and atmospheric carbon dioxide, and the human effects on them. The book can also be used for a one-semester course at an intermediate to advanced level addressing the behavior of the carbon and related cycles.
Carbon and nitrogen in the terrestrial environment
Carbon and Nitrogen in the Terrestrial Environment is a comprehensive, interdisciplinary description of C and N fluxes between the atmosphere and the terrestrial biosphere; issues related to C and N management in different ecosystems and their implications for the environment and global climate change; and the approaches to mitigate emission of greenhouse gases.Drawing upon the most up-to-date books, journals, bulletins, reports, symposia proceedings and internet sources documenting interrelationships between different aspects of C and N cycling in the terrestrial environment, Carbon and Nitrogen in the Terrestrial Environment fills the gap left by most of the currently available books on C and N cycling. They either deal with a single element of an ecosystem, or are related to one or a few selected aspects like soil organic matter (SOM) and agricultural or forest management, emission of greenhouse gases, global climate change or modeling of SOM dynamics.
Carbon and Its Domestication
Carbon is chemically versatile and is thus the body and soul of biological, geological, ecological and economic systems. Its appropriation by humans through diversion of its biogeochemical cycle has been a mainstay of development. This domestication is characterized by a number of thresholds: control of fire, development of agriculture, expansion of Europe, fossil-fuel use and biotechnology. All have exacted an environmental toll, not least being climatic change and biodiversity loss. Carbon management now and in the future is a ‘hot’ political issue.
Carbohydrate-protein interactions : Methods and protocols
Provides new and updated tools for studying protein-carbohydrate interactions ranging from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes detailing methods for screening and quantifying CAZyme activity, investigating the interactions between proteins, carbohydrate ligands, methods for the visualization of carbohydrates, protein-carbohydrate complexes, structural and “omic” approaches for studying systems of CAZymes.
Carbohydrate-based therapeutics
Explores new frontiers in carbohydrate-based therapeutic applications, utilizing a unique approach by providing a detailed background of diseases coupled with subsequent carbohydrate-based therapies. The link between chemistry and design of novel carbohydrate-based medicines is highlighted and a broad overview of all the potential applications of carbohydrates is given. Emphasis is laid on concepts used for carbohydrate drug design, structure– activity relationship, and impact on health and diseases. The text also discusses newer topics like nanoparticles, material science, and tissue generation.
Capital, Systems, and Objects : The Foundation and Future of Organizations
Provides a set of integrated frameworks—capital, systems, and objects—that transcend managerial or technology hype by focusing on the long-term fundamentals that sustain organizational success. Many organizations are currently addressing two important transformational issues: ecological sustainability and digitization. Sustainability is a goal, an end, and digitization is a process, a means to achieve a goal. This book introduces a flexible model that can be applied to current and future organizational challenges, including sustainability and digitization, because the fundamentals are constant.
Capital Punishment and the Criminal Corpse in Scotland, 1740–1834
This book provides the most in-depth study of capital punishment in Scotland between the mid-eighteenth and early nineteenth century to date. Based upon an extensive gathering and analysis of previously untapped resources, it takes the reader on a journey from the courtrooms of Scotland to the theatre of the gallows. It introduces them to several of the malefactors who faced the hangman’s noose and explores the traditional hallmarks of the spectacle of the scaffold. It demonstrates that the period between 1740 and 1834 was one of discussion, debate and fundamental change in the use of the death sentence and how it was staged in practice. In addition, the study provides an innovative investigation of the post-mortem punishment of the criminal corpse. It offers the reader an insight into the scene at the foot of the gibbets from which criminal bodies were displayed, and around the dissection tables of Scotland’s main universities where criminal bodies were used as cadavers for anatomical demonstration. In doing so it reveals an intermediate stage in the long-term disappearance of public bodily punishment.
Capital project management ; Vol.2 : Capital project finance
Describes the strategic challenge of adding real economic value, properly and rigorously defined. The author explains how this is accomplished through the capital budgeting process; discusses the importance of free cash flow and finally, capital projects, as financial options, are discussed, as a way to manage risk while enhancing the likelihood of project approval.
Capital project management ; Vol.1 : Capital project strategy
Tells the Tesla story and then presents chapters that address, in order: corporate governance and project stakeholder or communication management, project portfolios as strategic corporate portfolios, and an executive-level review of the best-practice project management paradigm, as applied to capital projects.
Capillary Forces in Microassembly : Modeling, Simulation, Experiments, and Case Study
Capillary Forces in Microassembly discusses the use of capillary forces as a gripping principle in microscale assembly. Clearly written and well-organized, this text brings together physical concepts at the microscale with practical applications in micromanipulation. Throughout this work, the reader will find a review of the existing gripping principles, elements to model capillary forces as well as descriptions of the simulation and experimental test bench developed to study the design parameters. Using well-known concepts from surface science (such as surface tension, capillary effects, wettability, and contact angles) as inputs to mechanical models, the amount of effort required to handle micro-components is predicted. These developments are then applied in a case study concerning the pick and place of balls in a watch ball bearing.
Capacity Building and Training for Female Social workers at NGOs in Syria : The Case of Child Rights Association
The purpose of this dissertation is to build the capacity of female volunteer supervisors and staff to have a positive impact on the individual and society, building the community for the long term. The importance of capacity building for female supervisors in NGOs enhance the skills and competencies and capacities of local people and communities in developing societies so that they can overcome the reasons for their suffering. Organizational capacity building is used by NGOs and governments to guide their internal development and activities.
Cannabinoids and sleep : Molecular, functional and clinical aspects
Offers a comprehensive overview on cannabinoids and their effects on sleep Provides novel research findings on the therapeutic potential of cannabinoids Discusses the effect of cannabinoids in several neurological disorders
Candy’s family
المشروع مساحة مكونة من أربعة طوابق مصممة لتكون عالماً نابضاً بالألوان والفرح، مستوحاة من عالم الحلوى والمارشميلو. يهدف المشروع إلى تقديم تجربة حسية وترفيهية متكاملة تجمع بين البيع، الترفيه والإبداع ضمن بيئة تبعث على البهجة والراحة النفسية. ويعد المشروع من أوائل المفاهيم المتخصصة بهذا الطابع في البلد ما يجعله وجهة فريدة تستقطب مختلف الفئات العمرية.
Cancer vaccination and challenges Vol.2 : delivery strategies for cancer vaccine and immunotherapy in the management of various carcinomas
Covers delivery strategies of cancer vaccines for the management of various forms of carcinoma, examining the prospects of delivering immuno-oncology therapies, focusing specifically on effective drug delivery strategies for the treatment of lung, prostate, and pancreatic carcinomas.
Cancer vaccination and challenges Vol.1 : strategies for therapeutic cancer vaccine development
Deals with different strategies of cancer vaccine development, focusing on techniques for the development of therapeutic cancer vaccines and the roles of tumor antigens, proteins/peptides, microbial genes, and stem cells for the development of vaccines for cancer management.
Cancer Survivorship : Today and Tomorrow
A diagnosis of cancer provokes myriad responses in patients, chief among them the question: "how long do I have to live?" Increasingly, the answer to that question is not one of months or years, but decades. While there are now nearly 10 million people in the United States who have recovered or are currently recovering from cancer (increased from three million in 1971), the unique challenges encountered by survivors are often met with uncertainity by even the most seasoned physicians, nurses, and clinical social workers because of a lack of formal guidelines for post-treatment care and follow-up.
Cancer Research Center = مركز أبحاث للسرطان
المشروع يضم عباره عن قسم أبحاث للسرطان و قسم معاينه وعلاج للمرضى المتطوعين للتجارب السريره ملحقه باقامه مؤقته و دائمه ويضم مدرج لالقاء المحاضرات النظريه والعمليه من قبل المختصيين والباحثيين وأخيرا يضم سكن لأطباء والباحثيين
Cancer Proteomics : From Bench to Bedside
the authors collectively provide the current status of proteomics in cancer therapy and offers the existing technologies used in proteomics that allow for protein profiling and for the identification of druggable targets in human samples. Mass spectrometry based protein characterization and protein microarrays hold great promise of predicting response to specific drugs in cancer therapy. Insightful to the reader with broad perspectives on topics related to the use of proteomic strategies in cancer therapy, Cancer Proteomics offers anticipated challenges that may arise from its application in daily practice.
