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High Performance SQL Server " Consistent Response for Mission-Critical Applications
An excellent complement to query performance tuning books and provides the other half of what you need to know by focusing on configuring the instances on which mission-critical queries are executed. You will: Understand SQL Server's database engine and how it processes queries / Configure instances in support of high-throughput applications / Provide consistent response times to varying user numbers and query volumes / Design databases for high-throughput applications with focus on performance / Record performance baselines and monitor SQL Server instances against them / Troubleshot and fix performance problems
High performance computing in science and engineering 04 ; Transactions of the High Performance Computing Center, Stuttgart (HLRS) 2004
This book presents the state-of-the-art in modelling and simulation on supercomputers. Leading German research groups present their results achieved on high-end systems of the High Performance Computing Center Stuttgart (HLRS) for the year 2004. The reports cover all fields of computational science and engineering ranging from computational fluid dynamics via computational physics and chemistry to computer science. Special emphasis is given to industrially relevant applications. Presenting results for both vector-systems and micro-processor based systems the book allows to compare performance levels and usability of a variety of supercomputer architectures. In the light of the success of the Japanese Earth-Simulator this book may serve as a guide book for a US response
Herbal immunity boosters against COVID-19
Provides an introduction to COVID-19 and herbal medications that boost the human immune system against SARS-CoV-2. The topics are covered in 7 chapters starting with an introduction to the disease, followed by notes on nutraceuticals and common herbal medicines that have therapeutic potential by enhancing the patient’s immune response. Special topics such as COVID-19 risk factors and Indian traditional medicines are also included to supplement the contents. The editors have taken advantage of the vast body of knowledge accumulated since the start of the COVID-19 pandemic in 2019.
Hepatitis C virus-host interactions and therapeutics : Current insights and future perspectives
The burden of hepatitis C virus (HCV) infection on the public health care system continues to remain significant despite the remarkable progress made in HCV therapeutics in the recent past. There are now almost a dozen oral interferon-free direct-acting antivirals available for the treatment of hepatitis C virus infection. Despite advances in the treatment of HCV, therapeutic gaps remain that are yet to be fully explored. Researchers and scientists still strive to understand virus-host interactions to map the disease’s progression along with extrahepatic manifestations and virus invasion strategies impacting the host’s immune system. This book briefly discusses the biology of HCV infection, virus-host interactions, molecular epidemiology of the infection, and the full spectrum of immune responses to hepatitis C. It also provides in-depth information about HCV, clinical diagnostics, and therapeutic knowledge to all stakeholders involved in HCV screening, diagnosis, treatment, and management.
Hepatitis C Virus Disease
Emphasizes the most recent advances on the Hepatitis C virus infection (HCV) moving from basic research to clinical application. In spite of the numerous studies on HCV infection, its pathogenesis and medical treatment have not been fully explained. The first chapters of this volume analyize the full spectrum of immune responses to HCV taking into account either innate or adoptive immunity involvement. The volume also includes a series of contributions which explain the state of art of IFN-alpha treatment in HCV patients and the effectiveness of therapy also in relation to HCV genotypes. The use and applications of pegylated IFNs will also be discussed as well as the complicated HCV disease and its treatment. Hepatitis C Virus Disease: Immunobiology and Clinical Applications is an ideal volume for researchers, scientists, professionals, clinicians, physicians and graduate students in the fields of infectious disease, immunology, virology, microbiology, pharmacology and medicine.
Heat Shock Proteins and the Brain : Implications for Neurodegenerative Diseases and Neuroprotection
Neurodegenerative disorders such as Alzheimer’s disease, Huntington’s disease, Parkinson’s disease and amyotrophic lateral sclerosis have been termed ‘protein misfolding disorders’ that are char- terized by the neural accumulation of protein aggregates. Manipulation of the cellular stress response involving the induction of heat shock proteins offers a the- peutic strategy to counter conformational changes in neural proteins that trigger pathogenic cascades resulting in neurodegenerative diseases. Heat shock proteins are protein repair agents that provide a line of defense against misfolded, aggregati- prone proteins. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV).
Heat shock proteins : Potent mediators of inflammation and immunity
Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provides answers as to its biological significance to the host.
Hard Disk Drive Servo Systems
The second edition of this monograph provides a systematic treatment of the design of modern hard disk drive servo systems updated with the latest research results to reflect recent improvements in spindle speed and bit density and other changes in this fast-moving field. In particular, it focuses on the applications of some newly developed results in control theory, i.e., robust and perfect tracking control and composite non-linear feedback control which are suitable for track following and seeking respectively. Emphasis is placed on hard disk drive servo systems with single- or dual-stage actuation using a voice-coil-motor actuator enhanced in the latter case by the addition of a micro-actuator providing faster responses and therefore higher bandwidth in track following. Other issues such as modeling and compensation of nonlinearities and friction in microdrives, disturbance rejection and resonance compensation are also addressed.
Happiness is the Wrong Metric : A Liberal Communitarian Response to Populism
This timely book addresses the conflict between globalism and nationalism. It provides a liberal communitarian response to the rise of populism occurring in many democracies. The book highlights the role of communities next to that of the state and the market. It spells out the policy implications of liberal communitarianism for privacy, freedom of the press, and much else. In a ersuasive argument that speaks to politics today from Europe to the United States to Australia, the author offers a compelling vision of hope. Above all, the book offers a framework for dealing with moral challenges people face as they seek happiness but also to live up to their responsibilities to others and the common good.
Handbook of Response to Intervention : The Science and Practice of Assessment and Intervention
Education professionals have traditionally relied on a wait-to-fail formula to identify and assist students experiencing academic difficulties. With the reauthorization of the Individuals with Disabilities Education Improvement Act, however, a unique early-identification tool – known as response to intervention (RTI) – now offers professionals the option of implementing a collaborative, problem-solving tool designed to ensure that all students achieve academic success.
Handbook of neurochemistry and molecular neurobiology : Development and Aging Changes in the Nervous System
In the animal nervous system, a very high metabolic turnover, fragile but steep ionic gradients, and morphological and structural constraints - dictated by the necessity for prompt neuronal transmission of electrical impulses and necessary plasticity - result in a highly fragile organ system. Here, we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging. These chapters stress the dynamic features of neuronal responses to internal (developmental) cues or the more harmful external events (injury and disease) in a modern perspective.
Handbook of Bioterrorism and Disaster Medicine
This comprehensive volume, written by experts in the field, is the essential portable handbook on bioterrorism and disaster medicine. The volume covers all pertinent topics with meticulous organization and includes an abundance of invaluable web-based resources. Written as both a practical and clinical guide to various types of disasters, it includes planning and response procedures to help mitigate the impact of disasters on affected individuals and communities. Designed to be used in the field, all the essential aspects are included: public health, bioterror agents, chemical warfare, radioactive agents, manmade disasters, natural disasters, humanitarian disasters, infectious and tropical diseases, and basics of emergency medicine. Handbook of Bioterrorism and Disaster Medicine is the ideal tool for researchers, first responders, medical students, physicians, and other healthcare providers who work in the field.
Groupware : Design, Implementation, and Use ; 14th International Workshop, CRIWG 2008, Omaha, NE, USA, September 14-18, 2008, Revised Selected Papers
This book constitutes the refereed post-conference proceedings of the 14th International Workshop on Groupware: Design, Implementation, and Use, held in Omaha, Nebraska, USA, during September 14-18, 2008.The 30 papers presented were carefully reviewed and selected from numerous submission. The topics covered are groupware solutions, co-located groups, groupware for health care, collaborative systems development, collaborative emergency response, groupware approaches, patterns of collaboration.
Graph drawing ; Vol. 3843 ; 13 th International symposium, GD 2005, Limerick, Ireland, September 12-14, 2005, Revised Papers
The 13th International Symposium on Graph Drawing (GD 2005) was held in Limerick, Ireland, September 12-14, 2005. One hundred and ?fteen participants from 19 countries attended GD 2005. In response to the call for papers the Program Committee received 101 subm- sions, each detailing original research or a system demonstration. Each submission was reviewed by at least three Program Committee members; each referee’s c- ments were returned to the authors. Following extensive discussions, the comm- tee accepted 38 long papers, 3 short papers and 3 long system demos, each of which were presented during one of the conference’s 12 sessions. Eight posters were also accepted and were on display throughout the conference.
Graph drawing ; 15th International symposium, GD 2007, Sydney, Australia, September 24-26, 2007. Revised Papers
The 16th International Symposium on Graph Drawing (GD 2008) was held in Hersonissos, near Heraklion, Crete, Greece, September 21-24, 2008, and was attended by 91 participants from 19 countries. In response to the call for papers the Program Committee received 83 s- missions,eachdescribing originalresearchand/or a systemdemonstration.Tamassia showed how graph drawing techniques can be used as an e?ective tool in computer security and pointed to future research directions in this area. Following what is now a tradition, the 15th Annual Graph Drawing Contest was held during the conference, also including a Graph Drawing Challenge to the conference attendees.
Granular dynamic theory and its applications
Granular Dynamic Theory and Its Applications introduces both theory and applications in detail, including differential dynamical models of granular shearing, dynamical strength characteristics and the excited response of granules subject to vibration, granular liquefaction properties and the mechanisms under vibration, granular flow theory and vibration-aided flow, propagation laws of waves in granular media and their mechanism, fractal properties of granules, the vibrating ore-drawing technologies, and so on
Global Lessons from the AIDS Pandemic : Economic, Financial, Legal and Political Implications
This book examines the global HIV/AIDS pandemic from a multidisciplinary perspective, analyzing its economic impact, the reasons behind the political response to the pandemic, international laws relating to public health and patents and mechanisms for financing global and national responses. The authors paint a global picture of the HIV/AIDS pandemic one issue, one country and one region at a time and show why prevention, treatment and human rights protection must each form part of a comprehensive HIV/AIDS strategy. The book analyzes the successes and failures of national governments, international organizations and the private sector in fighting the HIV/AIDS pandemic and recommends changes to our international economic, financial, legal and political institutions. This book highlights the lessons the world has to learn from our experience with HIV/AIDS in order to improve the way we address global diseases.
Global Health Collaboration : Challenges and Lessons
Details the innovative work of the Pan Institution Network for Global Health in creating collaborative research-based answers to large-scale health issues. Equitable partnerships among member universities representing North America, Africa, Asia, and Europe reverse standard cross-national dynamics to develop locally relevant responses to health challenges as well as their underlying disparities. Case studies focusing on multiple morbidities and effects of urbanization on health illustrate open dialogue in addressing HIV, maternal/child health, diabetes, and other major concerns. These instructive examples model collaborations between global North and South as meaningful steps toward the emerging global future of public health.
GI Microbiota and Regulation of the Immune System
This book opens with two general reference chapters, which provide an over-view of current knowledge of gastrointestinal immunology and the commensal microbiology of the gut. Next are two chapters dedicated to current methodologies used to investigate the icrobiota and host: molecular analysis of microbial diver-sity and gnotobiotic research. Both positive and negative interactions between the microbiota and the immune system can take place in the gut, with chapters dedicated to probiotics and intestinal diseases associated with unhealthy rnicrobiota.
Geo-information for Disaster Management
Geo-information technology offers an opportunity to support disaster management: industrial accidents, road collisions, complex emergencies, earthquakes, fires, floods and similar catastrophes (for example the recent huge disaster with the Tsunami in South-East Asia on 26 December 2004). Access to needed information, facilitation of the interoperability of emergency services, and provision of high-quality care to the public are a number of the key requirements. The book provides a broad overview of the (geo-information) technology, software, systems needed, used and to be developed for disaster management. The book provokes a wide discussion on systems and requirements for use of geo-information under time and stress constraints and unfamiliar situations, environments and circumstances.
