Page 59
Page 59
Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery
There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.
Mechanisms of mineralization of vertebrate skeletal and dental tissues
Presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues.
Mechanisms of Lymphocyte Activation and Immune Regulation X ; Innate Immunity
Mechanisms of Lymphocyte Activation and Immune Regulation X: Innate Immunity is the proceedings of the Xth International Conference on Mechanisms of Lymphocyte Activation and Immune Regulation: Innate Immunity, held February 6-8, 2004 in Newport Beach, California. It is the tenth volume of its kind to appear in the series Advances in Experimental Medicine and Biology. Topics include toll receptors, dendritic cells, NK cells, and complement receptors.
Mechanisms of Insulin Action
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
Mechanics of the 21st Century ; Proceedings of the 21st International Congress of Theoretical and Applied Mechanics, Warsaw, Poland, 15-21 August 2004
Contains the proceedings of the 21st International Congress of Theoretical and Applied Mechanics, ICTAM04, held in Warsaw, in August 2004. This book discusses the field of mechanics, and is aimed at engineers and scientists. The texts of 27 invited lectures are included along with a CD-ROM with 1225 extended summaries of presented papers.
Mechanics of Structural Elements : Theory and Applications
The book systematically presents variational principles and methods of analysis for applied elasticity and structural mechanics. The variational approach is used consistently for both, constructing numerical procedures and deriving basic governing equations of applied mechanics of solids; it is the derivation of equations where this approach is most powerful and best grounded by mathematics. The book is oriented towards experts in civil engineering, researchers, developers of software for mechanical strength, stability, and oscillation analysis; it can be used by practical engineers who employ software tools to do their job and who want to know more about the theoretical background of the strength analysis. The book will be useful to senior and postgraduate students of engineering, to professors of structural analysis at civil or mechanical engineering departments of technical universities.
Mechanics of Microelectromechanical Systems
This book offers a comprehensive coverage to the mechanics of microelectromechanical systems (MEMS), which are analyzed from a mechanical engineer’s viewpointelectric energy.
Mechanics of Materials
Provides a precise presentation of subjects illustrated with numerous engineering examples that students both understand and relate to theory and application. The tried and true methodology for presenting material gives students the best opportunity to succeed in this course. From the detailed examples, to the homework problems, instructors and students can be confident the material is clearly explained and accurately represented.
Mechanics of Material Forces
The book covers both theoretical and numerical developments. Conceptually speaking, common continuum mechanics in the sense of Newton—which gives rise to the notion of spatial (mechanical) forces—considers the response to variations of spatial placements of "physical particles” with respect to the ambient space, whereas continuum mechanics in the sense of Eshelby—which gives rise to the notion of material (configurational) forces—is concerned with the response to variations of material placements of "physical particles” with respect to the ambient material. Well-known examples of material forces are driving forces on defects like the Peach-Koehler forece, the J-Integral in fracture mechanics, and energy release. The consideration of material forces goes back to the works of Eshelby, who investigated forces on defects; therefore this area of continuum mechanics is sometimes denoted Eshelbian mechanics.
Mechanics of Composite Materials with MATLAB
This textbook makes use of the popular computer program MATLAB as the major computer tool to study Mechanics of Composite Materials. It is written specifically for students in Engineering and Materials Science examining step-by-step solutions of composite material mechanics problems using MATLAB.
Mechanics of Civil Engineering Structures
Presents the material needed by practicing engineers engaged in the design of civil engineering structures, and students of civil engineering. The book covers the fundamental principles of mechanics needed to understand the responses of structures to different types of load and provides the analytical and empirical tools for design. The title presents the mechanics of relevant structural elements—including columns, beams, frames, plates and shells—and the use of mechanical models for assessing design code application. Eleven chapters cover topics including stresses and strains; elastic beams and columns; inelastic and composite beams and columns; temperature and other kinematic loads; energy principles; stability and second-order effects for beams and columns; basics of vibration; indeterminate elastic-plastic structures; plates and shells.
Mechanics of biomaterials : Fundamental principles for implant design
Teaching mechanical and structural biomaterials concepts for successful medical implant design, this self-contained text provides a complete grounding for students and newcomers to the field. Split into three sections: Materials, Mechanics and Case Studies, it begins with a review of sterilization, biocompatibility and foreign body response before presenting the fundamental structures of synthetic biomaterials and natural tissues. Mechanical behavior of materials is then discussed in depth, covering elastic deformation, viscoelasticity and time-dependent behavior, multiaxial loading and complex stress states, yielding and failure theories, and fracture mechanics. The final section on clinical aspects of medical devices provides crucial information on FDA regulatory issues.
Mechanics of Biological Tissue
The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book highlights some important research directions that combine mechanical sciences with exciting new developments in biology. This collection of papers should be of interest to theoretical, computational and experimental researchers and doctoral students in the area of biomechanics and in related areas of engineering, biology and medicine.
Mechanics and Physics of Fracture : Multiscale Modeling of the Failure Behavior of Solids
Provides a comprehensive understanding of the macroscopic failure behavior of solids from the description of the microscopic failure processes and their coupling with the microstructure. Several fundamental questions were addressed: the relation between the microstructural features of materials and their fracture properties and crack trajectories; the role of damage mechanisms and non-linear deformations near the crack tip on the failure behavior of solids; and finally the role of dynamic inertial effects during fast fracture was more briefly evoked.
Mechanics and natural philosophy before the scientific revolution
This volume deals with a variety of moments in the history of mechanics when conflicts arose within one textual tradition, between different traditions, or between textual traditions and the wider world of practice. Its purpose is to show how the accommodations sometimes made in the course of these conflicts ultimately contributed to the emergence of modern mechanics.
Mechanics : From Newton's Laws to Deterministic Chaos
This updated and revised fourth edition covers all topics in mechanics from elementary Newtonian mechanics, canonical and rigid body mechanics to relativistic mechanics and nonlinear dynamics. In particular, symmetries and invariance principles, geometrical structures and continuum mechanics play an important role. This book will enable the reader to develop general principles from which equations of motions may be derived, to understand the importance of symmetries as a basis for quantum mechanics and to get practice in using theoretical tools and concepts that are essential for all branches of physics. The book contains numerous problems with complete solutions, and some practical examples.This will be appreciated in particular by students using the text to accompnay lectures on mechanics. The book ends with some historical remarks on important pioneers in mechanics.
Mechanical Wave Vibrations: Analysis and Control
Delivers an expert discussion of the wave analysis approach (as opposed to the modal-based approach) to mechanical vibrations in structures. The book begins with deriving the equations of motion using the Newtonian approach based on various sign conventions before comprehensively covering the wave vibration analysis approach. It concludes by exploring passive and active feedback control of mechanical vibration waves in structures.
Mechanical Ventilation
This book represents a state-of-the-art review by the leading experts in this field and covers a number of important topics including epidemiology, underlying physiological concepts, and approaches to monitoring. The pros and cons of various modes of ventilation are reviewed, as are novel forms of ventilation that may play a role in the future management of patients with respiratory failure. The importance of patient-ventilator synchrony and ventilator-induced lung injury are reviewed, with a focus on recent clinical trials and the challenges of implementing the results into clinical practice.
Mechanical Sytems, Classical Models ; Vol. I : Particle Mechanics
The guideline of the present book is precisely the mathematical model of mechanics. A special accent is put on the solving methodology as well as on the mathematical tools used; vectors, tensors and notions of field theory. Continuous and discontinuous phenomena, various mechanical magnitudes are presented in a unitary form by means of the theory of distributions.
