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Complement and Kidney Disease
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Competence and Vulnerability in Biomedical Research
In this book, the author develops a novel justificatory framework for making judgments of decisional competence to consent to biomedical research with reference to five groups of cognitively vulnerable individuals - older children and adolescents, adults with intellectual disabilities, adults with depression, adults with schizophrenia and adults with dementia, including Alzheimer’s disease.
Comparative Skeletal Anatomy : A Photographic Atlas for Medical Examiners, Coroners, Forensic Anthropologists, and Archaeologists
The goal of this guide is to help experienced archaeologists and forensic scientists distinguish human remains from common animal species, including horses, cows, goats, rabbits, chickens, ducks, sheep, and pigs, among others. Comprehensive and timely, Comparative Skeletal Anatomy.
Comparative Placentation : Structures, Functions and Evolution
Science produces fascinating puzzles: why is there such a range of placental structures when other mammalian organs are so structurally uniform ? Why and how did the different placental structures evolve ? Comparative placental studies can facilitate the identification of the common factors in placental growth, differentiation and function and their relevance to possible evolutionary pathways. Comparative Placentation is the only book presenting up-to-date data illustrating the great variety of structure but uniform function of vertebrate placentas from fish to man. This information is essential for selection of suitable models to investigate particular practical problems of impaired or anomalous growth in human and animal placentation. The unique collection of the best light and electron micrographs from the last thirtyfive years which precisely illustrate the structural range in each taxon, make the book the most authoritative publication in this field and a vital source of information for anyone interested on reproductive physiology, anatomy and medicine.
Comparative Hepatitis
This volume reviews today’s knowledge about hepatitis with emphasis on comparative aspects between hepatitis in humans and animals, but also between different etiological agents. This particular viewpoint makes the book relevant for scientists from both human and veterinary medicine, gastroenterologists, pathologists, virologists and students of human and veterinary medicine.
Comparative genomics ; Vol.15 : Using Fungi as Models
Fungal comparative genomics started in 2000 by the genome sequencing of several yeast species other than the canonical Saccharomyces cerevisiae. Since then, over 30 fungal genome sequences have become available. This set represents a total evolutionary divergence comparable to that between vertebrates and arthropods, but also contains closely related genomes. This volume describes how we can use this set of genomes to trace large and small-scale events in genome evolution, to extract information about highly conserved and less conserved sequence elements, and to develop novel methods in genomics that will have an impact on genomics at large.
Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality, with at least one third of cases requiring hospitalization, exceeding the numbers admitted for myocardial infarction and stroke. Despite a broad armamentarium of antimicrobials available, it remains an important cause of death in industrialized countries. CAP is caused by a variety of pathogens with their order of importance dependent on the location and population studied. Despite the importance of CAP, reliable data and a recommended evidence-based therapy are lacking, and basic research must be improved. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered. The volume is of interest to researchers and clinicians in virology, epidemiology and biomedicine.
Community pharmacy : symptoms, diagnosis and treatment
Support pharmacists in identifying, diagnosing, treating or referring the illnesses and conditions they will commonly encounter in the community. A logical structure covers the full range of common presentations, including respiratory, ear, eye, gastroenterological and skin conditions. Clear pictures, referral criteria and summaries of treatment options support clinical reasoning, differential diagnosis and selection of appropriate products. Suitable for both pharmacy students and qualified pharmacists, the sixth edition has been fully updated to align with changes to the pharmacy curriculum and the rapidly expanding scope of pharmacists working in primary care and community pharmacy.
Communication in Plants : Neuronal Aspects of Plant Life
Plant neurobiology is a newly emerging field of plant sciences. It covers signalling and communication at all levels of biological organization – from molecules up to ecological communities. In this book, plants are presented as intelligent and social organisms with complex forms of communication and information processing. Authors from diverse backgrounds such as molecular and cellular biology, electrophysiology, as well as ecology treat the most important aspects of plant communication, including the plant immune system, abilities of plants to recognize self, signal transduction, receptors, plant neurotransmitters and plant neurophysiology. Further, plants are able to recognize the identity of herbivores and organize the defence responses accordingly. The similarities in animal and plant neuronal/immune systems are discussed too. All these hidden aspects of plant life and behaviour will stimulate further intense investigations in order to understand the communicative plants in their whole complexity.
Common complications in endodontics : Prevention and management
Describes the most commonly encountered endodontic complications and provides up-to-date information on their prevention and management. The opening chapters explain the importance of accurate diagnosis and treatment planning, outline the role of digital radiography and CBCT in managing complications, and highlight the need for close attention to anatomic landmarks in order to avoid damage to neurovascular anatomy. Endodontic problems associated with different procedural errors are then discussed in detail, covering a wide variety of access- and instrumentation-related complications and the difficulties that may arise when using obturation techniques. Readers will also find information on the endodontic–periodontal relationship, special issues in geriatric patients, and the potential medical emergencies and precautions in specific patient subsets.
Clinical oral medicine and pathology
The book has been well received internationally by a wide audience of clinicians, including general dentists, oral surgeons, otolaryngologists, primary care physicians, nurse practitioners, dental hygienists, physician assistants, and dermatologists, and sales have been strong among students and post-graduate residents training in medical, dental, and allied health fields, supporting the versatility of this work and serving as testimony to its value in both the academic and private practice arenas. Several key updates and improvements have been made to the second edition. All informational content has been updated to ensure accuracy and relevance, particularly in the rapidly evolving fields of oncology and pharmacology. A new chapter has been added entitled "Oral Sequelae of Cancer and Cancer Therapy" which better organizes and consolidates previous content while expanding on topics such as targeted therapies and hematopoietic stem cell transplantation. Additional clinical images have been included throughout the book so that the full clinical spectrum of any given condition is well-represented. Furthermore, the print quality, as well as the positioning and layout of the clinical images has been improved for optimal utility. Lastly, the summary boxes that follow each condition have been reconfigured with color-coded icons for improved definition, ease of use and cross-referencing.
Clinical microbiology made ridiculously simple
Is a brief, clear, thorough, and updated approach to clinical microbiology, brimming with mnemonics, humor, summary charts, and illustrations. Topics include Ebola, AIDS, flesh-eating bacteria, mad cow disease, hantavirus, anthrax, smallpox, and tuberculosis; the latest antibiotics; pandemic flu, including H7N9; SARS-like coronavirus; hepatitis C treatment options; HIV diagnostics and approved HIV meds; Zika virus; measles; and a new chapter on the latest emerging infectious diseases and drug-resistant bacteria. The major update to this book is the addition of a new chapter on the SARS-COV-2 virus and COVID-19 disease, which delves into the nature of the virus such as infectivity within the body, transmission between individuals, timeline of infectivity, symptoms, risk factors, therapeutics, and vaccines approved for use.
Clinical metabolomics applications in genetic diseases
Helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. Covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms.
Clinical Hematology and Fundamentals of Hemostasis ; 6th ed.
A full-color text, lab manual, & atlas--all in one!. Here are all the tools medical laboratory science students need to master the principles of hematology and the fundamentals of hemostasis. Author Denise M. Harmening has curated contributions from a team of expert educators and clinicians. With support from her Associate Editor LeAnne Hutson, she brings you comprehensive, yet focused coverage that prepares you for the real world in which you will practice
Clinical evaluation of medical devices : Principles and case studies
It include the many innovations and clinical research methods that have developed since the first edition, as well as current information on the regulatory, legal, and reimbursement environment for medical devices. The book's deeply experienced authors summarize the key principles and approaches employed in medical device clinical trials and illustrate their uses in a revealing series of detailed, real-world case studies.
Clinical dental pharmacology
Quick reference for drugs relevant to clinical dentistry. It delivers an essential reference for dental practitioners seeking quick, easy access to current and accurate information about drugs used by dentists in clinical practice. The book covers common drugs prescribed by dental practitioners as well as systemic medications which may impact on provision of clinical dental care. A separate section on recognition and management common medical emergencies in dental practice is also included.
Clinical decision support systems : Theory and practice
Writes the editor, "If used properly, CDSS have the potential to change the way medicine has been taught and practiced." As clinical decision support systems (CDSS) gain an increasingly central role in the delivery of high quality health care, it becomes more important for the health care community to understand their use. This text is designed as a resource for practicing clinicians, informaticians, teachers and students alike, and provides the most current, comprehensive look a the development and evaluation of clinical decision support systems.
Clinical consultation skills in medicine : A primer for MRCP PACES
Follows the revised format of the Practical Assessment Clinical Examination Skills (PACES) exam conducted by the Royal College of Physicians in the UK, where ‘clinical consultation skills’ will be tested twice in two separate stations. Thus, coming closest to what doctors do in real life: obtain a structured history, perform a focussed examination and explain the problem to the patient in lay terms. This book takes readers through a rational approach to 63 common presenting symptoms or laboratory abnormalities in medicine. It is aimed at improving the clinical consultation skills of young doctors and preparing them for the new format of MRCP PACES
Clinical Cases in Orofacial Pain
Individual cases cover temporomandibular joint disorders, masticatory muscle disorders, headache, neuropathic pain, dental pain, tooth wear, and dystonia. Following the popular Clinical Cases series style, cases are presented with associated academic commentary, including background information, diagnostic criteria and fundamental points that might influence the diagnosis, treatment planning or management of the case.
Clinical cases in implant dentistry
Presents 49 actual clinical cases, accompanied by academic commentary, that question and educate the reader about essential topics in implant dentistry, encompassing diagnosis, surgical site preparation and placement, restoration, and maintenance of dental implants. Unique case-based format supports problem-based learning Promotes independent learning through self-assessment and critical thinking Highly illustrated with full-color clinical cases Covers all essential topics within implant dentistry
