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Drug repurposing : A new fashion for a new hope
The repurposing of drugs is becoming increasingly attractive as it avoids the long process and cost implications associated with bringing a novel drug to market i.e., drug repurposing is cost effective and time saving. This study will discuss the repositioning of several drugs that belong to different pharmaceutical classifications such as antimicrobials (itraconazole and fluoroquinolones), anti-diabetic agents (metformin and sodium glucose co-transporter 2 inhibitors), cardiovascular drugs (β-blockers and digoxin), anticonvulsants (topiramate), immunosuppressants (sirolimus), non-steroidal anti-inflammatory drugs (NSAIDs e.g., COX inhibitors), and cholesterol lowering drugs (statins).
Digital Libraries : Universal and Ubiquitous Access to Information ; 11th International Conference on Asian Digital Libraries, ICADL 2008, Bali, Indonesia, December 2-5, 2008. Proceedings
This book constitutes the refereed proceedings of the 11th International Conference on Asian Digital Libraries, ICADL 2008, held in Bali, Indonesia, in December 2008.
Digital Libraries : International Collaboration and Cross-Fertilization; 7th International Conference on Asian Digital Libraries, ICADL 2004, Shanghai, China, December 13-17, 2004, Proceedings
The International Conference on Asian Digital Libraries (ICADL) is an annual international forum that provides opportunities for librarians, researchers and experts to exchange their research results, innovative ideas, service experiences and state-- the-art developments in the field of digital libraries. Building on the success of the first six ICADL conferences, the 7th ICADL conference hosted by the Shanghai Jiao Tong University and the Shanghai Library in Shanghai, China aimed to further strengthen the academic collaboration and strategic alliance in the Asia- Pacific Region in the development of digital libraries.
Digital libraries : Implementing strategies and sharing experiences ; 8th International Conference on Asian digital libraries, ICADL 2005, Bangkok, Thailand, December 12-15, 2005, Proceedings
Constitutes the proceedings of the 8th International Conference on Asian Digital Libraries, ICADL 2005. This book is organized in topical sections on concepts and models for digital library systems, case studies in digital libraries, digital archives and museums, multimedia digital libraries, digital libraries for community building, and more
Dental anatomy and morphology
Conveys the practical knowledge of dental anatomy and the art of sculpting it in wax. The ideal anatomy of each dental structure is described in detail and the waxing techniques are beautifully illustrated step by step for visual reference. The author demonstrates that for every morphologic feature there is an explanation in nature, assigning significance to every minute feature of dental morphology. Organized by tooth and arch, this book views morphology through a clinical lens and repeatedly draws connections between anatomical features and clinical concepts. The fundamental knowledge presented in this text is essential for improving waxing and sculpting techniques and will be useful for students and specialists alike.
Database Systems for Advanced Applications ; Vol. 3882 ; 11th International Conference, DASFAA 2006, Singapore, April 12-15, 2006, Proceedings
This book constitutes the refereed proceedings of the 11th International Conference on Database Systems for Advanced Applications, DASFAA 2006, held in Singapore in April 2006.
Database systems for advanced applications ; Vol. 3453 ; 10th international conference, DASFAA 2005, Beijing, China, April 17-20, 2005, Proceedings
Data Stream Mining and Resource Adaptive Computation.- Purpose Based Access Control for Privacy Protection in Database Systems.- Complex Networks and Network Data Mining.- Bioinformatics.- Indexing DNA Sequences Using q-Grams.- PADS: Protein Structure Alignment Using Directional Shape Signatures.- LinkageTracker: A Discriminative Pattern Tracking Approach to Linkage Disequilibrium Mapping.- Watermarking and Encryption.- Query Optimization in Encrypted Database Systems.- Watermarking Spatial Trajectory Database.- Effective Approaches for Watermarking XML Data.- XML Query Processing.- A Unifying Framework for Merging and Evaluating XML Information.- Efficient Evaluation of Partial Match Queries for XML Documents Using Information Retrieval Techniques.- PathStack: A Holistic Path Join Algorithm for Path Query with Not-Predicates on XML Data.- XML Coding and Metadata Management.- An Improved Prefix Labeling Scheme: A Binary String Approach for Dynamic Ordered XML.- Efficiently Coding and Indexing XML Document.- XQuery-Based TV-Anytime Metadata Management.- Data Mining.- Effective Database Transformation and Efficient Support Computation for Mining Sequential Patterns.
Database and XML Technologies ; Vol. 4156 ; 4th International XML Database Symposium, XSym 2006, Seoul, Korea, September 10-11, 2006, Proceedings
The theme of the XML Database Symposium (XSym) is the convergence of database technology with XML technology. Since the first International XML Symposium in 2003, XSym has continued to provide a forum for academics, practitioners, users and vendors to discuss the use of and synergy between advanced XML technologies. XSym 2006 received 32 full paper submissions. Each submitted paper underwent a rigorous review by independent referees. These proceedings represent a collection of eight excellent research papers. Their focus is on building XML repositories and covers the following topics: XML query processing, caching, indexing and navigation support, structural matching, temporal XML, and XML updates.
Database and XML Technologies ; Vol. 3671 ; 3rd international XML database symposium, XSym 2005, Trondheim, Norway, August 28-29, 2005, Proceedings
Constitutes the proceedings of the Third International XML Database Symposium, XSym 2005, held in Trondheim, Norway in August 2005. The 15 papers are organized in sections on indexing support for the evaluation of XPath and XQuery; benchmarks and algorithms for XQuery and XPath evaluation; algorithms for constraint satisfaction checking, and more.
Data Science-Based Full-Lifespan Management of Lithium-Ion Battery : Manufacturing, Operation and Reutilization
This book comprehensively consolidates studies in the rapidly emerging field of battery management. The primary focus is to overview the new and emerging data science technologies for full-lifespan management of Li-ion batteries, which are categorized into three groups, namely (i) battery manufacturing management, (ii) battery operation management, and (iii) battery reutilization management. The key challenges, future trends as well as promising data-science technologies to further improve this research field are discussed.
Data parallel C++programming accelerated systems using C++ and SYCL
Full of practical advice, detailed explanations, and code examples to illustrate key topics. SYCL enables access to parallel resources in modern accelerated heterogeneous systems. Now, a single C++ application can use any combination of devices–including GPUs, CPUs, FPGAs, and ASICs–that are suitable to the problems at hand. This book teaches data-parallel programming using C++ with SYCL and walks through everything needed to program accelerated systems. The book begins by introducing data parallelism and foundational topics for effective use of SYCL. Later chapters cover advanced topics, including error handling, hardware-specific programming, communication and synchronization, and memory model considerations.
Data Mining in Bioinformatics
8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biological research has shifted from genome sequences to protein functionality. Withwhole-genomedraftsofmouseandhumaninhand,scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erent tissues, its3Dstructure and activesites,its functionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support.
Data mining and knowledge management ; Chinese academy of sciences symposium CASDMKD 2004, Beijing, China, July 12-14, 2004, Revised Paper
Knowledge management for enterprise: These papers address various issues related to the application of knowledge management in corporations using various techniques. A particular emphasis here is on coordination and cooperation. • Risk management: Better knowledge management also requires more advanced techniques for risk management, to identify, control, and minimize the impact of uncertain events, as shown in these papers, using fuzzy set theory and other approaches for better risk management. • Integration of data mining and knowledge management: As indicated earlier, the integration of these two research fields is still in the early stage. Nevertheless, as shown in the papers selected in this volume, researchers have endearored to integrate data mining methods such as neural networks with various aspects related to knowledge management,
Data Management in Grids ; 1st VLDB Workshop, DMG 2005, Trondheim, Norway, September 2-3, 2005, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Data Management in Grids, DMG 2005, held in Trondheim, Norway in September 2005 in conjunction with VLDB 2005. papers address all current research activities in relation to data management in dynamic, heterogeneous and cross-organizational environments, i.e. grids. They show unique expertise in the management of very large, widely distributed databases.
Data Integration in the Life Sciences ; Vol. 4075 ; 3rd International Workshop, DILS 2006, Hinxton, UK, July 20-22, 2006, Proceedings
Data management and data integration are fundamental problems in the life sciences. Advances in molecular biology and molecular medicine are almost u- versallyunderpinned by enormouse?orts in data management,data integration, automatic data quality assurance, and computational data analysis. Many hot topics in the life sciences, such as systems biology, personalized medicine, and pharmacogenomics, critically depend on integrating data sets and applications producedby di?erent experimentalmethods, in di?erent researchgroups,andat di?erent levels of granularity.
Data integration in the life sciences ; Vol. 3615 ; 2nd international workshop, DILS 2005, San Diego, CA, USA, July 20-22, 2005, Proceedings
Constitutes the refereed proceedings of the Second International Workshop on Data Integration in the Life Sciences, DILS 2005, held in San Diego, CA, USA in July 2005. The papers are organized in sections on user applications, ontologies, data integration, and others, and address the issues in data integration from the life science point of view.
Data Integration in the Life Sciences ; 4th International Workshop, DILS 2007, Philadelphia, PA, USA, June 27-29, 2007, Proceedings
it cover a wide spectrum of theoretical and practical issues including scienti?c work?ows, - notation in data integration, mapping and matching techniques, and modeling of life science data. It presenting research on new models, methods, or algorithms and 6 papers presenting imp- mentation of systems or experience with systems in practice.
Cyanobacterial Harmful Algal Blooms : State of the Science and Research Needs
Humans can be exposed to cyanobacterial toxins by drinking water that contains the toxins, swimming in water that contains high concentrations of cyanobacterial cells, or breathing air that contains cyanobacterial cells or toxins (while watering a lawn with contaminated water, for example). Health effects associated with exposure to high concentrations of cyanobacterial toxins include: - stomach and intestinal illness; -trouble breathing; - allergic responses; - skin irritation; - liver damage; and neurotoxic reactions, such as tingling fingers and toes. Scientists are exploring the human health effects associated with long-term exposure to low levels of cyanobacterial toxins. Some studies have suggested that such exposure could be associated with chronic illnesses, such as liver cancer and digestive-system cancer. This monograph contains the proceedings of the International Symposium on Cyanobacterial Harmful Algal Blooms held in Research Triangle Park, NC, September 6-10, 2005.
Cutaneous Lymphomas : Unusual Cases 2
This book describes unusual cases of cutaneous lymphomas and is of special interest for clinicians and pathologists dealing with the vexing subject of cutaneous lymphoma. In addition to the case description, it gives the clinical, histological, and in most cases also the phenotypical features and the results of molecular techniques. A commentary puts the observations into the context of cutaneous lymphomas.
Current Trends in High Performance Computing and Its Applications ; Proceedings of the International Conference on High Performance Computing and Applications, August 8-10, 2004, Shanghai, P.R. China
This book contains variety of subjects in modern high performance computing and its applications, such as numerical and software algorithm design and analysis, grid computing advance, adaptive and par- lel algorithm development, distributing debugging tools, computational grid and network environment design, computer simulation and visualization, and computational language study and their applications to science, engineering, and medicine.
