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Regulation of Sertoli Cell and Germ Cell Differentiation
Unwanted childlessness affects approximately one in six couples worldwide. - though the exact proportion of the predominant cause of the problem remains controversial, according to the World Health Organization (WHO), in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. Based on these ?gures, the - cidence of male factor infertility in the general population is approximately 7%. The majority of these men, approximately 30%, experience irreversible idiopathic infertility and cannot father children without some form of medical intervention. Male factor infertility, in addition, may be caused by testicular germ cell cancer, which is known to represent the most common cancer among young men, aged 15 to 35 years, in Western industrialized countries. The number of affected men has increased dramatically over the past 50 years. There is now growing evidence that human testicular germ cell cancer originates from fetal germ cells exhibiting an aberrant programme of gene expression, and tumour progression may be favoured by an aberrant Sertoli cell-germ cell communication.
Reelin Glycoprotein : Structure, Biology and Roles in Health and Disease
Reelin glycoprotein is a major secretory protein with important roles in embryogenesis and during adult life. Reelin gene mutations or deficiency of the protein product cause abnormal cortical development and reelin signaling impairment in brain. Since the first discovery of the reelin mutant mouse in 1951 by Falconer, and later discovery of the gene for reelin in 1995, there has been an explosion of new knowledge about this important molecule. Reelin Glycoprotein: Structure, Biology and Roles in Health and Disease, written by an international panel of experts, summarizes the state of the knowledge on various aspects of reelin. Topics include the reelin gene and its receptors, downstream effector molecules in reelin signaling cascade, chemistry and structure of reelin, comparative anatomy of reelin, presence of reelin in various body tissues, reelin mutations, and abnormalities of reelin production in neuropsychiatric disorders and cancer. This book will serve as a foundation for analysis of this emerging novel protein for all neuroscientists and clinicians.
Reconstructive Neurosurgery
International experts present in this volume advances in reconstructive neurosurgery focusing on the fields of neurotrauma and neurodegenerative disorders. The highlights include building an international strategy for risk reduction, documentating an multidisciplinary approach towards restoration of function in paraplegic spinal cord-injured patients, describing a new approach for statistical analysis in traumatic brain injury trials, describing blood flow changes in diffuse brain injury, discussing rehabilitation programs in Germany following acute brain injury, describing research data form Taiwan on neurotrauma, showing the neuropsychiatric effects from deep brain stimuation fro ovement disorders, difining the role played by imanging for deep brain stimulation targeting in mental illness, using radiosurgery in decompresssion in the treatment of trigeminal neuralgia, describing the development of radiosurgery from brain to the spine, listing new transgenic animal models of Parkinson's disease, discussing gene therapy for neuropathic pain and Parkinson's disease, and finally, discussing constrained-induced movement therapy fro stroke patients, and endovascular therapy for cerebrovenous disorders.
Recent Advances in Thrombosis and Hemostasis
Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis.
Rational Emotive Behavioral Approaches to Childhood Disorders : Theory, Practice and Research
Since the groundbreaking first edition of Rational Emotive Approaches to the Problems of Childhood by Albert Ellis and Michael Bernard two decades ago, our understanding of the nature and treatment of children’s problems has grown considerably. Now in a completely new volume, Albert Ellis and children’s REBT specialist Professor Michael Bernard have revised and updated this pioneering volume to reflect both the latest in clinical practice and research.
Radiotherapy for Non-Malignant Disorders
This volume discusses the general background, radiobiology, radiophysics and clinical applications of radiation therapy in the treatment of non-malignant diseases. Within 39 chapters, it documents the rationale and indications for the use of state-of-the-art radiotherapy for various non-malignant disorders of the CNS, head and neck, eye, skin and soft tissues, bone and joints, and the vascular system. In so doing, it draws attention to and elucidates the scope for application of radiotherapy beyond the treatment of malignancies. Both the risks and the benefits of such treatment are fully considered, the former ranging from minor clinical problems to life-threatening diseases. With the assistance of many tables and colored figures, the extensive data from clinical studies are presented in a well-structured and informative way. Each chapter concludes with a list of key points, allowing the reader to quickly comprehend the main facts.
Radiology of the Stomach and Duodenum
A number of imaging techniques, many of them complementary, are used in the investigation and treatment of disorders of the stomach and duodenum. Optimal patient treatment requires a thorough knowledge of the application of these techniques, as well as a sound understanding of pathology of the stomach and its presenting symptomatology. This well-illustrated book covers the various investigative methods in detail, discussing their advantages and disadvantages and explaining their role in specific settings. It will be of great value to both trainee and experienced radiologists, and should assist in promoting effective and judicious patient management.
Quality of Life Impairment in Schizophrenia, Mood and Anxiety Disorders : New Perspectives on Research and Treatment
Over the past few decades health-related quality of life (HRQL) has emerged as the new image of medicine viewed from a psychosocial perspective. The concept of Quality of Life has attracted a good deal of interest, not only from a clinical perspective but also from psychosocial, health economics as well as cultural aspects. More recently, the neurobiological brain substrates that modulate many aspects of subjective experiences, which is relevant to quality of life such as affect, mood, cognition, pleasure, reward responses as well as feeling of wellbeing and satisfaction has been explored and elucidated. Such increased interest in HRQL is highlighted by the large number of recent publications.
PTSD : Brain Mechanisms and Clinical Implications
This book breaks new ground by offering neuroscientific insights into PTSD and their implications for diagnosis, prevention, and treatment. The recent explosion of biological investigation into this distressing and disabling condition has been led by this volume’s authors, who range from skilled basic scientists to experienced diagnosticians and therapists. Their contributions epitomize state-of-the-art, translational research in clinical neuroscience, and will prove to be an invaluable source of reference for practitioners and researchers in this field.
Psychosomatics diseases
Psychosomatics definition is a branch of medicine that deals with psychosomatic diseases which are diseases in which the mental and psychological factors of the patient greatly influence their emergence, development and turbulence, such as: migraine, eczema, ulcers, irritable bowel ... Etc., and in the event of a medical examination, no physical or organic causes appear for these diseases, or in the event of a disease resulting from an emotional or mood state such as anger, anxiety, depression, or guilt, in this case such cases are considered psychosomatic diseases. Psychosomatic diseases differ from transformational hysteria in that hysteria does not include a true organic defect, where the organ is healthy but is unable to perform its function, while in psychosomatic diseases, emotional and psychological factors lead to a defect in the anatomical formation of the affected organ, such as cases of stomach ulcers or inflammation Joints..etc.
Psychopharmacogenetics
In this book, the basic and advanced knowledge on psychiatric disorders will be provided for non-clinicians: What is schizophrenia? What are the risk factors? What are the core symptoms? How is it treated? What are the efficacy and side effects of the available treatments and their mechanisms? Are there already some psychopharmacogenetic data useful in clinical practice?
Psychoneuroimmunology
Central nervous system (CNS) immune privilege is an experimentally defined phenomenon. Tissues that are rapidly rejected by the immune system when grafted in sites, such as the skin, show prolonged survival when grafted into the CNS. Initially, CNS immune privilege was construed as CNS isolation from the immune system by the blood-brain barrier (BBB), the lack of draining lymphatics, and the apparent non immunocompetence of microglia, the resident CNS macrophage.
Psychological Approaches to Generalized Anxiety Disorder : A Clinician's Guide to Assessment and Treatment
One of the hallmarks of generalized anxiety disorder, along with diffuse pathological worry and somatic complaints, is its resistance to therapy. Of available treatment modalities for GAD, cognitive-behavioral therapy garners the best empirical support in terms of successful long-term results. Psychological Approaches to Generalized Anxiety Disorder offers clinicians a wide variety of CBT strategies to help clients develop core anxiety-reduction skills, presented so that readers can hone their own clinical skills.
Psychiatry for Neurologists
On the one hand, the authors illuminate the neurological aspects of such psychiatric disorders as depression, anxiety disorders, schizophrenia, hysteria, catatonia, addictions, and personality disorders. On the other hand, they also explain in detail the psychiatric evaluation of the neurological patient and discuss the behavioral aspects of the major neurological disorders, including psychiatric complications of dementia and stroke, neuromuscular disorders, the psychiatric aspects of Parkinson's disease, epilepsy, Huntington's disease, Tourette's syndrome, and multiple sclerosis. Additional chapters examine childhood and geriatric disorders, fatigue, delirium, psychopharmacology, and the problems of managing psychiatric emergencies in a neurological practice.
Psychiatric drugs explained
Provides a comprehensive review of drug effects, action and side-effects. There is an emphasis on the lived experience of patients, providing the reader with a sense of what the adverse effects of drugs might feel like to those who use them.
Psychiatric Disorders in Pregnancy and the Postpartum : Principles and Treatment
Although psychiatric disorders during pregnancy and the postpartum period are common, clinicians often feel apprehensive about treating such patients because of the potential adverse effects of prenatal medication. In Psychiatric Disorders in Pregnancy and the Postpartum: Principles and Treatment, a panel of top experts in perinatal psychiatry reviews the many recent studies on the use of psychiatric medications in pregnancy and postpartum and assesses their impact on the diagnosis and treatment of pregnant / postpartum women. The authors focus on each of the major psychiatric illnesses, including depression, anxiety disorder, bipolar disorder, schizophrenia, substance abuse, eating disorders, and mental illness, as well as on the potential impact of these illnesses on infants and children.
Psychiatric disorders : Genetics and treatments
Mental disorders are very common around us, the etiological factors and the secrets behind them have only begun to unwrap through hardwork and extenssive research. will discuss three important disorders which are Post Traumatic Stress Disorder (PTSD), Depression, and Schizophrenia. It will discuss an overview about each disorder including symptoms and risk factors, clinical chemistry will also be discussed and how neurotransmitters change in each disorder. The paper will also focus on genetic studies and whether there is an actual link between genetics and these disorders, and finally an insight about the medications used in each disorder with information about the most important drugs being used.
Protocollo per la valutazione delle abilità prassiche e della coordinazione motoria APCM = Protocol for the evaluation of practical skills and motor coordination APCM
Intended to provide valuable support in formulating a definitive diagnosis in children with multiple developmental difficulties (learning disabilities, attention deficit hyperactivity disorder, and signs of dyspraxia). The authors also emphasize the importance of carefully observing certain aspects of the behavior of children with these difficulties. Recent research, based on the concept of embodied cognition, has shown that experiences derived from the body, and therefore the development and control of motor functions, play a crucial role in the development of the mind, or cognitive development.
Protein misfolding, aggregation and conformational diseases ; Part A : Protein aggregation and conformational diseases
Protein Misfolding, Aggregation, and Conformational Disease, is the first book to discuss significant achievements in protein structure-function relationships in the areas of biochemistry, molecular biology and molecular medicine. This volume summarizes recent achievements in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders.
Proteases in the Brain
In all organs of the body proteases have critical roles to play both in normal development and functioning and in disease states. The brain is no exception to this, with proteases having emerging roles in synaptic plasticity, memory, neurodegenerative disorders such as Alzheimer’s, Parkinson’s and prion diseases, ischemia and traumatic brain injury, inflammatory and infectious diseases, and tumour progression. Proteases in the Brain brings together a wide range of topics under this central theme and highlights the large number of proteases involved in these normal and disease processes.
