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Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery
There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.
Mechanisms of Insulin Action
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metabolic syndrome, the dysmetabolic syndrome, syndrome X, or the insulin resistance syndrome. In all of these disorders, a central component of the pathophysiology is insulin resistance, i.e., reduced responsiveness to insulin in tissues such as muscle, fat and liver. Insulin resistance is also closely linked to other common health problems, including obesity, polycystic ovarian disease, hyperlipidemia, hypertension, and atherosclerosis. In this book, we will attempt to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. We explore insulin action at the most basic levels, through complex systems. The book will be appealing to basic and clinical scientists.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
Mechanics of Microelectronics
Written by the leading experts with both profound knowledge and rich practical experience in advanced mechanics and microelectronics industry, this book aims to provide the cutting edge knowledge and solutions for various mechanical related problems, in a systematic way. It contains essential and detailed information about the state-of-the-art theories, methodologies, the way of working and real case studies.
Mechanics of Materials
Provides a precise presentation of subjects illustrated with numerous engineering examples that students both understand and relate to theory and application. The tried and true methodology for presenting material gives students the best opportunity to succeed in this course. From the detailed examples, to the homework problems, instructors and students can be confident the material is clearly explained and accurately represented.
Mechanics of Materials
Provides a review of statics, covering the topics needed to begin the study of mechanics of materials including free-body diagrams, equilibrium, trusses, frames, centroids, and distributed loads. It presents the foundations and applications of mechanics of materials with emphasis on visual analysis, using sequences of figures to explain concepts and giving detailed explanations of the proper use of free-body diagrams. The Cauchy tetrahedron argument is included, which allows determination of the normal and shear stresses on an arbitrary plane for a general state of stress. An optional chapter discusses failure and modern fracture theory, including stress intensity factors and crack growth.
Mechanics of Material Forces
The book covers both theoretical and numerical developments. Conceptually speaking, common continuum mechanics in the sense of Newton—which gives rise to the notion of spatial (mechanical) forces—considers the response to variations of spatial placements of "physical particles” with respect to the ambient space, whereas continuum mechanics in the sense of Eshelby—which gives rise to the notion of material (configurational) forces—is concerned with the response to variations of material placements of "physical particles” with respect to the ambient material. Well-known examples of material forces are driving forces on defects like the Peach-Koehler forece, the J-Integral in fracture mechanics, and energy release. The consideration of material forces goes back to the works of Eshelby, who investigated forces on defects; therefore this area of continuum mechanics is sometimes denoted Eshelbian mechanics.
Mechanics of Civil Engineering Structures
Presents the material needed by practicing engineers engaged in the design of civil engineering structures, and students of civil engineering. The book covers the fundamental principles of mechanics needed to understand the responses of structures to different types of load and provides the analytical and empirical tools for design. The title presents the mechanics of relevant structural elements—including columns, beams, frames, plates and shells—and the use of mechanical models for assessing design code application. Eleven chapters cover topics including stresses and strains; elastic beams and columns; inelastic and composite beams and columns; temperature and other kinematic loads; energy principles; stability and second-order effects for beams and columns; basics of vibration; indeterminate elastic-plastic structures; plates and shells.
Mechanics of biomaterials : Fundamental principles for implant design
Teaching mechanical and structural biomaterials concepts for successful medical implant design, this self-contained text provides a complete grounding for students and newcomers to the field. Split into three sections: Materials, Mechanics and Case Studies, it begins with a review of sterilization, biocompatibility and foreign body response before presenting the fundamental structures of synthetic biomaterials and natural tissues. Mechanical behavior of materials is then discussed in depth, covering elastic deformation, viscoelasticity and time-dependent behavior, multiaxial loading and complex stress states, yielding and failure theories, and fracture mechanics. The final section on clinical aspects of medical devices provides crucial information on FDA regulatory issues.
Mechanics and Physics of Fracture : Multiscale Modeling of the Failure Behavior of Solids
Provides a comprehensive understanding of the macroscopic failure behavior of solids from the description of the microscopic failure processes and their coupling with the microstructure. Several fundamental questions were addressed: the relation between the microstructural features of materials and their fracture properties and crack trajectories; the role of damage mechanisms and non-linear deformations near the crack tip on the failure behavior of solids; and finally the role of dynamic inertial effects during fast fracture was more briefly evoked.
Mechanics and natural philosophy before the scientific revolution
This volume deals with a variety of moments in the history of mechanics when conflicts arose within one textual tradition, between different traditions, or between textual traditions and the wider world of practice. Its purpose is to show how the accommodations sometimes made in the course of these conflicts ultimately contributed to the emergence of modern mechanics.
Mechanical Ventilation
This book represents a state-of-the-art review by the leading experts in this field and covers a number of important topics including epidemiology, underlying physiological concepts, and approaches to monitoring. The pros and cons of various modes of ventilation are reviewed, as are novel forms of ventilation that may play a role in the future management of patients with respiratory failure. The importance of patient-ventilator synchrony and ventilator-induced lung injury are reviewed, with a focus on recent clinical trials and the challenges of implementing the results into clinical practice.
Mechanical Sytems, Classical Models ; Vol. I : Particle Mechanics
The guideline of the present book is precisely the mathematical model of mechanics. A special accent is put on the solving methodology as well as on the mathematical tools used; vectors, tensors and notions of field theory. Continuous and discontinuous phenomena, various mechanical magnitudes are presented in a unitary form by means of the theory of distributions.
Mechanical System Dynamics
This textbook gives a clear and thorough presentation of the fundamental principles of mechanical systems and their dynamics. It provides both the theory and applications of mechanical systems in an intermediate theoretical level, ranging from the basic concepts of mechanics, constraint and multibody systems over dynamics of hydraulic systems and power transmission systems to machine dynamics and robotics.
Mechanical Behaviour of Engineering Materials : Metals, Ceramics, Polymers, and Composites
How do engineering materials deform when bearing mechanical loads? To answer this crucial question, the book bridges the gap between continuum mechanics and materials science. The different kinds of material deformation (elasticity, plasticity, fracture, creep, fatigue) are explained in detail. The book also discusses the physical processes occurring during the deformation of all classes of engineering materials (metals, ceramics, polymers, and composites) and shows how these materials can be strengthened to meet the design requirements. It provides the knowledge needed in selecting the appropriate engineering material for a certain design problem. The reader will thus learn how to critically employ design rules and thus to avoid failure of mechanical components.
Mechanical Behavior of Materials : Fundamentals, Analysis, and Calculations
Provides a holistic understanding of mechanical behavior of materials, and enables critical thinking through mathematical modeling and problem solving.Each of the 15 chapters first introduces readers to the technologic importance of the topic and provides basic concepts with diagrammatic illustrations; and then its engineering analysis/mathematical modelling along with calculations are presented.
Meccanica quantistica : problemi scelti : 100 problemi risolti di meccanica quantistica = Quantum mechanics : chosen problems : 100 solved problems of quantum mechanics
This book is mainly dedicated to students preparing for the written exam of a Quantum Mechanics course. Consequently, this collection can also be very useful for teachers who have to propose problems to their students both in class and for exams. It is assumed that the contents of the course are substantially identical to those of a traditional course of Institutions of Theoretical Physics of the old systems of the degree course in Physics. In the new regulations, the same topics were, in general, spread over several courses.
Meccanica delle strutture e Controllo attivo strutturale: Modellistica di edifici, ponti, camini, strutture speciali
The basic texts of Structural Engineering, present in the literature, mostly give introductory examples. This text, however, after having given the disciplinary foundations, goes further to guide the reader in the construction of advanced mathematical models ... It is an unprecedented "compromise" between basic theory text and advanced text for advanced-professionals and researchers. Furthermore, the presence in the volume of "synoptic panels" and software cards gives the reader the possibility of always having at hand the foundations of a complex discipline.
Meat Biotechnology
The main goal of this book is to provide the reader with the recent developments in biotechnology and their applications in the meat processing chain. To achieve this goal, the book is divided into four parts. The first part deals with the use of modern biotechnology applied to farm animals. The second part focuses on the recent biotechnological developments in starter cultures for better meat fermentation. The third part discusses current approaches to improve the quality and nutritional properties of meats. The final part presents the latest advances in protection against foodborne pathogens, and other recent trends in the field. Written by distinguished international contributors, this book brings together the advances in such varied and different biotechnological topics
Measuring the Value of Culture : Methods and Examples in Cultural Economics
Acknowledgement of the value of culture and cultural goods is increasing world-wide. So too is interest in finding methods to quantify this value so that governments and private sponsors can make efficient funding decisions. "Measuring the Value of Culture" documents methods that can be used to put a price on the arts and cultural goods, including theatre, heritage, cultural events (like arts festivals), museums, archaeological sites and libraries. The methods discussed include economic impact studies, which use market data, as well as non-market valuation techniques, like willingness to pay studies, and the newer choice experiments. In addition, advances in more qualitative valuation methods are considered.
