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Microarray technology and cancer gene profiling
Cancer is a heterogeneous disease in most respects, including its cellularity, different genetic alterations and diverse clinical behaviors. In the present book, written by leading experts in each field, the technical features characterizing this powerful laboratory tool are discussed, and the applications so far described in the field of oncology are reviewed.
Microalgae Building Enclosures : Design and Engineering Principles
Aims to provide design, engineering, and biotechnical guidelines for microalgae building enclosures that need to be considered for symbiotic relations among the built environment, humans, and ecosystems. Introduces the theoretical background of microalgae as a bioremediator and future energy system and their potential roles toward sustainable and healthy built environments. Part II exemplifies interventions and multiple benefits of microalgae systems in product, architecture, urban, and infrastructure applications across the globe including Africa, Asia, Australia, Europe, South America, and North America. Part III explains the design and engineering criteria, biotechnical design requirements, and various performance metrics for microalgae architecture. Finally, Part IV investigates potential building applications in low-rise buildings, high-rise buildings, and energy-efficient retrofitting. The book also includes international case studies of microalgae building systems within various building types and climates.
Micro-, Meso- and Macro-Dynamics of the Brain
This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The topics cover the most fascinating facets of neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory and mental illness, brain controlled robots, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Overall, this volume offers an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
Micro-, Meso- and Macro-Connectomics of the Brain
Highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.
Michael Van Valkenburgh Associates : Allegheny Riverfront Park
Part of the "Source Books in Landscape" series, this book focuses on Michael Van Valkenburgh's Allegheny Riverfront Park project for Pittsburgh, Pennsylvania. It provides documentation of this project, following its development from conception through completion using sketches, drawings, models, renderings, working drawings, and photographs.
MICAI 2005 : Advances in Artificial Intelligence ; 4th Mexican International Conference on Artificial Intelligence, Monterrey, Mexico, November 14-18, 2005, Proceedings
Constitutes the refereed proceedings of the 4th Mexican International Conference on Artificial Intelligence, MICAI 2005, held Mexico, in November 2005. This book is organized in topical sections on knowledge representation and management, logic and constraint programming, uncertainty reasoning, multiagent systems and distributed AI, and others.
mHealth Innovation in Asia : Grassroots Challenges and Practical Interventions
Offers a detailed account of a range of mHealth initiatives across South, Southeast and East Asia. It provides readers with deep insights into the challenges such initiatives face on the ground, and a view of the diverse cultural contexts shaping strategies for overcoming these challenges. The book brings together various discussions on the broader mHealth literature, and demonstrates how a research focus on diverse Asian contexts influences the success and/or failure of current mHealth initiatives. It also highlights the important roles social scientists can play in advancing theoretical approaches, as well as planning, implementing and evaluating mHealth initiatives. The book is a valuable resource for project planners, policy developers in NGOs and government institutions, as well as academics, researchers and students in the fields of public health, communications and development studies.
Metric Structures for Riemannian and Non-Riemannian Spaces
The first stages of the new developments were presented in Gromov's course in Paris, which turned into the famous "Green Book" by Lafontaine and Pansu (1979). The present English translation of that work has been enriched and expanded with new material to reflect recent progress. Additionally, four appendices—by Gromov on Levy's inequality, by Pansu on "quasiconvex" domains, by Katz on systoles of Riemannian manifolds, and by Semmes overviewing analysis on metric spaces with measures—as well as an extensive bibliography and index round out this unique and beautiful book.
Metric Spaces
The abstract concepts of metric ces are often perceived as difficult. This book offers a unique approach to the subject which gives readers the advantage of a new perspective familiar from the analysis of a real line. Rather than passing quickly from the definition of a metric to the more abstract concepts of convergence and continuity, the author takes the concrete notion of distance as far as possible, illustrating the text with examples and naturally arising questions. Attention to detail at this stage is designed to prepare the reader to understand the more abstract ideas with relative ease.
Metric Handbook : Planning and Design Data
A major handbook of planning and design data for architects and architecture students. Covering basic design data for all the major building types, it is the ideal starting point for any project. For each building type, the book gives the basic design requirements and all the principal dimensional data, and succinct guidance on how to use the information and what regulations the designer needs to be aware of.
Methods to study litter decomposition : A practical guide
Decomposition of organic matter is a major ecosystem process involving an array of different organisms, including bacteria, fungi and invertebrates. The main objective of this book is to provide students and laboratory instructors at universities and professional ecologists with a broad range of established methods to study plant litter decomposition. Detailed protocols for direct use in the field or laboratory are presented in an easy to follow step-by-step format. A short introduction to each protocol reviews the ecological significance and principles of the technique and points to key references. Although most methods are described for freshwater ecosystems, many will work equally well in the presented or slightly modified form for studies in marine and terrestrial environments.
Methods of nonlinear analysis : Applications to differential equations
In this book, fundamental methods of nonlinear analysis are introduced, discussed and illustrated in straightforward examples. Every method considered is motivated and explained in its general form, but presented in an abstract framework as comprehensively as possible. Applications and generalizations are shown. In particular, a large number of methods is applied to boundary value problems for partial differential equations.
Methods of microarray data analysis V
In this volume, all investigators analyzed a single dataset on the lifecycle of the most deadly of malaria parasites, Plasmodium falciparum. The emphasis this year is on the application of novel and existing computational methodologies towards infectious disease. We highlight an introductory chapter by Raphael D. Isokpehi, a leading expert in the field of malaria. Ten of the papers presented at the conference are included, which range from the inference of genetic networks to the analysis of the spatial correlation of array data. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state-of-the-art in microarray data analysis.
Methods of microarray data analysis IV
As studies using microarray technology have evolved, so have the data analysis methods used to analyze these experiments. The CAMDA conference plays a role in this evolving field by providing a forum in which investors can analyze the same data sets using different methods. METHODS OF MICROARRAY DATA ANALYSIS IV is the fourth book in this series, and focuses on the important issue of associating array data with a survival endpoint. Previous books in this series focused on classification (Volume I), pattern recognition (Volume II), and quality control issues (Volume III). In this volume, four lung cancer data sets are the focus of analysis. We highlight three tutorial papers, including one to assist with a basic understanding of lung cancer, a review of survival analysis in the gene expression literature, and a paper on replication. In addition, 14 papers presented at the conference are included. This book is an excellent reference for academic and industrial researchers who want to keep abreast of the state-of-the-art of microarray data analysis.
Methods of Legal Reasoning
The book attempts to describe and criticize four methods used in legal practice, legal dogmatics and legal theory: logic, analysis, argumentation and hermeneutics. Apart from a presentation of basic ideas connected with the above mentioned methods, the essays contained in this book seek to answer questions concerning the assumptions standing behind these methods, the limits of using them and their usefulness in the practice and theory of law. A specific feature of the book is that in one study four different, sometimes competing concepts of legal method are discussed. The panorama, sketched like this, allows one to reflect deeply on the questions concerning the methodological conditioning of legal science and the existence of a unique, specific legal method. The authors argue that there exists no such method.
Methods of IT Project Management
Provides students with all the concepts, techniques, artifacts, and methods found in the leading project management reference books and modern development methodologies (agile, hybrid, and traditional), while also conveying practical knowledge that can immediately be applied in real-world settings.
Methods of Celestial Mechanics: Vol. I: Physical, Mathematical, and Numerical Principles
G. Beutler's Methods of Celestial Mechanics is a coherent textbook for students in physics, mathematics and engineering as well as an excellent reference for practitioners. This Volume I gives a thorough treatment of celestial mechanics and presents all the necessary mathematical details that a professional would need. After a brief review of the history of celestial mechanics, the equations of motion (Newtonian and relativistic versions) are developed for planetary systems (N-body-problem), for artificial Earth satellites, and for extended bodies (which includes the problem of Earth and lunar rotation). Perturbation theory is outlined in an elementary way from generally known mathematical principles without making use of the advanced tools of analytical mechanics. The variational equations associated with orbital motion - of fundamental importance for parameter estimation (e.g., orbit determination), numerical error propagation, and stability considerations - are introduced and their properties discussed in considerable detail. Numerical methods, especially for orbit determination and orbit improvement, are discussed in considerable depth. The algorithms may be easily applied to objects of the planetary system and to Earth satellites and space debris.
Methods of Celestial Mechanics ; Vol. II : Application to Planetary System, Geodynamics and Satellite Geodesy
G. Beutler's Methods of Celestial Mechanics is a coherent textbook for students as well as an excellent reference for practitioners. Volume II is devoted to the applications and to the presentation of the program system CelestialMechanics. Three major areas of applications are covered: (1) Orbital and rotational motion of extended celestial bodies. The properties of the Earth-Moon system are developed from the simplest case (rigid bodies) to more general cases, including the rotation of an elastic Earth, the rotation of an Earth partly covered by oceans and surrounded by an atmosphere, and the rotation of an Earth composed of a liquid core and a rigid shell (Poincaré model). (2) Artificial Earth Satellites. The oblateness perturbation acting on a satellite and the exploitation of its properties in practice is discussed using simulation methods (CelestialMechanics) and (simplified) first order perturbation methods. The perturbations due to the higher-order terms of the Earth's gravitational potential and resonant perturbations are considered thereafter. Special attention is paid to satellites of the Global Navigation Satellite Systems and to geostationary satellites. The characteristics of and models for the two most important non-gravitational forces, atmospheric drag and radiation pressure, are presented as well as the most relevant forces acting on high- and low-orbiting satellites. (3) Evolution of the Planetary System. The outer planetary system consisting of the planets Jupiter to Pluto is studied over long time intervals using simulation methods and spectral analysis (CelestialMechanics). The properties of the inner systems, in particular of the Earth's orbit, are made visible by integrating the entire system over long time intervals relevant for climate change. The distribution of minor planets and their orbital properties, regular orbits, and chaotic orbits are easily generated and analyzed using CelestialMechanics. The volume concludes with the discussion of important mathematical tools of the program system and of the principles of spectral analysis.
Methods in Nonlinear Analysis
Nonlinear analysis has developed rapidly in the last three decades. Theories, techniques and results in many different branches of mathematics have been combined in solving nonlinear problems. This book collects and reorganizes up-to-date materials scattered throughout the literature from the methodology point of view, and presents them in a systematic way. It contains the basic theories and methods with many interesting problems in partial and ordinary differential equations, differential geometry and mathematical physics as applications.There are five chapters that cover linearization, fixed-point theorems based on compactness and convexity, topological degree theory, minimization and topological variational methods. Each chapter combines abstract, classical and applied analysis. Particular topics included are bifurcation, perturbation, gluing technique, transversality, Nash–Moser technique, Ky Fan's inequality and Nash equilibrium in game theory, setvalued mappings and differential equations with discontinuous nonlinear terms, multiple solutions in partial differential equations, direct method, quasiconvexity and relaxation, Young measure, compensation compactness method and Hardy space, concentration compactness and best constants, Ekeland variational principle, infinite-dimensional Morse theory, minimax method, index theory with group action, and Conley index theory.
Methods in Modern Biophysics
Incorporating recent dramatic advances, this textbook presents a fresh and timely introduction to modern biophysical methods. An array of new, faster and higher-power biophysical methods now enables scientists to examine the mysteries of life at a molecular level. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobility spectrometry, mass spectrometry, proteomics, and protein folding and structure. Incorporating much information previously unavailable in tutorial form, Nölting employs worked examples and 267 illustrations to fully detail the techniques and their underlying mechanisms.
