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Metabolomics : A powerful tool in systems biology
This book brings together the latest results in the field of metabolomics. It comprehensively presents the current state of the metabolomics field by underscoring experimental methods, analysis techniques, standardization practices, and advances in specific model systems. As a result, it significantly broadens our perspective on the principles and strategies underpinning this emerging field.
Metabolome Analyses : Strategies for Systems Biology
Metabolome Analyses is intended as a follow-up to Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (Kluwer, 2003). That text offered guidelines to currently available technology, bioinformatics and databases. Evidence was presented showing metabolic profiling as a valuable addition to genomics and proteomics strategies devoted to drug discovery and development. This book focuses on how metabolic profiling is being more comprehensively integrated with the other "omics" technologies. It provides more practical applications of such "panomics" or "Systems Biology" approaches. The expanding use of mass spectrometry as a measurement technology in metabolic profiling is addressed through demonstrated applications. The integration of metabolic profiling and proteomics is probably most developed for plant-based studies, which was not addressed in Volume 1. Other areas related to metabolic profiling continue to show significant development. These include database strategies and an increased acceptance by the pharmaceutical industry of metabolic profiling. Also covered is the use of in silico metabolic networks. Again the focus is primarily on the pharmaceutical industry but the importance of metabolic profiling to studies on human nutrition (a burgeoning area) is discussed.
Metabolism and Functions of Bioactive Ether Lipids in the Brain
This book will be particularly useful to neuroscience graduate students, academics, and researchers. Clinicians will find this book useful for understanding molecular aspects of neurodegeneration in acute neural trauma and neurodegenerative diseases that are mediated by plamalogen-selective phospholipases A2 and PAF acetyl hydrolases. This monograph is the first to provide a comprehensive description of not only metabolism and role of plasmalogen and platelet activating factor in brain tissue but also the involvement of these lipids with abnormal signal transduction processes in neurological disorders.
Messung von Ressourceneffizienz mit der ESSENZ-Methode : Integrierte Methode zur ganzheitlichen Bewertung = Measuring resource efficiency with the ESSENCE method : Integrated method for holistic evaluation
Develops a reliable method for evaluating the use of resources. This is necessary because the strong economic growth of the last decades has led to an intensive use of natural resources. With their increasing use, there are also additional burdens on the environment and restrictions on the availability of resources. For these reasons, efficient use of resources is required as an important contribution to sustainable development.
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Mercury
Mercury, the planet closest to the Sun, is different in several respects from the other three terrestrial planets. In appearance, it resembles the heavily cratered surface of the Moon, but its density is high, it has a magnetic field and magnetosphere, but no atmosphere or ionosphere. This book reviews the progress made in Mercury studies since the flybys by Mariner 10 in 1974-75, based on the continued research using the Mariner 10 archive, on observations from Earth, and on increasingly realistic models of its interior evolution.
Mental Health, Social Mirror
The essays in this volume reassert the centrality of research in mental health to sociology. First, they articulate the contributions that mental health research has made and can make to resolving key theoretical and empirical debates in important areas of sociological study. Second, they draw from mainstream theories and concepts to reconsider the potential of sociology to provide answers to critical questions regarding the social origins of and social responses to mental illness. As reflected in the title, the sociological study of mental health provides a reflection of the central processes that characterize our society.
MEMS/NEMS : (1) Handbook Techniques and Applications Design Methods, (2) Fabrication Techniques, (3) Manufacturing Methods, (4) Sensors and Actuators, (5) Medical Applications and MOEMS
Micro-Electro Mechanical Systems (MEMS) is the integration of mechanical elements, sensors, actuators, and electronics on a common silicon substrate. While the electronics are fabricated using integrated circuit (IC) process sequences (e.g., CMOS, Bipolar, or BICMOS processes),the micromechanical components are fabricated using compatible micromachining processes that selectively etch away parts of the silicon wafer or add new structural layers to form the mechanical and electromechanical devices. MEMS promises to revolutionize nearly every product category by bringing together silicon-based microelectronics with micromachining technology, thereby, making possible the realization of complete systems-on-a-chip.
Memories : Molecules and Circuits
This volume surveys the recent advances and provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.
Mémento de la recherche biomédicale portant sur un médicament à usage humain = Summary of biomedical research on a medicinal product for human use
Presents the reference texts, structures and authorities that govern clinical research in France, as well as its practical aspects. It is aimed at all of its stakeholders, both caregivers and patients. It will allow the most novices to familiarize themselves with the specific vocabulary of this discipline, to answer the questions raised during the conduct or participation in a therapeutic trial, and the most experienced to consider setting up a research structure. clinic in the rules of art.
Membrane Trafficking in Viral Replication
The ability of viruses to exploit cellular functions for their own ends makes them highly effective pathogens and exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. Each of the eight chapters in this volume deals with a specific aspect of viral interactions with cellular membranes. These include chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. These chapters should provide both an overview of cellular membrane trafficking mechanisms and viral interactions with these systems, as well as reviews of the current state of each of the fields.
Membrane Computing; 8th International Workshop, WMC 2007 Thessaloniki, Greece, June 25-28, 2007 Revised Selected and Invited Papers
This volume contains a selection of papers presented at the Eighth Workshop on Membrane Computing, WMC8, which took place in Thessaloniki, Greece, during June 25–28, 2008. Special attention was paid to the interaction of membrane computing with biology and computer science, focusing on the - ological roots of membrane computing, on applications of membrane computing in biology and medicine, and on possible electronically based implementations.
Membrane Computing ; Vol. 4361 ; 7th International Workshop, WMC 2006, Leiden, Netherlands, July 17-21, 2006, Revised, Selected, and Invited Papers
The present volume contains a selection of papers presented at the Seventh Workshop on Membrane Computing, WMC7, which took place in Leiden, The Netherlands, during July 17–21, 2006. The ?rst three workshops on membrane computing were organized in Curtea de Arge¸ s, Romania – they took place in August 2000 (with the proceedings published in Lecture Notes in Computer Science, volume2235),in August 2001(with a selection of papers published asa special issue of Fundamenta Informaticae, volume 49, numbers 1–3, 2002), and in August 2002 (with the proceedings published in Lecture Notes in Computer Science, volume 2597). The next three workshops were organized in Tarragona, Spain, in July 2003, in Milan, Italy, in June 2004, and in Vienna, Austria, in July 2005, with the proceedings published as volumes 2933, 3365, and 3850, respectively, of Lecture Notes in Computer Science. The 2006edition of WMC wasorganized(and supported) byLorentzCenter, Leiden, under the auspices of the European Molecular Computing Consortium (EMCC). Special attention was paid to the interaction of membrane computing with biology, focusing both on the biological roots of membrane computing and on applications of membrane computing in biology and medicine.
Membrane Computing ; Vol. 3850 ; 6th International Workshop, WMC 2005, Vienna, Austria, July 18-21, 2005, Revised Selected and Invited Papers
The papers in this volume cover all the main directions of research in membrane computing, ranging from theoretical topics in mathematics and computer science, to application issues, especially in biology. More specifically, these papers present research on topics such as: computational power and complexity classes, new types of P systems, relationships to Petri nets, quantum computing, and brane calculi, determinism vs. nondeterminism, hierarchies, the size of small families, algebraic approaches, and designing polynomial solutions to NP-complete problems through the use of membrane systems. Like the previous workshops,
Membrane Computing ; Vol. 3365 ; 5th International Workshop, WMC 2004, Milan, Italy, June 14-16, 2004, Revised Selected and Invited Papers
Constitutes the refereed extended postproceedings of the 5th International Workshop on Membrane Computing, held in Italy, in June 2004. This book addresses various topics in the area of membrane computing, ranging from mathematics and theoretical computer science to applications in biology, linguistics, and computer graphics.
Melting Hadrons, Boiling Quarks - From Hagedorn Temperature to Ultra-Relativistic Heavy-Ion Collisions at CERN : With a Tribute to Rolf Hagedorn
Shows how the study of multi-hadron production phenomena in the years after the founding of CERN culminated in Hagedorn's pioneering idea of limiting temperature, leading on to the discovery of the quark-gluon plasma -- announced, in February 2000 at CERN.
Meeting Basic Learning Needs in the Informal Sector : Integrating Education and Training for Decent Work, Empowerment and Citizenship
This anthology brings together basic facts and features about basic learning needs and skills of people working and living in the informal economy and presents case studies from different countries examining educational and training strategies for meeting these learning needs. It portrays the grave problems facing educational and training systems vis-á-vis informal sector workers, even as they look at holistic solutions that take into account principles of lifelong learning and innovations in informal, non-formal and formal adult learning, and show a growing awareness that education is a human right of fundamental significance to promoting decent work and humane living conditions.
Medium-Range Weather Prediction : The European Approach
The European Centre for Medium-Range Weather Forecasts is widely acknowledged to be a world leader in the field of numerical weather prediction." "This authoritative and readable book tells the interesting story of how the Centre was conceived in the confusing and difficult political period of the 1960s in Europe. It summarises the political, scientific, technical and financial discussions that led to its establishment, and how it came to be built 60 km west of London, England.
Mediterranean Land-surface Processes Assessed from Space
1. 1 Space View and Ground Observations 1 1. 2 Mediterranean Climatic Environment 2 1. 3 Processes at Surfaces 10 1. 3. 1 Deforestation and Land-use Changes 10 1. 3. 2 Water Related Problems 16 1. 3. 3 Fire, Grazing, and Land Degradation 19 1. 3. 4 Drought, Floods, Frost, and Desertification 21 1. 3. 5 Coupling Between Surface and Atmosphere: The Role of the Atmospheric Boundary Layer 25 1. 4 Role and Capabilities of Measurements Made From Space 30 1. 4. 1 Research Programmes 30 1. 4. 2 Expected Information 32 1. 4. 3 Research Strategy 33 1. 4. 4 Observation of Changes in Heterogeneous Landscapes: Spatial and Temporal Scales 35 1. 4. 5 Land-surface Change Indicators Observable from Space 36 Spectral Characteristics of Vegetation and Soils (36); Responses of Remote Sensing Signals to Changes of Land-surface Properties (40) 1. 5 About this Book 48 Chapter 2 Processing and Archiving of Satellite and Ancillary Data 51 2. 1 Introduction 51 2. 2 The Remote Sensing Data Base 55 2. 2. 1 Satellite Instruments 55 The NOAA Observing System (55); Meteosat (57); Nimbus-7 (59); Landsat (59); SPOT (61); DMSP (62); ERS-1 and ERS-2 (62); TRMM (63); Terra (64); Envisat (65); Aqua (66) 2. 2. 2 Aircraft Instruments 66 The Use of Aircraft for Land-surface Process Studies (66); AVIRIS (67); TMS (68); AIRSAR (68); DIAL (69) 2. 3 Reception, Acquisition and Availability of Satellite Data 70 2. 3.
Mediterranean Island Landscapes : Natural and Cultural Approaches
Mediterranean islands exhibit many similarities in their biotic ecological, physical and environmental characteristics. There are also many differences in terms of their human colonization and current anthropogenic pressures. This book addresses in three sections these characteristics and examines the major environmental changes that the islands experienced during the Quaternary period. The first section provides details on natural and cultural factors which have shaped island landscapes. It describes the environmental and cultural changes of the Holocene and their effects on biota, as well as on the current human pressures that are now threats to the sustainability of the island communities. The second section focuses on the landscapes of the largest islands namely Sicily, Sardinia, Corsica, Cyprus, Crete, Malta and the Balearics. Each island chapter includes a special topic reflecting a particular characteristic of the island. Part three presents strategies for action towards sustainability in Mediterranean islands and concludes with a comparison between the largest islands.
