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Drug development for rare diseases
A disease is defined as rare if the prevalence is fewer than 200,000 in the United States. It is estimated that there are more than 7,000 rare diseases, which collectively affect 30 million Americans or 10% of the US population. This diverse and complex disease area poses challenges for patients, caregivers, regulators, drug developers, and other stakeholders. This book is proposed to give an overview of the common issues facing rare disease drug developers, summarize challenges specific to clinical development in small populations, discuss drug development strategies in the evolving regulatory environment, explain generation and utilization of different data and evidence
Drawing imagining building : Embodiment in architectural design practices
Drawing Imagining Building focuses on the history of hand-drawing practices to capture some of the most crucial and overlooked parts of the process. Using 80 black and white images to illustrate the examples, it examines architectural drawing practices to elucidate the ways drawing advances the architect’s imagination.
Drawing Climate : Visualising Invisible Elements of Architecture
Investigates the history, theory and applications of climatic design in the built environment examining architecture and landscapes from various time periods. Based on a collaboration between the University of Sydney and the National University of Singapore, the book brings together contributing authors from Australia, Singapore, and the United States.
Drawing architecture and the Urban
Provides an instrumental approach to drawing, especially computer-generated drawings; it outlines how drawings should be used to convey clear and analytical information in the process of design, as well as the communication and discussion of a project. In depth examples are provided how to communicate effectively. The final section demonstrates how to transform case-studies, directly connecting an analytical approach with the design process.
Double Balloon Endoscopy : Theory and Practice
The chapters of this book describe the principles, insertion technique, and clinical applications of double-balloon endoscopy, which will become the gold standard of enteroscopy and may well eliminate the need for intraoperative enteroscopy in many patients.
Distributed, High-Performance and Grid Computing in Computational Biology ; International Workshop, GCCB 2006, International Workshop, GCCB 2006, Eilat, Israel, January 21, 2007, Proceedings
Modern computational biology and bioinformatics are characterized by large and complex structured data and by applications requiring considerable computing resources, such as processing units, storage elements and software programs. In addition, these disciplines are intrinsically geographically distributed in terms of their instruments, communities and computing resources. Tackling the computational challenges in computational biology and bioinformatics increasingly requires high-end and distributed computing infrastructures, systems and tools.
Distributed systems and mobile computing
About Distributed Systems and Mobile Computing. This is a branch of Computer Science devoted to the study of systems whose components are in different physical locations and have limited communication capabilities. Such components may be static, often organized in a network, or may be able to move in a discrete or continuous environment. The theoretical study of such systems has applications ranging from swarms of mobile robots (e.g., drones) to sensor networks, autonomous intelligent vehicles, the Internet of Things, and crawlers on the Web. The book includes five articles. Two of them are about networks: the first one studies the formation of networks by agents that interact randomly and have the ability to form connections; the second one is a study of clustering models and algorithms. The three remaining articles are concerned with autonomous mobile robots operating in continuous space.
Distributed applications and interoperable systems ; Vol. 3543 ; 5th IFIP WG 6.1 International conference, DAIS 2005, Athens, Greece, June 15-17, 2005, Proceedings
ThisvolumecontainstheproceedingsoftheIFIPWG6. 1InternationalWorking Conference on Distributed Applications and Interoperable Systems V held in Athens, Greece, on June 15–17, 2005. The conference program presented the state of the art in research concerning distributed and interoperable systems. The emergence of 4th-generation c- munication systems, the evolution of Internet technologies, the convergence of telecom and datacom, wireless and ?xed communication systems and appli- tions pave the path for ubiquitous service and application provision. Innovative solutions are required for the development, implementation and operation of distributed applications in complex IT environments full of diversity and h- erogeneity. Today, the emerging wide spectrum of distributed systems.
Distributed and Parallel Systems : In Focus : Desktop Grid Computing
In this book contributors investigate parallel and distributed techniques, algorithms, models and applications; present innovative software tools, environments and middleware; focus on various aspects of grid computing; and introduce novel methods for development, deployment, testing and evaluation.
Distributed and parallel computing ; 6th International conference on algorithms and architectures for parallel processing, ICA3PP, Melbourne, Australia, October 2-3, 2005, Proceedings
There are many applications that require parallel and distributed processing to allow complicated engineering, business and research problems to be solved in a reasonable time. Parallel and distributed processing is able to improve company profit, lower costs of design, production, and deployment of new technologies, and create better business environments. The major lesson learned by car and aircraft engineers, drug manufacturers, genome researchers and other specialist is that a computer system is a very powerful tool that is able to help them solving even more complicated problems. That has led computing specialists to new computer system architecture and exploiting parallel computers, clusters of clusters, and distributed systems in the form of grids.
Disease in Wild Animals : Investigation and Management
Wildlife diseases have become increasingly important recently due to their effect upon human health, veterinary medicine, wildlife, and conservation biology. Gary Wobeser's successful book from 1994 has been completely updated and enlarged in a new second edition. An in-depth overview of the available techniques for the investigation and management of disease in free-ranging animals is provided. The subjects are illustrated with examples drawn from around the world, with emphasis on the special requirements involved in working with wild animals. Techniques are assessed critically with regard to their efficacy and effectiveness.
Discrete-time Markov jump linear systems
Safety critical and high-integrity systems, such as industrial plants and economic systems, can be subject to abrupt changes - for instance, due to component or interconnection failure, sudden environment changes, etc. Combining probability and operator theory, Discrete-Time Markov Jump Linear Systems provides a unified and rigorous treatment of recent results for the control theory of discrete jump linear systems, which are used in these areas of application. The book is designed for experts in linear systems with Markov jump parameters, but is also of interest for specialists in stochastic control since it presents stochastic control problems for which an explicit solution is possible - making the book suitable for course use.
Directions in strong motion instrumentation ; Proceedings of the NATO SFP Workshop on Future Directions in Instrumentation for Strong Motion and Engineering Seismology, Kusadasi, Izmir, May 17-21, 2004
This book, which contains papers by invited authorities, represents a unique interaction between seismologists and earthquake engineers who examine issues of mutual concern in an overlapping area of major interest. The papers have been grouped around three major areas. -Seismic Hazard and Extreme Motions -Engineering Uses of Strong Motion Seismograms -Arrays and Observations.
Direct and Large-Eddy Simulation VI ; Proceedings of the Sixth International ERCOFTAC Workshop on Direct and Large-Eddy Simulation, held at the University of Poitiers, September 12-14, 2005
this workshop addressed numerous theoretical and physical aspects of transitional and turbulent flows. At an applied level it contributed to the solution of problems related to energy production, transportation and the environment. Since the prediction and analysis of fluid turbulence and transition continues to challenge engineers, mathematicians and physicists, DLES-6 covered a large range of topics, from the more technical ones like numerical methods, initial and inflow conditions, the coupling of RANS and LES zones, subgrid and wall modelling to topics with a stronger focus on flow physics such as aero-acoustics, compressible and geophysical flows, flow control, multiphase flow and turbulent combustion, to quote only a few.
Dimensions of the Sustainable City
The CityForm consortium’s latest book, Dimensions of the Sustainable City, is the first book to report on an empirical multi-disciplinary study specifically designed to address urban sustainability. Drawing together the various dimensions of sustainability – economic, social, transport, energy and ecological – the book examines their relationships both to each other and to urban form. The book investigates the sustainability dimensions of cities through a series of projects based on a common list of elements of urban form, and which draw on the consortium’s latest research to review the sustainability issues of each dimension. The elements of urban form include density, land use, location, accessibility, transport infrastructure and characteristics of the built environment.
Dilated Cardiomyopathy : From Genetics to Clinical Management
This book presents a comprehensive overview of dilated cardiomyopathy, providing readers with practical guidelines for its clinical management. The first part of the book analyzes in detail the disease’s pathophysiology, its diagnostic work up as well as the prognostic stratification, and illustrates the role of genetics and gene-environment interaction. The second part presents current and future treatment options, highlighting the importance of long-term and individualized treatments and follow-up.
Digital transformation of the design, construction and management processes of the built environment
This book focuses on the development of methods, interoperable and integrated ICT tools, and survey techniques for optimal management of the building process.
Digital Terrain Modelling : Development and Applications in a Policy Support Environment
This book presents a set of papers on Digital Terrain Modelling for Policy Support which aims to be informative and stimulating for both developers and users of digital terrain models. It should also be useful for professi- als who are interested in the wider aspects of the applications of terrain models in support for policies and decision making. There is an increasing demand for regional and continental scale data for use in environmental modelling and spatial analysis to support envir- mental policy development and implementation. Important environmental processes act at regional and continental scales, for example climatic change inducing floods and soil erosion, and management of these pr- esses for the sustainable development of society requires policies to be - plied at the corresponding scales. One of the most important factors inf- encing these environmental processes which act on the earth’s surface is the surface topography, hence the need for extensive, harmonised digital terrain models.
Digital Technologies in Construction Engineering : Selected Papers
Includes the latest advances, innovations, and applications in the field of construction engineering, as presented by researchers and engineers at the Digital Technologies in Construction Engineering conference, held in Belgorod, Russia, on June 8-9, 2021. It covers highly diverse topics, including industrial and civil construction, building materials; environmental engineering and protection; sustainability; structure safety and special construction structures. The contributions, which were selected by means of a rigorous international peer-review process, highlight numerous exciting ideas that will spur novel research directions and foster multidisciplinary collaborations.
Digital Soil Mapping with Limited Data
This book focuses on digital soil mapping methodologies and applications for areas where data are limited, and has the following sections (i) introductory papers, (ii) dealing with limited spatial data infrastructures, (iii) methodology development, and (iv) examples of digital soil mapping in various parts of the globe (including USA, Brazil, UK, France, Czech Republic, Honduras, Kenya, Australia). The final chapter summarises priorities for digital soil mapping.
