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Model-Driven Design Using Business Patterns
This book takes exactly this step: it shows you how to apply the pattern ideas in business applications and presents more than 20 structural and behavioral business patterns that use the REA (resources, events, agents) pattern as a common backbone. If you are a developer working on business frameworks, you can use the patterns presented to derive the right abstractions (e.g., business objects) and to design and ensure that the meta-rules (e.g., process patterns) are followed by the developers of the actual applications. And if you are an application developer, you can use these patterns to design your business application, to ensure that it does not violate the domain rules, and to adapt the application to changing requirements without the need to change the overall architecture. As with patterns in general, this approach allows for both more flexible and more solid software architectures and hence better software quality.
Mid-Infrared Coherent Sources and Applications
Coherent sources of mid-infrared (mid-IR) radiation are of great interest for a wide range of scienti?c and technological applications from spectroscopy and frequency metrology to information technology, industrial process control, pho- chemistry, photobiology and photomedicine. The mid-IR spectrum, which may be de?ned as wavelengths beyond ?2µm, covers important atmospheric windows, and numerous molecular gases, toxic agents, air, water, and soil pollutants, c- ponents of human breath, and several explosive agents have strong absorption ?ngerprints in this region. The development of practical coherent solid-state sources in the mid-IR can thus provide indispensable tools for a variety of - plications in environmental monitoring and pollution control, detection of water and soil contaminants, food quality control, agriculture and life sciences, and n- invasive disease diagnosis and therapy through breath analysis.
Micropropagation methods in temporary immersion systems
Presents vital techniques for the commercial micropropagation of plants. It explores numerous micropropagation protocols in different types of temporary immersion systems for plant species with agricultural, medicinal, ornamental, and forestry interest, detailing the type of bioreactor and the optimal parameters necessary to guarantee obtaining the largest number of commercial propagules. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Microfluidics diagnostics : Methods and protocols
Explores a wide range of microfluidic-based approaches that exploit the unique features of microfluidic devices, which hold significant potential in the field of diagnosis. Beginning with a section on microchips for sample preparation, including cell-free DNA, exosomes, and cells, the book continues by covering protein marker analysis and detection, single-cell analysis, analysis of bacteria and viruses, as well as human cell-based culture and analysis. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Metal Catalyzed Reductive C-C Bond Formation : A Departure from Preformed Organometallic Reagents
The prototypical catalytic reductive C–C bond formations, the Fischer-Tropsch reaction [1] and alkene hydroformylation [2], were discovered in 1922 and 1938, respectively [3,4]. These processes, which involve reductive coupling to carbon monoxide, have long been applied to the industrial manufacture of commodity chemicals [5]. Notably, alkene hydroformylation, also known as the oxo-synthesis, has emerged as the largest volume application of homogeneous metal catalysis, accounting for the production of over 7 million metrictons of aldehyde annually. Despite the impact of these prototypical reductive C–C bond formations, this field of research lay fallow for several decades.
Memory B-cells : Methods and protocols
Details in methods to assess memory B cell formation and function in mice and humans. Chapters guide readers through tetramer-based methods to assess antigen-specific memory B cell dynamics in humans and mice in different vaccine, next-generation deep-sequencing, single-cell techniques to assess epigenomic, VDJ landscapes, lymph node aspirates from humans, advanced imaging, murine models to determine memory B cells formation, and bioinformatic techniques and in silico modelling of memory b cell formation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Medicinal spice and condiment crops
Spices are used in small quantities to add flavor, aroma, color, and texture in food preparation. However, spices and condiments have also been recognized as having medicinal value. They have been used traditionally as curative and preventive agents, the bioactive compounds obtained from these plants are used in herbal drug formulations in modern times.
Medicinal plants and antimicrobial therapies
Serves as an excellent comprehensive material covering the current understandings and updates on antimicrobial resistance (AMR) and the use of medicinal plant resources for tackling it. Chapters cover important aspects of AMR and strategies to address this threatening issue with medicinal plants and their resources. One health perspectives for addressing AMR have been presented for the readers. Antimicrobial medicinal plant therapeutic resources including crude extracts, active fractions, pure molecules and essential oils, besides using them as functionalizing agents for nano-antimicrobials have been covered. Further, plant endophytes as a source of antimicrobial compounds have been discussed. Chapters cover both the bactericidal as well as resistance-reversal (or potentiating/ combinatorial therapies) potencies of medicinal plant resources. The book also focuses on how medicinal plant resources effectively target major determinants of AMR.
Medicinal compounds in modern healthcare : From tradition to innovation
Reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.
Medical Treatment of Intoxications and Decontamination of Chemical Agents in the Area of Terrorist Attack
This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled?Medical Treatment of Intoxications and Decontamination of Chemical Agent in the Area of Terrorist Attack?. The focus of this workshop was assessment of scientific concepts and practical means for management of chemical agent casualties in the area of terrorist attack with emphasis on improving the medical treatment and decontamination. These problems were analyzed from an interdisciplinary perspective. The primary objective of the ARW was to provide countries in which chemical-defense systems are currently under development with the experience and expertise of those that are more advanced and/or have already been exposed and responded to a chemical-terrorist attack. . The main areas covered were: 1. new approaches in pre-treatment and prophylaxis of nerve agent intoxication; 2. diagnosis of exposure to chemical agents ; 3. therapy of chemical agent intoxication; 4. development of personal decontamination; 5. decontamination of intoxication with chemical agents.
Medical laboratory technology procedure : manual for routine diagnostic tests ; Vol.3
Salient features Predominantly tailored to the requirements of laboratories with limited facilities in developing countries, this manual: Introduces methods and procedures for producing reliable laboratory findings Describes all tests in a step-by-step manner with guidelines to avoid errors and hazards Explains care and use of laboratory equipment and preparation of reagents Details Zika and Chikungunya virus infections Highlights the clinical significance of laboratory findings Provides illustrations for easy comprehension The fourth edition features a number of important additions containing the latest topics relevant to the subject
Mechanizing Mathematical Reasoning : Essays in Honor of Jörg H. Siekmann on the Occasion of His 60th Birthday
By presenting state-of-the-art results in logical reasoning and formal methods in the context of artificial intelligence and AI applications, this book commemorates the 60th birthday of Jörg H. Siekmann. The 30 revised reviewed papers are written by former and current students and colleagues of Jörg Siekmann; also included is an appraisal of the scientific career of Jörg Siekmann entitled "A Portrait of a Scientist: Logics, AI, and Politics." The papers are organized in four parts on logic and deduction, applications of logic, formal methods and security, and agents and planning.
Mechanisms of Angiogenesis
Is it advisable to go back from bedside to the bench? During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.
Measuring Globalisation : Gauging Its Consequences
Globalization a timely and controversial topic Presents comprehensive synthesis/overview of perspectives/approaches to "globalization", defines the term in more objective, scientific terms Presents rigorous empirical measures of globalization and its economic, political and social impact, w/implications for management and policy Authors represent different theoretical perspectives; are prolific and well-respected in the field
Mathematics and Democracy : Recent Advances in Voting Systems and Collective Choice
In this book, different quantitative approaches to the study of electoral systems have been developed: game-theoretic, decision-theoretic, statistical, probabilistic, combinatorial, geometric, and optimization ones. All the authors are prominent scholars from these disciplines. Quantitative approaches offer a powerful tool to detect inconsistencies or poor performance in actual systems. Applications to concrete settings such as EU, American Congress, regional, and committee voting are discussed.
Irreversible Decisions under Uncertainty : Optimal Stopping Made Easy
In real life, as well as in economic models, individuals often make decisions in an uncertain environment. In many cases, a problem which an optimizing agent faces can be formulated or reformulated as a problem of optimal timing of a certain irreversible or partially reversible action or optimal stopping problem. In this book, the authors present an alternative approach to optimal stopping problems. The basic ideas and techniques of the approach can be explained much simpler than the standard methods in the literature on optimal stopping problems. The monograph will teach the reader to apply the technique to many problems in economics and finance, including new ones. From the technical point of view, the method can be characterized as option pricing via the Wiener-Hopf factorization.
Iron metabolism : Methods and protocols
Explores classical and cutting-edge methods optimized and validated to analyze various aspects of iron metabolism, from in vitro to multi-organ level. Opening with a section on basic iron metabolism methods, the book continues with methods applicable to a variety of systems, ranging from bacteria to cultured mammalian cells and tissues, with a focus on cellular heme and iron-sulfur cluster species, as well as mitochondrial iron and its derivatives. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
IP Network-based Multi-agent Systems for Industrial Automation : Information Management, Condition Monitoring and Control of Power Systems
IP Network-based Multi-agent Systems for Industrial Automation is the first book to present an introduction to the use of the Internet protocol suite and multi-agent systems for the information management, online monitoring and control of distributed power system substations. An open architecture is proposed, in which mobile agents are applied to the retrieval and analysis of substation data, and to remote operator intervention. A prototype implementation of this architecture is also described, which has been demonstrated and evaluated using a substation simulator.
Investigative Electrocardiography in Epidemiological Studies and Clinical Trials
It reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents.
Intuitive Human Interfaces for Organizing and Accessing Intellectual Assets ; International Workshop, Dagstuhl Castle, Germany, March 1-5, 2004, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the 2004 International Workshop on Intuitive Human Interfaces for Organizing and Accessing Intellectual Assets, held in Dagstuhl Castle, Germany in March 2004. The 17 revised full papers presented together with an introductory overview have gone through two rounds of reviewing and revision. The papers are organized in topical sections on man-machine interface for intuitive knowledge access, intelligent pad and meme media, visualization and design of information access spaces, and semantics and narrative organization and access of knowledge.
