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Novel Carrier Systems for Targeted and Controlled Drug Delivery
Presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers.
Notes on Coxeter Transformations and the McKay Correspondence
One of the beautiful results in the representation theory of the finite groups is McKay's theorem on a correspondence between representations of the binary polyhedral group of SU(2) and vertices of an extended simply-laced Dynkin diagram. The Coxeter transformation is the main tool in the proof of the McKay correspondence, and is closely interrelated with the Cartan matrix and Poincaré series. The Coxeter functors constructed by Bernstein, Gelfand and Ponomarev plays a distinguished role in the representation theory of quivers.
Non-spectral Asymptotic Analysis of One-Parameter Operator Semigroups
In this book, non-spectral methods are presented and discussed that have been developed over the last two decades for the investigation of asymptotic behavior of one-parameter operator semigroups in Banach spaces. This concerns in particular Markov semigroups in L1-spaces, motivated by applications to probability theory and dynamical systems. Recently many results on the asymptotic behaviour of Markov semigroups were extended to positive semigroups in Banach lattices with order-continuous norm, and to positive semigroups in non-commutative L1-spaces. Related results, historical notes, exercises, and open problems accompany each chapter.
Nonsmooth Analysis
The book treats various concepts of generalized derivatives and subdifferentials in normed spaces, their geometric counterparts (tangent and normal cones) and their application to optimization problems. It starts with the subdifferential of convex analysis, passes to corresponding concepts for locally Lipschitz continuous functions and finally presents subdifferentials for general lower semicontinuous functions. All basic tools are presented where they are needed; this concerns separation theorems, variational and extremal principles as well as relevant parts of multifunction theory. The presentation is rigorous, with detailed proofs. Each chapter ends with bibliographic notes and exercises.
Nonparametric Functional Data Analysis : Theory and Practice
Modern apparatuses allow us to collect samples of functional data, mainly curves but also images. On the other hand, nonparametric statistics produces useful tools for standard data exploration. This book links these two fields of modern statistics by explaining how functional data can be studied through parameter-free statistical ideas. This book starts from theoretical foundations including functional nonparametric modeling, description of the mathematical framework, construction of the statistical methods, and statements of their asymptotic behaviors. It proceeds to computational issues including R and S-PLUS routines. Several functional datasets in chemometrics, econometrics, and pattern recognition are used to emphasize the wide scope of nonparametric functional data analysis in applied sciences. The companion Web site includes R and S-PLUS routines, command lines for reproducing examples presented in the book, and the functional datasets. Rather than set application against theory, this book is really an interface of these two features of statistics. A special effort has been made in writing this book to accommodate several levels of reading.
Non-metallic biomaterials for tooth repair and replacement
Focuses on the use of biomaterials for a range of applications in tooth repair and, in particular, dental restoration. Part one reviews the structure, modification and repair of dental tissues. The properties of enamel and dentin and their role in adhesive dental restoration are discussed, along with biomineralization and biomimicry of tooth enamel, and enamel matrix proteins (EMPs) for periodontal regeneration. Part two goes on to discuss the processing, bonding and wear properties of dental ceramics, glasses and sol-gel derived bioactive glass ceramics for tooth repair and replacement. Dental composites for tooth repair and replacement are then the focus of part three, including composite adhesive and antibacterial restorative materials for dental applications. T
NonlinearWaves and Solitons on Contours and Closed Surfaces
The present volume is an introduction to nonlinear waves and soliton theory in the special environment of compact spaces such a closed curves and surfaces and other domain contours. It assumes familiarity with basic soliton theory and nonlinear dynamical systems.
Nonlinear Parabolic-Hyperbolic Coupled Systems and Their Attractors
This book presents recent results concerning the global existence in time, the large-time behaviour, decays of solutions and the existence of global attractors for some nonlinear parabolic-hyperbolic coupled systems of evolutionary partial differential equations arising from physics, mechanics and material science, such as the compressible Navier-Stokes equations, thermo(visco)elastic systems and elastic systems. To keep the book as self-contained as possible, the first chapter introduces to the needed results and tools from functional analysis, Sobolev spaces, differential and integral inequa.
Nonlinear Ill-posed Problems of Monotone Type
This monograph offers a systematic and thorough exposition of the theory and applications of non-linear equations and variational inequalities with monotone and accretive operators. … The authors have collected, classified, and properly arranged a great deal of results . The present book will certainly help the reader to obtain an introduction to basic ideas and results of the contemporary theory of solution methods for nonlinear monotone problems.
Nonlinear Elliptic and Parabolic Problems : A Special Tribute to the Work of Herbert Amann
The present volume is dedicated to celebrate the work of the renowned mathematician Herbert Amann, who had a significant and decisive influence in shaping Nonlinear Analysis. Most articles published in this book, which consists of 32 articles in total, written by highly distinguished researchers, are in one way or another related to the scientific works of Herbert Amann. The contributions cover a wide range of nonlinear elliptic and parabolic equations with applications to natural sciences and engineering. Special topics are fluid dynamics, reaction-diffusion systems, bifurcation theory, maximal regularity, evolution equations, and the theory of function spaces.
Non-Formal Education : Flexible Schooling or Participatory Education?
This is the first full study of non-formal education on an international scale since the 1980s. The book describes the emergence of the concept in the context of development and educational reform. It traces the debate about non-formal education from its origins in 1968 to the mid 1980s, and looks at the issues that this debate raised. It then describes a number of programmes in different parts of the world which call themselves ‘non-formal’, pointing out the wide range of different views about what is and what is not non-formal. Rogers asks whether we should drop the term altogether or try to reconceptualise it in terms of flexible schooling or participatory education.
Non-equilibrium Thermodynamics and the Production of Entropy: Life, Earth, and Beyond
The present volume studies the application of concepts from non-equilibrium thermodynamics to a variety of research topics. Emphasis is on the Maximum Entropy Production (MEP) principle and applications to Geosphere-Biosphere couplings. Written by leading researchers form a wide range of background, the book proposed to give a first coherent account of an emerging field at the interface of thermodynamics, geophysics and life sciences.
Noise-Induced Transitions : Theory and Applications in Physics, Chemistry, and Biology
This classic text, an often-requested reprint, develops and explains the foundations of noise-induced processes. At its core is a self-contained, textbook-style presentation of the elements of probability theory, of the theory of Markovian diffusion processes and of the theory of stochastic differential equations, on which the modeling of fluctuating natural and artificial environments is based. Following an introduction to the mathematical tools, the occurrence and the properties of noise-induced transitions are then analyzed for rapidly fluctuating environments describable by the white-noise idealization. Subsequently, more realistic and general types of colored noises are considered. Appropriate practical methods for dealing with these situations are developed. The latter part of the book contains applications and experimental studies illustrating the many facets of noise-induced transitions. The following applications are considered in Noise-Induced Transitions: population dynamics, electrical circuits, chemical and photochemical reactions, non-linear optics, and hydrodynamical systems.
NMR in Biological Systems : From Molecules to Human
During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or functional aspect of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials.
NL ARMS Netherlands Annual Review of Military Studies 2020 : Deterrence in the 21st Century—Insights from Theory and Practice
This book surveys the state of the field to examine whether a fifth wave of deterrence theory is emerging. Bringing together insights from world-leading experts from three continents, the volume identifies the most pressing strategic challenges, frames theoretical concepts, and describes new strategies.
Nine algorithms that changed the future : The ingenious ideas that drive today’s computers
Every day, we use our computers to perform remarkable feats. A simple web search picks out a handful of relevant needles from the world’s biggest haystack. Uploading a photo to Facebook transmits millions of pieces of information over numerous error-prone network links, yet somehow a perfect copy of the photo arrives intact. Without even knowing it, we use public-key cryptography to transmit secret information like credit card numbers, and we use digital signatures to verify the identity of the websites we visit. How do our computers perform these tasks with such ease?
Nicotinic Acetylcholine Receptor Signaling in Neuroprotection
Presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology.
N-Heterocyclic Carbenes in Transition Metal Catalysis
It was only in the early 1990s that carbenes with the carbene carbon being incorporated in a nitrogen containing heterocycle (N-heterocyclic carbenes or NHCs) were found to be stable enough to be isolated. Since the first report on the application of NHCs as ligands in transition metal catalysis in 1995, NHC have found numerous applications and have been established as a versatile and indispensable class of ligands. For many reactions like metathesis or cross-coupling reactions NHCs have often become the ligands of choice, allowing otherwise difficult transformations. In this book leading experts have surveyed major areas of application of NHC metal complexes in catalysis. The authors have placed a special focus on nickel- and palladium-catalyzed reactions, on applications in metathesis reactions, on oxidation reactions and on the use of chiral NHC-based catalysts. This compilation is rounded out by an introductory chapter and a chapter dealing with synthetic routes to NHC metal complexes.
NF-kB/Rel Transcription Factor Family
Since its first discovery in the early 90’s, the NF-kB/Rel transcription factor family has drawn the attention of experimental biologists, medical profession, and biotech/pharmaceutical industries for its broad and diverse roles in all aspects of human biology and disease. NF-kB/Rel Transcription Factor Family intends to provide an up-to-date guide to the ever-expanding knowledge in the field of NF-kB/Rel transcription factor family.
Nez, gorge, oreille en médecine traditionelle chinoise = Nose, throat, ear in traditional Chinese medicine
ENT doctor for forty years, acupuncturist for thirty years, Bernard Cygler occupies a privileged position between "West" and "East". Chinese vision provides incomparable help in understanding and attempting to cure ailments that are particularly hopeless in Western medicine such as nasal polyposis, anosmia, and tinnitus. It is valuable in that it offers the possibility of avoiding surgical procedures or allopathic treatments with sometimes unpleasant side effects. This approach aims to treat the patient rather than the symptom, the whole rather than the disease itself. With his medico-surgical experience and his practice of Chinese medicine, the author tried to "marry" the two facets of his exercise while remaining faithful to traditional texts in the spirit of the French Acupuncture Association. , to which it belongs. The humanist approach delivered by the author, combining "tradition and modernity", is characterized by a desire for transmission so that a certain idea of the art of healing may live on for longer. Doctor Bernard Cygler, former intern and former head of clinic-assistant of hospitals, head of hospital ENT department from 1972 to 2003 is a member of the French Acupuncture Association and of the French Acupuncture College. He has written numerous publications in traditional Chinese medicine.
