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The Moral, Social, and Commercial Imperatives of Genetic Testing and Screening : The Australian Case
This is a dynamic book that successfully combines global and local thinking with regard to an emerging technology that will contribute to the expansion of proteomics and pharmacogenomics, the science of tailored healthcare and treatments. Genetic testing and screening will change the way people understand health, diagnostic knowledge, illness but also crime, databases and private information, paternity, and self-knowledge. In addition to giving individuals the opportunity to think differently about their well-being, it installs a new taxonomy in terms of illness, because its probabilistic effects will introduce a new narrative in the health discourse of 21st century society. While in the past people could be classified as being healthy or sick, now, through genetic testing and screening, adults can be classified as being healthy, predisposed to an illness, probably at risk, at risk, or carriers of certain risks. The effects of this taxonomy do not remain confined to the individual who is tested but extends to an entire family, as genetic knowledge is family knowledge. But the technology of genetic testing and screening installs a second dramatic register in the prenatal phase when cells and embryos are tested and subsequently altered in order to hit targets of perfection.
The Moon that Wasn’t : The Saga of Venus’ Spurious Satellite
This book details the history of one of astronomy’s many spurious objects, the satellite of Venus. First spotted in 1645, the non-existing moon was observed more than a dozen times until the late eighteenth century. Although few astronomers believed in the existence of the moon after about 1770, it continued to attract attention for at least another century. However, it has largely disappeared from the history of astronomy, and the rich historical sources have never been exploited. By telling the story of the enigmatic satellite in its proper historical context it is demonstrated that it was much more than a mere curiosity in the annals of astronomy – Frederick II of Prussia was familiar with it, and so was Bonnet, Kant and Voltaire.
The Molecular Genetics of Lung Cancer
Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk. The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.
The Missing Links in Teacher Education Design : Developing a Multi-linked Conceptual Framework
This ground-breaking, internationally oriented book brings together a number of excellent contributions on new directions in the design of teacher education programs. Moreover, the ideas are connected through a clear and stimulating conceptual framework that has the potential to guide effective innovation in the field.Teacher education program design demands a conceptualization built on strong interlinked foundations so that coursework and practice complement each another as a dynamic whole. Hoban offers an outstanding explication of exactly that through his Missing Links in Teacher Education. In so doing he offers a way of enhancing the quality of teacher education programs for those scholars passionate about, and committed to the work of teaching and learning about teaching.
The Metaphysics of Memory
This book investigates central issues in the philosophy of memory. Does remembering require a causal process connecting the past representation to its subsequent recall and, if so, what is the nature of the causal process? Of what kind are the primary intentional objects of memory states? How do we know that our memory experiences portray things the way they happened in the past? Given that our memory is not only a passive device for reproducing thoughts but also an active device for processing stored thoughts, when are thoughts sufficiently similar to be memory-related? The Metaphysics of Memory defends a version of the causal theory of memory, argues for direct realism about memory, proposes an externalist response to skepticism about memory knowledge, and develops a contextualist account of the factivity constraint on memory.
The MESSENGER Mission to Mercury
The articles in this book, written by the experts in each area of the MESSENGER mission, describe the mission, spacecraft, scientific objectives, and payload. The book is of interest to all potential users of the data returned by the MESSENGER mission, to those studying the nature of the planet Mercury, and by all those interested in the design and implementation of planetary exploration missions.
The Mediterranean Sea
This volume deals with several aspects of the chemical contamination of the Mediterranean Sea and its health. After a description of the general physical and socio-economic context, exploration of processes governing the fate of chemicals, the budget of both inorganic and organic major and preoccupant contaminants and a description of new tools to study the impact of pollution on the Mediterranean Sea are discussed. The book serves as a reference source for the chemical aspects of the Mediterranean Sea for students and scientists and a practical guide for those who have professional responsibility for the management and operation of environmental impact assessment programmes.
The Medical Basis of Psychiatry
The major goal of the this edition of this classic book was to update the busy clinician, psychiatric resident and medical student with the most up-to-date information on etiology, diagnosis and treatment of psychiatric disorders.
The Mathematica GuideBook for Symbolics
"The Mathematica GuideBook for Symbolics"deals with Mathematica's symbolic mathematical capabilities. Structural and mathematical operations on single and systems of polynomials are fundamental to many symbolic calculations and they are covered in considerable detail. The solution of equations and differential equations, as well as the classical calculus operations (differentiation, integration, summation, series expansion, limits) are exhaustively treated.
The many faces of health, competence and well-being in old age : Integrating Epidemiological, Psychological and Social Perspectives
These key issues are addressed based on three converging research streams: social-ecological research, which assumes that major processes and outcomes of ageing such as day-to-day competence are shaped by social and physical-spatial environments; geropsychology research, which is driven by a life-span developmental conception of ageing; and epidemiology, which offers most fundamental disease, function and prevention-related data. Each of the three major research directions are outlined by a short introduction, followed by three chapters treating in an empirical manner most recent key research questions. All chapters are then also discussed by renowned ageing experts. This volume links ageing research with policy considerations and implications and establishes a link between European research and the knowledge base of the international scientific community concerned with ageing.
The Malliavin Calculus and Related Topics
In Chapter 1, the derivative and divergence operators are introduced in the framework of an isonormal Gaussian process associated with a general 2 Hilbert space H. The case where H is an L -space is trated in detail aft- s,p wards (white noise case). The Sobolev spaces D , with s is an arbitrary real number, are introduced following Watanabe’s work. Chapter 2, includes a general estimate for the density of a one-dimensional random variable, with application to stochastic integrals. Also, the c- position of tempered distributions with nondegenerate random vectors is discussed following Watanabe’s ideas. This provides an alternative proof of the smoothness of densities for nondegenerate random vectors. Some properties of the support of the law are also presented.
The Making of Islamic Heritage : Muslim Pasts and Heritage Presents
Offering key insights into critical debates on the construction, management and destruction of heritage in Muslim contexts, this volume considers how Islamic heritages are constructed through texts and practices which award heritage value. It examines how the monolithic representation of Islamic heritage (as a singular construct) can be enriched by the true diversity of Islamic heritages and how endangerment and vulnerability in this type of heritage construct can be re-conceptualized. Assessing these questions through an interdisciplinary lens including heritage studies, anthropology, history, conservation, religious studies and archaeology, this pivot covers global and local examples including heritage case studies from Indonesia, Egypt, Saudi Arabia, Iran, Jordan, and Pakistan.
The Making of Information Systems : Software Engineering and Management in a Globalized World
"Kurbel … has succeeded in writing a book that collects a wealth of information on software engineering without being a traditional software engineering book. Nearly all aspects of the practice of software engineering are presented here. … This book is useful for software developers and managers who need an updated, comprehensive view of the spectrum of software engineering methods and is a good reference for a graduate course on software engineering and information systems. Summing Up: Highly recommended. Upper-division undergraduate through professional collections."
The Maintenance Management Framework : Models and Methods for Complex Systems Maintenance
The Maintenance Management Framework describes and reviews the concept, process and framework of modern maintenance management of complex systems; concentrating specifically on modern modelling tools (deterministic and empirical) for maintenance planning and scheduling. It presents a new perspective of maintenance management by: focusing on the course of maintenance actions; presenting a structure that ensures proper support for current maintenance managers; clarifying the functionality that is required from information technology when applied to maintenance and the functions of modern maintenance engineering; and creating a set of practical models for maintenance management planning and scheduling. The discussion of all of these issues is supported through the use of case studies.
The Machines of Leonardo Da Vinci and Franz Reuleaux : Kinematics of Machines from the Renaissance to the 20th Century
This book is about the evolution of these machines and the inv- tors and engineers who created them from the early Renaissance to the early 20th century. I have chosen two personalities who are icons of these two machine ages, Leonardo da Vinci [1452–1519] and Franz Reuleaux [1829– 1905], recognizing both the cadre of machine designers who in?uenced them as well as those who were in?uenced by the accomplishments of these two engineers. A major thesis of this book is that the evolution of machine design methodology, from the intuitive methods of the workshop to the math-based, engineering science analysis and synthesis of modern industrial design, was of equal achievement as the creation of the marvelous machines themselves. In the past two decades there has been increasing interest in rational me- ods of design from topology and optimization theories to genetic algorithms. In the teaching of design at the novitiate level, the importance of design - cles and iteration is emphasized. Yet often the historical background for e- lution of machine design is minimal or missing.
The Lucky Few : Between the Greatest Generation and the Baby Boom
Born during the Great Depression and World War Two (1929 – 1945) - between the Greatest Generation and the Baby Boom - an entire generation has slipped between the cracks of history. Yet behind the scenes, these Lucky Few became the first American generation smaller than the one before them, and the luckiest generation of Americans ever. Lucky Few women married earlier than any other generation of the century and helped give birth to the Baby Boom, yet also gained in education compared to earlier generations. More than any other generation, Lucky Few men advanced into professional and white-collar jobs while Lucky Few women concentrated in the clerical "pink-collar ghetto." Even in retirement and old age the Lucky Few remain in the right place at the right time. Here is their story, and the story of how they have affected other recent generations of Americans before and since.
The Longleaf Pine Ecosystem : Ecology, Silviculture, and Restoration
The longleaf pine ecosystem, once one of the most extensive ecosystems in North America, is now among the most threatened. Over the past few centuries, land clearing, logging, fire suppression, and the encroachment of more aggressive plants have led to an overwhelming decrease in the ecosystem’s size, to approximately 2.2% of its original coverage. Despite this devastation, the range of the longleaf still extends from Virginia to Texas. Through the combined efforts of organizations such as the USDA Forest Service, the Longleaf Alliance, and the Nature Conservancy, extensive programs to conserve, restore, and manage the ecosystem are currently underway.
The Lisbon Treaty : EU Constitutionalism without a Constitutional Treaty?
When EU leaders signed the Lisbon Treaty in late 2007, it seemed that the constitutional process in Europe was close to fruition. This volume presents several works by renowned EU lawyers discussing the consequences of 'Lisbon' in various policy fields, as well as the pros and cons of the Union's 'constitution' as it stands with the Lisbon Treaty.
The Link Between Inflammation and Cancer : Wounds that do not heal
The transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This finding should not have come as a surprise since there exists a link between inflammation and many types of cancer which was already suggested by Galen and later demonstrated by Virchow. This link, of crucial importance for the design of novel strategies for cancer treatment, is the topic of this book.
The Libyan Economy : Economic Diversification and International Repositioning
Delivers a thorough and essential analysis of current economic policy, transformation and legislative changes in Libya. The authors have comprehensively surveyed and analysed the country’s social development and trends, its current infrastructural deficit, and its often controversial foreign relations. Thereby, they answer many questions about Libya’s distinctive society and economic system and explain the necessity for the major restructuring of the Libyan economy which is currently in process.
