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Antisense RNA Design, Delivery, and Analysis
This volume gathers a variety of models, delivery systems, and approaches that can be used to assess RNA technology for exploiting antisense as a therapeutic intervention. Beginning with a section on the design of antisense technology and their delivery, the book continues by covering model systems developed to evaluate efficacy, both in vivo and in vitro, as well as methods to evaluate preclinically the toxicity associated with these new potential drugs, and intellectual property considerations. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Anti-fragile ICT Systems
Introduces a novel approach to the design and operation of large ICT systems. It views the technical solutions and their stakeholders as complex adaptive systems and argues that traditional risk analyses cannot predict all future incidents with major impacts. To avoid unacceptable events, it is necessary to establish and operate anti-fragile ICT systems that limit the impact of all incidents, and which learn from small-impact incidents how to function increasingly well in changing environments. The book applies four design principles and one operational principle to achieve anti-fragility for different classes of incidents. It discusses how systems can achieve high availability, prevent malware epidemics, and detect anomalies. Analyses of Netflix’s media streaming solution, Norwegian telecom infrastructures, e-government platforms, and Numenta’s anomaly detection software show that cloud computing is essential to achieving anti-fragility for classes of events with negative impacts.
Antiangiogenic Agents in Cancer Therapy
Antiangiogenesis remains a dynamic and evolving field in oncology. New therapeutic targets continue to emerge followed by the rapid development of new therapeutic agents to be investigated in clinical trials. Optimizing the therapeutic potential of antiangiogenic agents in combination with the other therapies in the armamentarium to fight cancer will be an on-going challenge. Antiangiogenic Agents in Cancer Therapy, Second Edition provides a current, up-dated perspective on the state of the art of angiogenesis and therapy with a compendium of scientific findings and approaches to the study of angiogenesis in cancer. Leaders in the field present chapters on such topics as the environmental influences and the genetic and physiologic abnormalities that mediate angiogenesis and its role in the progression of malignant disease, working models of tumor angiogenesis, and the role of angiogenesis inhibition in the therapy of malignant disease in humans. Comprehensive and cutting-edge, Antiangiogenic Agents in Cancer Therapy, Second Edition is an ideal, valuable guide to the most recent advances in the field, and a collection that will be useful for many years to come.
Antecedents of venture firms' internationalization : A conjoint analysis of international entrepreneurship in the net economy
With the continuing dispersion of the global digital network and performance improvements of information and communication technologies, resource-poor start-ups with online business models have emerged in large numbers. These firms are able to deploy their competitive advantages across their country borders early in their life-cycle and engage in international commerce at a fast pace. An increased immediacy between the firms and the globally accessible customer is observed. Julia Christofor’s study aims to analyze the conditions of the initial internationalization decision in the Net Economy. Based on Information Systems, International Entrepreneurship, and Entrepreneurship literature, factors, which constitute the internationalization propensity, are derived. The results of this study suggest that a holistic perspective including the founder, business model and the firm level should be considered when explaining the internationalization propensity of entrepreneurs.
Animation Media
مجمع تتم فيه عملية إنتاج الرسوم المتحركة والأفلام وعرضها في السينما بالإضافة إلى فعاليات ثقافية وترفيهية وتعليمية لشريحة الشباب والأطفال
Animating Unpredictable Effects : Nonlinearity in Hollywood’s R&D Complex
Uncanny computer-generated animations of splashing waves, billowing smoke clouds, and characters’ flowing hair have become a ubiquitous presence on screens of all types since the 1980s. This Open Access book charts the history of these digital moving images and the software tools that make them. Unpredictable Visual Effects uncovers an institutional and industrial history that saw media industries conducting more private R&D as Cold War federal funding began to wane in the late 1980s. In this context studios and media software companies took concepts used for studying and managing unpredictable systems like markets, weather, and fluids and turned them into tools for animation. Unpredictable Visual Effects theorizes how these animations are part of a paradigm of control evident across society, while at the same time exploring what they can teach us about the relationship between making and knowing.
Animal Models of T Cell-Mediated Skin Diseases
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
Analysis and Design of Advanced Multiservice Networks Supporting Mobility, Multimedia, and Internetworking : COST Action 279 Final Report
This book reports on the state-of-the-art work developed during the four years of operation of COST Action 279, Analysis and Design of Advanced Multiservice Networks Supporting Mobility, Multimedia, and Internetworking, by its participating researchers, originating from over 40 research institutions from the academic, industrial, and telecom operator worlds. The work includes both fundamental, methodological, and applied aspects of network performance evaluation and design. The book contains a detailed account of the work developed, supported on an extensive bibliography of material published in the peer-reviewed literature.
Analisi matematica I : Teoria ed esercizi con complementi in rete = Mathematical analysis I : Theory and exercises with online complements
Intends to support a first teaching of Mathematical Analysis according to the principles of the new Didactic Regulations. It is especially designed for Engineering, Computer Science, Physics. The text has three different levels of reading. An essential level allows the student to grasp the essential concepts of the subject and to familiarize himself with the related calculation techniques. An intermediate level provides justifications for the main findings and enriches the presentation with useful observations and complements. A third level of reading, based on numerous references to a virtual text available online, allows the more motivated and interested student to deepen his or her preparation on the subject. Numerous examples and exercises with solutions complete the text. The captivating 2-color graphics make this text a fundamental point of reference for the study of the discipline.
Analisi Matematica I : Teoria ed esercizi con complementi in rete
Il testo intende essere di supporto ad un primo insegnamento di Analisi Matematica secondo i principi dei nuovi Ordinamenti Didattici. È in particolare pensato per Ingegneria, Informatica, Fisica. Il testo presenta tre diversi livelli di lettura. Un livello essenziale permette allo studente di cogliere i concetti indispensabili della materia e di familiarizzarsi con le relative tecniche di calcolo. Un livello intermedio fornisce le giustificazioni dei principali risultati e arricchisce l'esposizione mediante utili osservazioni e complementi. Un terzo livello di lettura, basato su numerosi riferimenti ad un testo virtuale disponibile in rete, permette all'allievo più motivato ed interessato di approfondire la sua preparazione sulla materia. Completano il testo numerosi esempi ed esercizi con soluzioni. La grafica accattivante, a 2 colori, fa di questo testo un punto di riferimento fondamentale per lo studio della disciplina.
Anafilassi in pediatria = Anaphylaxis in pediatrics
Anaphylaxis is defined as an immediate systemic reaction due to the rapid IgE mediated release of potent mediators from tissue mast cells and peripheral blood basophils and represents a generalized clinical condition that includes skin, respiratory, cardiovascular and gastrointestinal signs and symptoms. It includes various clinical pictures, which derive from the association of symptoms such as urticaria, angioedema, vomiting, diarrhea, asthma, dyspnoea, edema of the glottis, hypotension, shock, etc., not always easy to identify, which however require a timely and correct diagnostic approach. .
An Introduction to Network Programming with Java
This book provides an overview of Java … . Each chapter is supplemented with practical programming exercises.The combination of code templates with good supporting discussions allows a competent Java programmer to rapidly expand his or her skill base to include network programming.
An Interactive Multimedia Introduction to Signal Processing
A didactic concept is undertaken for microelectronics, computer technology and communication engineering, which deals with the visualization of signals and processes in addition to graphical programming of signal processing systems. Through the utilization of a professional and globally supported software for metrology and control engineering, DasyLab, useful applications can be developed, modified and optimized. Computer supported processing of real signals is made possible over the sound card and the parallel port. Over two hundred pre-programmed signal engineering systems and design transparencies are provided. Pictures also play a dominant rule in this book: there are numerous introduction-videos, one for every chapter, more than 250 high-quality pictures and - most important – all the "living" experiments and their results are visualized. With this learning system, readers can now make use of "equipment" and software, which was practically unaffordable for individuals in the past. What's more, here is a very new concept for learning Signal Processing, not only from the physically-based scientific fundamentals, but also from the didactic perspective, based on modern results of brain research.
Allergy in Practice
This book reflects the rich personal experience of a German allergist with international training and reputation, who is active in immunology and allergy research and practice for almost 30 years. In this book, not only IgE-mediated allergic reactions are covered but all other kinds of allergies such as atopic eczema, contact dermatitis, drug eruptions, anaphylaxis and food allergies are equally represented as well as psychosomatic aspects and problems of environmental intolerances.
Algorithmic Aspects in Information and Management ; 3rd International Conference, AAIM 2007, Portland, OR, USA, June 6-8, 2007, Proceedings
This Book is intended for or- inal algorithmic research on immediate applications and/or fundamental pr- lems pertinent to information management and management science, broadly construed.
Algebra, Meaning, and Computation ; Essays dedicated to Joseph A. Goguen on the Occasion of His 65th Birthday
This Festschrift volume - published to honor Joseph Goguen on his 65th Birthday on June 28, 2006 - includes 32 refereed papers by leading researchers in the different areas spanned by Joseph Goguen's work. The papers address a broad variety of topics from meaning, meta-logic, specification and composition, behavior and formal languages, as well as models, deduction, and computation.The papers were presented at a Symposium in San Diego, California, USA in June 2006.
Algebra and Analysis for Engineers and Scientists
This is an intermediate level text, with exercises, whose avowed purpose is to provide the science and engineering graduate student with an appropriate modern mathematical (analysis and algebra) background in a succinct.
AJCC Atlante per la stadiazione dei tumori maligni = Atlas for the Staging of Malignant Tumors
he atlas contains over 400 specially created black and white illustrations describing the anatomical extent of the malignant tumor in the primary site (T), regional lymph nodes (N) and distant metastases (M) for various sites, including the head and neck area, the digestive system, the thorax, the musculoskeletal system, the soft tissues, the breast, the urinary system and the genital system. Each illustration provides precise and detailed descriptions designed to clarify the crucial anatomical structures and to provide the reader with an immediate view of the progressive extension of the disease. The most important anatomical structures are identified by specific definitions.
AI*IA 2007 : Artificial intelligence and human-oriented computing ; 10th Congress of the Italian Association for Artificial Intelligence, Rome, Italy, September 10-13, 2007, Proceedings
The book is organized in topical sections on knowledge representation and reasoning, multiagent systems, distributed AIai, knowledge engineering, ontologies and the semantic Web, machine learning, natural language processing, information retrieval and extraction, planning and scheduling, AI and applications. Three special tracks depicting progresses in significant application fields that represent increasingly relevant topics contain 18 additional papers on AI and robotics, AI and expressive media, and intelligent access to multimedia information
AI voice dubbing = الدبلجة الصوتية بالذكاء الاصطناعي
The advent of artificial intelligence has revolutionized numerous domains, including media and entertainment. This project focuses on developing an AI Voice Dubbing application that facilitates the seamless dubbing of audio content from English to Arabic. Unlike traditional robotic voice outputs, our application ensures that the dubbed content retains the original voice characteristics, providing a natural and authentic listening experience. The system also offers users the option to select alternative output voices, including those of celebrities, or any other voice by uploading their media, providing a YouTube link, or recording audio directly. The core functionality of the application is to produce a dubbed audio file, maintaining high fidelity to the original speaker's voice tone and style, the application provides a text output of the dubbed content, which users can edit as needed to ensure accuracy and personal preference.
