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Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Drug disposition and pharmacokinetics : Principles and applications for medicine, toxicology and biotechnology
Delivers an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.
Drug Courts : A New Approach to Treatment and Rehabilitation
This cutting-edge sourcebook is ideal for physicians, addiction treatment practitioners, probation officers, testing programs, judges and anyone else facing challenges in practice with the treatment of drug court participants. This book includes knowledge in treatment of addiction and withdrawal, treatment for patients with dual diagnoses of mental illness and addiction, and treatment of diseases associated with drug use, such as tuberculosis, hepatitis, and HIV infection. Unparalleled discussions of the drug court system and the medical problems of drug court patients are presented.
Drinking in Victorian and Edwardian Britain : Beyond the Spectre of the Drunkard
Investigates the reasons why Victorians and Edwardians consumed alcohol in the ways that they did and explores the ideas about alcohol that circulated in the period. This book shows that they had many reasons for purchasing and consuming alcoholic substances and these were driven by broader social, cultural, medical and commercial factors. Although drunkenness may have been the most visible consequence of alcohol consumption, it was not the only type of drinking behaviour. Alcohol played an important social role in the everyday lives of Victorians and Edwardians where its consumption held many different meanings.
Dream catcher
Dream Catcher is a video generation application that helps in many fields as science fiction, imagine event’s scenarios, education, animation and montage. By applying artificial algorithms implemented and trained on a dataset containing video samples and there descriptions to generate videos from any given text. The idea of generating videos from text is a new idea that was first presented at 2017, even that international companies like Google and OpenAi In the last year, was working on developing models to generate images from text. To make it easier to use the application, there are many ways to enter the text either by an image, voice or Typing from the keyboard.
Drawing Ideas
Focuses on the three key types of drawing, explanatory sketches, notational sketches and visual narratives that help designers think through and communicate their ideas. Through these three fundamentals, Drawing Ideas provides a thorough course in creating clear graphic layouts and diagrams, including expressive human forms, thumbnailing a process, adding effective colour and text and more. In addition, a drawing boot camp provides a refesher course in accurately drawing geometric forms. By getting back to the basics, readers will not only benefit from updated freehand drawing skills, but will also succeed in presenting and explaining their drawings and designs to others.
Drawing for Interior Designers
The perfect guide to producing successful hand drawings of interior designs. Sitting quietly at home, sketchbook in hand, is the ideal way to tackle drawing. In fact, your home is an absolute mine of subjects to draw. Perhaps you already have a plan in your head for a makeover or conversion? This book is filled with practical principles which will help you put your plans down on paper and better express your ideas, for no serious project gets made without a progressive plan. Teaches you some tricks of the trade and conventions which are part of an architect's know-how and which will help you with ideas. Packed with beautiful sketches, provides advice from drawing perspective, floor plans and furniture to rendering rooms and taking down a partition wall.
DNA Binders and Related Subjects
advances in technology and the application of new methods to outstanding problems have played a major part in the development of ideas about drug-nucleic acid recognition. The field has undergone an explosive diversification as wider and wider problems became accessible to study using the new ideas and techniques. This volume reflects that diversification by offering accounts of selected areas that illustrate recent advances in the study of ligand–nucleic acid binding over disparate areas of the subject. There are chapters dealing specifically with the invention and application of new methodology, and a particularly thoughtful essay on the interpretation of X-ray diffraction data which may not be as straightforward as is often imagined. Other chapters illustrate the diversity and complexity of drug-DNA binding from several perspectives, referring to particular groups of related compounds or the potential attractions of the less-preferred DNA major groove as a target for nucleotide sequence recognition by ligands.
Distributed Ledgers : Design and Regulation of Financial Infrastructure and Payment Systems
In this book, Robert Townsend steps back from the hype and controversy surrounding DLT (and the related, but not synonymous, innovations of blockchain and Bitcoin) to offer an economic analysis of what distributed ledgers can do and a blueprint for the optimal design and regulation of financial systems. He analyzes four crucial components of distributed ledgers—ledgers as accounts, e-messages and e-value transfers, cryptography, and contracts—assessing each in terms of both economics and computer science, and forges some middle ground. Relatedly, Townsend highlights hybrid systems in which some of these components allow useful innovation while legacy or alternative pieces deal with the problem of scale.
Distributed Embedded Control Systems : Improving Dependability with Coherent Design
Distributed Embedded Control Systems handles the domains encountered when designing a distributed embedded computer control system as an integrated whole. First to be discussed are some basic issues about real-time systems and their properties, specifically safety. Then, system and hardware architectures are dealt.
Distributed computing and internet Technology ; Vol. 3816 ; 2nd International conference, ICDCIT 2005, Bhubaneswar, India, December 22-24, 2005, Proceedings
The opening ceremony and pre-conference tutorials on various related topics were held on December 21. The technical program started on December 22 and continued for three days. The program was arranged in single track so as to enable participants to attend sessions of di?erent tracks. Papers from the DM, IT, SE, and SS tracks were divided into two sessions, whereas DC track sessions were held on the ?rst two days of the conference. The program also included two plenary talks. The ?rst talk was delivered by S. S. Iyengar from Louisiana State University, USA. The second talk was delivered by He Jifeng from the International Institute for Software Technology (IIST) Macau. Prof. Iyenger’s talk on “The Distributed Sensor Networks — An Emerging Technology” was focused on new ideas about the use of distributed systems for emerging technology, while Prof. Jifeng’s talk on “Linking Theories of Concurrency by Retraction” dealt with semantics of concurrency.
Distinguished Figures in Mechanism and Machine Science
This is the first volume of a series of edited books whose aim is to collect contributed papers in a framework that can serve as a dictionary of names of individuals who have made contributions to the discipline of MMS (Me- anism and Machine Science). This dictionary project has the peculiarity that, through descriptions of the ideas and work of these individuals, the papers will illustrate mainly technical developments in the historical evolution of the individual fields that today de?ne the scope of MMS. Thus the core of each contribution will be a survey of biographical notes describing the efforts and experiences of these people. Finding appropriate technical experts as authors for such papers and - couraging them to write them has been a challenge; it is a demanding and time-consuming effort to produce such in-depth articles that delve deeply into the historical background of their topics of expertise.
Dissonant Heritages and Memories in Contemporary Europe
This book discusses political, economic, social, and humanitarian challenges that influence both how people deal with their past and how they build their identities in contemporary Europe. Ongoing debates on migration, on local, national, inter- and transnational levels, prove that it is a divisive issue with regards to understanding European integration and identity. At the same time, the European Union increasingly invests in projects related to European heritage, museums, and cultural memory networks, while having to take dissonant heritages into account. These processes in their combination offer an interesting dynamic and form the complex puzzle that poses challenging questions for anyone involved in academic research, heritage practices, and policy debates. With this puzzle at its core, this book explicitly focuses on slippery and transforming notions of Europe and critically discusses ongoing and transforming power structures of heritage and memory in today’s Europe.
Dissipative Solitons : From Optics to Biology and Medicine
The dissipative soliton concept is a fundamental extension of the concept of solitons in conservative and integrable systems. It includes ideas from three major sources, namely standard soliton theory developed since the 1960s, nonlinear dynamics theory, and Prigogine's ideas of systems far from equilibrium. These three sources also correspond to the three component parts of this novel paradigm. This book explains the above principles in detail and gives the reader various examples from optics, biology and medicine. These include laser systems, optical transmission lines, cortical networks, models of muscle contraction, localized vegetation structures and waves in brain tissues.
Dissecting the Criminal Corpse : Staging Post-Execution Punishment in Early Modern England
Those convicted of homicide were hanged on the public gallows before being dissected under the Murder Act in Georgian England. Yet, from 1752, whether criminals actually died on the hanging tree or in the dissection room remained a medical mystery in early modern society. Dissecting the Criminal Corpse takes issue with the historical cliché of corpses dangling from the hangman’s rope in crime studies. Some convicted murderers did survive execution in early modern England. Establishing medical death in the heart-lungs-brain was a physical enigma. Criminals had large bullnecks, strong willpowers, and hearty survival instincts. Extreme hypothermia often disguised coma in a prisoner hanged in the winter cold. The youngest and fittest were capable of reviving on the dissection table. Many died under the lancet. Capital legislation disguised a complex medical choreography that surgeons staged. They broke the Hippocratic Oath by executing the Dangerous Dead across England from 1752 until 1832.
Diseases of the Heart, Chest & Breast : Diagnostic Imaging and Interventional Techniques
This book deals with imaging of diseases of heart, chest and breast. These fields have substantially advanced during the last few years, driven by both clinical developments and advances in imaging technology.لإheir chapters are disease-oriented and cover all the relevant imaging modalities, including standard radiography, CT, nuclear medicine with PET, ultrasound and magnetic resonance imaging, as well as imaging-guided interventions. As a result, this book presents a comprehensive review of current knowledge in imaging of the heart and chest , as well as thoracic interventions and a selection of "hot topics" of breast imaging.
Diseases of the Brain, Head & Neck, Spine : Diagnostic Imaging and Interventional Techniques 40th International Diagnostic Course in Davos (IDKD) Davos, March 30–April 4, 2008
This book deals with imaging of diseases of brain, head and neck, and spine. These fields have substantially advanced during the last few years, driven by both clinical developments and advances in imaging technology.
Diseases of the Abdomen and Pelvis 2018-2021 : Diagnostic Imaging - IDKD Book
This open access book deals with imaging of the abdomen and pelvis, an area that has seen considerable advances over the past several years, driven by clinical as well as technological developments. The respective chapters, written by internationally respected experts in their fields, focus on imaging diagnosis and interventional therapies in abdominal and pelvic disease; they cover all relevant imaging modalities, including magnetic resonance imaging, computed tomography, and positron emission tomography. As such, the book offers a comprehensive review of the state of the art in imaging of the abdomen and pelvis. It will be of interest to general radiologists, radiology residents, interventional radiologists, and clinicians from other specialties who want to update their knowledge in this area.
Diseases of the abdomen and Pelvis : Diagnostic Imaging and Interventional Techniques
This volume is a collection of chapters dealing with imaging diagnosis and interventional therapies in abdominal and pelvic disease. The different topics are disease-oriented and encompass all the relevant imaging modalities including X-ray technology, nuclear medicine, ultrasound and magnetic resonance, as well as image-guided interventional techniques.
Discrete Spectral Synthesis and Its Applications
In order to study discrete Abelian groups with wide range applications, the use of classical functional equations, difference and differential equations, polynomial ideals, digital filtering and polynomial hypergroups is required. This book covers several different problems in this field and is unique in being the only comprehensive coverage of this topic.
