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Cell Cycle Regulation
The cell cycle is tightly regulated on many different levels to ensure properly controlled proliferation. Deregulation of cell cycle regulation is a hallmark of cancer. In this book, many aspects of cell cycle regulation are discussed, which include G1, S, M phase control, ubiquitin-mediated degradation, DNA damage response, mitotic spindle checkpoint, the centrosome cycle, Retinoblastoma protein family, the Myc oncogene, and mouse models for tumor suppressors, cyclin-dependent kinases, and meiosis. These chapters written by experts provide an updated view on how the cell cycle is regulated in vivo and about the involvement of cell cycle regulators in cancer.
Celiac disease
Celiac Disease is a chronic small intestinal immune-mediated enteropathy caused by the ingestion of dietary gluten proteins in genetically susceptible individuals. CD is one of the most common autoimmune diseases, affecting around 1.4% of the population globally . Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options. Finding alternative diet and trying different lifestyle still under debates. However, complete exclusion of the gluten-containing food from the patient's diet is the only effective treatment to avoid the disease complications
Catastrophic Events Caused by Cosmic Objects
Many times all of us could hear from mass media that an asteroid approached and swept past the Earth. Such an asteroid or comet will inevitably strike the planet some day. This volume considers hazards due to collisions with cosmic objects, particularly in light of recent investigations of impacts by the authors. Each chapter written by an expert contains an overview of an aspect and new findings in the field. The main hazardous effects – cratering, shock, aerial and seismic waves, fires, ejection of dust and soot, tsunami are described and numerically estimated. Numerical simulations of impacts and impact consequences have received much attention in the book. Fairly small impacting objects 50 -100 m in diameter pose a real threat to humanity and their influence on the atmosphere and ionosphere is emphasized.
Case-Based Reasoning on Images and Signals
This book is the first edited book that deals with the special topic of signals and images within Case-Based Reasoning (CBR). It offers different learning capabilities, for all phases of a signal-interpreting system, that satisfy different needs during the development process of a signal-interpreting system.
Case Studies in Building Rehabilitation
Presents recent research and practical insights relating to building pathology. As such it contributes toward the systematization and dissemination of knowledge regarding structural and hygrothermal pathologies, durability and diagnostic techniques, while at the same time, demonstrating the latest advances in this domain. It includes new developments in the field of building pathology and rehabilitation, bridging the gap between current approaches to the surveying of buildings and the detailed study of defect diagnosis, prognosis and remediation. It also features a number of case studies and a detailed list of references and suggestions for further reading. Providing an overview of the current state of the art in the field, the book will appeal to scientists, students, practitioners and lecturers. Furthermore, the topics covered are relevant to a variety of scientific and engineering disciplines, including civil, materials and mechanical engineering.
Carbon in the Geobiosphere : Earth's outer shell
Carbon and carbon dioxide always played an important role in the geobiosphere that is part of the Earth’s outer shell and surface environment. The book’s eleven chapters cover the fundamentals of the biogeochemical behavior of carbon near the Earth’s surface, in the atmosphere, minerals, waters, air-sea exchange, and inorganic and biological processes fractionating the carbon isotopes, and its role in the evolution of inorganic and biogenic sediments, ocean water, the coupling to nutrient nitrogen and phosphorus cycles, and the future of the carbon cycle in the Anthropocene. This book is mainly a reference text for Earth and environmental scientists; it presents an overview of the origins and behavior of the carbon cycle and atmospheric carbon dioxide, and the human effects on them. The book can also be used for a one-semester course at an intermediate to advanced level addressing the behavior of the carbon and related cycles.
Capital Punishment and the Criminal Corpse in Scotland, 1740–1834
This book provides the most in-depth study of capital punishment in Scotland between the mid-eighteenth and early nineteenth century to date. Based upon an extensive gathering and analysis of previously untapped resources, it takes the reader on a journey from the courtrooms of Scotland to the theatre of the gallows. It introduces them to several of the malefactors who faced the hangman’s noose and explores the traditional hallmarks of the spectacle of the scaffold. It demonstrates that the period between 1740 and 1834 was one of discussion, debate and fundamental change in the use of the death sentence and how it was staged in practice. In addition, the study provides an innovative investigation of the post-mortem punishment of the criminal corpse. It offers the reader an insight into the scene at the foot of the gibbets from which criminal bodies were displayed, and around the dissection tables of Scotland’s main universities where criminal bodies were used as cadavers for anatomical demonstration. In doing so it reveals an intermediate stage in the long-term disappearance of public bodily punishment.
Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Cadmium toxicity : challenges and solutions
Offers a comprehensive collection of review and case chapters that cover cadmium toxicity and remediation. It covers sources of cadmium contamination, its impact on human health, and prospective remediation strategies, taking a multi-disciplinary approach a focus on application of recent advanced biological technology. The chapters here bring together a diverse group of environmental science, sustainability and health researchers to address the challenges caused by cadmium contamination, explaining the routes of exposure to environmental cadmium, how cadmium is transported in ecosystems, and the health risks linked to cadmium exposure in food and the environment.
C# 10 in a Nutshell : The Definitive Reference
When you have questions about C# 10.0 or .NET 6, this guide has the answers you need. C# is a language of unusual flexibility and breadth, but with its continual growth, there's so much more to learn. In the tradition of O'Reilly's Nutshell guides, this thoroughly updated edition is simply the best one-volume reference to the C# language available today. Organized around concepts and use cases, this comprehensive and complete reference provides intermediate and advanced programmers with a concise map of C# and .NET that also plumbs significant depths
Broadband satellite communication systems and the challenges of mobility ; IFIP TC6 Workshops on broadband satellite communication systems and challenges of mobility, world computer congress ; August 22-27, 2004, Toulouse, France
This book constitutes the refereed proceedings of IFIP TC6 Workshops on Broadband Satellite Communication Systems and Challenges of Mobility, World Computer Congress, 2004, Toulouse, France includTopics Communications Engineering, Networks Computer Communication Networks / Software Engineering/Programming and Operating Systems / Computer Systems Organization and Communication Networks / Information Systems and Communication Service / Multimedia Information Systems
Broadband in Europe: How Brussels Can Wire the Information Society
Broadband is a key enabler of the information society, increasing productivity and competitiveness across all sectors of the economy. Unlike traditional n- rowband connections, broadband provides high speed, always-on connections to the Internet and supports innovative content and services. Direct consumer welfare gains from mass-market adoption of broadband across the EU could easily reach 50 billion euros or more per annum. This is quite apart from the more profound societal shifts that ubiquitous broadband could bring. It may allow the individual to distribute content and ideas independent of traditional media and bring together communities of interest without regard to borders. Public policy for broadband will have a big impact on whether and how quickly these benefits are realised. Getting policy right could bring large benefits for consumers.
British Media Coverage of the Press Reform Debate : Journalists Reporting Journalism
This book provides a detailed exploration of the British media coverage of the press reform debate that arose from the News of the World phone hacking scandal and the Leveson Inquiry. Gathering data from a content analysis of 870 news articles, Ogbebor shows how journalists cover debates on media policy and illustrates the impact of their coverage on democracy
Bright modernity : Color, commerce, and consumer culture
Color is a visible technology that invisibly connects so many puzzling aspects of modern Western consumer societies research and development, making and selling, predicting fashion trends, and more. Building on Regina Lee Blaszczyk’s go-to history of the “color revolution” in the United States, This book explores further transatlantic and multidisciplinary dimensions of the topic. Covering history from the mid nineteenth century into the immediate past, it examines the relationship between color, commerce, and consumer societies in unfamiliar settings and in the company of new kinds of experts. Readers will learn about the early dye industry, the dynamic nomenclature for color, and efforts to standardize, understand, and educate the public about color.
Bridging divides : Maritime canals as invasion corridors
Maritime canals dissolve natural barriers to the dispersal of marine organisms, thus providing novel opportunities for natural dispersal, as well as for shipping-mediated transport. The introduction of alien species has proved to be one of the most profound and damaging of anthropogenic deeds - with both ecological and economic costs. This book is the first to assess the impacts of the world’s three principal maritime canals – the Kiel, the Panama, the Suez – as invasion corridors for alien biota. These three canals differ in their hydrological regimes, the types of biotas they connect, and in their permeability to invasions.
Breast cancer chemosensitivity
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.
Branded content : The fateful merging of media and marketing
This is a critical study of the changing relationship between media and marketing communications in the digital age. It examines the growth of content funded by brands, including brands’ own media, native advertising, and the integration of branded content across film, television, journalism and publishing, online, mobile, and social media.
Brand hate : Navigating consumer negativity in the digital world, 2nd
Focuses on the concept of “brand hate” and consumer negativity in today’s digital markets. It explores the emotional detachment consumers generate against valued brands and how negative experiences affect their and other consumers' loyalty. The book defines consumer brand hate and discusses its dimensions, antecedents, and consequences as well as the semiotics and legality of such brand hate activities based on current brand dilution arguments. It describes the situations which lead to anti-branding and how consumers choose to express their dissatisfaction with a company on individual and social levels. This newly updated edition discusses recent research findings from brand hate literature with new cases and extended managerial analysis.
Borrelia burgdorferi : Methods and protocols
Covers the latest advancements and techniques used to understand the fastidious bacterium, Borrelia burgdorferi, and its significance in infectious disorders by combining both conventional and cutting-edge approaches. This book covers diverse topics, including direct detection, diagnostic methods, immune response analysis, alternative model systems, advanced proteomics, social media analysis, and clinical research. It also discusses unconventional wet lab research such as content analysis, the use of ChatGPT, clinical algorithms for chronic Lyme, establishment of a pregnancy Lyme disease biobank, and investigates Lyme in pregnant women. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Bone augmentation in implant dentistry : A step-by-step guide to predictable alveolar ridge and sinus grafting
Implant dentistry has evolved tremendously over the past three decades and is rapidly progressing as new materials and protocols become available each year. With the number of advancements made in digitally based media and marketing, it is imperative that the clinician is able to separate new trends from evidence-based protocols to make sound and predictable choices for the ultimate benefit of patients. This textbook presents cases from the author's 35-year practice to show the successes and failures of various treatment approaches and protocols. Early chapters discuss the relevant biomaterials and instruments utilized for bone augmentation protocols, including barrier membranes, bone grafting materials, and growth factors. Surgical chapters dedicated to extraction socket management, alveolar ridge augmentation, and sinus grafting follow, each chapter detailing specific indications and patient selection criteria as well as step-by-step surgical procedures, aspects of postoperative treatment, and complications. The final chapter focuses on full-arch reconstruction using fully guided immediate reconstruction protocols. The author's teaching institute is credited with preparing some of the world's best clinicians, and this book will pave the way for countless more.
