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Köhlers Invention
This scientific biography commemorates the 10th anniversary of Köhler's untimely death. It describes his scientific and personal biography, based on 10 years of close personal and professional relationship between Eichmann and Köhler, as well as interviews with many colleagues and friends, including his "Doktorvater" and mentor Fritz Melchers. Köhler's scientific achievements are explained in a way to make them understandable for the general public and discussed in the historical context of the immunological research at the time.
Kinase Drug Discovery : Modern Approaches
Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations.
Killer Lymphocytes
This extensively documented, comprehensive survey of cell-mediated cytotoxicity (CMC) traces the history of killer lymphocytes from 1960 to the present, providing a definitive resource for specialists and non-specialists alike.
Killer Cell Dynamics : Mathematical and Computational Approaches to Immunology
Reviews how mathematics can be used in combination with biological data in order to improve understanding of how the immune system works. This is illustrated largely in the context of viral infections. Mathematical models allow scientists to capture complex biological interactions in a clear mathematical language and to follow them to their precise logical conclusions. This can give rise to counter-intuitive insights which would not be attained by experiments alone, and can be used for the design of further experiments in order to address the mathematical results.
Ketamine for Treatment-Resistant Depression : Neurobiology and Applications
Ketamine for Treatment-Resistant Depression: Neurobiology and Applications provides a simple, evidence-based overview for neuropsychiatrists and translational researchers on this medication, its mechanisms of actions, eligibility of patients for treatment, and the preparation and implementation of ketamine clinics.
Java for Bioinformatics and Biomedical Applications
Illustrates how individual bioinformatics applications (such as BLAST and Genscan) can be stitched together into a pipeline so that users can direct the output of one tool (for example, gene predictions using Genscan) to perform further analysis (say, homology searching using BLAST).
IUTAM Symposium on Physicochemical and Electromechanical Interactions in Porous Media
The purpose of the IUTAM symposium from which this proceedings volume has been compiled was to dive deep into the mechanics of those porous media that involve mechanics and chemistry, mechanics and electromagnetism, mechanics and thermal fluctuations of mechanics and biology.
ITI treatment guide, Vol.14 : Immediate implant placement and loading-single or multiple teeth requiring replacement
Outlines the current literature on immediate implant placement and immediate loading and elaborates on our understanding of the biology surrounding tooth extraction and osseointegration that underpin these treatment concepts. The importance of patient and site selection in conjunction with comprehensive treatment planning is highlighted and a risk assessment tool to aid decision making is provided. All key aspects of both the surgical and loading procedures are described in order to provide protocols that optimize the final treatment outcome. This volume also presents 9 step-by-step clinical cases performed by experts in the field, and typical complications of immediate implants are discussed, along with recommendations on how these can be prevented.
Issues of Decapod Crustacean Biology
This volume presents the proceedings of the eighth Colloquium Crustacea Decapoda Mediterranea, which was held at the Ionian University on Corfu Island, Greece, from 2 to 6 September 2002, and reflects recent advancements in decapod crustacean research. The meeting is the oldest European carcinological event, organized regularly at 3-year intervals since 1972. Although focused on the Mediterranean Sea, worldwide contributions provided a forum for fruitful contact and scientific exchange. The book covers up-to-date issues in decapod crustacean research, including genetics, morphology, reproduction, ecology, behaviour and fisheries, and it is primarily aimed at scientists interested in decapod crustacean research, but other scientists and decision-makers working on marine ecology and fisheries will also find up-to-date information on relevant issues.
Computational biology in drug discovery and repurposing
Takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designin
Computation and Logic in the Real World ; 3rd Conference on Computability in Europe, CiE 2007, Siena, Italy, June 18-23, 2007, Proceedings
This volume, Computation and Logic in the Real World, is the proceedings of the third in a series of conferences of CiE Computability in Europe, (CiE) is an informal network working on computability theory including its foundations, technical development, and applications. It performed with discrete or continuous data by all kinds of algorithms, programs, and machines. The sources of new ideas and methods include practical developments in areas such as neural networks, quantum computation, natural computation, molecular computation, computational learning.
Complexity of Constraints : An Overview of Current Research Themes
This state-of-the-art survey contains the papers that were invited by the organizers after conclusion of an International Dagstuhl-Seminar on Complexity of Constraints, held in Dagstuhl Castle, Germany, in October 2006.
Complexity in chemistry, biology, and ecology
This book, written by an international team of experts, introduces the reader to various aspects of complexity theory and its applications. It illustrates the latest trends in science to go beyond the mechanistic Newtonian view of the world by shifting the focus to self-organization, adaptation, and emergent phenomena. The authors discuss these properties of complex systems in biology, ecology and chemistry along with the structure and interconnectedness of the "layers" of complexity. The qualitative description is complemented by a discussion of methods for complexity quantification. Networks are covered in detail as a universal language of the complex world.
Complex Intracellular Structures in Prokaryotes
The new series "Microbiology Monographs" begins with two volumes on intracellular components in prokaryotes. In this second volume, "Complex Intracellular Structures in Prokaryotes", the components, labeled complex intracellular structures, encompass a multitude of important cellular functions. Continuing and newly initiated research will provide a clearer understanding of the complex intracellular structures known at present and will bring to light surprising new ones as well.
Complement and Kidney Disease
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Comparative genomics ; Vol.4205 ; RECOMB 2006 International Workshop, RECOMB-CG 2006, Montreal, Canada, September 24-26, 2006, Proceedings
The papers address a broad variety of aspects and components of the field of comparative genomics, ranging from new quantitative discoveries about genome structure and process to theorems on the complexity of computational problems inspired by genome comparison.
Comparative genomics ; Vol. 3678 : RECOMB 2005 International Workshop, RCG 2005, Dublin, Ireland, September 18-20, 2005, Proceedings
This book constitutes the refereed proceedings of the RECOMB 2005 Satellite Workshop, the 3rd RECOMB Comparative Genomics meeting RCG 2005, held in Dublin, Ireland in September 2005. The 14 revised full papers presented were carefully reviewed and selected from 21 initial submissions. The papers address a broad variety of aspects and components of the field of comparative genomics, ranging from new quantitative discoveries about genome structure and process to theorems on the complexity of computational problems inspired by genome comparison.
Comparative genomics ; Vol. 3388 : RECOMB 2004 International Workshop, RCG 2004, Bertinoro, Italy, October 16-19, 2004, Revised Selected Papers
This papers investigates the problem of conservation of combinatorial structures in genome rearrangement scenarios. We give a characterization of a class of scenarios that conserve all common intervals, called commuting scenarios, and a characterization of permutations for which commuting scenarios exist. We show that measuring conservation of common intervals can be useful tool in assessing the quality of rearrangement scenarios, by investigating in detail three specific scenarios involving the mouse, rat and human X chromosomes.
Comparative genomics ; RECOMB 2007, International Workshop, RECOMB-CG 2007, San Diego, CA, USA, September 16-18, 2007, Proceedings
This book provides an evolutionary conceptual framework for comparative genomics, with the ultimate objective of understanding the loss and gain of genes during evolution, the interactions among gene products, and the relationship between genotype, phenotype and the environment. The many examples in the book have been carefully chosen from primary research literature based on two criteria: their biological insight and their pedagogical merit. The phylogeny-based comparative methods, involving both continuous and discrete variables, often represent a stumbling block for many students entering the field of comparative genomics. They are numerically illustrated and explained in great detail.
Comparative genomics ; International Workshop, RECOMB-CG 2008, Paris, France, October 13-15, 2008. Proceedings
This book constitutes the refereed proceedings of the 6th RECOMB Comparative Genomics Satellite Workshop, RECOMB-CG 2008, held in Paris, France, in October 2008.
