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Genome editing in drug discovery
In Genome Editing in Drug Discovery, a team of distinguished biologists delivers a comprehensive exploration of genome editing in the drug discovery process, with coverage of the technology’s history, current issues and techniques, and future perspectives and research directions. The book discusses techniques for disease modeling, target identification with CRISPR, safety studies, therapeutic editing, and intellectual property issues.
Genome Editing : Gene Therapy or Gene Optimization?
Genome editing technology is considered one of the most revolutionary techniques lately. The ability of modifying the human genome has been one of the biggest dreams for therapist for the reason that the genetic modification with exogenous DNA can be considered a problem solver for many diseases and disorders (genetic disorders), especially those with high risks and low survival rates, on this case, gene therapy appears as the tool to be used, with its many protocols and approaches. Gene therapy is based on delivering a therapeutic gene throw suitable vectors, which is most of the time-modified viruses to carry the therapeutic genes to the target cells and so on providing the functional copy of the defective gene.
Genetics of Adaptation
What is the genetic basis of adaptive evolution? In this volume, a new generation of biologists have taken up this challenge. Using advances in both molecular genetic and statistical techniques, evolutionary geneticists have made considerable progress in this emerging field. In this volume, a diversity of examples from plant and animal studies provides valuable information for those interested in the genetics and evolution of complex traits.
Genetic surgery : from genes to solutions
As a tool for modifying the genome, gene editing technologies has developed rapidly in recent years, the application of these technologies in basic biomedical research has yielded significant advances in identifying and studying key molecular targets relevant to human diseases and their treatment. The clinical translation of genome editing techniques offers unprecedented biomedical engineering capabilities in the diagnosis, prevention, and treatment of disease or disability...
Genetic Programming Theory and Practice V
Genetic Programming Theory and Practice V was developed from the fifth workshop at the University of Michigan’s Center for the Study of Complex Systems to facilitate the exchange of ideas and information related to the rapidly advancing field of Genetic Programming (GP). Contributions from the foremost international researchers and practitioners in the GP arena examine the similarities and differences between theoretical and empirical results on real-world problems. The text explores the synergy between theory and practice, producing a comprehensive view of the state of the art in GP application.
Generative and transformational techniques in software engineering II : International Summer School, GTTSE 2007, Braga, Portugal, July 2-7, 2007. Revised Papers
This tutorial book presents an augmented selection of the material presented at the International Summer School on Generative and Transformational Techniques in Software Engineering, GTTSE 2007, held in Braga, Portugal, in July 2007.The 7 tutorial lectures presented together with 5 short tutorials and 4 contributions to the participants workshop were carefully selected during multiple rounds of reviewing and improvement. The tutorials given by renowned representatives of complementary approaches and problem domains combine foundations, methods, examples, and tool support.
Generative and transformational techniques in software engineering ; International Summer School, GTTSE 2005, Braga, Portugal, July 4-8, 2005. Revised Papers
This tutorial book presents an augmented selection of material presented at the International Summer School on Generative and Transformational Techniques in Software Engineering, GTTSE 2005. The book comprises 7 tutorial lectures presented together with 8 technology presentations and 6 contributions to the participants workshop.
Generalized collocations methods : Solutions to nonlinear problems
This book examines various mathematical tools—based on generalized collocation methods—to solve nonlinear problems related to partial differential and integro-differential equations. Covered are specific problems and models related to vehicular traffic flow, population dynamics, wave phenomena, heat convection and diffusion, transport phenomena, and pollution. Based on a unified approach combining modeling, mathematical methods, and scientific computation, each chapter begins with several examples and problems solved by computational methods; full details of the solution techniques used are given. The last section of each chapter provides problems and exercises giving readers the opportunity to practice using the mathematical tools already presented.
Gastrointestinal malignancies
Details the advances in drug discovery and delivery and the present need for emerging technologies. Throughout the text new micro and nanofabrication techniques are described, including methods such as electrohydrodynamic processes, additive manufacturing, and microfluidics, which have the potential to produce drug delivery systems that were not possible a few years ago. This book is of great use to both entry-level and experienced researchers in the field of emerging technologies for the manufacturing of drug delivery devices.
Gastrointestinal Cancer
Gastrointestinal cancer includes cancer of the digestive system - the esophagus, colon, rectum, anus, liver, pancreas, and other digestive organs. Taken as a whole, there are an estimated 250,600 new cases in the US. Colon and rectum cancer is the third leading cause of cancer and cancer deaths in the US. Gastrointestinal Cancer is the third volume in the M.D. Anderson Cancer Care series, featuring the current standard approach to GI cancer care from the experts at M.D. Anderson Cancer Center. Designed for the practicing oncologist, this clinical guidebook allows for quick, authoritative access to the latest and best multimodality therapies. Topics covered in this volume include AJCC staging of gastrointestinal malignancies, recent advances in histopathology of gastroinestinal cancers, imaging techniques and endoscopy in the management of GI malignancies, colorectal cancer, liver cancer, gastric cancer, esophageal cancer, anal cancer, and palliative therapy. Each of the 20 chapters ends with an up-to-date list of suggested readings, as well as "key practice points" highlighting the most principles and practices of each chapter for at-a-glance reference. More than 80 illustrations complement the text. This thorough, practical volume is the essential clinical guide for the oncologists, surgeons, and all physicians involved in the care of patients with GI cancer.
Galaxy Formation
This second edition of Galaxy Formation is an up-to-date text on astrophysical cosmology, expounding the structure of the classical cosmological models from a contemporary viewpoint. This forms the background to a detailed study of the origin of structure and galaxies in the Universe. The derivations of many of the most important results are derived by simple physical arguments which illuminate the results of more advanced treatments. A very wide range of observational data is brought to bear upon these problems, including the most recent results from WMAP, the Hubble Space Telescope, galaxy surveys like the Sloan Digital Sky Survey and the 2dF Galaxy Redshift Survey, studies of Type 1a supernovae, and many other observations.
Galaxies in the Local Vol.
Studies of Nearby Galaxies are currently the focus of many observations and numerical simulations. This book presents an overview of the galaxies within the Local Volume (D < 10 Mpc), including the Local Group (D < 1 Mpc) and our closest neighbours, the Andromeda Galaxy and the Magellanic Clouds. Presented are the latest results from radio, infrared and optical surveys as well as detailed multi-wavelength studies of individual galaxies. Accurate distances are now available for the majority of Local Volume galaxies providing a true 3-dimensional view of their distribution and flow pattern as well as their star formation.
Galaxies and How to Observe Them
Satisfies the need for a modern, comprehensive review in combining the three major aspects: the physical background on the nature and data of galaxies, the relevant instrumentation and viewing techniques, and finally the targets and their individual appearance in telescopes of various apertures. To illustrate the latter, a comprehensive sample of galaxies, including quasars, groups and clusters of galaxies is presented. This combination of theoretical knowledge and practical information guarantees successful observing sessions. The book could become a standard source on galaxy observing for all kinds of amateur observers, from the beginner to the experienced.
Fuzzy systems and knowledge discovery ; Vol. 4223 ; Third International Conference, FSKD 2006, Xi'an, China, September 24-28, 2006, Proceedings
ICNC-FSKD 2006 featured the most up-to-date research results in com- tational algorithms inspired from nature, including biological, ecological, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide rangeof techniques and methods arebeing studied for dealing with large, complex, and dynamic problems.
Fuzzy systems and knowledge discovery ; Vol. 3614 ; 2nd International Conference, FSKD 2005, Changsha, China, August 27-29, 2005, Proceedings, Part II
This book and its sister volume, LNAI 3613 and 3614, constitute the proce- ings of the Second International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2005), jointly held with the First International Conference on Natural Computation (ICNC 2005, LNCS 3610, 3611, and 3612) from - gust 27–29, 2005 in Changsha, Hunan, China. FSKD 2005 successfully attracted 1249 submissions from 32 countries/regions (the joint ICNC-FSKD 2005 received 3136 submissions). After rigorous reviews, 333 high-quality papers, i. e. , 206 long papers and 127 short papers, were included in the FSKD 2005 proceedings, r- resenting an acceptance rate of 26. 7%. The ICNC-FSKD 2005 conference featured the most up-to-date research - sults in computational algorithms inspired from nature, including biological, e- logical, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide range of techniques and methods are being studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cross-fertilization over these exciting and yet closely-related areas, which had a signi?cant impact on the advancement of these important technologies. Speci?c areas included computation with words, fuzzy computation, granular com- tation, neural computation, quantum computation, evolutionary computation, DNA computation, chemical computation, information processing in cells and tissues, molecular computation, arti?cial life, swarm intelligence, ants colony, arti?cial immune systems, etc. , with innovative applications to knowledge d- covery, ?nance, operations research, and more.
Fuzzy systems and knowledge discovery ; Vol. 3613 ; 2nd International Conference, FSKD 2005, Changsha, China, August 27-29, 2005, Proceedings, Part I
This book and its sister volume, LNAI 3613 and 3614, constitute the proce- ings of the Second International Conference on Fuzzy Systems and Knowledge Discovery (FSKD 2005), jointly held with the First International Conference on Natural Computation (ICNC 2005, LNCS 3610, 3611, and 3612) from - gust 27–29, 2005 in Changsha, Hunan, China. FSKD 2005 successfully attracted 1249 submissions from 32 countries/regions (the joint ICNC-FSKD 2005 received 3136 submissions). After rigorous reviews, 333 high-quality papers, i. e. , 206 long papers and 127 short papers, were included in the FSKD 2005 proceedings, r- resenting an acceptance rate of 26. 7%. The ICNC-FSKD 2005 conference featured the most up-to-date research - sults in computational algorithms inspired from nature, including biological, e- logical, and physical systems. It is an exciting and emerging interdisciplinary area in which a wide range of techniques and methods are being studied for dealing with large, complex, and dynamic problems. The joint conferences also promoted cross-fertilization over these exciting and yet closely-related areas, which had a signi?cant impact on the advancement of these important technologies. Speci?c areas included computation with words, fuzzy computation, granular com- tation, neural computation, quantum computation, evolutionary computation, DNA computation, chemical computation, information processing in cells and tissues, molecular computation, arti?cial life, swarm intelligence, ants colony, arti?cial immune systems, etc. , with innovative applications to knowledge d- covery, ?nance, operations research, and more.
Fuzzy Logic and Applications ; Vol. 3849 ; 6th International Workshop, WILF 2005, Crema, Italy, September 15-17, 2005, Revised Selected Papers
This volume contains the proceedings of the 6th International Workshop on Soft Computing and Applications (WILF 2005), which took place in Crema, Italy, on September 15–17, 2005, continuing an established tradition of biannual meetings among researchers and developers from both academia and industry to report on the latest scienti?c and theoretical advances, to discuss and debate major issues, and to demonstrate state-of-the-art systems. This edition of the workshop included two special sessions, sort of subwo- shops, focusing on the application of soft computing techniques (or compu- tional intelligence) to image processing (SCIP) and bioinformatics (CIBB).
Fuzzy Logic and Applications ; Vol. 2955 ; 5th International Workshop, WILF 2003, Naples, Italy, October 9-11, 2003, Revised Selected Papers
This volume constitutes the thoroughly refereed post-workshop proceedings of the 5th International Workshop on Fuzzy Logic and Applications held in Naples, Italy, in October 2003. The 40 revised full papers presented have gone through two rounds of reviewing and revision. All current issues of theoretical, experimental and applied fuzzy logic and related techniques are addressed with special attention to rough set theory, neural networks, genetic algorithms and soft computing.
Fuzzy Engineering Economics with Applications
This book handles the fuzzy cases of classical engineering economics topics. It contains 15 original research and application chapters including different topics of fuzzy engineering economics. This book will provide a useful resource of ideas, techniques, and methods for present and further research in the applications of fuzzy sets in engineering economics.
Fuzzy database modeling with XML
Fuzzy Database Modeling with XML aims to provide a single record of current research and practical applications in the fuzzy databases. This volume is the outgrowth of research the author has conducted in recent years. Fuzzy Database Modeling with XML introduces state of the art information to the database research, while at the same time serving the information technology professional faced with a non-traditional application that defeats conventional approaches. The research on fuzzy conceptual models and fuzzy object-oriented databases is receiving increasing attention, in addition to fuzzy relational database models. With rapid advances in network and internet techniques as well, the databases have been applied under the environment of distributed information systems. It is essential in this case to integrate multiple fuzzy database systems. Since databases are commonly employed to store and manipulate XML data, additional requirements are necessary to model fuzzy information with XML. Second, this book maps fuzzy XML model to the fuzzy databases. Very few efforts at investigating these issues have thus far occurred.
