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DNA Methylation : Development, Genetic Disease and Cancer
It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.
DNA Methylation : Basic Mechanisms
The structural and functional importance of the correct patterns of DNA methylation in all parts of a mammalian genome is not well understood. The stability, inheritability, and developmental flexibility of these patterns point to a major role that these patterns appear to play in determining structure and function of the genome.
DNA Conformation and Transcription
the first book that compiles the fruits of the studies that have been performed to date to solve the riddle ‘written’ in DNA conformation ("conformation code"). This book provides a comprehensive overview of the field by covering history of the field, up-to-date topics, clarifications of present day research, and future perspective of what is still to be discovered. Thus, it serves as an invaluable source of information on the "conformation code".
Diversity and Evolution of Butterfly Wing Patterns : An Integrative Approach
is book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as “evo-devo,” “eco-devo,” ”developmental genetics,” “ecology and adaptation,” “food plants,” and “theoretical modeling.”
Diverse Roles of Integrin Receptors in Articular Cartilage
Recent studies from the authors' laboratory and from other leading groups have shown that ß1-integrins are essential for cell signalling and communication in chondrocytes. Furthermore, ß1-integrins function as mechanoreceptors in the chondrocyte mechanotransduction pathway. Their expression is therefore essential for maintaining the chondrocyte phenotype, preventing chondrocyte apoptosis and regulating chondrocyte-specific gene expression. This book volume summarizes the work that the authors have done on ß1-integrins over the last 18 years and focuses on the expression and regulation of these proteins in chondrocytes and their role in the context of the unique function of chondrocytes within articular cartilage.
Distribution and phenotype of proliferating cells in the Forebrain of adult macaque monkeys after transient global cerebral ischemia
The authors' results show that ischemia differentially activates endogenous neural precursors residing in diverse locations of the adult primate central nervous system. A limited endogenous potential for postischemic neuronal repair exists in neocortex and striatum, but not in the hippocampus proper of the adult macaque monkey brain. The presence of putative parenchymal progenitors and of sustained progenitors in germinative centers opens novel possibilities for precursor cell recruitment.
Dissecting the Molecular Anatomy of Tissue
The book provides an updated overview of molecular analysis of human tissues, and the impact this analysis has on diagnosis and prognosis of human diseases. Special emphasis is placed on human cancer and the future directions of the field. Methods of handling clinical tissue samples, including the impact of handling on subsequent molecular analysis, are also discussed. In addition, detailed protocols for molecular analysis of DNA, RNA and protein, with special emphasis on molecular analysis of highly complex human tissue samples containing mixtures of cell populations, are provided.
Dislocation and Degradation of Proteins from the Endoplasmic Reticulum
The present volume of Current Topics in Microbiology and Immunology c- tains seven chapters that illuminate various aspects of a protein’s genesis and terminal fate in the endoplasmic reticulum (ER). Increased knowledge of the biosynthetic pathways of glycoproteins allowed the identi?cation of the ER as an important site where such quality control decisions were made.
Disease in Wild Animals : Investigation and Management
Wildlife diseases have become increasingly important recently due to their effect upon human health, veterinary medicine, wildlife, and conservation biology. Gary Wobeser's successful book from 1994 has been completely updated and enlarged in a new second edition. An in-depth overview of the available techniques for the investigation and management of disease in free-ranging animals is provided. The subjects are illustrated with examples drawn from around the world, with emphasis on the special requirements involved in working with wild animals. Techniques are assessed critically with regard to their efficacy and effectiveness.
Discovering Biomolecular Mechanisms with Computational Biology
In this anthology, leading researchers present critical reviews of methods and high-impact applications in computational biology that lead to results that also non-bioinformaticians must know to design efficient experimental research plans. Discovering Biomolecular Mechanisms with Computational Biology also summarizes non-trivial theoretical predictions for regulatory and metabolic networks that have received experimental confirmation. Discovering Biomolecular Mechanisms with Computational Biology is essential reading for life science researchers and higher-level students that work on biomolecular mechanisms and wish to understand the impact of computational biology for their success.
Discoveries in Photosynthesis
Conceived of as a way of summarizing the history of research advances in photosynthesis as of millennium 2000, the book evolved into a majestic and encyclopedic saga involving all of the basic sciences. This book is meant not only for the researchers and graduate students, but also for advanced undergraduates in Plant Biology, Microbiology, Cell Biology, Biochemistry, Biophysics and History of Science.
Dipeptidyl Aminopeptidases : Basic Science and Clinical Applications
Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses, and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in the field will contribute to this book, which will present a state-of-the-art view on these enzymes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent. The sections of the book will focus on various topics including DP IV and related enzymes in: expression and function, metabolic disorders, immune mechanisms and immune disorders, neuronal diseases and cancer, and related drug development.
Dioxygen Binding and Sensing Proteins : A Tribute to Beatrice and Jonathan Wittenberg
Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments.This book is dedicated to Jonathan’s and Bea’s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
Dictyostelium discoideum : Methods and protocols
Discusses the latest advancements and techniques used to study Dictyostelium discoideum. The chapters in this book cover topics such as cytokinesis, membrane function and damage, and nutrient/bacterial processing; autophagy activation and function; protein localization, interaction, and activation; cell migration and contact guidance for quantification of cytoskeletal dynamics; and global mutational screening, transcriptome analyses, and proteomics that apply to all stages of the Dictyostelium life cycle and that may generalize to human disease models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Diapause in Aquatic Invertebrates : Theory and Human Use
Contributors to this new book are leaders in the field of diapause studies, and many authors were participants at a recent workshop on diapause in aquatic invertebrates (Pallanza, Italy 2003). The book consists of two major parts, as indicated in its title: Phenomenology of diapause and significance of this adaptation in scientific and practical uses. Application to newly developing areas such as cultivation of live food, like rotifers or Artemia, in modern aquaculture is covered, as are aspects of diapause that promote the colonization of new environments by facilitating the passive transport of resting stages of invasive species. Creation of artificial ecosystems outside of the Earth’s biosphere using dormant propagules becomes an actual possibility as humankind develops plans to colonize our nearest planets.
Diagnosis and Treatment of Human Mycoses
Diagnosis and Treatment of Human Mycoses brings together globally-recognized mycoses experts to guide readers in the use of current knowledge in the field of medical mycology to manage those who suffer from fungal infections (mycoses). Often, diagnostic strategies and tests, including basic and directed culturing techniques, histopathology with standard and special stains, serological methods, and radiological studies all need to be considered and commonly combined to make the diagnosis of fungal infection. This volume first introduces and reviews these tools separately and then as they pertain to specific infections or groups of diseases. The volume consists of four parts. Parts I-III provide an overview of diagnostic and therapeutic tools, and part IV presents the human mycoses.Diagnosis and Treatment of Human Mycoses is meant to be a concise text that will provide the busy infectious disease, hematology–oncology, pulmonology, or critical care specialist a practical tool to diagnose and manage fungal infections. In addition, the depth of the material in the text will provide these and other medical specialists and trainees an excellent reference and learning resource.
Developments in Fish Telemetry ; Proceedings of the Sixt Conference on Fish Telemetry held in Europe
This volume includes 33 peer-reviewed papers presented at the Sixth Conference on Fish Telemetry held in Europe (Sesimbra, Portugal, 5-11 June 2005). The papers focus on the application of aquatic telemetry techniques by scientists to investigate fundamental aspects of animal biology in order to conserve and manage natural resources. The topics addressed in this issue are human impacts and fisheries, migration and behaviour, species conservation and habitat rehabilitation, and methodology and new technology. This book is aimed at scientists and engineers actively involved in aquatic telemetry projects, aquatic biologists (marine and freshwater), fisheries biologist and managers.
Developmental Neurobiology
The text will serve as a readily tractable source for advanced undergraduate neuroscience majors and beginning graduate students who will benefit from a single source to begin their study of a more detailed understanding of neural development. Each chapter is peppered with a sound mixture of historical context and descriptions from both the vertebrate and invertebrate literature that best illustrate specific aspects of development. The liberal use of simple diagrams and tables, which readily illustrate complex issues, is a welcome addition for instructor and student alike.
Developmental Biology of Neoplastic Growth
In this book, tumour growth is perceived as a deviation from the normal development of the human organism. The molecular, cellular, and tissue determinants of different tumours are discussed showing that each is a different disease, often corresponding to a particular developmental stage. The natural history of several cancers illustrates how clinical incidence can be just the visible part of the iceberg, while the first changes at the tissue level sometimes occur several years before tumour growth becomes manifest.
Development of the Inner Ear
This book describes the embryonic development of the vertebrate inner ear in six chapters that span all aspects of inner ear development, In each chapter, a particular aspect of development of the inner ear is examined in terms of both classic embryologic experiments and more recent advances using molecular biological techniques.
