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Cyclized Helical Peptides : Synthesis, Properties and Therapeutic Applications
Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity
Cyber-physical systems of systems : Foundations : A conceptual model and some derivations : The AMADEOS legacy
Technical Systems-of-Systems (SoS) – in the form of networked, independent constituent computing systems temporarily collaborating to achieve a well-defined objective – form the backbone of most of today’s infrastructure. The energy grid, most transportation systems, the global banking industry, the water-supply system, the military equipment, many embedded systems, and a great number more, strongly depend on systems-of-systems. The correct operation and continuous availability of these underlying systems-of-systems are fundamental for the functioning of our modern society.
Cybernetical Physics : From Control of Chaos to Quantum Control
This book is, perhaps, the first attempt to present a unified exposition of the subject and methodology of cybernetical physics as well as solutions to some of its problems. Emphasis of the book is on the examination of fundamental limits on energy transformation by means of control procedures in both conservative and dissipative systems.
Curve e superfici
The book provides an introduction to Differential Geometry of Curves and Surfaces. The theory of curves starts with a discussion of possible definitions of the concept of curve, proving in particular the classification of 1-dimensional manifolds. We then present the classical local theory of parametrized plane and space curves (curves in n-dimensional space are discussed in the complementary material): curvature, torsion, Frenet’s formulas and the fundamental theorem of the local theory of curves. Then, after a self-contained presentation of degree theory for continuous self-maps of the circumference
Current Developments in Solid-state Fermentation
Over the period of last two decades, there has been significant resurgence in solid-state fermentation due to the numerous benefits it offers, especially in the engineering and environmental aspects. SSF has shown much promise in the development of several bioprocesses and products. This resurgence gained further momentum during the last 5-6 years with the developments in fundamental and applied aspects. A good deal of information has been generated in published literature and patented information. Several commercial ventures have come up based on SSF in different parts of the world. The contents are organized into four parts: Part 1 deals with the General and Fundamentals aspects of SSF; Part 2 deals with the production of bulk chemicals and products such as enzymes, organic acids, spores and mushrooms in SSF; Part 3 is on the use of SSF for specialty chemicals such as gibberellic acid, antibiotics and other pharmaceutically valuable secondary metabolites, pigments, and aroma compounds; Part 4 deals with the use of SSF miscellaneous application such as SSF for food and feed applications, agro-industrial residues as substrates in SSF and the production of silage and vermicompost.
CSS Mastery : Advanced Web Standards Solutions
This book is your indispensable guide to cutting-edge CSS development—all you need to work your way up to CSS professional. While CSS is a relatively simple technology to learn, it is a difficult one to master. When you first start developing sites using CSS, you will come across all kinds of infuriating browser bugs and inconsistencies. It sometimes feels like there are a million and one different techniques to master, spread across a bewildering array of websites. The range of possibilities seems endless and makes for a steep and daunting learning curve. It begins with a brief recap of CSS fundamentals such as the importance of meaningful markup, how to structure and maintain your code, and how the CSS layout model really works.
Crystallography and the World of Symmetry
Symmetry exists in realms from crystals to patterns, in external shapes of living or non-living objects, as well as in the fundamental particles and the physical laws that govern them. In fact, the search for this symmetry is the driving force for the discovery of many fundamental particles and the formulation of many physical laws. While one can not imagine a world which is absolutely symmetrical nor can one a world which is absolutely asymmetrical. These two aspects of nature are intermingled with each other inseparably. This is the basis of the existence of aperiodicity manifested in the liquid crystals and also quasi-crystals also discussed in Crystallography and the World of Symmetry.
Cryogenic Mixed Refrigerant Processes
Cryogenic refrigerators operating with refrigerant mixtures were developed under classified and proprietary programs for many years, and it was only after 1991 that the world realized the importance of the mixed refrigerant systems for cryogenic refrigeration. Mixed refrigerant cryogenic processes are also used in most large base load natural gas liquefaction plants. Hundreds of patents exist on different aspects of mixed refrigerant processes for liquefaction of natural gas, as well as the composition of mixtures for Joule-Thomson and other refrigerators. Still, the fundamental aspects of these processes continued to not receive the attention they deserve in open literature in the view of these commercial interests.
Crossroads of Entrepreneurship
Crossroads of Entrepreneurship presents works from scholars belonging to a number of different disciplines - business history, economics, sociology and management - and addresses a cross section of issues in the entrepreneurship field. Contributions are arranged in different sections, emphasizing dialogue across disciplines and paradigms, rather than boundaries between them. The first section of the work is a compilation of papers that trace the historical roots of study in entrepreneurship in different disciplinary domains, and highlight the fundamental issues addressed by past research. A second section gathers empirical studies adopting various methods and investigating different aspects of entrepreneurial action. The third section collects contributions investigating the development of entrepreneurship in different national settings. The work reveals a convergence of issues and interests, despite paradigmatic differences, and the potential benefits of more intense conversation across disciplines.
Critique de la valeur fondamentale = Critique of fundamental value
This work takes stock of the different conceptions of fundamental value in finance, the methods of its calculation and the ongoing debates in financial theory as in professional practices. The book reports on the alternatives offered by mathematical modeling.
Critical Infrastructures at Risk : Securing the European Electric Power System
This book explores the potential risks and vulnerabilities of the European electricity infrastructure, other infrastructures and our society as whole increasingly depend on. The work was initiated by the need to verify the potential effects of the ongoing market and technical transformation of the infrastructure, which is fundamentally changing its operation and performance. The final aim is to set the basis for an appropriate industrial and political European-wide response to the risk challenges.
Craig’s Restorative Dental Materials ; 1st ed.
Covers everything you need to know to understand the science of selecting dental materials when designing and fabricating restorations. It begins with fundamentals and moves on to advanced skills in the manipulation of dental materials, providing insight on the latest advances and research along the way. From an expert author team led by Ronald Sakaguchi, this comprehensive resource is considered to be the standard in the field of dental restorations.
Cours doptique : Simulations et exercices résolus avec Maple, Matlab, Mathematica, Mathcad = Optics course: Simulations and exercises solved with Maple, Matlab, Mathematica, Mathcad
Intended for students at the L and M levels of the university as well as for engineers wishing to study certain subjects in greater depth. It covers all the themes of a traditional optics course, from geometric optics to holography, interference, diffraction, coherence and the use of the Fourier transform for spectroscopy. The presentation is developed from mathematical models deriving from typical situations and fundamental examples which are presented in the form of computer programs ready to be implemented. These programs are also available on the CD accompanying the book, for each of the following scientific programming environments: Matlab, Maple, Mathematica and Mathcad. Thus, the reader will be able to modify the parameters of the examples proposed to adapt them to new situations.
Cost-Based Oracle Fundamentals
In Cost-Based Oracle Fundamentals, the first book in a series of three, Jonathan Lewis—one of the foremost authorities in this field—describes the most commonly used parts of the model, what the optimizer does with your statistics, and why things go wrong. With this information, you'll be in a position to fix entire problem areas, not just single SQL statements, by adjusting the model or creating more truthful statistics.
Corporate finance workbook : Economic foundations and financial modeling
Corporate Finance: Economic Foundations and Financial Modeling Workbook, will help you: Synthesize essential material from the main Corporate Finance text using real-world applications. Understand the key fundamentals of the corporate finance discipline. Work toward specific chapter objectives to internalize important information.
Core Java ; Vol. I : Fundamentals ; 12th ed.
The definitive guide to writing robust, maintainable code. Whatever version of Java you are using—up to and including Java 17—this book will help you achieve a deep and practical understanding of the language and APIs. With hundreds of realistic examples, Cay S. Horstmann reveals the most powerful and effective ways to get the job done.
Coping with Uncertainty : Modeling and Policy Issues
Ongoing global changes bring fundamentally new scientific problems requiring new concepts and tools. A key issue concerns a vast variety of practically irreducible uncertainties, which challenge our traditional models and require new concepts and analytical tools. The complexity of new problems does not allow to achieve enough certainty by increasing the resolution of models or by bringing in more links. Hence, new tools for modeling and management of uncertainty are needed, as given in this book.
Convex Functional Analysis
This volume is dedicated to the fundamentals of convex functional analysis. It presents those aspects of functional analysis that are extensively used in various applications to mechanics and control theory. The purpose of the text is essentially two-fold. On the one hand, a bare minimum of the theory required to understand the principles of functional, convex and set-valued analysis is presented. Numerous examples and diagrams provide as intuitive an explanation of the principles as possible. On the other hand, the volume is largely self-contained. Those with a background in graduate mathematics will find a concise summary of all main definitions and theorems.
Controlled Markov Processes and Viscosity Solutions
This book is intended as an introduction to optimal stochastic control for continuous time Markov processes and to the theory of viscosity solutions. Stochastic control problems are treated using the dynamic programming approach. It approachs stochastic control problems by the method of dynamic programming. The fundamental equation of dynamic programming is a nonlinear evolution equation for the value function. For controlled Markov diffusion processes, this becomes a nonlinear partial differential equation of second order, called a Hamilton-Jacobi-Bellman (HJB) equation. Typically, the value function is not smooth enough to satisfy the HJB equation in a classical sense. Viscosity solutions provide framework in which to study HJB equations, and to prove continuous dependence of solutions on problem data. The theory is illustrated by applications from engineering, management science, and financial economics.
Control of Dead-time Processes
Control of Dead-time Processes introduces the fundamental techniques for controlling dead-time processes ranging from simple monovariable to complex multivariable cases. Solutions to dead-time-process-control problems are studied using classical proportional-integral-differential (PID) control for the simpler examples and dead-time-compensator (DTC) and model predictive control (MPC) methods for progressively more complex ones. Although MPC and DTC approaches originate in different areas of control, both use predictors to overcome the effects of dead time. Using this fact, the text analyses MPC as a dead-time-compensation strategy and shows how it can be used synergistically with robust DTC tuning methodologies.
