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Dynamics of Rods
The book consists of nine chapters and appendices and may be conventionally divided into two parts. That is, Chapters 1 to 6 contain, in the main, theoretical material, whereas Chapters 7 to 9 illustrate the application of the theoretical results to problems of practical interest. Problems for self-study are found in Chapters 3, 5, and 7. The solutions to most of the problems are given in Appendix B.
Dynamics of Complex Interconnected Systems : Networks and Bioprocesses
This volume comprises the proceedings of the NATO Advanced Study Institute on Dynamics of Complex Interconnected Biosensor Systems: Networks and Bioprocesses,held at Geilo, Norway, 11-21 April 2005.
Dynamical Vision ; ICCV 2005 and ECCV 2006 Workshops, WDV 2005 and WDV 2006, Beijing, China, October 21, 2005, Graz, Austria, May 13, 2006, Revised Papers
Classical multiple-view geometry studies the reconstruction of a static scene - served by a rigidly moving camera. However, in many real-world applications the scene may undergo much more complex dynamical changes. For instance, the scene may consist of multiple moving objects (e.g., a trafic scene) or arti- lated motions (e.g., a walking human) or even non-rigid dynamics (e.g., smoke, fire, or a waterfall). In addition, some applications may require interaction with the scene through a dynamical system (e.g., vision-guided robot navigation and coordination). To study the problem of reconstructing dynamical scenes, many new al- braic, geometric, statistical, and computational tools have recently emerged in computer vision, computer graphics, image processing, and vision-based c- trol.
Dynamic Games : Theory and Applications
Dynamic games continue to attract strong interest from researchers interested in modelling competitive as well as conflict situations exhibiting an intertemporel aspect. Applications of dynamic games have proven to be a suitable methodology to study the behaviour of players (decision-makers) and to predict the outcome of such situations in many areas including engineering, economics, management science, military, biology and political science. Dynamic Games: Theory and Applications collects thirteen articles written by established researchers.
Duality for Nonconvex Approximation and Optimization
Most recently, many researchers have been studying more complicated classes of problems that still can be studied by means of convex analysis, so-called "anticonvex" and "convex-anticonvex" optimizaton problems.
Dualisability : Unary Algebras and Beyond
Natural duality theory is one of the major growth areas within general algebra. This text provides a short path to the forefront of research in duality theory. It presents a coherent approach to new results in the area, as well as exposing open problems. Unary algebras play a special role throughout the text. Individual unary algebras are relatively simple and easy to work with. But as a class they have a rich and complex entanglement with dualisability. This combination of local simplicity and global complexity ensures that, for the study of natural duality theory, unary algebras are an excellent source of examples and counterexamples.
Drug transporters : Molecular characterization and role in drug disposition
Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.
Drug repurposing : A new fashion for a new hope
The repurposing of drugs is becoming increasingly attractive as it avoids the long process and cost implications associated with bringing a novel drug to market i.e., drug repurposing is cost effective and time saving. This study will discuss the repositioning of several drugs that belong to different pharmaceutical classifications such as antimicrobials (itraconazole and fluoroquinolones), anti-diabetic agents (metformin and sodium glucose co-transporter 2 inhibitors), cardiovascular drugs (β-blockers and digoxin), anticonvulsants (topiramate), immunosuppressants (sirolimus), non-steroidal anti-inflammatory drugs (NSAIDs e.g., COX inhibitors), and cholesterol lowering drugs (statins).
Drug discovery with privileged building Blocks : Tactics in medicinal chemistry
Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book.
Drug Delivery Systems
Expands on the previous editions with a discussion of new and updated methods used to study drug delivery. Chapters cover topics such as drug delivery in cancer and intrathecal delivery of analgesics in humans. The increasing role of nanobiotechnology is reflected in eight of the sixteen chapters that include synthesis of gold nanoparticles; targeted siRNA delivery; and lipid nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Draughtsmen, Botanists and Nature : The Construction of Eighteenth-Century Botanical Illustrations
This book is the first in-depth study of eighteenth-century botanical illustrations, and its findings offer a completely new insight into the working practices of the botanists and scientific draughtsmen of this period. The author describes the different production stages of these illustrations, traces their uses by means of the private correspondence of participants and the documentation of the learned societies and academies, and explores their visual language, with particular emphasis placed on the difficult issue of colour. Finally, and for the first time, the author presents a convincing description of how these botanical illustrations developed.
Doing integrated history and philosophy of science : A case study of the origin of genetics
offers an integrated historical and philosophical examination of the origin of genetics. The author contends that an integrated HPS analysis helps us to have a better understanding of the history of genetics, and sheds light on some general issues in the philosophy of science. consists of three parts. It begins with historical problems, revisiting the significance of the work of Mendel, de Vries, and Weldon. Then it turns to integrated HPS problems, developing an exemplar-based analysis of the development and the progress in early genetics. Finally, it discusses philosophical problems: conceptual change, evidence, and theory choice.
Do-All Computing in Distributed Systems : Cooperation in the Presence of Adversity
Do-All Computing in Distributed Systems: Cooperation in the Presence of Adversity is the first book that presents an in depth study of cooperation problems, abstracted in terms of the Do-All problem, where a collection of processors cooperatively perform a collection of independent tasks in the presence of adversity.
DNA Binders and Related Subjects
advances in technology and the application of new methods to outstanding problems have played a major part in the development of ideas about drug-nucleic acid recognition. The field has undergone an explosive diversification as wider and wider problems became accessible to study using the new ideas and techniques. This volume reflects that diversification by offering accounts of selected areas that illustrate recent advances in the study of ligand–nucleic acid binding over disparate areas of the subject. There are chapters dealing specifically with the invention and application of new methodology, and a particularly thoughtful essay on the interpretation of X-ray diffraction data which may not be as straightforward as is often imagined. Other chapters illustrate the diversity and complexity of drug-DNA binding from several perspectives, referring to particular groups of related compounds or the potential attractions of the less-preferred DNA major groove as a target for nucleotide sequence recognition by ligands.
DNA barcoding : Methods and protocols
Covers the latest advancements and methods used to study DNA barcoding. The chapters in this book are organized into six parts: theory, DNA manipulation, specialized barcoding methods, analysis of DNA barcodes, completing a successful DNA barcode project, and barcoding as citizen science. Part One looks at several theoretical issues in DNA barcoding concerned with DNA barcodes that can and should be used. Part Two discusses protocols for processing samples into DNA barcodes, including DNA isolation, sequencing and managing samples, and the resulting DNA barcodes. Part Three explores the next generation of DNA barcoding such as FRET-based detection, dual nanopore detection, skimming, and closed-tube methods. Part Four addresses programs and websites that handle DNA barcoding data, and includes character-based approaches, barcode gap methods, integrated approaches, and Barcode of Life Database
Divinity Compromised : A Study of Divine Accommodation in the Thought of John Calvin
This book is the first monograph devoted to the theme of divine accommodation in the writings of John Calvin to appear in any language. The work offers careful analysis of the topic along several different lines: it analyzes the character of Calvin’s thinking on accommodation. It gives an account of the ways in which accommodation expresses itself in his writings. It probes the question of the penetration of accommodation into Calvin’s theology and particularly its implications for his doctrine of God. And it compares Calvin’s handling of accommodation with that of other exegetes in order to set his thinking in context.
Distributed systems and mobile computing
About Distributed Systems and Mobile Computing. This is a branch of Computer Science devoted to the study of systems whose components are in different physical locations and have limited communication capabilities. Such components may be static, often organized in a network, or may be able to move in a discrete or continuous environment. The theoretical study of such systems has applications ranging from swarms of mobile robots (e.g., drones) to sensor networks, autonomous intelligent vehicles, the Internet of Things, and crawlers on the Web. The book includes five articles. Two of them are about networks: the first one studies the formation of networks by agents that interact randomly and have the ability to form connections; the second one is a study of clustering models and algorithms. The three remaining articles are concerned with autonomous mobile robots operating in continuous space.
Distributed Multimedia Retrieval Strategies for Large Scale Networked Systems
Distributed Multimedia Retrieval Strategies for Large Scale Networked Systems presents an up-to-date research status in the domain of distributed video retrieval. This professional book will include several different techniques that are in place for long duration video retrieval. An experimentally tested technology under the JINI platform, demonstrates a practical working system which serves as a feasibility study, as well as the first step in realizing such a technology.
Disseminative Capabilities : A Case Study of Collaborative Product Development in the Automotive Industry
Nowadays, cooperating in Product Development seems to be a dominant strategy to lower costs and risks, to fully utilize capacities, and to gain access to lacking knowledge assets. Oppat analyzes cooperations in Product Development with a special focus on the automotive industry. He seeks answers to the question of how knowledge transfer between involved partners takes place. Although knowledge transfer and its success levers (e.g. absorptive capacity) are well-researched phenomena, equivalent investigations of the sender and her capabilities (DiC - Disseminative Capabilities) impacting inter-organizational transfer success are lacking. The in-depth case studies conducted concentrate on joint car development projects between Magna Steyr, an Austrian-based company, and German-based BMW, Mercedes Benz, and Audi. The research results clearly indicate that DiC have an impact on the knowledge transfer process and can explain why the analyzed projects differ in terms of transfer success. Based on the research findings, this work provides managerial implications for all eight dimensions of DiC and, by deploying insights from the empirical investigations, outlines ways to develop them successfully.
