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Cancer drug safety and public health policy : A changing landscape
Description and analysis of recent developments and current trends in health policy with regard to cancer drug safety. Opens with an overview of pharmacovigilance for cancer blockbuster drugs, covering both general considerations and efforts to develop a structured framework for the identification and reporting of adverse drug reactions (ADRs). A number of important examples of serious ADRs to hematology and oncology drugs are then reviewed, with evaluation of the lessons learned and the policy implications of the ensuing legal cases and their settlements. Further, the difficulty of reporting such blockbuster side effects in the medical literature is explored in an empirical study. Significant advances have been achieved in analytic methods for the identification of ADRs, and here there is a particular focus on the value of optimal discriminant analysis. Finally, the impacts on pharmacovigilance and drug safety of the huge fines paid under the U.S. False Claims Act relating to the defrauding of governmental programs also receive careful attention – these fines are playing an important role in changing the landscape for pharmaceutical safety.
Canadian Semantic Web
This book covers a variety of well known topics of interest to practitioners in industry and research scientists. The range of topics includes languages, tools and methodologies for the semantic Web, semantic Web-based ontology management and engineering, semantic Web services, practical applications of the semantic Web techniques, artificial intelligence methods and tools for the semantic Web, software agents on the semantic Web, visualization and modeling of the semantic Web. The goal of this book is to provide a state-of-the-art review of the research as well as to introduce topics of interest to experts.
C++ /CLI : The Visual C++ Language for .NET
C++/CLI: The Visual C++ Language for .NET introduces Microsoft's extensions to the C++ syntax that allow you to target the common language runtime the key to the heart of the .NET 3.0 platform. In 12 no-fluff chapters, Microsoft insider Gordon Hogenson takes you into the core of the C++/CLI language and explains both how the language elements work and how Microsoft intends them to be used.
Business Ethics of Innovation
Firms that operate in a market economy often depend upon innovations in order to achieve competitive advantages that sustainably secure their survival. Business ethics is thus largely concerned with questions about the decisional freedoms involved in innovation processes. Innovations oftentimes raise novel questions about the role of the state or the structure of society. Business ethics needs to provide a framework for balancing the different perspectives, values, and interests at stake. This balance must be achieved at the level of the firm in order to facilitate adequate long term decisions, but it should also be sought at higher, including regulatory, levels. Achieving this balance will require an ethical framework for entrepreneurial action.
Business agility and information technology diffusion ; IFIP TC8 WG 8.6 International working Conference, May 8-11, 2005, Atlanta, Georgia, USA
Addresses issues related to business agility and the diffusion of Information Technology (IT). Success, even survival, in today's business environment has been made complex and difficult by technologically-based competitive pressure. One promising strategy is to be agile and ready to adapt quickly to changes in the environment or market. Such strategy takes shape as an agile software development, agile manufacturing, agile modeling and agile iterations. In contrast, successful IT diffusion is known to be a process that takes time and careful effort. Many IT projects that succeeded in developing a product have subsequently failed in changing the behavior of the target group when diffusion just didn't happen. Therefore this volume responds to the question: What is the relationship between agility and IT diffusion? The book's scope will cover information systems and technology issues, as well as organizational and managerial issues, related to agility and IT diffusion. The planned perspectives include topics such as diffusion of agile methods, enabling business agility with IT, creating agile environments that facilitate diffusion of IT, theories and frameworks for understanding diffusion and agility issues, best practices relating to business agility and IT diffusion, software process improvement and agility, diffusion studies of specific agile technologies, and impacts of diffusion of IT agile methods.
Building Spring 2 Enterprise Applications
This book covers the first steps of using Spring while discussing the relevant technologies that Spring can be integrated with, what to be aware of, and how working with Spring makes them easier to use. Focuses on the most useful features of Spring, including persistence and transaction management as well as the complete Spring web tools portfolio. Introduces three-tier application design and how to test these designs.
Building ASIPs : The Mescal Methodology
A number of system designers use ASIP's rather than ASIC's to implement their system solutions. This book gives a comprehensive methodology for the design of these application-specific instruction processors (ASIPs). It includes demonstrations of applications of the methodologies using the Tipi research framework.
Browning Agents and Active Particles : Collective Dynamics in the Natural and Social Sciences
Lays out a vision for a coherent framework for understanding complex systems'' (from the foreword by J. Doyne Farmer). By developing the genuine idea of Brownian agents, the author combines concepts from informatics, such as multiagent systems, with approaches of statistical many-particle physics. This way, an efficient method for computer simulations of complex systems is developed which is also accessible to analytical investigations and quantitative predictions. The book demonstrates that Brownian agent models can be successfully applied in many different contexts, ranging from physicochemical pattern formation, to active motion and swarming in biological systems, to self-assembling of networks, evolutionary optimization, urban growth, economic agglomeration and even social systems.
Brexit and the Control of Tobacco Illicit Trade
This book assesses the consequences of Brexit for the control of illicit trade in tobacco products in the UK and EU. Based on the currently applicable legal framework, it examines the significance of a possible non-application of the acquis communautaire in the UK in matters relating to anti-illicit trade in tobacco legislation.
Bone : Biology, harvesting, and grafting for dental implants
Dental implant placement often requires bone grafting to ensure sufficient bony support for the implants being placed. Depending on the biologic conditions of the patient, including the level of bone atrophy and the status of the remaining teeth in the mouth, more adjunctive procedures like bone harvesting or sinus grafting may be required. This book covers it all, from the biology of bone and how dental implants work within that framework to the many procedures for harvesting bone and using it to augment sites for implant placement. The different types of bone grafts and membranes are discussed as well as procedures to preserve the alveolar ridge following tooth extraction.
Bond Portfolio Optimization
1 The tools of modern portfolio theory are in general use in the equity markets, either in the form of portfolio optimization software or as an accepted frame- 2 work in which the asset managers think about stock selection. In the ?xed income market on the other hand, these tools seem irrelevant or inapplicable. Bond portfolios are nowadays mainly managed by a comparison of portfolio 3 4 risk measures vis ¶a vis a benchmark. The portfolio manager’s views about the future evolution of the term structure of interest rates translate th- selves directly into a positioning relative to his benchmark, taking the risks of these deviations from the benchmark into account only in a very crude 5 fashion, i.e. without really quantifying them probabilistically. This is quite surprising since sophisticated models for the evolution of interest rates are commonly used for interest rate derivatives pricing and the derivation of ?xed 6 income risk measures.
Blockchain : Empowering Secure Data Sharing
The book explains the security architecture model and the practice of building data sharing from the blockchain infrastructure, allowing readers to understand the importance of data sharing security based on the blockchain framework, as well as the threats to security and privacy. Further, by presenting specific data sharing case studies, it offers insights into solving data security sharing problems in more practical fields. The book is intended for readers with a basic understanding of the blockchain infrastructure, consensus mechanisms, smart contracts, secure multiparty computing, homomorphic encryption and image retrieval technologies.
Blind Speech Separation
This is the first book to provide a cutting edge reference to the fascinating topic of blind source separation (BSS) for convolved speech mixtures. Through contributions by the foremost experts on the subject, the book provides an up-to-date account of research findings, explains the underlying theory, and discusses potential applications. The individual chapters are designed to be tutorial in nature with specific emphasis on an in-depth treatment of state of the art techniques. Blind Speech Separation is divided into three parts:Part 1 presents overdetermined or critically determined BSS. Here the main technology is independent component analysis (ICA). ICA is a statistical method for extracting mutually independent sources from their mixtures. Part 2 addresses underdetermined BSS, where there are fewer microphones than source signals. Here, the sparseness of speech sources is very useful; we can utilize time-frequency diversity, where sources are active in different regions of the time-frequency plane.Part 3 presents monaural BSS where there is only one microphone. Here, we can separate a mixture by using the harmonicity and temporal structure of the sources. We can build a probabilistic framework by assuming a source model, and separate a mixture by maximizing the a posteriori probability of the sources.
Biosimilars : Regulatory, clinical, and biopharmaceutical development
Provides a comprehensive overview of the biosimilar regulatory framework, the development process and clinical aspects for development of biosimilars. The development path of a biosimilar is just as unique as a development path of a new drug, tailored by the mechanism of action, the quality of the molecule, published information on the reference product, the current competitive environment, the target market and regulatory guidance, and most importantly, the emerging totality of evidence for the proposed biosimilar during development.
Bio-mechanisms of swimming and flying ; Fluid dynamics, biomimetic robots, and sports science
This book follows "Bio-mechanisms of Animals in Swimming and Flying" published in 2004 including 11 chapters. This time, the book includes 31 chapters on the latest researches into natural autonomous systems and locomotion in both flying and swimming organisms. The area of sports science such as analysis and simulation of human swimming is newly added. The computational frameworks for the modeling, simulation and optimization of animals in swimming and flying demonstrate an important role in the progress of interdisciplinary work in the fields of biology and engineering. An innovative technology is exhibited for the flight of an insect size micro air vehicle. Neuronal science is not only unveiling the locomotion mechanisms of swimming in fish from the aspect of the neuronal activities, but also applied to underwater biomimetic robots. The interdisciplinary works are exhibited in the fields of biology and engineering, yielding real-world benefits in innovative technologies.
Biological invaders in inland waters : Profiles, distribution, and threats
The book examines the identity, distribution, and impact of freshwater non-indigenous species and the dynamics of their invasion. Rather than providing a broad and comprehensive review of the issue, Biological invaders in inland waters focuses on old and new invaders and also raises questions and opens perspectives that provide a starting point for further research. The ultimate purpose of this book is to help define a more general framework for our knowledge of invasions in fresh waters. Such a framework will be indispensable to the planning of a science-based management program.
Bioethics and the Holocaust : A Comprehensive Study in How the Holocaust Continues to Shape the Ethics of Health, Medicine and Human Rights
This book offers a framework for understanding how the Holocaust has shaped and continues to shape medical ethics, health policy, and questions related to human rights around the world. The field of bioethics continues to face questions of social and medical controversy that have their roots in the lessons of the Holocaust, such as debates over beginning-of-life and medical genetics, end-of-life matters such as medical aid in dying, the development of ethical codes and regulations to guide human subject research, and human rights abuses in vulnerable populations. As the only example of medically sanctioned genocide in history, and one that used medicine and science to fundamentally undermine human dignity and the moral foundation of society, the Holocaust provides an invaluable framework for exploring current issues in bioethics and society today. This book, therefore, is of great value to all current and future ethicists, medical practitioners and policymakers – as well as laypeople.
Beyond the Worst-Case Analysis of Algorithms
There are no silver bullets in algorithm design, and no single algorithmic idea is powerful and flexible enough to solve every computational problem. Nor are there silver bullets in algorithm analysis, as the most enlightening method for analyzing an algorithm often depends on the problem and the application. However, typical algorithms courses rely almost entirely on a single analysis framework, that of worst-case analysis, wherein an algorithm is assessed by its worst performance on any input of a given size. The purpose of this book is to popularize several alternatives to worst-case analysis and their most notable algorithmic applications, from clustering to linear programming to neural network training. Forty leading researchers have contributed introductions to different facets of this field, emphasizing the most important models and results, many of which can be taught in lectures to beginning graduate students in theoretical computer science and machine learning.
Beginning xml with C# 2008 : From novice to professional
Beginning XML with C# 2008 focuses on XML and how it is used within .NET 3.5. As you'd expect of a modern application framework, .NET 3.5 has extensive support for XML in everything from data access to configuration, from raw parsing to code documentation. This book demystifies all of this. It explains the basics of XML as well as the namespaces and objects you need to know in order to work efficiently with XML. You will see clear, practical examples that illustrate best practices in action. With this book, you'll learn everything you need to know from the basics of reading and writing XML data to using the DOM, from LINQ and SQL Server integration to SOAP and web services.
Beginning Web Development, Silverlight, and ASP.NET AJAX : From novice to professional
Beginning Web Development, Silverlight, and ASP.NET AJAX: From Novice to Professional aims to give you the skills you need to start building web applications with Microsoft's next–generation technology as quickly as possible. Whether you're interested in ASP.NET AJAX, Silverlight, or the technologies that support them (WPF, WCF, WF, etc.), this book is the starting point that you need. It adopts a “zero to hero” approach that concentrates on achieving practical results you can use in real projects rather than presenting a deep academic treatment that can't be immediately applied.
